First Header Logo Second Header Logo

Yusuke Takahashi PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentBiochemistry
Address
vCardDownload vCard

    Collapse Biography 
    Collapse education and training
    Faculty of Science and Engineering, Ishinomaki Senshu University, Miyagi, JAPANBachelor03/1995 Biotechnology
    Graduate School of Information Sciences, Tohoku University, Miyagi, JAPANMaster03/1997Information Sciences
    Graduate School of Information Sciences, Tohoku University, Miyagi, JAPANPh.D.03/2000Information Sciences
    Department of Biology, University of Washington, Seattle, WA03/2003Molecular Biology
    Department of Biology, Syracuse University, Syracuse, NY05/2003Molecular Biology
    Department of Biology, Emory University, Atlanta, GA06/2004Molecular Biology
    Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK12/2007Endocrinology and Diabetes

    Collapse Research 
    Collapse research activities and funding
    R01EY032930     (MA, JIAN-XING)Aug 1, 2021 - Jun 30, 2026
    NIH
    Studies of retinyl ester hydrolase in the visual cycle
    Role: Co-Investigator
    R01EY032931     (TAKAHASHI, YUSUKE)Sep 1, 2021 - May 31, 2026
    NIH
    Dysregulation of Wnt signaling in subretinal fibrosis in AMD
    Role: Principal Investigator
    R01EY033330     (MA, JIAN-XING)May 1, 2022 - Apr 30, 2027
    NIH
    cGAS-STING signaling in diabetic retinopathy
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dong L, Cheng R, Ma X, Liang W, Hong Y, Li H, Zhou K, Du Y, Takahashi Y, Zhang X, Li X, Ma JX. Regulation of monocyte activation by PPARa through interaction with the cGAS-STING pathway. Diabetes. 2023 Apr 14. PMID: 37058417.
      Citations:    
    2. Liang W, Huang L, Whelchel A, Yuan T, Ma X, Cheng R, Takahashi Y, Karamichos D, Ma JX. Peroxisome proliferator-activated receptor-a (PPARa) regulates wound healing and mitochondrial metabolism in the cornea. Proc Natl Acad Sci U S A. 2023 Mar 28; 120(13):e2217576120. PMID: 36943878.
      Citations:    
    3. Hara M, Wu W, Malechka VV, Takahashi Y, Ma JX, Moiseyev G. PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle. Cell Rep. 2023 Feb 08; 42(2):112091. PMID: 36763501.
      Citations:    
    4. Ma X, Wu W, Liang W, Takahashi Y, Cai J, Ma JX. Modulation of cGAS-STING signaling by PPARa in a mouse model of ischemia-induced retinopathy. Proc Natl Acad Sci U S A. 2022 Nov 29; 119(48):e2208934119. PMID: 36409895.
      Citations:    
    5. Wu W, Takahashi Y, Shin HY, Ma X, Moiseyev G, Ma JX. The interplay of environmental luminance and genetics in the retinal dystrophy induced by the dominant RPE65 mutation. Proc Natl Acad Sci U S A. 2022 Mar 15; 119(11):e2115202119. PMID: 35271391.
      Citations:    
    6. Ma X, Takahashi Y, Wu W, Chen J, Dehdarani M, Liang W, Shin YH, Benyajati S, Ma JX. Soluble very low-density lipoprotein receptor (sVLDLR) inhibits fibrosis in neovascular age-related macular degeneration. FASEB J. 2021 Dec; 35(12):e22058. PMID: 34820908.
      Citations:    
    7. Ma X, Takahashi Y, Wu W, Liang W, Chen J, Chakraborty D, Li Y, Du Y, Benyajati S, Ma JX. ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium. J Biol Chem. 2021 Oct; 297(4):101185. PMID: 34509473.
      Citations:    
    8. Singh HD, Ma JX, Takahashi Y. Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina. Biochem Biophys Res Commun. 2021 Mar 19; 545:8-13. PMID: 33545636.
      Citations:    
    9. He X, Cheng R, Huang C, Takahashi Y, Yang Y, Benyajati S, Chen Y, Zhang XA, Ma JX. A novel role of LRP5 in tubulointerstitial fibrosis through activating TGF-ß/Smad signaling. Signal Transduct Target Ther. 2020 Apr 29; 5(1):45. PMID: 32345960.
