"Down-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015536
|
| MeSH Number(s) |
G02.111.087.225 G02.149.115.225 G05.355.315.200 G07.690.812.230 G07.700.680.230
|
| Concept/Terms |
Down-Regulation- Down-Regulation
- Down Regulation
- Downregulation
- Down-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Down-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Down-Regulation".
This graph shows the total number of publications written about "Down-Regulation" by people in this website by year, and whether "Down-Regulation" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 3 | 4 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 5 | 5 |
| 2005 | 1 | 4 | 5 |
| 2006 | 0 | 5 | 5 |
| 2007 | 1 | 6 | 7 |
| 2008 | 1 | 3 | 4 |
| 2009 | 0 | 5 | 5 |
| 2010 | 0 | 5 | 5 |
| 2011 | 2 | 4 | 6 |
| 2012 | 1 | 7 | 8 |
| 2013 | 1 | 7 | 8 |
| 2014 | 1 | 5 | 6 |
| 2015 | 1 | 4 | 5 |
| 2016 | 3 | 5 | 8 |
| 2017 | 0 | 4 | 4 |
| 2018 | 0 | 8 | 8 |
| 2019 | 1 | 2 | 3 |
| 2020 | 0 | 2 | 2 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Down-Regulation" by people in Profiles.