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Keith T. Gagnon PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentBiochemistry
Address
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nukala SB, Jousma J, Yan G, Han Z, Kwon Y, Cho Y, Liu C, Gagnon K, Pinho S, Rehman J, Shao NY, Ong SB, Lee WH, Ong SG. Modulation of lncRNA links endothelial glycocalyx to vascular dysfunction of tyrosine kinase inhibitor. Cardiovasc Res. 2023 Jun 02. PMID: 37267414.
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    2. Bosmeny MS, White AA, Pater AA, Crew J, Geltz J, Gagnon KT. Global mpox lineage discovery and rapid outbreak tracking with nanopore sequencing. Virol J. 2023 May 06; 20(1):90. PMID: 37149667.
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    3. Sudhakar S, Barkau CL, Chilamkurthy R, Barber HM, Pater AA, Moran SD, Damha MJ, Pradeepkumar PI, Gagnon KT. Binding to the conserved and stably folded guide RNA pseudoknot induces Cas12a conformational changes during ribonucleoprotein assembly. J Biol Chem. 2023 May; 299(5):104700. PMID: 37059184.
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    4. Chilamkurthy R, White AA, Pater AA, Jensik PJ, Gagnon KT. Efficient Cloning and Sequence Validation of Repetitive and High GC-Content Short Hairpin RNAs. Hum Gene Ther. 2022 Aug; 33(15-16):829-839. PMID: 35726380.
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    5. Gagnon KT, Huang V. Special issue editorial: Methods to facilitate SARS-CoV-2 and COVID-19 research. J Biol Methods. 2021; 8(COVID 19 Spec Iss):e157. PMID: 35036458.
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    6. Ageely EA, Chilamkurthy R, Jana S, Abdullahu L, O'Reilly D, Jensik PJ, Damha MJ, Gagnon KT. Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles. Nat Commun. 2021 Nov 15; 12(1):6591. PMID: 34782635.
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    7. Pater AA, Bosmeny MS, White AA, Sylvain RJ, Eddington SB, Parasrampuria M, Ovington KN, Metz PE, Yinusa AO, Barkau CL, Chilamkurthy R, Benzinger SW, Hebert MM, Gagnon KT. High throughput nanopore sequencing of SARS-CoV-2 viral genomes from patient samples. J Biol Methods. 2021; 8(COVID 19 Spec Iss):e155. PMID: 34631911.
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    8. Barkau CL, O'Reilly D, Eddington SB, Damha MJ, Gagnon KT. Small nucleic acids and the path to the clinic for anti-CRISPR. Biochem Pharmacol. 2021 Jul; 189:114492. PMID: 33647260.
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    9. Kartje ZJ, Janis HI, Mukhopadhyay S, Gagnon KT. Revisiting T7 RNA polymerase transcription in vitro with the Broccoli RNA aptamer as a simplified real-time fluorescent reporter. J Biol Chem. 2021; 296:100175. PMID: 33303627.
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    10. Asefifeyzabadi N, Alkhaldi R, Qamar AZ, Pater AA, Patwardhan M, Gagnon KT, Talapatra S, Shamsi MH. Label-free Electrochemical Detection of CGG Repeats on Inkjet Printable 2D Layers of MoS2. ACS Appl Mater Interfaces. 2020 Nov 18; 12(46):52156-52165. PMID: 33151065.
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    11. Price DA, Kartje ZJ, Hughes JA, Hill TD, Loth TM, Watts JK, Gagnon KT, Moran SD. Infrared Spectroscopy Reveals the Preferred Motif Size and Local Disorder in Parallel Stranded DNA G-Quadruplexes. Chembiochem. 2020 Oct 01; 21(19):2792-2804. PMID: 32372560.
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    12. Habibian M, Harikrishna S, Fakhoury J, Barton M, Ageely EA, Cencic R, Fakih HH, Katolik A, Takahashi M, Rossi J, Pelletier J, Gagnon KT, Pradeepkumar PI, Damha MJ. Effect of 2'-5'/3'-5' phosphodiester linkage heterogeneity on RNA interference. Nucleic Acids Res. 2020 May 21; 48(9):4643-4657. PMID: 32282904.
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    13. Rohilla KJ, Ovington KN, Pater AA, Barton M, Henke AJ, Gagnon KT. Systematic microsatellite repeat expansion cloning and validation. Hum Genet. 2020 Oct; 139(10):1233-1246. PMID: 32277284.