      Citations:    
    10. Shao Y, Dong LJ, Takahashi Y, Chen J, Liu X, Chen Q, Ma JX, Li XR. miRNA-451a regulates RPE function through promoting mitochondrial function in proliferative diabetic retinopathy. Am J Physiol Endocrinol Metab. 2019 Mar 01; 316(3):E443-E452. PMID: 30576241.
      Citations:    
    11. Shin Y, Moiseyev G, Petrukhin K, Cioffi CL, Muthuraman P, Takahashi Y, Ma JX. A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration. Biochim Biophys Acta Mol Basis Dis. 2018 Jul; 1864(7):2420-2429. PMID: 29684583.
      Citations:    
    12. Pearsall EA, Cheng R, Zhou K, Takahashi Y, Matlock HG, Vadvalkar SS, Shin Y, Fredrick TW, Gantner ML, Meng S, Fu Z, Gong Y, Kinter M, Humphries KM, Szweda LI, Smith LEH, Ma JX. PPARa is essential for retinal lipid metabolism and neuronal survival. BMC Biol. 2017 Nov 28; 15(1):113. PMID: 29183319.
      Citations:    
    13. Malechka VV, Moiseyev G, Takahashi Y, Shin Y, Ma JX. Impaired Rhodopsin Generation in the Rat Model of Diabetic Retinopathy. Am J Pathol. 2017 Oct; 187(10):2222-2231. PMID: 28734946.
      Citations:    
    14. Chen Q, Qiu F, Zhou K, Matlock HG, Takahashi Y, Rajala RVS, Yang Y, Moran E, Ma JX. Pathogenic Role of microRNA-21 in Diabetic Retinopathy Through Downregulation of PPARa. Diabetes. 2017 Jun; 66(6):1671-1682. PMID: 28270521.
      Citations:    
    15. Chen Q, Takahashi Y, Oka K, Ma JX. Functional Differences of Very-Low-Density Lipoprotein Receptor Splice Variants in Regulating Wnt Signaling. Mol Cell Biol. 2016 Oct 15; 36(20):2645-54. PMID: 27528615.
      Citations:    
    16. Tryggestad JB, Vishwanath A, Jiang S, Mallappa A, Teague AM, Takahashi Y, Thompson DM, Chernausek SD. Influence of gestational diabetes mellitus on human umbilical vein endothelial cell miRNA. Clin Sci (Lond). 2016 Nov 01; 130(21):1955-67. PMID: 27562513.
      Citations:    
    17. Cheng R, Ding L, He X, Takahashi Y, Ma JX. Interaction of PPARa With the Canonic Wnt Pathway in the Regulation of Renal Fibrosis. Diabetes. 2016 Dec; 65(12):3730-3743. PMID: 27543085.
      Citations:    
    18. Takahashi Y, Chen Q, Rajala RVS, Ma JX. MicroRNA-184 modulates canonical Wnt signaling through the regulation of frizzled-7 expression in the retina with ischemia-induced neovascularization. FEBS Lett. 2015 Apr 28; 589(10):1143-1149. PMID: 25796186.
      Citations:    
    19. Lee K, Shin Y, Cheng R, Park K, Hu Y, McBride J, He X, Takahashi Y, Ma JX. Receptor heterodimerization as a novel mechanism for the regulation of Wnt/ß-catenin signaling. J Cell Sci. 2014 Nov 15; 127(Pt 22):4857-69. PMID: 25271056.
      Citations:    
    20. Takahashi Y, Moiseyev G, Ma JX. Identification of key residues determining isomerohydrolase activity of human RPE65. J Biol Chem. 2014 Sep 26; 289(39):26743-26751. PMID: 25112876.
      Citations:    
    21. Ding L, Cheng R, Hu Y, Takahashi Y, Jenkins AJ, Keech AC, Humphries KM, Gu X, Elliott MH, Xia X, Ma JX. Peroxisome proliferator-activated receptor a protects capillary pericytes in the retina. Am J Pathol. 2014 Oct; 184(10):2709-20. PMID: 25108226.
