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J. M. Cline DVM, PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentPathology, Comparative Medicine
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentClinical and Translational Science Institute

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentPhysiology & Pharmacology

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentRadiation Oncology

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentWake Forest Institute for Regenerative Medicine


    Collapse Research 
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    T32RR007009     (CLINE, J. MARK)Jul 1, 1982 - May 31, 2013
    NIH
    Laboratory Animal &Comparative Medicine Training
    Role: Principal Investigator
    T32OD010957     (CLINE, J. MARK)Jul 1, 1982 - Mar 31, 2023
    NIH
    Laboratory Animal & Comparative Medicine Training
    Role: Principal Investigator
    R01AT000639     (CLINE, J. MARK)Sep 18, 2000 - Jun 30, 2013
    NIH
    SOY AND ESTROGEN INTERACTIONS IN THE BREAST
    Role: Principal Investigator
    R03CA103111     (CLINE, J. MARK)Sep 8, 2003 - Aug 31, 2006
    NIH
    Effects of Dietary Soy on Biomarkers in Prostate Cancer
    Role: Principal Investigator
    T35RR025836     (CLINE, J. MARK)Apr 1, 2009 - Mar 31, 2014
    NIH
    Summer Veterinary Student Research Fellows at Wake Forest University
    Role: Principal Investigator
    T35OD010946     (KAVANAGH, KYLIE)Apr 1, 2009 - May 31, 2024
    NIH
    Summer Veterinary Student Research Fellows at Wake Forest University
    Role: Co-Principal Investigator
    G20OD020291     (CLINE, J. MARK)Jul 1, 2015 - Jun 30, 2016
    NIH
    Enhanced Imaging Resources for Clinical Care of Research Animals
    Role: Principal Investigator
    U01AI150578     (CLINE, J. MARK)Aug 1, 2020 - Jul 31, 2027
    NIH
    The Wake Forest Nonhuman Primate Radiation Survivor Cohort
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kosowski E, Olson JD, Gardin J, Schaaf GW, Nishita D, Authier S, Chang P, Brenner DJ, Fornace AJ, Cline JM, Laiakis EC. Long-term Radiation Signal Persistence in Urine and Blood: A Two-year Analysis in Non-human Primates Exposed to a 4 Gy Total-Body Gamma-Radiation Dose. Radiat Res. 2024 Nov 07. PMID: 39504997.
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    2. Barnet IR, Emerzian SR, Behzad R, Brooks DJ, Tedtsen T, Granados M, Park S, Moore J, Olson JD, Karim L, Bouxsein ML, Cline JM, Willey JS. Total body irradiation is associated with long-term deficits in femoral bone structure but not mechanical properties in male rhesus macaques. Sci Rep. 2024 Oct 08; 14(1):23379. PMID: 39379502.
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    3. Nelson OL, Rosales R, Turbov J, Thaete LG, Balamayooran G, Cline JM, Pike JW, Rodriguez GC. Vitamin D Significantly Inhibits Carcinogenesis in the Mogp-TAg Mouse Model of Fallopian Tube Ovarian Cancer. Nutrients. 2024 Sep 30; 16(19). PMID: 39408285.
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    4. Vail KJ, Bourland JD, Dugan GO, Chen BJ, Clarkson TB, Cline JM, Meléndez GC. Exogenous Growth Hormone Exacerbates Post-Irradiation Atherosclerosis in Susceptible Epicardial Coronary Arteries. Toxicol Pathol. 2024 Aug; 52(6):308-318. PMID: 39254136.
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    5. Kanagaraj K, Phillippi MA, Ober EH, Shuryak I, Kleiman NJ, Olson J, Schaaf G, Cline JM, Turner HC. BAX and DDB2 as biomarkers for acute radiation exposure in the human blood ex vivo and non-human primate models. Sci Rep. 2024 Aug 20; 14(1):19345. PMID: 39164366.
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    6. Harrison WT, Cline JM, Caudell DL, Huber HF, Shively CA, Register TC, Craft S, Struthers JD. Alzheimer disease-like neuropathologic changes in a geriatric baboon (Papio hamadryas). J Vet Sci. 2024 Aug 07. PMID: 39231785.
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    7. Balamayooran G, Tooze JA, Gardin JF, Long MC, Caudell DL, Cline JM, Kock ND, Paitsel M, Moore S, Jorgensen MJ. Age and sex associated organ weight differences in vervets/African green monkeys (Chlorocebus aethiops sabaeus). J Med Primatol. 2024 Aug; 53(4):e12721. PMID: 39048121.
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    8. Park SH, Peters M, Aguayo C, Farris MK, Hughes RT, Moore J, Munley MT, Reno KE, Gardin J, Cline JM, Peters CM, Willey JS. Secretory factors released from high dose radiation-activated osteoclasts increase the expression level of pain-associated neuropeptides in sensory neuronal cultures. Res Sq. 2024 Jul 01. PMID: 39011106.
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    9. Santen RJ, Karaguzel G, Livaoglu M, Yue W, Cline JM, Ratan A, Sasano H. Role of ERa and Aromatase in Juvenile Gigantomastia. J Clin Endocrinol Metab. 2024 Jun 17; 109(7):1765-1772. PMID: 38227777.
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    10. Caudell DL, Dugan GO, Babitzki G, Schubert C, Braendli-Baiocco A, Wasserman K, Acona G, Stern M, Passioukov A, Cline JM, Charo J. Systemic immune response to a CD40 agonist antibody in nonhuman primates. J Leukoc Biol. 2024 May 29; 115(6):1084-1093. PMID: 38372596.
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    11. Deycmar S, Johnson BJ, Ray K, Schaaf GW, Ryan DP, Cullin C, Dozier BL, Ferguson B, Bimber BN, Olson JD, Caudell DL, Whitlow CT, Solingapuram Sai KK, Romero EC, Villinger FJ, Burgos AG, Ainsworth HC, Miller LD, Hawkins GA, Chou JW, Gomes B, Hettich M, Ceppi M, Charo J, Cline JM. Epigenetic MLH1 silencing concurs with mismatch repair deficiency in sporadic, naturally occurring colorectal cancer in rhesus macaques. J Transl Med. 2024 Mar 19; 22(1):292. PMID: 38504345.
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    12. Johnson BJ, Lipford ME, Barcus RA, Olson JD, Schaaf GW, Andrews RN, Kim J, Dugan GO, Deycmar S, Reed CA, Whitlow CT, Cline JM. Assessing cerebrovascular reactivity (CVR) in rhesus macaques (Macaca mulatta) using a hypercapnic challenge and pseudo-continuous arterial spin labeling (pCASL). Neuroimage. 2024 Jan; 285:120491. PMID: 38070839.
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    13. Brickey WJ, Caudell DL, Macintyre AN, Olson JD, Dai Y, Li S, Dugan GO, Bourland JD, O'Donnell LM, Tooze JA, Huang G, Yang S, Guo H, French MN, Schorzman AN, Zamboni WC, Sempowski GD, Li Z, Owzar K, Chao NJ, Cline JM, Ting JPY. The TLR2/TLR6 ligand FSL-1 mitigates radiation-induced hematopoietic injury in mice and nonhuman primates. Proc Natl Acad Sci U S A. 2023 Dec 12; 120(50):e2122178120. PMID: 38051771.
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    14. Tomasino AM, Olson JD, Schaaf GW, Cox AO, Furdui CM, Cline JM, Cohen EP. A New Method for Estimating Glomerular Filtration Rate in Rhesus Macaques (Macaca mulatta). Radiat Res. 2023 Dec 01; 200(6):548-555. PMID: 37902230.
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    15. Johnson BJ, Barcus RA, Olson JD, Lipford ME, Andrews RN, Dugan GO, Tooze JA, Kim J, Deycmar S, Whitlow CT, Cline JM. Total-Body Irradiation Alters White Matter Volume and Microstructural Integrity in Rhesus Macaques. Int J Radiat Oncol Biol Phys. 2024 May 01; 119(1):208-218. PMID: 37972714.