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    14. Taki M, Rohilla KJ, Barton M, Funneman M, Benzabeh N, Naphade S, Ellerby LM, Gagnon KT, Shamsi MH. Novel probes for label-free detection of neurodegenerative GGGGCC repeats associated with amyotrophic lateral sclerosis. Anal Bioanal Chem. 2019 Oct; 411(26):6995-7003. PMID: 31435686.
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    15. Barkau CL, O'Reilly D, Rohilla KJ, Damha MJ, Gagnon KT. Rationally Designed Anti-CRISPR Nucleic Acid Inhibitors of CRISPR-Cas9. Nucleic Acid Ther. 2019 Jun; 29(3):136-147. PMID: 30990769.
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    16. Gagnon KT, Corey DR. Guidelines for Experiments Using Antisense Oligonucleotides and Double-Stranded RNAs. Nucleic Acid Ther. 2019 Jun; 29(3):116-122. PMID: 30907681.
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    17. O'Reilly D, Kartje ZJ, Ageely EA, Malek-Adamian E, Habibian M, Schofield A, Barkau CL, Rohilla KJ, DeRossett LB, Weigle AT, Damha MJ, Gagnon KT. Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity. Nucleic Acids Res. 2019 Jan 25; 47(2):546-558. PMID: 30517736.
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    18. Kartje ZJ, Barkau CL, Rohilla KJ, Ageely EA, Gagnon KT. Chimeric Guides Probe and Enhance Cas9 Biochemical Activity. Biochemistry. 2018 May 29; 57(21):3027-3031. PMID: 29746102.
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    19. Rohilla KJ, Gagnon KT. RNA biology of disease-associated microsatellite repeat expansions. Acta Neuropathol Commun. 2017 Aug 29; 5(1):63. PMID: 28851463.
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    20. Ageely EA, Kartje ZJ, Rohilla KJ, Barkau CL, Gagnon KT. Quadruplex-Flanking Stem Structures Modulate the Stability and Metal Ion Preferences of RNA Mimics of GFP. ACS Chem Biol. 2016 Sep 16; 11(9):2398-406. PMID: 27467146.
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    21. Kalantari R, Hicks JA, Li L, Gagnon KT, Sridhara V, Lemoff A, Mirzaei H, Corey DR. Stable association of RNAi machinery is conserved between the cytoplasm and nucleus of human cells. RNA. 2016 Jul; 22(7):1085-98. PMID: 27198507.
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    22. Dodd DW, Tomchick DR, Corey DR, Gagnon KT. Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches. Biochemistry. 2016 Mar 08; 55(9):1283-6. PMID: 26878348.
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    23. Gagnon KT. Loading of Argonaute Protein with Small Duplex RNA in Cellular Extracts. Methods Mol Biol. 2016; 1421:53-67. PMID: 26965257.
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    24. Gagnon KT, Corey DR. Stepping toward therapeutic CRISPR. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):15536-7. PMID: 26644585.
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    25. Hu J, Liu J, Li L, Gagnon KT, Corey DR. Engineering Duplex RNAs for Challenging Targets: Recognition of GGGGCC/CCCCGG Repeats at the ALS/FTD C9orf72 Locus. Chem Biol. 2015 Nov 19; 22(11):1505-1511. PMID: 26584779.
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    26. Gagnon KT, Maxwell ES. Assessing intermolecular RNA:RNA interactions within a ribonucleoprotein complex using heavy metal cleavage mapping. Methods Mol Biol. 2015; 1240:125-34. PMID: 25352141.
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    27. Gagnon KT, Li L, Janowski BA, Corey DR. Analysis of nuclear RNA interference in human cells by subcellular fractionation and Argonaute loading. Nat Protoc. 2014 Sep; 9(9):2045-60. PMID: 25079428.
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    28. Gagnon KT, Li L, Chu Y, Janowski BA, Corey DR. RNAi factors are present and active in human cell nuclei. Cell Rep. 2014 Jan 16; 6(1):211-21. PMID: 24388755.
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    29. Matsui M, Chu Y, Zhang H, Gagnon KT, Shaikh S, Kuchimanchi S, Manoharan M, Corey DR, Janowski BA. Promoter RNA links transcriptional regulation of inflammatory pathway genes. Nucleic Acids Res. 2013 Dec; 41(22):10086-109. PMID: 23999091.