      Citations:    
    22. Moran E, Ding L, Wang Z, Cheng R, Chen Q, Moore R, Takahashi Y, Ma JX. Protective and antioxidant effects of PPARa in the ischemic retina. Invest Ophthalmol Vis Sci. 2014 May 13; 55(7):4568-76. PMID: 24825105.
      Citations:    
    23. Hu Y, Chen Y, Ding L, He X, Takahashi Y, Gao Y, Shen W, Cheng R, Chen Q, Qi X, Boulton ME, Ma JX. Pathogenic role of diabetes-induced PPAR-a down-regulation in microvascular dysfunction. Proc Natl Acad Sci U S A. 2013 Sep 17; 110(38):15401-6. PMID: 24003152.
      Citations:    
    24. Murray AR, Chen Q, Takahashi Y, Zhou KK, Park K, Ma JX. MicroRNA-200b downregulates oxidation resistance 1 (Oxr1) expression in the retina of type 1 diabetes model. Invest Ophthalmol Vis Sci. 2013 Mar 05; 54(3):1689-97. PMID: 23404117.
      Citations:    
    25. Lee K, Hu Y, Ding L, Chen Y, Takahashi Y, Mott R, Ma JX. Therapeutic potential of a monoclonal antibody blocking the Wnt pathway in diabetic retinopathy. Diabetes. 2012 Nov; 61(11):2948-57. PMID: 22891217.
      Citations:    
    26. Takahashi Y, Moiseyev G, Nikolaeva O, Ma JX. Identification of the key residues determining the product specificity of isomerohydrolase. Biochemistry. 2012 May 22; 51(20):4217-25. PMID: 22512451.
      Citations:    
    27. Zhou T, He X, Cheng R, Zhang B, Zhang RR, Chen Y, Takahashi Y, Murray AR, Lee K, Gao G, Ma JX. Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy. Diabetologia. 2012 Jan; 55(1):255-66. PMID: 22016045.
      Citations:    
    28. Hu Y, Chen Y, Moiseyev G, Takahashi Y, Mott R, Ma JX. Comparison of ocular pathologies in vitamin A-deficient mice and RPE65 gene knockout mice. Invest Ophthalmol Vis Sci. 2011 Jul 25; 52(8):5507-14. PMID: 21551411.
      Citations:    
    29. Takahashi Y, Moiseyev G, Chen Y, Nikolaeva O, Ma JX. An alternative isomerohydrolase in the retinal Müller cells of a cone-dominant species. FEBS J. 2011 Aug; 278(16):2913-26. PMID: 21676174.
      Citations:    
    30. Takahashi Y, Moiseyev G, Chen Y, Farjo K, Nikolaeva O, Ma JX. An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain. FEBS J. 2011 Apr; 278(6):973-87. PMID: 21235714.
      Citations:    
    31. Moiseyev G, Nikolaeva O, Chen Y, Farjo K, Takahashi Y, Ma JX. Inhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease. Proc Natl Acad Sci U S A. 2010 Oct 12; 107(41):17551-6. PMID: 20876139.
      Citations:    
    32. Nikolaeva O, Takahashi Y, Moiseyev G, Ma JX. Negative charge of the glutamic acid 417 residue is crucial for isomerohydrolase activity of RPE65. Biochem Biophys Res Commun. 2010 Jan 22; 391(4):1757-61. PMID: 20043869.
      Citations:    
    33. Farjo KM, Moiseyev G, Takahashi Y, Crouch RK, Ma JX. The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins. Invest Ophthalmol Vis Sci. 2009 Nov; 50(11):5089-97. PMID: 19458327.
      Citations:    
    34. Nikolaeva O, Takahashi Y, Moiseyev G, Ma JX. Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane. FEBS J. 2009 Jun; 276(11):3020-30. PMID: 19490105.
      Citations:    
    35. Takahashi Y, Moiseyev G, Farjo K, Ma JX. Characterization of key residues and membrane association domains in retinol dehydrogenase 10. Biochem J. 2009 Apr 01; 419(1):113-22, 1 p following 122. PMID: 19102727.
      Citations:    
    36. Takahashi Y, Moiseyev G, Ablonczy Z, Chen Y, Crouch RK, Ma JX. Identification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65. J Biol Chem. 2009 Jan 30; 284(5):3211-3218. PMID: 19049981.