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    16. Schaaf GW, Olson JD, Dugan GO, Pray BA, Cleary JA, Cline JM. Dose-Dependent Testicular Injury and Recovery after Total-Body Irradiation in Rhesus Monkeys. Radiat Res. 2023 Oct 01; 200(4):321-330. PMID: 37702414.
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    17. Chino Y, Olson JD, Schaaf GW, Cline JM, Johnson TE. Longitudinal Analysis of Leukocyte Total and Differential Count of Rhesus Macaques (Macaca mulatta) after Total-Body Irradiation. Radiat Res. 2023 Oct 01; 200(4):349-356. PMID: 37590486.
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    18. Schaaf GW, Justice JN, Quillen EE, Cline JM. Resilience, aging, and response to radiation exposure (RARRE) in nonhuman primates: a resource review. Geroscience. 2023 Dec; 45(6):3371-3379. PMID: 37188889.
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    19. Olson JD, Tooze JA, Bourland DJ, Cline JM, Faria EB, Cohen EP. Measurement of renal cortical fibrosis by CT scan. Res Diagn Interv Imaging. 2023 Mar; 5. PMID: 37155521.
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    20. Thakur P, Olson JD, Dugan GO, Bourland JD, Kock ND, Cline JM. Quantitative Assessment and Comparative Analysis of Longitudinal Lung CT Scans of Chest-Irradiated Nonhuman Primates. Radiat Res. 2023 Jan 01; 199(1):39-47. PMID: 36394559.
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    21. Deycmar S, Gomes B, Charo J, Ceppi M, Cline JM. Spontaneous, naturally occurring cancers in non-human primates as a translational model for cancer immunotherapy. J Immunother Cancer. 2023 Jan; 11(1). PMID: 36593067.
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    22. French MJ, Wuerker R, Dugan G, Olson JD, Sanders BR, Tooze JA, Caudell DL, Cline JM, Sempowski GD, Macintyre AN. Long-Term Immunological Consequences of Radiation Exposure in a Diverse Cohort of Rhesus Macaques. Int J Radiat Oncol Biol Phys. 2023 Mar 15; 115(4):945-956. PMID: 36288757.
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    23. Ruggiero AD, Davis MA, Davis AT, DeStephanis D, Williams AG, Vemuri R, Fanning KM, Sherrill C, Cline JM, Caudell DL, Kavanagh K. Delayed effects of radiation in adipose tissue reflect progenitor damage and not cellular senescence. Geroscience. 2023 Feb; 45(1):507-521. PMID: 36136223.
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    24. Little MP, Brenner AV, Grant EJ, Sugiyama H, Preston DL, Sakata R, Cologne J, Velazquez-Kronen R, Utada M, Mabuchi K, Ozasa K, Olson JD, Dugan GO, Pazzaglia S, Cline JM, Applegate KE. Age effects on radiation response: summary of a recent symposium and future perspectives. Int J Radiat Biol. 2022 May 02; 1-11. PMID: 35394411.
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    25. Amato R, Gardin JF, Tooze JA, Cline JM. Organ Weights in Relation to Age and Sex in Cynomolgus Monkeys (Macaca fascicularis). Toxicol Pathol. 2022 Jul; 50(5):574-590. PMID: 35383510.
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    26. Sills WS, Tooze JA, Olson JD, Caudell DL, Dugan GO, Johnson BJ, Kock ND, Andrews RN, Schaaf GW, Lang RA, Cline JM. Total-Body Irradiation Is Associated With Increased Incidence of Mesenchymal Neoplasia in a Radiation Late Effects Cohort of Rhesus Macaques (Macaca mulatta). Int J Radiat Oncol Biol Phys. 2022 Jul 01; 113(3):661-674. PMID: 35361520.
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    27. Hobi G, Cline JM, Ethun KF, Simillion C, Keller I, Stute P. Impact of 6 month conjugated equine estrogen versus estradiol-treatment on biomarkers and enriched gene sets in healthy mammary tissue of non-human primates. PLoS One. 2022; 17(3):e0264057. PMID: 35298474.
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    28. Vemuri R, Ruggiero A, Whitfield JM, Dugan GO, Cline JM, Block MR, Guo H, Kavanagh K. Hypertension promotes microbial translocation and dysbiotic shifts in the fecal microbiome of nonhuman primates. Am J Physiol Heart Circ Physiol. 2022 Mar 01; 322(3):H474-H485. PMID: 35148233.
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    29. Nelson OL, Rosales R, Turbov JM, Thaete LG, Cline JM, Rodriguez GC. Progestin Significantly Inhibits Carcinogenesis in the Mogp-TAg Transgenic Mouse Model of Fallopian Tube Cancer. Cancer Prev Res (Phila). 2022 Feb; 15(2):75-86. PMID: 34844992.
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    30. Kundu P, Zimmerman B, Perez R, Whitlow CT, Cline JM, Olson JD, Andrews RN, Raber J. Apolipoprotein E levels in the amygdala and prefrontal cortex predict relative regional brain volumes in irradiated Rhesus macaques. Sci Rep. 2021 Nov 11; 11(1):22130. PMID: 34764354.
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    31. Hayes JM, Olson JD, Chino Y, Bourland JD, Cline JM, Johnson TE. Pseudo Pelger-Huët anomalies as potential biomarkers for acute exposure radiation dose in rhesus macaques (Macaca mulatta). Int J Radiat Biol. 2022; 98(5):913-923. PMID: 34699313.
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    32. Arnone AA, Cline JM, Soto-Pantoja DR, Cook KL. Investigating the role of endogenous estrogens, hormone replacement therapy, and blockade of estrogen receptor-a activity on breast metabolic signaling. Breast Cancer Res Treat. 2021 Nov; 190(1):53-67. PMID: 34448090.
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    33. Thakur P, DeBo R, Dugan GO, Bourland JD, Michalson KT, Olson JD, Register TC, Kock ND, Cline JM. Clinicopathologic and Transcriptomic Analysis of Radiation-Induced Lung Injury in Nonhuman Primates. Int J Radiat Oncol Biol Phys. 2021 Apr 20. PMID: 33848608.
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    34. Macintyre AN, French MJ, Sanders BR, Riebe KJ, Shterev ID, Wiehe K, Hora B, Evangelous T, Dugan G, Bourland JD, Cline JM, Sempowski GD. Long-Term Recovery of the Adaptive Immune System in Rhesus Macaques After Total Body Irradiation. Adv Radiat Oncol. 2021; 6(5):100677. PMID: 34646962.
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    35. Dewi FN, Cline JM. Nonhuman primate model in mammary gland biology and neoplasia research. Lab Anim Res. 2021 Jan 05; 37(1):3. PMID: 33397518.
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    36. Waldhauer I, Gonzalez-Nicolini V, Freimoser-Grundschober A, Nayak TK, Fahrni L, Hosse RJ, Gerrits D, Geven EJW, Sam J, Lang S, Bommer E, Steinhart V, Husar E, Colombetti S, Van Puijenbroek E, Neubauer M, Cline JM, Garg PK, Dugan G, Cavallo F, Acuna G, Charo J, Teichgräber V, Evers S, Boerman OC, Bacac M, Moessner E, Umaña P, Klein C. Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy. MAbs. 2021 Jan-Dec; 13(1):1913791. PMID: 33974508.
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    37. Cote JL, Argetsinger LS, Flores A, Rupp AC, Cline JM, DeSantis LC, Bedard AH, Bagchi DP, Vander PB, Cacciaglia AM, Clutter ES, Chandrashekar G, MacDougald OA, Myers MG, Carter-Su C. Deletion of the Brain-Specific a and d Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity. Diabetes. 2021 02; 70(2):400-414. PMID: 33214137.
