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Baisong Lu PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentWake Forest Institute for Regenerative Medicine
Address
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    Collapse Research 
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    R01HD058058     (LU, BAISONG)Jul 27, 2009 - Jun 30, 2012
    NIH
    Mitochondrial generation of superoxide in male reproduction
    Role: Principal Investigator
    20428006/M16093     (Baisong Lu)Oct 20, 2018
    The Meyer family via American Endowment Foundation
    Gene therapy for Dent’s disease
    Role: PI
    W81XWH2010265     (Baisong Lu)Aug 1, 2020 - Jul 31, 2023
    USAMRAA
    Novel Cas9/gRNA Ribonucleoprotein Bionanoparticles for Safe and Efficient Inactivation of ALS
    HT9425-23-1-0050     (Baisong Lu)Feb 1, 2023 - Jan 31, 2026
    USAMRAA
    A novel high throughput lipid nanoparticle barcode surveying method for developing nanoparticles for Friedreich's ataxia genome editing
    Role Description: The goal of this project is to develop lipid nanoparticles for gene editing to treat Friedreich's ataxia.
    Role: I am the PI and will manage the project and communicate with the program officer.
    RF1MH130782     (LU, BAISONG)Sep 1, 2023 - Aug 31, 2026
    NIH
    A germline- and promoter-independent strategy to gain access to all cell types in the brain
    Role: Principal Investigator
    HT94252310685     (USAMRAA)Sep 30, 2023 - Sep 29, 2026
    USAMRAA
    High-Throughput Screening for Lipid Nanoparticles Efficient for Systemic Delivery to Tissues Affected by DMD
    Role Description: The goal is to develop lipid nanoparticles for genome editing of DMD.
    Role: I am the PI and will manage the project and communicate with the program officer.
    HDTRA12410013     (Baisong Lu)Dec 7, 2023 - Dec 7, 2024
    DTRA
    Enabling high-throughput screening of lipid nanoparticles for airway drug delivery
    Role Description: The goal of this project is to validate a high-throughput screening method for developing lipid nanoparticles for airway drug delivery.
    Role: I am the PI and will manage the project and communicate with the program officer.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lyu P, Yoo KW, Chen Z, Lu F, Cogal A, Harris PC, Lieske JC, Lu B. Database of CLCN5 Pathogenic Variants Causing Dent Disease. Kidney Int Rep. 2026 May; 11(5):106475. PMID: 42006202.
      Citations:    
    2. Lu B, Mou H, Liang C. Editorial: Insights in genome editing in human health and disease 2023/2024. Front Genome Ed. 2025; 7:1697828. PMID: 41058710.
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    3. Lyu P, Yadav MK, Yoo KW, Jiang C, Li Q, Atala A, Lu B. Gene therapy of Dent disease type 1 in newborn ClC-5 null mice for sustained transgene expression and gene therapy effects. Gene Ther. 2024 Nov; 31(11-12):563-571. PMID: 39322766.
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    4. Durán M, Ariceta G, Semidey ME, Castells-Esteve C, Casal-Pardo A, Lu B, Meseguer A, Cantero-Recasens G. Renal antiporter ClC-5 regulates collagen I/IV through the ß-catenin pathway and lysosomal degradation. Life Sci Alliance. 2024 Jul; 7(7). PMID: 38670633.
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    5. Liu C, Li Q, Ma JX, Lu B, Criswell T, Zhang Y. Exosome-mediated renal protection: Halting the progression of fibrosis. Genes Dis. 2024 Nov; 11(6):101117. PMID: 39263535.
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    6. Lu Z, Miao X, Song Q, Ding H, Rajan SAP, Skardal A, Votanopoulos KI, Dai K, Zhao W, Lu B, Atala A. Detection of lineage-reprogramming efficiency of tumor cells in a 3D-printed liver-on-a-chip model. Theranostics. 2023; 13(14):4905-4918. PMID: 37771785.
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    7. Ma Y, Liang RM, Ma N, Mi XJ, Cheng ZY, Zhang ZJ, Lu BS, Li PA. Immp2l Mutation Induces Mitochondrial Membrane Depolarization and Complex III Activity Suppression after Middle Cerebral Artery Occlusion in Mice. Curr Med Sci. 2023 Jun; 43(3):478-488. PMID: 37243806.
      Citations:    
    8. Hu Y, Lu B, Deng Z, Xing F, Hsu W. Virus-like particle-based delivery of Cas9/guide RNA ribonucleoprotein efficiently edits the brachyury gene and inhibits chordoma growth in vivo. Discov Oncol. 2023 May 18; 14(1):70. PMID: 37198417.
