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Liliya M. Yamaleyeva MD, MS, FAHA

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentSurgery, Hypertension
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    R21HL110072     (BROSNIHAN, KATHLEEN BRIDGET)Aug 1, 2012 - May 31, 2015
    NIH
    ACE2 Deficiency: A new model of maternal and fetal growth restriction.
    Role: Co-Principal Investigator
    13SDG17390009     (YAMALEYEVA, LILIYA M)Jul 1, 2013 - Jun 30, 2018
    AHA
    The Role of ACE2 in Pregnancy
    Role: Principal Investigator
    R21HD086357     (YAMALEYEVA, LILIYA M)Sep 17, 2015 - Aug 31, 2018
    NIH
    Longitudinal Assessments of Placental Oxygenation and Perfusion Using Ultrasound and Photoacoustics.
    Role: Principal Investigator
    19TPA34910092     (YAMALEYEVA, LILIYA M)Jul 1, 2019 - Jun 30, 2022
    AHA
    ACE2 and CD47 Interactions to Regulate Fetal Growth
    Role: Principal Investigator
    R01HL155420     (YAMALEYEVA, LILIYA M)Jul 1, 2021 - Apr 30, 2025
    NIH
    Endogenous Apelin Receptor Ligands and Early Stages of Preeclamptic Pregnancy
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Charles C Okechukwu, Nancy T Pirro, Mark C Chappell, Liliya M Yamaleyeva. Human Urinary Exosomes Contain Functional ACE2. Hypertension. 2021; 78(Suppl_1):AMP36. View Publication.
    2. Kozakiewicz ML, Zhang J, Leone-Kabler S, Yamaleyeva LM, McDonald AG, Brost BC, Howlett AC. Differential Expression of CB1 Cannabinoid Receptor and Cannabinoid Receptor Interacting Protein 1a in Labor. Cannabis Cannabinoid Res. 2021 Apr 16. PMID: 33998898.
      Citations:    
    3. Victor M Pulgar, Ibrahim Elsaangeedy, Liliya M Yamaleyeva. Sex Dimorphism in Prostaglandins’ Role in Thromboxane-dependent Contraction in the Rat Middle Cerebral Artery. Circulation. 2020; 142(Suppl_3):A15585. View Publication.
    4. Liliya M Yamaleyeva, Ebrahim Elsangeedy, Jeffrey S Willey, Victor M Pulgar. Sex Differences In Aortic Stiffness Following Simulated Microgravity In Middle Aged Rats. Hypertension. 2020; 76(Suppl_1):AP078. View Publication.
    5. Fatima Ryalat, N Cruz-Diaz, W Graham, T Gwathmey-Williams, PE Gallagher, EA Tallant, LM Yamaleyeva, DI Diz. Sex And Age Specific Circulating Aldosterone Changes In Transgenic Hypertensive (mRen2)27 Rats And Hannover Sprague Dawley (SD) Rats And Its Association With Blood Pressure And Cardiac Function. Hypertension. 2020; 76(Suppl_1):AP045. View Publication.
    6. Nildris Cruz Diaz, A'ja V Duncan, Wayne Graham, Brian Westwood, Patricia E. Gallagher, E. Ann Tallant, Mark C. Chappell, Liliya M. Yamaleyeva, Debra I. Diz. Enhanced Exercise Capacity By Muscadine Grape Extract Treatment Is Only Evident In Older Hypertensive Female Rats And Is Independent Of Blood Pressure. Hypertension. 2020; 76(Suppl_1):AP053. View Publication.
    7. Ebrahim Elsangeedy, Stephanie Rideout Danner, Liliya M Yamaleyeva. The Analysis Of Regional Placental Hemodynamics Using Combined Photoacoustic Imaging And Contrast-enhanced Ultrasound. Hypertension. 2020; 76(Suppl_1):AP226. View Publication.
    8. Brosnihan KB, Merrill DC, Yamaleyeva LM, Chen K, Neves L, Joyner J, Givner C, Lanier K, Moorefield C, Westwood B. Longitudinal study of angiotensin peptides in normal and pre-eclamptic pregnancy. Endocrine. 2020 08; 69(2):410-419. PMID: 32319014.
      Citations:    
    9. Melissa L. Kozakiewicz, Jie Zhang, Sandra Leone-Kabler, Liliya M. Yamaleyeva, Brian C. Brost, Allyn C. Howlett. CB1 cannabinoid receptor and cannabinoid receptor interacting protein in human myometrium and placenta during labor. AJOG. 2020; 222(1):S560; 902. View Publication.