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    38. Andrews RN, Bloomer EG, Olson JD, Hanbury DB, Dugan GO, Whitlow CT, Cline JM. Non-Human Primates Receiving High-Dose Total-Body Irradiation are at Risk of Developing Cerebrovascular Injury Years Postirradiation. Radiat Res. 2020 09 16; 194(3):277-287. PMID: 32942304.
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    39. Cohen EP, Olson JD, Tooze JA, Bourland JD, Dugan GO, Cline JM. Detection and quantification of renal fibrosis by computerized tomography. PLoS One. 2020; 15(2):e0228626. PMID: 32053617.
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    40. Bacarella N, Ruggiero A, Davis AT, Uberseder B, Davis MA, Bracy DP, Wasserman DH, Cline JM, Sherrill C, Kavanagh K. Whole Body Irradiation Induces Diabetes and Adipose Insulin Resistance in Nonhuman Primates. Int J Radiat Oncol Biol Phys. 2020 03 15; 106(4):878-886. PMID: 31805366.
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    41. Belcher SM, Cline JM, Conley J, Groeters S, Jefferson WN, Law M, Mackey E, Suen AA, Williams CJ, Dixon D, Wolf JC. Endocrine Disruption and Reproductive Pathology. Toxicol Pathol. 2019 Dec; 47(8):1049-1071. PMID: 31833458.
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    42. Dodda BR, Bondi CD, Hasan M, Clafshenkel WP, Gallagher KM, Kotlarczyk MP, Sethi S, Buszko E, Latimer JJ, Cline JM, Witt-Enderby PA, Davis VL. Co-administering Melatonin With an Estradiol-Progesterone Menopausal Hormone Therapy Represses Mammary Cancer Development in a Mouse Model of HER2-Positive Breast Cancer. Front Oncol. 2019; 9:525. PMID: 31355130.
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    43. Claus C, Ferrara C, Xu W, Sam J, Lang S, Uhlenbrock F, Albrecht R, Herter S, Schlenker R, Hüsser T, Diggelmann S, Challier J, Mössner E, Hosse RJ, Hofer T, Brünker P, Joseph C, Benz J, Ringler P, Stahlberg H, Lauer M, Perro M, Chen S, Küttel C, Bhavani Mohan PL, Nicolini V, Birk MC, Ongaro A, Prince C, Gianotti R, Dugan G, Whitlow CT, Solingapuram Sai KK, Caudell DL, Burgos-Rodriguez AG, Cline JM, Hettich M, Ceppi M, Giusti AM, Crameri F, Driessen W, Morcos PN, Freimoser-Grundschober A, Levitsky V, Amann M, Grau-Richards S, von Hirschheydt T, Tournaviti S, Mølhøj M, Fauti T, Heinzelmann-Schwarz V, Teichgräber V, Colombetti S, Bacac M, Zippelius A, Klein C, Umaña P. Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy. Sci Transl Med. 2019 06 12; 11(496). PMID: 31189721.
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    44. Michalson KT, Macintyre AN, Sempowski GD, Bourland JD, Howard TD, Hawkins GA, Dugan GO, Cline JM, Register TC. Monocyte Polarization is Altered by Total-Body Irradiation in Male Rhesus Macaques: Implications for Delayed Effects of Acute Radiation Exposure. Radiat Res. 2019 08; 192(2):121-134. PMID: 31161966.
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    45. Caudell DL, Michalson KT, Andrews RN, Snow WW, Bourland JD, DeBo RJ, Cline JM, Sempowski GD, Register TC. Transcriptional Profiling of Non-Human Primate Lymphoid Organ Responses to Total-Body Irradiation. Radiat Res. 2019 07; 192(1):40-52. PMID: 31059377.
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    46. Hale LP, Rajam G, Carlone GM, Jiang C, Owzar K, Dugan G, Caudell D, Chao N, Cline JM, Register TC, Sempowski GD. Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques. PLoS One. 2019; 14(2):e0210663. PMID: 30759098.
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    47. Michalson KT, Groban L, Howard TD, Shively CA, Sophonsritsuk A, Appt SE, Cline JM, Clarkson TB, Carr JJ, Kitzman DW, Register TC. Estradiol Treatment Initiated Early After Ovariectomy Regulates Myocardial Gene Expression and Inhibits Diastolic Dysfunction in Female Cynomolgus Monkeys: Potential Roles for Calcium Homeostasis and Extracellular Matrix Remodeling. J Am Heart Assoc. 2018 11 06; 7(21):e009769. PMID: 30571375.
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    48. Yu J, Francisco AMC, Patel BG, Cline JM, Zou E, Berga SL, Taylor RN. IL-1ß Stimulates Brain-Derived Neurotrophic Factor Production in Eutopic Endometriosis Stromal Cell Cultures: A Model for Cytokine Regulation of Neuroangiogenesis. Am J Pathol. 2018 10; 188(10):2281-2292. PMID: 30031725.
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    49. Andrews RN, Caudell DL, Metheny-Barlow LJ, Peiffer AM, Tooze JA, Bourland JD, Hampson RE, Deadwyler SA, Cline JM. Fibronectin Produced by Cerebral Endothelial and Vascular Smooth Muscle Cells Contributes to Perivascular Extracellular Matrix in Late-Delayed Radiation-Induced Brain Injury. Radiat Res. 2018 10; 190(4):361-373. PMID: 30016219.
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    50. Farris M, McTyre ER, Okoukoni C, Dugan G, Johnson BJ, Blackstock AW, Munley MT, Bourland JD, Cline JM, Willey JS. Cortical Thinning and Structural Bone Changes in Non-Human Primates after Single-Fraction Whole-Chest Irradiation. Radiat Res. 2018 07; 190(1):63-71. PMID: 29738279.
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    51. Balamayooran G, Atkins HM, Whitlow CT, Aycock ST, Nader MA, Cline JM, Caudell DL. Labyrinthitis Ossificans in a Cynomolgus Macaque (Macaca fascicularis). Comp Med. 2018 Apr 12. PMID: 29650059.
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    52. Cline JM, Dugan G, Bourland JD, Perry DL, Stitzel JD, Weaver AA, Jiang C, Tovmasyan A, Owzar K, Spasojevic I, Batinic-Haberle I, Vujaskovic Z. Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation. Antioxidants (Basel). 2018 Mar 07; 7(3). PMID: 29518913.
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    53. Ghandhi SA, Turner HC, Shuryak I, Dugan GO, Bourland JD, Olson JD, Tooze JA, Morton SR, Batinic-Haberle I, Cline JM, Amundson SA. Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells. PLoS One. 2018; 13(1):e0191402. PMID: 29351567.
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    54. Fanning KM, Pfisterer B, Davis AT, Presley TD, Williams IM, Wasserman DH, Cline JM, Kavanagh K. Changes in microvascular density differentiate metabolic health outcomes in monkeys with prior radiation exposure and subsequent skeletal muscle ECM remodeling. . 2017 Sep 01; 313(3):R290-R297. PMID: 28701320.
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    55. Andrews RN, Metheny-Barlow LJ, Peiffer AM, Hanbury DB, Tooze JA, Bourland JD, Hampson RE, Deadwyler SA, Cline JM. Cerebrovascular Remodeling and Neuroinflammation is a Late Effect of Radiation-Induced Brain Injury in Non-Human Primates. Radiat Res. 2017 05; 187(5):599-611. PMID: 28398880.
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    56. Hanbury DB, Peiffer AM, Dugan G, Andrews RN, Cline JM. Long-Term Cognitive Functioning in Single-Dose Total-Body Gamma-Irradiated Rhesus Monkeys ( Macaca mulatta ). Radiat Res. 2016 Nov; 186(5):447-454. PMID: 27740889.
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    57. Kiguchi N, Ding H, Peters CM, Kock ND, Kishioka S, Cline JM, Wagner JD, Ko MC. Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys. Biochim Biophys Acta Mol Basis Dis. 2017 01; 1863(1):274-283. PMID: 27751964.