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    9. Yadav MK, Yoo KW, Atala A, Lu B. Lentiviral vector mediated gene therapy for type I Dent disease ameliorates Dent disease-like phenotypes for three months in ClC-5 null mice. Mol Ther Methods Clin Dev. 2022 Dec 08; 27:149-166. PMID: 36284768.
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    10. Lyu P, Lu B. New Advances in Using Virus-like Particles and Related Technologies for Eukaryotic Genome Editing Delivery. Int J Mol Sci. 2022 Aug 06; 23(15). PMID: 35955895.
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    11. Wasala NB, Million ED, Watkins TB, Wasala LP, Han J, Yue Y, Lu B, Chen SJ, Hakim CH, Duan D. The gRNA Vector Level Determines the Outcome of Systemic AAV CRISPR Therapy for Duchenne Muscular Dystrophy. Hum Gene Ther. 2022 May; 33(9-10):518-528. PMID: 35350865.
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    12. Yoo KW, Yadav MK, Song Q, Atala A, Lu B. Targeting DNA polymerase to DNA double-strand breaks reduces DNA deletion size and increases templated insertions generated by CRISPR/Cas9. Nucleic Acids Res. 2022 04 22; 50(7):3944-3957. PMID: 35323942.
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    13. Yadav M, Atala A, Lu B. Developing all-in-one virus-like particles for Cas9 mRNA/single guide RNA co-delivery and aptamer-containing lentiviral vectors for improved gene expression. Int J Biol Macromol. 2022 Jun 01; 209(Pt A):1260-1270. PMID: 35461863.
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    14. Yao X, Lyu P, Yoo K, Yadav MK, Singh R, Atala A, Lu B. Engineered extracellular vesicles as versatile ribonucleoprotein delivery vehicles for efficient and safe CRISPR genome editing. J Extracell Vesicles. 2021 Mar; 10(5):e12076. PMID: 33747370.
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    15. Lu Z, Yao X, Lyu P, Yadav M, Yoo K, Atala A, Lu B. Lentiviral Capsid-Mediated Streptococcus pyogenes Cas9 Ribonucleoprotein Delivery for Efficient and Safe Multiplex Genome Editing. CRISPR J. 2021 Mar 16. PMID: 33733873.
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    16. Gonzalez-Armenta JL, Li N, Lee RL, Lu B, Molina AJA. Heterochronic Parabiosis: Old Blood Induces Changes in Mitochondrial Structure and Function of Young Mice. J Gerontol A Biol Sci Med Sci. 2021 Feb 25; 76(3):434-439. PMID: 33377482.
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    17. Lyu P, Lu Z, Cho SI, Yadav M, Yoo KW, Atala A, Kim JS, Lu B. Adenine Base Editor Ribonucleoproteins Delivered by Lentivirus-Like Particles Show High On-Target Base Editing and Undetectable RNA Off-Target Activities. CRISPR J. 2021 Feb; 4(1):69-81. PMID: 33616436.
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    18. Lu Z, Priya Rajan SA, Song Q, Zhao Y, Wan M, Aleman J, Skardal A, Bishop C, Atala A, Lu B. 3D scaffold-free microlivers with drug metabolic function generated by lineage-reprogrammed hepatocytes from human fibroblasts. Biomaterials. 2021 02; 269:120668. PMID: 33461059.
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    19. Lyu P, Wang L, Lu B. Virus-Like Particle Mediated CRISPR/Cas9 Delivery for Efficient and Safe Genome Editing. Life (Basel). 2020 Dec 21; 10(12). PMID: 33371215.
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    20. Lyu P, Yoo KW, Yadav MK, Atala A, Aartsma-Rus A, Putten MV, Duan D, Lu B. Sensitive and reliable evaluation of single-cut sgRNAs to restore dystrophin by a GFP-reporter assay. PLoS One. 2020; 15(9):e0239468. PMID: 32970732.
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    21. Javidi-Parsijani P, Lyu P, Makani V, Sarhan WM, Yoo KW, El-Korashi L, Atala A, Lu B. CRISPR/Cas9 increases mitotic gene conversion in human cells. Gene Ther. 2020 06; 27(6):281-296. PMID: 32020049.
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    22. Lyu P, Javidi-Parsijani P, Atala A, Lu B. Delivering Cas9/sgRNA ribonucleoprotein (RNP) by lentiviral capsid-based bionanoparticles for efficient 'hit-and-run' genome editing. Nucleic Acids Res. 2019 09 26; 47(17):e99. PMID: 31299082.