      Citations:    
    37. Moiseyev G, Takahashi Y, Chen Y, Kim S, Ma JX. RPE65 from cone-dominant chicken is a more efficient isomerohydrolase compared with that from rod-dominant species. J Biol Chem. 2008 Mar 28; 283(13):8110-7. PMID: 18216020.
      Citations:    
    38. Takahashi Y, Moiseyev G, Chen Y, Ma JX. The roles of three palmitoylation sites of RPE65 in its membrane association and isomerohydrolase activity. Invest Ophthalmol Vis Sci. 2006 Dec; 47(12):5191-6. PMID: 17122102.
      Citations:    
    39. Chen Y, Moiseyev G, Takahashi Y, Ma JX. Impacts of two point mutations of RPE65 from Leber's congenital amaurosis on the stability, subcellular localization and isomerohydrolase activity of RPE65. FEBS Lett. 2006 Jul 24; 580(17):4200-4. PMID: 16828753.
      Citations:    
    40. Takahashi Y, Chen Y, Moiseyev G, Ma JX. Two point mutations of RPE65 from patients with retinal dystrophies decrease the stability of RPE65 protein and abolish its isomerohydrolase activity. J Biol Chem. 2006 Aug 04; 281(31):21820-21826. PMID: 16754667.
      Citations:    
    41. Chen Y, Moiseyev G, Takahashi Y, Ma JX. RPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice. Invest Ophthalmol Vis Sci. 2006 Mar; 47(3):1177-84. PMID: 16505056.
      Citations:    
    42. Yokoyama S, Starmer WT, Takahashi Y, Tada T. Tertiary structure and spectral tuning of UV and violet pigments in vertebrates. Gene. 2006 Jan 03; 365:95-103. PMID: 16343816.
      Citations:    
    43. Moiseyev G, Takahashi Y, Chen Y, Gentleman S, Redmond TM, Crouch RK, Ma JX. RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle. J Biol Chem. 2006 Feb 03; 281(5):2835-40. PMID: 16319067.
      Citations:    
    44. Takahashi Y, Moiseyev G, Chen Y, Ma JX. Identification of conserved histidines and glutamic acid as key residues for isomerohydrolase activity of RPE65, an enzyme of the visual cycle in the retinal pigment epithelium. FEBS Lett. 2005 Oct 10; 579(24):5414-8. PMID: 16198348.
      Citations:    
    45. Moiseyev G, Chen Y, Takahashi Y, Wu BX, Ma JX. RPE65 is the isomerohydrolase in the retinoid visual cycle. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12413-8. PMID: 16116091.
      Citations:    
    46. Takahashi Y, Yokoyama S. Genetic basis of spectral tuning in the violet-sensitive visual pigment of African clawed frog, Xenopus laevis. Genetics. 2005 Nov; 171(3):1153-60. PMID: 16079229.
      Citations:    
    47. Takahashi Y, Ebrey TG. Molecular basis of spectral tuning in the newt short wavelength sensitive visual pigment. Biochemistry. 2003 May 27; 42(20):6025-34. PMID: 12755604.
      Citations:    
    48. Sakakibara S, Hiramatsu H, Takahashi Y, Hisatomi O, Kobayashi Y, Sakami S, Saito T, Tokunaga F. Opsin expression in adult, developing, and regenerating newt retinas. Brain Res Mol Brain Res. 2002 Jun 30; 103(1-2):28-35. PMID: 12106689.
      Citations:    
    49. Takahashi Y, Hisatomi O, Sakakibara S, Tokunaga F, Tsukahara Y. Distribution of blue-sensitive photoreceptors in amphibian retinas. FEBS Lett. 2001 Jul 20; 501(2-3):151-5. PMID: 11470275.
      Citations:    
    50. Hisatomi O, Takahashi Y, Taniguchi Y, Tsukahara Y, Tokunaga F. Primary structure of a visual pigment in bullfrog green rods. FEBS Lett. 1999 Mar 19; 447(1):44-8. PMID: 10218579.
      Citations:    
    Takahashi's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (244)
    Explore
    _
    Co-Authors (3)
    Explore
    _
    Same Department Expand Description
    Explore
    _