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    58. DeBo RJ, Lees CJ, Dugan GO, Caudell DL, Michalson KT, Hanbury DB, Kavanagh K, Cline JM, Register TC. Late Effects of Total-Body Gamma Irradiation on Cardiac Structure and Function in Male Rhesus Macaques. Radiat Res. 2016 07; 186(1):55-64. PMID: 27333082.
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    59. Atkins HM, Lombardini ED, Caudell DL, Appt SE, Dubois A, Cline JM. Decidualization of Endometriosis in Macaques. Vet Pathol. 2016 11; 53(6):1252-1258. PMID: 27281017.
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    60. Dewi FN, Wood CE, Willson CJ, Register TC, Lees CJ, Howard TD, Huang Z, Murphy SK, Tooze JA, Chou JW, Miller LD, Cline JM. Effects of Pubertal Exposure to Dietary Soy on Estrogen Receptor Activity in the Breast of Cynomolgus Macaques. Cancer Prev Res (Phila). 2016 05; 9(5):385-95. PMID: 27006379.
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    61. Willson CJ, Herbert RA, Cline JM. Hormone Receptor Expression in Spontaneous Uterine Adenocarcinoma in Fischer 344 Rats. Toxicol Pathol. 2015 Aug; 43(6):865-71. PMID: 26157037.
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    62. DeBo RJ, Register TC, Caudell DL, Sempowski GD, Dugan G, Gray S, Owzar K, Jiang C, Bourland JD, Chao NJ, Cline JM. Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques. Int J Radiat Biol. 2015 Jun; 91(6):510-8. PMID: 25786585.
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    63. Kavanagh K, Dendinger MD, Davis AT, Register TC, DeBo R, Dugan G, Cline JM. Type 2 Diabetes is a Delayed Late Effect of Whole-Body Irradiation in Nonhuman Primates. Radiat Res. 2015 Apr; 183(4):398-406. PMID: 25811716.
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    64. Fang X, Gyabaah K, Nickkholgh B, Cline JM, Balaji KC. Novel In Vivo model for combinatorial fluorescence labeling in mouse prostate. Prostate. 2015 Jun 15; 75(9):988-1000. PMID: 25753731.
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    65. Hanbury DB, Robbins ME, Bourland JD, Wheeler KT, Peiffer AM, Mitchell EL, Daunais JB, Deadwyler SA, Cline JM. Pathology of fractionated whole-brain irradiation in rhesus monkeys ( Macaca mulatta ). Radiat Res. 2015 Mar; 183(3):367-74. PMID: 25688996.
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    66. Maglic D, Stovall DB, Cline JM, Fry EA, Mallakin A, Taneja P, Caudell DL, Willingham MC, Sui G, Inoue K. DMP1ß, a splice isoform of the tumour suppressor DMP1 locus, induces proliferation and progression of breast cancer. J Pathol. 2015 May; 236(1):90-102. PMID: 25537728.
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    67. Williams JK, Eckman D, Dean A, Moradi M, Allickson J, Cline JM, Yoo JJ, Atala A. The dose-effect safety profile of skeletal muscle precursor cell therapy in a dog model of intrinsic urinary sphincter deficiency. Stem Cells Transl Med. 2015 Mar; 4(3):286-94. PMID: 25637189.
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    68. Dugan G, O'Donnell L, Hanbury DB, Cline JM, Caudell DL. Assessment of Multiplate platelet aggregometry using citrate, heparin or hirudin in Rhesus macaques. Platelets. 2015; 26(8):730-5. PMID: 25549285.
      Citations:    
    69. Pearce LR, Joe R, Doche ME, Su HW, Keogh JM, Henning E, Argetsinger LS, Bochukova EG, Cline JM, Garg S, Saeed S, Shoelson S, O'Rahilly S, Barroso I, Rui L, Farooqi IS, Carter-Su C. Functional characterization of obesity-associated variants involving the a and ß isoforms of human SH2B1. Endocrinology. 2014 Sep; 155(9):3219-26. PMID: 24971614.
      Citations:    
    70. Hernandez-Ramon EE, Sandoval NA, John K, Cline JM, Wood CE, Woodward RA, Poirier MC. Tamoxifen-DNA adduct formation in monkey and human reproductive organs. Carcinogenesis. 2014 May; 35(5):1172-6. PMID: 24501327.
      Citations:    
    71. Sharma A, Fonseca LL, Rajani C, Yanagida JK, Endo Y, Cline JM, Stone JC, Ji J, Ramos JW, Lorenzo PS. Targeted deletion of RasGRP1 impairs skin tumorigenesis. Carcinogenesis. 2014 May; 35(5):1084-91. PMID: 24464785.
      Citations:    
    72. Granfeldt A, Shi W, Schmarkey SL, Jiang R, Bone CC, Cline JM, Wogensen L, Dobson GP, Tønnesen E, Vinten-Johansen J. The effects of adenocaine (adenosine and lidocaine) on early post-resuscitation cardiac and neurological dysfunction in a porcine model of cardiac arrest. Resuscitation. 2013 Nov; 84(11):1611-8. PMID: 23851192.
      Citations:    
    73. Down JD, Medhora M, Jackson IL, Cline JM, Vujaskovic Z. Do variations in mast cell hyperplasia account for differences in radiation-induced lung injury among different mouse strains, rats and nonhuman primates? Radiat Res. 2013 Aug; 180(2):216-21. PMID: 23819595.
      Citations:    
    74. Ethun KF, Wood CE, Cline JM, Register TC, Appt SE, Clarkson TB. Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model. Menopause. 2013 Jul; 20(7):777-84. PMID: 23793168.
      Citations:    
    75. Dewi FN, Wood CE, Lees CJ, Willson CJ, Register TC, Tooze JA, Franke AA, Cline JM. Dietary soy effects on mammary gland development during the pubertal transition in nonhuman primates. Cancer Prev Res (Phila). 2013 Aug; 6(8):832-42. PMID: 23771522.
      Citations:    
    76. Buse E, Häeger JD, Svensson-Arvelund J, Markert UR, Faas MM, Ernerudh J, Dixon D, Cline JM, Pfarrer C. The placenta in toxicology. Part I: Animal models in toxicology: placental morphology and tolerance molecules in the cynomolgus monkey (Macaca fascicularis). Toxicol Pathol. 2014; 42(2):314-26. PMID: 23548606.
      Citations:    
    77. Göhner C, Svensson-Arvelund J, Pfarrer C, Häger JD, Faas M, Ernerudh J, Cline JM, Dixon D, Buse E, Markert UR. The placenta in toxicology. Part IV: Battery of toxicological test systems based on human placenta. Toxicol Pathol. 2014; 42(2):345-51. PMID: 23548605.
      Citations:    
    78. Svensson-Arvelund J, Ernerudh J, Buse E, Cline JM, Haeger JD, Dixon D, Markert UR, Pfarrer C, De Vos P, Faas MM. The placenta in toxicology. Part II: Systemic and local immune adaptations in pregnancy. Toxicol Pathol. 2014; 42(2):327-38. PMID: 23531796.
      Citations:    
    79. Cline JM, Dixon D, Ernerudh J, Faas MM, Göhner C, Häger JD, Markert UR, Pfarrer C, Svensson-Arvelund J, Buse E. The placenta in toxicology. Part III: Pathologic assessment of the placenta. Toxicol Pathol. 2014; 42(2):339-44. PMID: 23531795.
      Citations:    
    80. Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D'Agostino R, Danial N, Datta SR, Kulik G. Behavioral stress accelerates prostate cancer development in mice. J Clin Invest. 2013 Feb; 123(2):874-86. PMID: 23348742.
      Citations:    
    81. Shelton KA, Cline JM, Cann JA. 17-ß Estradiol reduces atherosclerosis without exacerbating lupus in ovariectomized systemic lupus erythematosus-susceptible LDLr(-/-) mice. Atherosclerosis. 2013 Apr; 227(2):228-35. PMID: 23395521.
