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Jian-xing Ma

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentBiochemistry
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentOphthalmology, Head & Neck Surgery

    TitleChair
    InstitutionWake Forest School of Medicine
    DepartmentBiochemistry


    Collapse Biography 
    Collapse education and training
    Jiangxi Medical College, NanchangMD08/1984Clinical Medicine
    Peking Union Medical University, BeijingMS08/1987Pharmacology
    Medical University of South Carolina, CharlestonPhD12/1993Biochemistry and Molecular Biology

    Collapse Research 
    Collapse research activities and funding
    R01EY028949     (MA, JIAN-XING)Sep 1, 2018 - Aug 31, 2021
    NIH
    A Novel Pathogenic Pathway for Diabetic Keratopathy
    Role: Principal Investigator
    R01EY032930     (MA, JIAN-XING)Aug 1, 2021 - Jun 30, 2026
    NIH
    Studies of retinyl ester hydrolase in the visual cycle
    Role: Principal Investigator
    R01EY033330     (MA, JIAN-XING ;TAKAHASHI, YUSUKE)May 1, 2022 - Apr 30, 2027
    NIH
    cGAS-STING signaling in diabetic retinopathy
    Role: Principal Investigator
    R01EY033477     (MA, JIAN-XING ;XU, QINGGUO)Sep 1, 2022 - Apr 30, 2027
    NIH
    Sustained release of fenofibrate for the treatment of diabetic retinopathy
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dong L, Cheng R, Ma X, Liang W, Hong Y, Li H, Zhou K, Du Y, Takahashi Y, Zhang X, Li X, Ma JX. Regulation of monocyte activation by PPARa through interaction with the cGAS-STING pathway. Diabetes. 2023 Apr 14. PMID: 37058417.
      Citations:    
    2. Liang W, Huang L, Whelchel A, Yuan T, Ma X, Cheng R, Takahashi Y, Karamichos D, Ma JX. Peroxisome proliferator-activated receptor-a (PPARa) regulates wound healing and mitochondrial metabolism in the cornea. Proc Natl Acad Sci U S A. 2023 Mar 28; 120(13):e2217576120. PMID: 36943878.
      Citations:    
    3. Hara M, Wu W, Malechka VV, Takahashi Y, Ma JX, Moiseyev G. PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle. Cell Rep. 2023 Feb 08; 42(2):112091. PMID: 36763501.
      Citations:    
    4. Wu W, Takahashi Y, Ma X, Moiseyev G, Ma JX. Environmental Light Has an Essential Effect on the Disease Expression in a Dominant RPE65 Mutation. Adv Exp Med Biol. 2023; 1415:415-419. PMID: 37440066.
      Citations:    
    5. Yuan T, Dong L, Pearsall EA, Zhou K, Cheng R, Ma JX. The Protective Role of Microglial PPARa in Diabetic Retinal Neurodegeneration and Neurovascular Dysfunction. Cells. 2022 Dec 01; 11(23). PMID: 36497130.
      Citations:    
    6. Ma X, Wu W, Liang W, Takahashi Y, Cai J, Ma JX. Modulation of cGAS-STING signaling by PPARa in a mouse model of ischemia-induced retinopathy. Proc Natl Acad Sci U S A. 2022 Nov 29; 119(48):e2208934119. PMID: 36409895.
      Citations:    
    7. Liang W, Huang L, Ma X, Dong L, Cheng R, Dehdarani M, Karamichos D, Ma JX. Pathogenic Role of Diabetes-Induced Overexpression of Kallistatin in Corneal Wound Healing Deficiency Through Inhibition of Canonical Wnt Signaling. Diabetes. 2022 Apr 01; 71(4):747-761. PMID: 35044447.
      Citations:    
    8. Wu W, Takahashi Y, Shin HY, Ma X, Moiseyev G, Ma JX. The interplay of environmental luminance and genetics in the retinal dystrophy induced by the dominant RPE65 mutation. Proc Natl Acad Sci U S A. 2022 Mar 15; 119(11):e2115202119. PMID: 35271391.
      Citations:    
    9. Ma X, Takahashi Y, Wu W, Chen J, Dehdarani M, Liang W, Shin YH, Benyajati S, Ma JX. Soluble very low-density lipoprotein receptor (sVLDLR) inhibits fibrosis in neovascular age-related macular degeneration. FASEB J. 2021 Dec; 35(12):e22058. PMID: 34820908.
      Citations:    
    10. Ma X, Takahashi Y, Wu W, Liang W, Chen J, Chakraborty D, Li Y, Du Y, Benyajati S, Ma JX. ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium. J Biol Chem. 2021 Oct; 297(4):101185. PMID: 34509473.
      Citations:    
    11. Hu Y, Chen Y, Ding L, He X, Takahashi Y, Gao Y, Shen W, Cheng R, Chen Q, Qi X, Boulton ME, Ma JX. Pathogenic role of diabetes-induced PPAR-a down-regulation in microvascular dysfunction. Proc Natl Acad Sci U S A. 2013 Sep 17; 110(38):15401-6. PMID: 24003152.
      Citations:    
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