    10. Elizabeth Stirling, Adam Wilson, Mitra Kooshki, Lilya Yamaleyeva, Guanxu Jin, Wei Zhang, Lance Miller, Pierre Triozzi, David Soto-Pantoja. The Thrombospondin-1/CD47 signaling axis serve as potential markers of immune checkpoint blockade response modulating immune cell bioenergetics in the tumor microenvironment. Journal for ImmunoTherapy of Cancer. 2019; 7(Suppl_1):O8; 190. View Publication.
    11. Fatima Ryalat, Liliya M Yamaleyeva, Nildris Cruz-Diaz, E A Tallant, Patricia E Gallagher, Debra I Diz. Chronic Muscadine Grape Extract Intake Improves Diastolic Function Associated With Lower Circulating Aldosterone in Hannover Sprague Dawley Male Rats. Hypertension. 2019; 74(Suppl_1):AP155. View Publication.
    12. Yamaleyeva LM, Brosnihan KB, Elsangeedy E, McGee C, Shi S, Caudell D, Miller C, Varagic J, Bader M, Dechend R, Shaltout HA. Systemic Outcomes of (Pyr1)-Apelin-13 Infusion at Mid-Late Pregnancy in a Rat Model with Preeclamptic Features. Sci Rep. 2019 06 12; 9(1):8579. PMID: 31189936.
      Citations:    
    13. Yismelin R. Feliz-Mosquea, Elizabeth Stirling, Katherine L. Cook, Adam Wilson, Manish Bharadwaj, Anthony J. Molina, Liliya Yamaleyeva, Pierre L. Triozzi, David R. Soto-Pantoja. Anti-CD47 immunotherapy regulates T cell metabolism and hypoxia in the tumor microenvironment. AACR; Cancer Res. 2018; 78(13):Abstract nr 3528. View Publication.
    14. Yamaleyeva LM, Brosnihan KB, Smith LM, Sun Y. Preclinical Ultrasound-Guided Photoacoustic Imaging of the Placenta in Normal and Pathologic Pregnancy. Mol Imaging. 2018 Jan-Dec; 17:1536012118802721. PMID: 30348036.
      Citations:    
    15. Liliya M Yamaleyeva, K. B Brosnihan, Tiffaney Bledsoe. Fetal Status Evaluation Using Photoacoustics and 3D Power Doppler Ultrasound. Hypertension. 2017; 70(Suppl_1):AP300. View Publication.
    16. Yamaleyeva LM, Sun Y, Bledsoe T, Hoke A, Gurley SB, Brosnihan KB. Photoacoustic imaging for in vivo quantification of placental oxygenation in mice. FASEB J. 2017 12; 31(12):5520-5529. PMID: 28842425.
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    17. Brosnihan KB, Pulgar VM, Bharadwaj MS, Neves LA, Yamaleyeva LM. Erratum to: Local intra-uterine Ang-(1-7) infusion attenuates PGE2 and 6-keto PGF1a in decidualized uterus of pseudopregnant rats. Reprod Biol Endocrinol. 2017 03 27; 15(1):22. PMID: 28347298.
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    18. Yamaleyeva LM, Lindsey SH. Potential for miRNAs as Biomarkers and Therapeutic Targets in Preeclampsia. Hypertension. 2017 04; 69(4):580-581. PMID: 28193710.
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    19. Liliya M Yamaleyeva, Tiffaney Bledsoe, K. Bridget Brosnihan. Photoacoustic Imaging - Novel In Vivo Quantification of Placental Hypoxia in a Mouse Model of Hypertensive Pregnancy. Hypertension. 2016; 68(Suppl_1):A029. View Publication.
    20. Smith LM, Varagic J, Yamaleyeva LM. Photoacoustic Imaging for the Detection of Hypoxia in the Rat Femoral Artery and Skeletal Muscle Microcirculation. Shock. 2016 11; 46(5):527-530. PMID: 27172152.
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    21. Brosnihan KB, Pulgar VM, Bharadwaj MS, Neves LA, Yamaleyeva LM. Local intra-uterine Ang-(1-7) infusion attenuates PGE2 and 6-keto PGF1a in decidualized uterus of pseudopregnant rats. Reprod Biol Endocrinol. 2016 10 18; 14(1):68. PMID: 27756404.
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    22. Yamaleyeva LM, Shaltout HA, Varagic J. Apelin-13 in blood pressure regulation and cardiovascular disease. Curr Opin Nephrol Hypertens. 2016 09; 25(5):396-403. PMID: 27258138.