      Citations:    
    82. Wood CE, Branstetter D, Jacob AP, Cline JM, Register TC, Rohrbach K, Huang LY, Borgerink H, Dougall WC. Progestin effects on cell proliferation pathways in the postmenopausal mammary gland. Breast Cancer Res. 2013; 15(4):R62. PMID: 23938070.
      Citations:    
    83. Doche ME, Bochukova EG, Su HW, Pearce LR, Keogh JM, Henning E, Cline JM, Saeed S, Dale A, Cheetham T, Barroso I, Argetsinger LS, O'Rahilly S, Rui L, Carter-Su C, Farooqi IS. Human SH2B1 mutations are associated with maladaptive behaviors and obesity. J Clin Invest. 2012 Dec; 122(12):4732-6. PMID: 23160192.
      Citations:    
    84. Hulchiy M, Zhang H, Cline JM, Hirschberg AL, Sahlin L. Receptors for thyrotropin-releasing hormone, thyroid-stimulating hormone, and thyroid hormones in the macaque uterus: effects of long-term sex hormone treatment. Menopause. 2012 Nov; 19(11):1253-9. PMID: 22713859.
      Citations:    
    85. Ethun KF, Wood CE, Register TC, Cline JM, Appt SE, Clarkson TB. Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys. Menopause. 2012 Nov; 19(11):1242-52. PMID: 23103754.
      Citations:    
    86. Sasseville VG, Mansfield KG, Mankowski JL, Tremblay C, Terio KA, Mätz-Rensing K, Gruber-Dujardin E, Delaney MA, Schmidt LD, Liu D, Markovits JE, Owston M, Harbison C, Shanmukhappa S, Miller AD, Kaliyaperumal S, Assaf BT, Kattenhorn L, Macri SC, Simmons HA, Baldessari A, Sharma P, Courtney C, Bradley A, Cline JM, Reindel JF, Hutto DL, Montali RJ, Lowenstine LJ. Meeting report: Spontaneous lesions and diseases in wild, captive-bred, and zoo-housed nonhuman primates and in nonhuman primate species used in drug safety studies. Vet Pathol. 2012 Nov; 49(6):1057-69. PMID: 23135296.
      Citations:    
    87. Davis VL, Shaikh F, Gallagher KM, Villegas M, Rea SL, Cline JM, Hughes CL. Inhibition of Neu-induced mammary carcinogenesis in transgenic mice expressing ER?3, a dominant negative estrogen receptor a variant. Horm Cancer. 2012 Dec; 3(5-6):227-39. PMID: 22968785.
      Citations:    
    88. Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE. Coronary artery vitamin D receptor expression and plasma concentrations of 25-hydroxyvitamin D: their association with atherosclerosis. Menopause. 2012 Sep; 19(9):967-73. PMID: 22617336.
      Citations:    
    89. Dewi FN, Wood CE, Lampe JW, Hullar MA, Franke AA, Golden DL, Adams MR, Cline JM. Endogenous and exogenous equol are antiestrogenic in reproductive tissues of apolipoprotein e-null mice. J Nutr. 2012 Oct; 142(10):1829-35. PMID: 22933749.
      Citations:    
    90. Schnatz PF, Nudy M, O'Sullivan DM, Jiang X, Cline JM, Kaplan JR, Clarkson TB, Appt SE. The quantification of vitamin D receptors in coronary arteries and their association with atherosclerosis. Maturitas. 2012 Oct; 73(2):143-7. PMID: 22542390.
      Citations:    
    91. Clafshenkel WP, King TL, Kotlarczyk MP, Cline JM, Foster WG, Davis VL, Witt-Enderby PA. Morinda citrifolia (Noni) Juice Augments Mammary Gland Differentiation and Reduces Mammary Tumor Growth in Mice Expressing the Unactivated c-erbB2 Transgene. Evid Based Complement Alternat Med. 2012; 2012:487423. PMID: 22619689.
      Citations:    
    92. Johnson NA, Ho A, Cline JM, Hughes CL, Foster WG, Davis VL. Accelerated mammary tumor onset in a HER2/Neu mouse model exposed to DDT metabolites locally delivered to the mammary gland. Environ Health Perspect. 2012 Aug; 120(8):1170-6. PMID: 22514210.
      Citations:    
    93. Wu M, Shi L, Cimic A, Romero L, Sui G, Lees CJ, Cline JM, Seals DF, Sirintrapun JS, McCoy TP, Liu W, Kim JW, Hawkins GA, Peehl DM, Xu J, Cramer SD. Suppression of Tak1 promotes prostate tumorigenesis. Cancer Res. 2012 Jun 01; 72(11):2833-43. PMID: 22467172.
      Citations:    
    94. Hulchiy M, Zhang H, Cline JM, Hirschberg AL, Sahlin L. Effects of long-term tibolone treatment on nuclear sex steroid hormone receptors and G-protein-coupled estrogen receptor-1 expression in the macaque uterus. Menopause. 2012 Mar; 19(3):332-8. PMID: 22027943.
      Citations:    
    95. Wood CE, Boue SM, Collins-Burow BM, Rhodes LV, Register TC, Cline JM, Dewi FN, Burow ME. Glyceollin-elicited soy protein consumption induces distinct transcriptional effects as compared to standard soy protein. J Agric Food Chem. 2012 Jan 11; 60(1):81-6. PMID: 22126086.
      Citations:    
    96. Stute P, Sielker S, Wood CE, Register TC, Lees CJ, Dewi FN, Williams JK, Wagner JD, Stefenelli U, Cline JM. Life stage differences in mammary gland gene expression profile in non-human primates. Breast Cancer Res Treat. 2012 Jun; 133(2):617-34. PMID: 22037779.
      Citations:    
    97. Ethun KF, Cline JM, Appt SE. Endocrine profile of an ovariectomized cynomolgus monkey (Macaca fascicularis) with a supernumerary ovary. Comp Med. 2011 Oct; 61(5):462-6. PMID: 22330356.
      Citations:    
    98. Zhang H, von Schoultz B, Cline JM, Sahlin L. Distribution of cyclooxygenases 1 and 2 in the uterus and breast of cynomolgus monkeys-effects of hormone treatment. Menopause. 2011 Sep; 18(9):1001-9. PMID: 21540754.
      Citations:    
    99. The role of soy isoflavones in menopausal health: report of The North American Menopause Society/Wulf H. Utian Translational Science Symposium in Chicago, IL (October 2010). Menopause. 2011 Jul; 18(7):732-53. PMID: 21685820.
      Citations:    
    100. Willard SL, Daunais JB, Cline JM, Shively CA. Hippocampal volume in postmenopausal cynomolgus macaques with behavioral depression. Menopause. 2011 May; 18(5):582-6. PMID: 21242818.
      Citations:    
    101. Hill GD, Moore AB, Kissling GE, Flagler ND, Ney E, Cline JM, Dixon D. Effects of hormonally active agents on steroid hormone receptor expression and cell proliferation in the myometrium of ovariectomized macaques. Toxicol Pathol. 2011 Apr; 39(3):508-15. PMID: 21411722.
      Citations:    
    102. Robbins ME, Bourland JD, Cline JM, Wheeler KT, Deadwyler SA. A model for assessing cognitive impairment after fractionated whole-brain irradiation in nonhuman primates. Radiat Res. 2011 Apr; 175(4):519-25. PMID: 21275607.
      Citations:    
    103. Wood CE, Tannehill-Gregg SH, Chen Z, Doorslaer Kv, Nelson DR, Cline JM, Burk RD. Novel betapapillomavirus associated with hand and foot papillomas in a cynomolgus macaque. Vet Pathol. 2011 May; 48(3):731-6. PMID: 20921322.
