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Gennadiy P. Moiseyev PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentBiochemistry
Address
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    Collapse Biography 
    Collapse education and training
    Institute of Molecular Biology, MoscowPhD10/1984Molecular Biology/Chemistry

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hara M, Wu W, Malechka VV, Takahashi Y, Ma JX, Moiseyev G. PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle. Cell Rep. 2023 Feb 08; 42(2):112091. PMID: 36763501.
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    2. Wu W, Takahashi Y, Ma X, Moiseyev G, Ma JX. Environmental Light Has an Essential Effect on the Disease Expression in a Dominant RPE65 Mutation. Adv Exp Med Biol. 2023; 1415:415-419. PMID: 37440066.
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    3. Wang Y, Ma X, Muthuraman P, Raja A, Jayaraman A, Petrukhin K, Cioffi CL, Ma JX, Moiseyev G. The novel visual cycle inhibitor (±)-RPE65-61 protects retinal photoreceptors from light-induced degeneration. PLoS One. 2022; 17(10):e0269437. PMID: 36227868.
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    4. Wu W, Takahashi Y, Shin HY, Ma X, Moiseyev G, Ma JX. The interplay of environmental luminance and genetics in the retinal dystrophy induced by the dominant RPE65 mutation. Proc Natl Acad Sci U S A. 2022 Mar 15; 119(11):e2115202119. PMID: 35271391.
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    5. Chen J, Shao Y, Sasore T, Moiseyev G, Zhou K, Ma X, Du Y, Ma JX. Interphotoreceptor Retinol-Binding Protein Ameliorates Diabetes-Induced Retinal Dysfunction and Neurodegeneration Through Rhodopsin. Diabetes. 2021 Mar; 70(3):788-799. PMID: 33334874.
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    6. Malechka VV, Chen J, Cheng R, Ma JX, Moiseyev G. The Single Administration of a Chromophore Alleviates Neural Defects in Diabetic Retinopathy. Am J Pathol. 2020 Jul; 190(7):1505-1512. PMID: 32275905.
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    7. Shin Y, Moiseyev G, Petrukhin K, Cioffi CL, Muthuraman P, Takahashi Y, Ma JX. A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration. Biochim Biophys Acta Mol Basis Dis. 2018 Jul; 1864(7):2420-2429. PMID: 29684583.
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    8. Du M, Phelps E, Balangue MJ, Dockins A, Moiseyev G, Shin Y, Kane S, Otalora L, Ma JX, Farjo R, Farjo KM. Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration. Invest Ophthalmol Vis Sci. 2017 Aug 01; 58(10):4375–4383. PMID: 28813718.
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    9. Malechka VV, Moiseyev G, Takahashi Y, Shin Y, Ma JX. Impaired Rhodopsin Generation in the Rat Model of Diabetic Retinopathy. Am J Pathol. 2017 Oct; 187(10):2222-2231. PMID: 28734946.
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    10. Shin Y, Moiseyev G, Chakraborty D, Ma JX. A Dominant Mutation in Rpe65, D477G, Delays Dark Adaptation and Disturbs the Visual Cycle in the Mutant Knock-In Mice. Am J Pathol. 2017 Mar; 187(3):517-527. PMID: 28041994.
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    11. Stiles M, Moiseyev GP, Budda ML, Linens A, Brush RS, Qi H, White GL, Wolf RF, Ma JX, Floyd R, Anderson RE, Mandal NA. PBN (Phenyl-N-Tert-Butylnitrone)-Derivatives Are Effective in Slowing the Visual Cycle and Rhodopsin Regeneration and in Protecting the Retina from Light-Induced Damage. PLoS One. 2015; 10(12):e0145305. PMID: 26694648.
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    12. Moiseyev G, Nikolaeva O, Chen Y, Farjo K, Takahashi Y, Ma JX. Inhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease. Proc Natl Acad Sci U S A. 2010 Oct 12; 107(41):17551-6. PMID: 20876139.
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    13. Moiseyev G, Takahashi Y, Chen Y, Kim S, Ma JX. RPE65 from cone-dominant chicken is a more efficient isomerohydrolase compared with that from rod-dominant species. J Biol Chem. 2008 Mar 28; 283(13):8110-7. PMID: 18216020.
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    14. Moiseyev G, Takahashi Y, Chen Y, Gentleman S, Redmond TM, Crouch RK, Ma JX. RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle. J Biol Chem. 2006 Feb 03; 281(5):2835-40. PMID: 16319067.
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    15. Moiseyev G, Chen Y, Takahashi Y, Wu BX, Ma JX. RPE65 is the isomerohydrolase in the retinoid visual cycle. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12413-8. PMID: 16116091.
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    16. Moiseyev G, Crouch RK, Goletz P, Oatis J, Redmond TM, Ma JX. Retinyl esters are the substrate for isomerohydrolase. Biochemistry. 2003 Feb 25; 42(7):2229-38. PMID: 12590612.
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