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    23. Liliya M Yamaleyeva, K. Bridget Brosnihan, Carolynne McGee, Sara Shi, Jasmina Varagic, Michael Bader, Ralf Dechend, Hossam A Shaltout. Systemic Administration of (Pyr1)-Apelin-13 at Late Pregnancy Reduces Blood Pressure, Proteinuria, and Improves Autonomic Function in Preeclamptic Rats. Hypertension. 2015; 66(Suppl_1):A126. View Publication.
    24. Hossam A Shaltout, Liliya M Yamaleyeva, Michael Bader, Ralph Dechend, Bridget Brosnihan. Impairment of Autonomic Function Precedes Blood Pressure Elevation in Rat Model of Pre-eclampsia. Hypertension. 2015; 66(Suppl_1):AP175. View Publication.
    25. Yamaleyeva LM, Chappell MC, Brosnihan KB, Anton L, Caudell DL, Shi S, McGee C, Pirro N, Gallagher PE, Taylor RN, Merrill DC, Mertz HL. Downregulation of apelin in the human placental chorionic villi from preeclamptic pregnancies. Am J Physiol Endocrinol Metab. 2015 Nov 15; 309(10):E852-60. PMID: 26394665.
      Citations:    
    26. Pulgar VM, Yamaleyeva LM, Varagic J, McGee C, Bader M, Dechend R, Brosnihan KB. Functional changes in the uterine artery precede the hypertensive phenotype in a transgenic model of hypertensive pregnancy. Am J Physiol Endocrinol Metab. 2015 Nov 01; 309(9):E811-7. PMID: 26394667.
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    27. Yamaleyeva LM, Pulgar VM, Lindsey SH, Yamane L, Varagic J, McGee C, daSilva M, Lopes Bonfa P, Gurley SB, Brosnihan KB. Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity. Am J Physiol Endocrinol Metab. 2015 Jul 01; 309(1):E84-94. PMID: 25968580.
      Citations:    
    28. Brosnihan KB, Pulgar VM, Gallagher PE, Neves LA, Yamaleyeva LM. Local uterine Ang-(1-7) infusion augments the expression of cannabinoid receptors and differentially alters endocannabinoid metabolizing enzymes in the decidualized uterus of pseudopregnant rats. Reprod Biol Endocrinol. 2015 Jan 17; 13:5. PMID: 25596750.
      Citations:    
    29. Guimarães-Souza NK, Yamaleyeva LM, Lu B, Ramos AC, Bishop CE, Andersson KE. Superoxide overproduction and kidney fibrosis: a new animal model. Einstein (Sao Paulo). 2015 Jan-Mar; 13(1):79-88. PMID: 25993073.
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    30. Liliya M Yamaleyeva, Mark C Chappell, K. Bridget Brosnihan, Lauren Anton, Nancy Pirro, Carolynne McGee, David C Merrill, Heather L Mertz. Apelin as a Novel Therapeutic Target in Preeclampsia. Hypertension. 2014; 64(Suppl_1):A634. View Publication.
    31. Liliya M Yamaleyeva, Victor M Pulgar, Sarah H Lindsey, Jasmina Varagic, Carolynne M McGee, Larissa Yamane, K. Bridget Brosnihan. Uterine Artery Dysfunction in ACE2 Deficient Mice is Associated with Placental Hypoxia and Reduced Umbilical Flow. Hypertension. 2014; 64(Suppl_1):A092. View Publication.
    32. K. Bridget Brosnihan, Victor M Pulgar, Jasmina Varagic, Kimberly Oliva, Michael Bader, Ralf Dechend, Patricia Gallagher, Brian F Thomas, Megan Grabenauer, Liliya M Yamaleyeva. Increased Uterine Interimplantation Levels of Ang II, AT1R, and CB1R are Associated with Reduced Uterine Permeability at Early Pregnancy in a Transgenic Model of Preeclampsia. Hypertension. 2014; 64(Suppl_1):A577. View Publication.
    33. Victor M Pulgar, Liliya M Yamaleyeva, Jasmina Varagic, Carolynne M McGee, Michael Bader, Ralf Dechend, K. Bridget Brosnihan. Increased Role of COX-derived Prostanoids in Regulating Ang II Induced Uterine Artery Contraction at Early Pregnancy in a Transgenic Model of Preeclampsia. Hypertension. 2014; 64(Suppl_1):A579. View Publication.
    34. Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Dechend R, Howlett AC, Brosnihan KB. Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. Hypertension. 2014 Sep; 64(3):619-25. PMID: 24935942.