      Citations:    
    104. Chen BJ, Deoliveira D, Spasojevic I, Sempowski GD, Jiang C, Owzar K, Wang X, Gesty-Palmer D, Cline JM, Bourland JD, Dugan G, Meadows SK, Daher P, Muramoto G, Chute JP, Chao NJ. Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. PLoS One. 2010 Jun 16; 5(6):e11056. PMID: 20585403.
      Citations:    
    105. Shahryarinejad A, Gardner TR, Cline JM, Levine WN, Bunting HA, Brodman MD, Ascher-Walsh CJ, Scotti RJ, Vardy MD. Effect of hormone replacement and selective estrogen receptor modulators (SERMs) on the biomechanics and biochemistry of pelvic support ligaments in the cynomolgus monkey (Macaca fascicularis). Am J Obstet Gynecol. 2010 May; 202(5):485.e1-9. PMID: 20452495.
      Citations:    
    106. Argetsinger LS, Stuckey JA, Robertson SA, Koleva RI, Cline JM, Marto JA, Myers MG, Carter-Su C. Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity. Mol Endocrinol. 2010 May; 24(5):1062-76. PMID: 20304997.
      Citations:    
    107. Wood CE, Kaplan JR, Fontenot MB, Williams JK, Cline JM. Endometrial profile of tamoxifen and low-dose estradiol combination therapy. Clin Cancer Res. 2010 Feb 01; 16(3):946-56. PMID: 20103679.
      Citations:    
    108. Steude JS, Maskarinec G, Erber E, Verheus M, Hernandez BY, Killeen J, Cline JM. Mammographic density and matrix metalloproteinases in breast tissue. Cancer Microenviron. 2010 Dec; 3(1):57-65. PMID: 20012240.
      Citations:    
    109. Wagner JD, Jorgensen MJ, Cline JM, Lees CJ, Franke AA, Zhang L, Ayers MR, Schultz C, Kaplan JR. Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring. Am J Primatol. 2009 Sep; 71(9):802-11. PMID: 19484707.
      Citations:    
    110. Cline JM, Wood CE. Estrogen/isoflavone interactions in cynomolgus macaques (Macaca fascicularis). Am J Primatol. 2009 Sep; 71(9):722-31. PMID: 19322873.
      Citations:    
    111. Verheus M, Maskarinec G, Erber E, Steude JS, Killeen J, Hernandez BY, Cline JM. Mammographic density and epithelial histopathologic markers. BMC Cancer. 2009 Jun 13; 9:182. PMID: 19523235.
      Citations:    
    112. Wood CE, Lees CJ, Cline JM. Mammary gland and endometrial effects of testosterone in combination with oral estradiol and progesterone. Menopause. 2009 May-Jun; 16(3):466-76. PMID: 19265727.
      Citations:    
    113. Hofling M, Ma L, Sahlin L, Haglund C, Nordling S, von Schoultz B, Cline JM. Expression of the androgen receptor and syndecan-1 in breast tissue during different hormonal treatments in cynomolgus monkeys. Climacteric. 2009 Feb; 12(1):72-9. PMID: 19003632.
      Citations:    
    114. Muhammad FS, Goode AK, Kock ND, Arifin EA, Cline JM, Adams MR, Hoyer PB, Christian PJ, Isom S, Kaplan JR, Appt SE. Effects of 4-vinylcyclohexene diepoxide on peripubertal and adult Sprague-Dawley rats: ovarian, clinical, and pathologic outcomes. Comp Med. 2009 Feb; 59(1):46-59. PMID: 19295054.
      Citations:    
    115. Maskarinec G, Erber E, Verheus M, Hernandez BY, Killeen J, Cashin S, Cline JM. Soy consumption and histopathologic markers in breast tissue using tissue microarrays. Nutr Cancer. 2009; 61(5):708-16. PMID: 19838945.
      Citations:    
    116. Cline JM, Wood CE, Vidal JD, Tarara RP, Buse E, Weinbauer GF, de Rijk EP, van Esch E. Selected Background Findings and Interpretation of Common Lesions in the Female Reproductive System in Macaques. Toxicol Pathol. 2008 Dec; 36(7):142s-163s. PMID: 21475639.
      Citations:    
    117. Cline JM, Wood CE. The Mammary Glands of Macaques. Toxicol Pathol. 2008 Dec; 36(7):134s-141s. PMID: 21475638.
      Citations:    
    118. Weinbauer GF, Niehoff M, Niehaus M, Srivastav S, Fuchs A, Van Esch E, Cline JM. Physiology and Endocrinology of the Ovarian Cycle in Macaques. Toxicol Pathol. 2008 Dec; 36(7S):7S-23S. PMID: 20852722.
      Citations:    
    119. Ma L, Hofling M, Masironi B, von Schoultz B, Cline JM, Sahlin L. Effects of tibolone and conventional HRT on the expression of estrogen and progesterone receptors in the breast. Maturitas. 2008 Dec 20; 61(4):345-9. PMID: 18980817.
      Citations:    
    120. Scott LM, Durant P, Leone-Kabler S, Wood CE, Register TC, Townsend A, Cline JM. Effects of prior oral contraceptive use and soy isoflavonoids on estrogen-metabolizing cytochrome P450 enzymes. J Steroid Biochem Mol Biol. 2008 Dec; 112(4-5):179-85. PMID: 18955142.
      Citations:    
    121. Scott LM, Xu X, Veenstra TD, Tooze JA, Wood CE, Register TC, Kock ND, Cline JM. Past oral contraceptive use and current dietary soy isoflavones influence estrogen metabolism in postmenopausal monkeys (Macaca fascicularis). Cancer Epidemiol Biomarkers Prev. 2008 Oct; 17(10):2594-602. PMID: 18843000.
      Citations:    
    122. Hardisty JF, Anderson DC, Brodie S, Cline JM, Hahn FF, Kolenda-Roberts H, Lele SM, Lowenstine LJ. Histopathology of the urinary bladders of cynomolgus monkeys treated with PPAR agonists. Toxicol Pathol. 2008 Oct; 36(6):769-76. PMID: 18776159.
      Citations:    
    123. Wood CE, Clarkson TB, Chen H, Veenstra TD, Xu X, Scott L, Cline JM. Comparative effects of oral conjugated equine estrogens and micronized 17beta-estradiol on breast proliferation: a retrospective analysis. Menopause. 2008 Sep-Oct; 15(5):890-8. PMID: 18520696.
      Citations:    
    124. Wood CE, Hester JM, Appt SE, Geisinger KR, Cline JM. Estrogen effects on epithelial proliferation and benign proliferative lesions in the postmenopausal primate mammary gland. Lab Invest. 2008 Sep; 88(9):938-48. PMID: 18607345.
      Citations:    
    125. Arifin E, Shively CA, Register TC, Cline JM. Polycystic ovary syndrome with endometrial hyperplasia in a cynomolgus monkey (Macaca fascicularis). Vet Pathol. 2008 Jul; 45(4):512-5. PMID: 18587099.
      Citations:    
    126. Sikoski P, Trybus J, Cline JM, Muhammad FS, Eckhoff A, Tan J, Lockard M, Jolley T, Britt S, Kock ND. Cystic mammary adenocarcinoma associated with a prolactin-secreting pituitary adenoma in a New Zealand white rabbit (Oryctolagus cuniculus). Comp Med. 2008 Jun; 58(3):297-300. PMID: 18589874.
      Citations:    
    127. Cline JM, Botts S, Lees CJ, Brommage R. Effects of lasofoxifene on the uterus, vagina, and breast in ovariectomized cynomolgus monkeys (Macaca fascicularis). Am J Obstet Gynecol. 2008 Aug; 199(2):158.e1-8. PMID: 18501325.
      Citations:    
    128. Edwards IJ, Sun H, Hu Y, Berquin IM, O'Flaherty JT, Cline JM, Rudel LL, Chen YQ. In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids. J Biol Chem. 2008 Jun 27; 283(26):18441-9. PMID: 18450755.
