A set of opposing, nonequilibrium reactions catalyzed by different enzymes which act simultaneously, with at least one of the reactions driven by ATP hydrolysis. The results of the cycle are that ATP energy is depleted, heat is produced and no net substrate-to-product conversion is achieved. Examples of substrate cycling are cycling of gluconeogenesis and glycolysis pathways and cycling of the triglycerides and fatty acid pathways. Rates of substrate cycling may be increased many-fold in association with hypermetabolic states resulting from severe burns, cold exposure, hyperthyroidism, or acute exercise.

Descriptor ID	D015219
MeSH Number(s)	G02.111.087.820 G02.149.115.820 G03.495.335.835
Concept/Terms	Substrate Cycling Substrate Cycling Cycling, Substrate Cyclings, Substrate Substrate Cyclings Futile Cycles Futile Cycles Cycle, Futile Cycles, Futile Futile Cycle Futile Substrate Cycles Cycle, Futile Substrate Cycles, Futile Substrate Futile Substrate Cycle Substrate Cycle, Futile Substrate Cycles, Futile Futile Substrate Cycling Cycling, Futile Substrate Cyclings, Futile Substrate Futile Substrate Cyclings Substrate Cycling, Futile Substrate Cyclings, Futile Futile Cycling Cycling, Futile Cyclings, Futile Futile Cyclings

Below are MeSH descriptors whose meaning is more general than "Substrate Cycling".

Below are MeSH descriptors whose meaning is related to "Substrate Cycling".

Below are MeSH descriptors whose meaning is more specific than "Substrate Cycling".