"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
|
| MeSH Number(s) |
G02.111.087.800 G02.149.115.800 G04.299.880
|
| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
|
Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 2 | 3 |
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 1 | 1 |
| 1997 | 2 | 0 | 2 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 3 | 5 | 8 |
| 2002 | 3 | 10 | 13 |
| 2003 | 3 | 6 | 9 |
| 2004 | 6 | 8 | 14 |
| 2005 | 4 | 11 | 15 |
| 2006 | 1 | 9 | 10 |
| 2007 | 10 | 18 | 28 |
| 2008 | 13 | 18 | 31 |
| 2009 | 11 | 11 | 22 |
| 2010 | 8 | 26 | 34 |
| 2011 | 10 | 15 | 25 |
| 2012 | 16 | 25 | 41 |
| 2013 | 13 | 34 | 47 |
| 2014 | 10 | 36 | 46 |
| 2015 | 14 | 25 | 39 |
| 2016 | 5 | 29 | 34 |
| 2017 | 8 | 19 | 27 |
| 2018 | 5 | 23 | 28 |
| 2019 | 7 | 29 | 36 |
| 2020 | 7 | 14 | 21 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 3 | 3 |
| 2024 | 1 | 2 | 3 |
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.