      Citations:    
    129. Wood CE, Register TC, Cline JM. Transcriptional profiles of progestogen effects in the postmenopausal breast. Breast Cancer Res Treat. 2009 Mar; 114(2):233-42. PMID: 18404370.
      Citations:    
    130. Rodriguez GC, Rimel BJ, Watkin W, Turbov JM, Barry C, Du H, Maxwell GL, Cline JM. Progestin treatment induces apoptosis and modulates transforming growth factor-beta in the uterine endometrium. Cancer Epidemiol Biomarkers Prev. 2008 Mar; 17(3):578-84. PMID: 18349275.
      Citations:    
    131. Luke CT, Oki-Idouchi CE, Cline JM, Lorenzo PS. RasGRP1 overexpression in the epidermis of transgenic mice contributes to tumor progression during multistage skin carcinogenesis. Cancer Res. 2007 Nov 01; 67(21):10190-7. PMID: 17974959.
      Citations:    
    132. Wood CE, Hester JM, Cline JM. Mammary gland development in early pubertal female macaques. Toxicol Pathol. 2007 Oct; 35(6):795-805. PMID: 17943653.
      Citations:    
    133. Shively CA, Wood CE, Register TC, Willard SL, Lees CJ, Chen H, Sitruk-Ware RL, Tsong YY, Cline JM. Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys. Psychoneuroendocrinology. 2007 Sep-Nov; 32(8-10):981-90. PMID: 17768011.
      Citations:    
    134. Wood CE, Sitruk-Ware RL, Tsong YY, Register TC, Lees CJ, Cline JM. Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model. Menopause. 2007 Jul-Aug; 14(4):639-47. PMID: 17224855.
      Citations:    
    135. Berquin IM, Min Y, Wu R, Wu J, Perry D, Cline JM, Thomas MJ, Thornburg T, Kulik G, Smith A, Edwards IJ, D'Agostino R, Zhang H, Wu H, Kang JX, Chen YQ. Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J Clin Invest. 2007 Jul; 117(7):1866-75. PMID: 17607361.
      Citations:    
    136. Perry DL, Spedick JM, McCoy TP, Adams MR, Franke AA, Cline JM. Dietary soy protein containing isoflavonoids does not adversely affect the reproductive tract of male cynomolgus macaques (Macaca fascicularis). J Nutr. 2007 Jun; 137(6):1390-4. PMID: 17513396.
      Citations:    
    137. Trybus J, Bain FT, Fikes JD, Carlson CS, O'Sullivan MG, Jayo MJ, Cline JM. Uterine infarctions in cynomolgus monkeys (Macaca fascicularis). Vet Pathol. 2007 May; 44(3):309-13. PMID: 17491071.
      Citations:    
    138. Wood CE, Chen Z, Cline JM, Miller BE, Burk RD. Characterization and experimental transmission of an oncogenic papillomavirus in female macaques. J Virol. 2007 Jun; 81(12):6339-45. PMID: 17428865; PMCID: PMC1900122.
      Citations:    
    139. Cline JM. Tibolone: example of qualitative and quantitative assessments of the mammary gland. Birth Defects Res B Dev Reprod Toxicol. 2007 Apr; 80(2):147-8. PMID: 17443694.
      Citations:    
    140. Cline JM. Assessing the mammary gland of nonhuman primates: effects of endogenous hormones and exogenous hormonal agents and growth factors. Birth Defects Res B Dev Reprod Toxicol. 2007 Apr; 80(2):126-46. PMID: 17443713.
      Citations:    
    141. Menon J, Soto-Pantoja DR, Callahan MF, Cline JM, Ferrario CM, Tallant EA, Gallagher PE. Angiotensin-(1-7) inhibits growth of human lung adenocarcinoma xenografts in nude mice through a reduction in cyclooxygenase-2. Cancer Res. 2007 Mar 15; 67(6):2809-15. PMID: 17363603.
      Citations:    
    142. Sikoski P, Register TC, Lees CJ, Lundeen S, Hutchison J, Brown KH, Cline JM. Effects of two novel selective estrogen receptor modulators, raloxifene, tamoxifen, and ethinyl estradiol on the uterus, vagina and breast in ovariectomized cynomolgus monkeys (Macaca fascicularis). Am J Obstet Gynecol. 2007 Jan; 196(1):75.e1-7. PMID: 17240242.
      Citations:    
    143. Wood CE, Register TC, Lees CJ, Chen H, Kimrey S, Cline JM. Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys. Breast Cancer Res Treat. 2007 Jan; 101(2):125-34. PMID: 16841178.
      Citations:    
    144. Wood CE, Register TC, Cline JM. Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeys. Carcinogenesis. 2007 Apr; 28(4):801-8. PMID: 17032659.
      Citations:    
    145. Appt SE, Kaplan JR, Clarkson TB, Cline JM, Christian PJ, Hoyer PB. Destruction of primordial ovarian follicles in adult cynomolgus macaques after exposure to 4-vinylcyclohexene diepoxide: a nonhuman primate model of the menopausal transition. Fertil Steril. 2006 Oct; 86(4 Suppl):1210-6. PMID: 16952357.
      Citations:    
    146. Wood CE, Usborne AL, Starost MF, Tarara RP, Hill LR, Wilkinson LM, Geisinger KR, Feiste EA, Cline JM. Hyperplastic and neoplastic lesions of the mammary gland in macaques. Vet Pathol. 2006 Jul; 43(4):471-83. PMID: 16846989.
      Citations:    
    147. Wood CE, Appt SE, Clarkson TB, Franke AA, Lees CJ, Doerge DR, Cline JM. Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys. Biol Reprod. 2006 Sep; 75(3):477-86. PMID: 16723506.
      Citations:    
    148. Wilkinson J, Di X, Schönig K, Buss JL, Kock ND, Cline JM, Saunders TL, Bujard H, Torti SV, Torti FM. Tissue-specific expression of ferritin H regulates cellular iron homoeostasis in vivo. Biochem J. 2006 May 01; 395(3):501-7. PMID: 16448386.
      Citations:    
    149. Wood CE, Kaplan JR, Stute P, Cline JM. Effects of soy on the mammary glands of premenopausal female monkeys. Fertil Steril. 2006 Apr; 85 Suppl 1:1179-86. PMID: 16616090.
      Citations:    
    150. Wood CE, Register TC, Franke AA, Anthony MS, Cline JM. Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breast. Cancer Res. 2006 Jan 15; 66(2):1241-9. PMID: 16424064.
      Citations:    
    151. Wood CE, Clarkson TB, Appt SE, Franke AA, Boue SM, Burow ME, McCoy T, Cline JM. Effects of soybean glyceollins and estradiol in postmenopausal female monkeys. Nutr Cancer. 2006; 56(1):74-81. PMID: 17176220.
      Citations:    
    152. Conner P, Register TC, Skoog L, Tani E, von Schoultz B, Cline JM. Expression of p53 and markers for apoptosis in breast tissue during long-term hormone therapy in cynomolgus monkeys. Am J Obstet Gynecol. 2005 Jul; 193(1):58-63. PMID: 16021059.
      Citations:    
    153. Ibdah JA, Perlegas P, Zhao Y, Angdisen J, Borgerink H, Shadoan MK, Wagner JD, Matern D, Rinaldo P, Cline JM. Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance. Gastroenterology. 2005 May; 128(5):1381-90. PMID: 15887119.
      Citations:    
    154. Angdisen J, Moore VD, Cline JM, Payne RM, Ibdah JA. Mitochondrial trifunctional protein defects: molecular basis and novel therapeutic approaches. Curr Drug Targets Immune Endocr Metabol Disord. 2005 Mar; 5(1):27-40. PMID: 15777202.
      Citations:    
    155. Cline JM, Wood CE. Hormonal effects on the mammary gland of postmenopausal nonhuman primates. Breast Dis. 2005-2006; 24:59-70. PMID: 16917139.