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    23. Lu B, Javidi-Parsijani P, Makani V, Mehraein-Ghomi F, Sarhan WM, Sun D, Yoo KW, Atala ZP, Lyu P, Atala A. Delivering SaCas9 mRNA by lentivirus-like bionanoparticles for transient expression and efficient genome editing. Nucleic Acids Res. 2019 05 07; 47(8):e44. PMID: 30759231.
      Citations:    
    24. Yoo KW, Li N, Makani V, Singh RN, Atala A, Lu B. Large-Scale Preparation of Extracellular Vesicles Enriched with Specific microRNA. Tissue Eng Part C Methods. 2018 11; 24(11):637-644. PMID: 30306827.
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    25. Lu P, Li H, Li N, Singh RN, Bishop CE, Chen X, Lu B. MEX3C interacts with adaptor-related protein complex 2 and involves in miR-451a exosomal sorting. PLoS One. 2017; 12(10):e0185992. PMID: 28982131.
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    26. Jiang Y, Liu C, Lei B, Xu X, Lu B. Mitochondria-targeted antioxidant SkQ1 improves spermatogenesis in Immp2l mutant mice. Andrologia. 2018 Mar; 50(2). PMID: 28703400.
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    27. Javidi-Parsijani P, Niu G, Davis M, Lu P, Atala A, Lu B. No evidence of genome editing activity from Natronobacterium gregoryi Argonaute (NgAgo) in human cells. PLoS One. 2017; 12(5):e0177444. PMID: 28494027.
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    28. Li X, Li Y, Liu C, Jin M, Lu B. Oocyte-Specific Expression of Mouse MEX3C652AA in the Ovary and Its Potential Role in Regulating Maternal Fos mRNA. Biol Reprod. 2016 05; 94(5):115. PMID: 27053362.
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    29. Liu C, Li X, Lu B. The Immp2l mutation causes age-dependent degeneration of cerebellar granule neurons prevented by antioxidant treatment. Aging Cell. 2016 Feb; 15(1):167-76. PMID: 26616244.
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    30. Guimarães-Souza NK, Yamaleyeva LM, Lu B, Ramos AC, Bishop CE, Andersson KE. Superoxide overproduction and kidney fibrosis: a new animal model. Einstein (Sao Paulo). 2015 Jan-Mar; 13(1):79-88. PMID: 25993073.
      Citations:    
    31. Pan C, Jia W, Lu B, Bishop CE. Expression of TAT recombinant Oct4, Sox2, Lin28, and Nanog proteins from baculovirus-infected Sf9 insect cells. Gene. 2015 Feb 10; 556(2):245-8. PMID: 25476026.
      Citations:    
    32. Bharadwaj MS, Zhou Y, Molina AJ, Criswell T, Lu B. Examination of bioenergetic function in the inner mitochondrial membrane peptidase 2-like (Immp2l) mutant mice. Redox Biol. 2014; 2:1008-15. PMID: 25460737.
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    33. Han C, Jiao Y, Zhao Q, Lu B. Mex3c mutation reduces adiposity partially through increasing physical activity. J Endocrinol. 2014 Jun; 221(3):457-68. PMID: 24741071.
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    34. Lu B, Atala A. Small molecules and small molecule drugs in regenerative medicine. Drug Discov Today. 2014 Jun; 19(6):801-8. PMID: 24252867.
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    35. Han C, Zhao Q, Lu B. The role of nitric oxide signaling in food intake; insights from the inner mitochondrial membrane peptidase 2 mutant mice. Redox Biol. 2013; 1:498-507. PMID: 24251118.
      Citations:    
    36. Hicks AN, Lorenzetti D, Gilley J, Lu B, Andersson KE, Miligan C, Overbeek PA, Oppenheim R, Bishop CE. Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo. PLoS One. 2012; 7(10):e47869. PMID: 23082226.
      Citations:    
    37. Jiao Y, George SK, Zhao Q, Hulver MW, Hutson SM, Bishop CE, Lu B. Mex3c mutation reduces adiposity and increases energy expenditure. Mol Cell Biol. 2012 Nov; 32(21):4350-62. PMID: 22927639.
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    38. Zhao Q, Lu B, George SK, Yoo JJ, Atala A. Safeguarding pluripotent stem cells for cell therapy with a non-viral, non-integrating episomal suicide construct. Biomaterials. 2012 Oct; 33(29):7261-71. PMID: 22795541.
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    39. George SK, Jiao Y, Bishop CE, Lu B. Oxidative stress is involved in age-dependent spermatogenic damage of Immp2l mutant mice. Free Radic Biol Med. 2012 Jun 1-15; 52(11-12):2223-33. PMID: 22569411.