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    35. Yamaleyeva LM, Merrill DC, Ebert TJ, Smith TL, Mertz HL, Brosnihan KB. Hemodynamic responses to angiotensin-(1-7) in women in their third trimester of pregnancy. Hypertens Pregnancy. 2014 Nov; 33(4):375-88. PMID: 24842292.
      Citations:    
    36. Yamaleyeva LM, Neves LA, Coveleskie K, Diz DI, Gallagher PE, Brosnihan KB. AT1, AT2, and AT(1-7) receptor expression in the uteroplacental unit of normotensive and hypertensive rats during early and late pregnancy. Placenta. 2013 Jun; 34(6):497-502. PMID: 23602334.
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    37. Gyabaah K, Aboushwareb T, Guimaraes Souza N, Yamaleyeva L, Varner A, Wang HJ, Atala A, Yoo JJ. Controlled regulation of erythropoietin by primary cultured renal cells for renal failure induced anemia. J Urol. 2012 Nov; 188(5):2000-6. PMID: 22999549.
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    38. Yamaleyeva LM, Lindsey SH, Varagic J, Zhang LL, Gallagher PE, Chen AF, Chappell MC. Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat. J Cardiovasc Pharmacol. 2012 Jun; 59(6):529-38. PMID: 22370956.
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    39. Yamaleyeva LM, Guimaraes-Souza NK, Krane LS, Agcaoili S, Gyabaah K, Atala A, Aboushwareb T, Yoo JJ. Cell therapy with human renal cell cultures containing erythropoietin-positive cells improves chronic kidney injury. Stem Cells Transl Med. 2012 May; 1(5):373-83. PMID: 23197816.
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    40. Yamaleyeva LM, Gilliam-Davis S, Almeida I, Brosnihan KB, Lindsey SH, Chappell MC. Differential regulation of circulating and renal ACE2 and ACE in hypertensive mRen2.Lewis rats with early-onset diabetes. Am J Physiol Renal Physiol. 2012 Jun 01; 302(11):F1374-84. PMID: 22378820.
      Citations:    
    41. Guimaraes-Souza NK, Yamaleyeva LM, AbouShwareb T, Atala A, Yoo JJ. In vitro reconstitution of human kidney structures for renal cell therapy. Nephrol Dial Transplant. 2012 Aug; 27(8):3082-90. PMID: 22287659.
      Citations:    
    42. Brosnihan KB, Bharadwaj MS, Yamaleyeva LM, Neves LA. Decidualized pseudopregnant rat uterus shows marked reduction in Ang II and Ang-(1-7) levels. Placenta. 2012 Jan; 33(1):17-23. PMID: 22101031.
      Citations:    
    43. Bharadwaj MS, Strawn WB, Groban L, Yamaleyeva LM, Chappell MC, Horta C, Atkins K, Firmes L, Gurley SB, Brosnihan KB. Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction. Hypertension. 2011 Nov; 58(5):852-8. PMID: 21968754.
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    44. Lindsey SH, Yamaleyeva LM, Brosnihan KB, Gallagher PE, Chappell MC. Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. Hypertension. 2011 Oct; 58(4):665-71. PMID: 21844484.
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    45. Chappell MC, Westwood BM, Yamaleyeva LM. Differential effects of sex steroids in young and aged female mRen2.Lewis rats: a model of estrogen and salt-sensitive hypertension. Gend Med. 2008; 5 Suppl A:S65-75. PMID: 18395684.
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    46. Groban L, Yamaleyeva LM, Westwood BM, Houle TT, Lin M, Kitzman DW, Chappell MC. Progressive diastolic dysfunction in the female mRen(2). Lewis rat: influence of salt and ovarian hormones. J Gerontol A Biol Sci Med Sci. 2008 Jan; 63(1):3-11. PMID: 18245755.
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    47. Yamaleyeva LM, Pendergrass KD, Pirro NT, Gallagher PE, Groban L, Chappell MC. Ovariectomy is protective against renal injury in the high-salt-fed older mRen2. Lewis rat. . 2007 Oct; 293(4):H2064-71. PMID: 17630347.
      Citations:    
    48. Yamaleyeva LM, Gallagher PE, Vinsant S, Chappell MC. Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2. Lewis rats. . 2007 Feb; 292(2):R819-26. PMID: 17023669.
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    49. Chappell MC, Yamaleyeva LM, Westwood BM. Estrogen and salt sensitivity in the female mRen(2). Lewis rat. . 2006 Nov; 291(5):R1557-63. PMID: 16825422.
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