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    30. Dodd DW, Gagnon KT, Corey DR. Digital quantitation of potential therapeutic target RNAs. Nucleic Acid Ther. 2013 Jun; 23(3):188-94. PMID: 23656494.
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    31. Gagnon KT, Biswas S, Zhang X, Brown BA, Wollenzien P, Mattos C, Maxwell ES. Structurally conserved Nop56/58 N-terminal domain facilitates archaeal box C/D ribonucleoprotein-guided methyltransferase activity. J Biol Chem. 2012 Jun 01; 287(23):19418-28. PMID: 22496443.
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    32. Gagnon KT, Corey DR. Argonaute and the nuclear RNAs: new pathways for RNA-mediated control of gene expression. Nucleic Acid Ther. 2012 Feb; 22(1):3-16. PMID: 22283730.
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    33. Gagnon KT, Watts JK, Pendergraff HM, Montaillier C, Thai D, Potier P, Corey DR. Antisense and antigene inhibition of gene expression by cell-permeable oligonucleotide-oligospermine conjugates. J Am Chem Soc. 2011 Jun 08; 133(22):8404-7. PMID: 21539318.
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    34. Biswas S, Buhrman G, Gagnon K, Mattos C, Brown BA, Maxwell ES. Comparative analysis of the 15.5kD box C/D snoRNP core protein in the primitive eukaryote Giardia lamblia reveals unique structural and functional features. Biochemistry. 2011 Apr 12; 50(14):2907-18. PMID: 21366326.
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    35. Hu J, Gagnon KT, Liu J, Watts JK, Syeda-Nawaz J, Bennett CF, Swayze EE, Randolph J, Chattopadhyaya J, Corey DR. Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs. Biol Chem. 2011 Apr; 392(4):315-25. PMID: 21294677.
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    36. Gagnon KT, Maxwell ES. Electrophoretic mobility shift assay for characterizing RNA-protein interaction. Methods Mol Biol. 2011; 703:275-91. PMID: 21125497.
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    37. Gagnon KT, Pendergraff HM, Deleavey GF, Swayze EE, Potier P, Randolph J, Roesch EB, Chattopadhyaya J, Damha MJ, Bennett CF, Montaillier C, Lemaitre M, Corey DR. Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat. Biochemistry. 2010 Nov 30; 49(47):10166-78. PMID: 21028906.
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    38. Yue X, Schwartz JC, Chu Y, Younger ST, Gagnon KT, Elbashir S, Janowski BA, Corey DR. Transcriptional regulation by small RNAs at sequences downstream from 3' gene termini. Nat Chem Biol. 2010 Aug; 6(8):621-9. PMID: 20581822.
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    39. Gagnon KT. HD Therapeutics - CHDI Fifth Annual Conference. IDrugs. 2010 Apr; 13(4):219-23. PMID: 20373247.
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    40. Gagnon KT, Zhang X, Qu G, Biswas S, Suryadi J, Brown BA, Maxwell ES. Signature amino acids enable the archaeal L7Ae box C/D RNP core protein to recognize and bind the K-loop RNA motif. RNA. 2010 Jan; 16(1):79-90. PMID: 19926724.
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    41. Bleichert F, Gagnon KT, Brown BA, Maxwell ES, Leschziner AE, Unger VM, Baserga SJ. A dimeric structure for archaeal box C/D small ribonucleoproteins. Science. 2009 Sep 11; 325(5946):1384-7. PMID: 19745151.
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    42. Hu J, Matsui M, Gagnon KT, Schwartz JC, Gabillet S, Arar K, Wu J, Bezprozvanny I, Corey DR. Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs. Nat Biotechnol. 2009 May; 27(5):478-84. PMID: 19412185.
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    43. Gagnon KT, Ju SY, Goshe MB, Maxwell ES, Franzen S. A role for hydrophobicity in a Diels-Alder reaction catalyzed by pyridyl-modified RNA. Nucleic Acids Res. 2009 May; 37(9):3074-82. PMID: 19304744.
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    44. Gagnon KT, Zhang X, Agris PF, Maxwell ES. Assembly of the archaeal box C/D sRNP can occur via alternative pathways and requires temperature-facilitated sRNA remodeling. J Mol Biol. 2006 Oct 06; 362(5):1025-42. PMID: 16949610.
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