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    40. Jiao Y, Bishop CE, Lu B. Mex3c regulates insulin-like growth factor 1 (IGF1) expression and promotes postnatal growth. Mol Biol Cell. 2012 Apr; 23(8):1404-13. PMID: 22357625.
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    41. Ma Y, Mehta SL, Lu B, Li PA. Deficiency in the inner mitochondrial membrane peptidase 2-like (Immp21) gene increases ischemic brain damage and impairs mitochondrial function. Neurobiol Dis. 2011 Dec; 44(3):270-6. PMID: 21824519.
      Citations:    
    42. George SK, Jiao Y, Bishop CE, Lu B. Mitochondrial peptidase IMMP2L mutation causes early onset of age-associated disorders and impairs adult stem cell self-renewal. Aging Cell. 2011 Aug; 10(4):584-94. PMID: 21332923.
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    43. Soler R, Füllhase C, Lu B, Bishop CE, Andersson KE. Bladder dysfunction in a new mutant mouse model with increased superoxide--lack of nitric oxide? J Urol. 2010 Feb; 183(2):780-5. PMID: 20022053.
      Citations:    
    44. Pan C, Lu B, Chen H, Bishop CE. Reprogramming human fibroblasts using HIV-1 TAT recombinant proteins OCT4, SOX2, KLF4 and c-MYC. Mol Biol Rep. 2010 Apr; 37(4):2117-24. PMID: 19669668.
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    45. Lu B, Poirier C, Gaspar T, Gratzke C, Harrison W, Busija D, Matzuk MM, Andersson KE, Overbeek PA, Bishop CE. A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects mitochondrial function and impairs fertility in mice. Biol Reprod. 2008 Apr; 78(4):601-10. PMID: 18094351.
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    46. Lu B, Geurts AM, Poirier C, Petit DC, Harrison W, Overbeek PA, Bishop CE. Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system. Mamm Genome. 2007 May; 18(5):338-46. PMID: 17557177.
      Citations:    
    47. Zhao QG, Zhou Y, Zhu HQ, Lu BS, Huang PT. Generation of mouse FANCL antibody and analysis of FANCL protein expression profile in mouse tissues. Yi Chuan Xue Bao. 2006 Jan; 33(1):49-55. PMID: 16450587.
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    48. Zhao Q, Zhou Y, Cao Z, Zhu H, Huang P, Lu B. Germ-cell specific protein gametogenetin protein 2 (GGN2), expression in the testis, and association with intracellular membrane. Mol Reprod Dev. 2005 Sep; 72(1):31-9. PMID: 15892049.
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    49. Zhao QG, Lu BS, Huang PT. [Functions of FANCL in primordial germ cell formation and Fanconi anemia]. Yi Chuan Xue Bao. 2005 Sep; 32(9):993-1000. PMID: 16201245.
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    50. Zhou Y, Zhao Q, Bishop CE, Huang P, Lu B. Identification and characterization of a novel testicular germ cell-specific gene Ggnbp1. Mol Reprod Dev. 2005 Mar; 70(3):301-7. PMID: 15625700.
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    51. Zhang J, Wang Y, Zhou Y, Cao Z, Huang P, Lu B. Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1. FEBS Lett. 2005 Jan 17; 579(2):559-66. PMID: 15642376.
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    52. Dai Q, Liu F, Zhou Y, Lu B, Yu F, Huang P. The synthesis of SO-3, a conopeptide with high analgesic activity derived from Conus striatus. J Nat Prod. 2003 Sep; 66(9):1276-9. PMID: 14510617.
      Citations:    
    53. Lu B, Bishop CE. Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. J Biol Chem. 2003 May 02; 278(18):16289-96. PMID: 12574169.
      Citations:    
    54. Lu B, Bishop CE. Late onset of spermatogenesis and gain of fertility in POG-deficient mice indicate that POG is not necessary for the proliferation of spermatogonia. Biol Reprod. 2003 Jul; 69(1):161-8. PMID: 12606378.
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    55. Agoulnik AI, Lu B, Zhu Q, Truong C, Ty MT, Arango N, Chada KK, Bishop CE. A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd. Hum Mol Genet. 2002 Nov 15; 11(24):3047-53. PMID: 12417526.
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    56. Gao C, Zhu XD, Zhou XW, Yu F, Lu BS, Huang PT. [Construction of eukaryotic expression vector using neomycin-resistance gene mutant as selectable marker]. Sheng Wu Gong Cheng Xue Bao. 2002 May; 18(3):308-12. PMID: 12192863.
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