      Citations:    
    156. Cohen KA, Liu TF, Cline JM, Wagner JD, Hall PD, Frankel AE. Safety evaluation of DT388IL3, a diphtheria toxin/interleukin 3 fusion protein, in the cynomolgus monkey. Cancer Immunol Immunother. 2005 Aug; 54(8):799-806. PMID: 15614527.
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    157. Stute P, Wood CE, Kaplan JR, Cline JM. Cyclic changes in the mammary gland of cynomolgus macaques. Fertil Steril. 2004 Oct; 82 Suppl 3:1160-70. PMID: 15474090.
      Citations:    
    158. Clarkson TB, Appt SE, Wood CE, Cline JM. Lessons to be learned from animal studies on hormones and the breast. Maturitas. 2004 Sep 24; 49(1):79-89. PMID: 15351099.
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    159. Clarkson TB, Anthony MS, Cline JM, Lees CJ, Ederveen AG. Multisystem evaluations of the long-term effects of tibolone on postmenopausal monkeys. Maturitas. 2004 Aug 30; 48 Suppl 1:S24-9. PMID: 15337245.
      Citations:    
    160. Cohen KA, Liu TF, Cline JM, Wagner JD, Hall PD, Frankel AE. Toxicology and pharmacokinetics of DT388IL3, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human interleukin 3 (IL3), in cynomolgus monkeys. Leuk Lymphoma. 2004 Aug; 45(8):1647-56. PMID: 15370220.
      Citations:    
    161. Wood CE, Register TC, Anthony MS, Kock ND, Cline JM. Breast and uterine effects of soy isoflavones and conjugated equine estrogens in postmenopausal female monkeys. J Clin Endocrinol Metab. 2004 Jul; 89(7):3462-8. PMID: 15240632.
      Citations:    
    162. Shively CA, Register TC, Grant KA, Johnson JL, Cline JM. Effects of social status and moderate alcohol consumption on mammary gland and endometrium of surgically postmenopausal monkeys. Menopause. 2004 Jul-Aug; 11(4):389-99. PMID: 15243276.
      Citations:    
    163. Wood CE, Cline JM, Anthony MS, Register TC, Kaplan JR. Adrenocortical effects of oral estrogens and soy isoflavones in female monkeys. J Clin Endocrinol Metab. 2004 May; 89(5):2319-25. PMID: 15126559.
      Citations:    
    164. Wood CE, Borgerink H, Register TC, Scott L, Cline JM. Cervical and vaginal epithelial neoplasms in cynomolgus monkeys. Vet Pathol. 2004 Mar; 41(2):108-15. PMID: 15017023.
      Citations:    
    165. Cline JM, Franke AA, Register TC, Golden DL, Adams MR. Effects of dietary isoflavone aglycones on the reproductive tract of male and female mice. Toxicol Pathol. 2004 Jan-Feb; 32(1):91-9. PMID: 14713553.
      Citations:    
    166. Cline JM. Neoplasms of the reproductive tract: the role of hormone exposure. ILAR J. 2004; 45(2):179-88. PMID: 15111737.
      Citations:    
    167. Suparto IH, Williams JK, Cline JM, Anthony MS, Fox JL. Contrasting effects of two hormone replacement therapies on the cardiovascular and mammary gland outcomes in surgically postmenopausal monkeys. Am J Obstet Gynecol. 2003 May; 188(5):1132-40. PMID: 12748457.
      Citations:    
    168. Cline JM, Register TC, Clarkson TB. Effects of tibolone and hormone replacement therapy on the breast of cynomolgus monkeys. Menopause. 2002 Nov-Dec; 9(6):422-9. PMID: 12439101.
      Citations:    
    169. Ramsey MM, Ingram RL, Cashion AB, Ng AH, Cline JM, Parlow AF, Sonntag WE. Growth hormone-deficient dwarf animals are resistant to dimethylbenzanthracine (DMBA)-induced mammary carcinogenesis. Endocrinology. 2002 Oct; 143(10):4139-42. PMID: 12239127.
      Citations:    
    170. Cline JM, Register TC, Clarkson TB. Comparative effects of tibolone and conjugated equine estrogens with and without medroxyprogesterone acetate on the reproductive tract of female cynomolgus monkeys. Menopause. 2002 Jul-Aug; 9(4):242-52. PMID: 12082360.
      Citations:    
    171. Blair RM, Cline JM, Anthony MS, Clarkson TB. Use of the progestin challenge test in nonhuman primates (Macaca fascicularis). Fertil Steril. 2002 Feb; 77(2):387-91. PMID: 11821102.
      Citations:    
    172. Register TC, Cline JM, Shively CA. Health issues in postmenopausal women who drink. Alcohol Res Health. 2002; 26(4):299-307. PMID: 12875041.
      Citations:    
    173. Wagner JD, Anthony MS, Cline JM. Soy phytoestrogens: research on benefits and risks. Clin Obstet Gynecol. 2001 Dec; 44(4):843-52. PMID: 11600865.
      Citations:    
    174. Wagner JD, Cline JM, Shadoan MK, Bullock BC, Rankin SE, Cefalu WT. Naturally occurring and experimental diabetes in cynomolgus monkeys: a comparison of carbohydrate and lipid metabolism and islet pathology. Toxicol Pathol. 2001 Jan-Feb; 29(1):142-8. PMID: 11215678.
      Citations:    
    175. Cline JM, Söderqvist G, Register TC, Williams JK, Adams MR, Von Schoultz B. Assessment of hormonally active agents in the reproductive tract of female nonhuman primates. Toxicol Pathol. 2001 Jan-Feb; 29(1):84-90. PMID: 11215689.
      Citations:    
    176. Wheeler KT, Wang LM, Wallen CA, Childers SR, Cline JM, Keng PC, Mach RH. Sigma-2 receptors as a biomarker of proliferation in solid tumours. Br J Cancer. 2000 Mar; 82(6):1223-32. PMID: 10735510; PMCID: PMC2363350.
      Citations:    
    177. Wilkinson LM, Wallace JM, Cline JM. Disseminated blastomycosis in a rhesus monkey (Macaca mulatta). Vet Pathol. 1999 Sep; 36(5):460-2. PMID: 10490216.
      Citations:    
    178. Hotchkiss CE, Hall PD, Cline JM, Willingham MC, Kreitman RJ, Gardin J, Latimer A, Ramage J, Feely T, DeLatte S, Tagge EP, Frankel AE. Toxicology and pharmacokinetics of DTGM, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human granulocyte-macrophage colony-stimulating factor, in cynomolgus monkeys. Toxicol Appl Pharmacol. 1999 Jul 15; 158(2):152-60. PMID: 10406930.
      Citations:    
    179. Cline JC, Connelly J. Intravenous clonidine for hypertensive emergencies. Am J Health Syst Pharm. 1999 Mar 15; 56(6):572-4. PMID: 10192695.
      Citations:    
    180. Williams JK, Cline JM, Honoré EK, Delansorne R, Paris J. Coadministration of nomegestrol acetate does not diminish the beneficial effects of estradiol on coronary artery dilator responses in nonhuman primates (Macaca fascicularis). Am J Obstet Gynecol. 1998 Nov; 179(5):1288-94. PMID: 9822518.
      Citations:    
    181. Gressani KM, Rollins LA, Leone-Kabler S, Cline JM, Miller MS. Induction of mutations in Ki-ras and INK4a in liver tumors of mice exposed in utero to 3-methylcholanthrene. Carcinogenesis. 1998 Jun; 19(6):1045-52. PMID: 9667743.
      Citations:    
    182. Cline JM, Soderqvist G, von Schoultz E, Skoog L, von Schoultz B. Effects of conjugated estrogens, medroxyprogesterone acetate, and tamoxifen on the mammary glands of macaques. Breast Cancer Res Treat. 1998 Apr; 48(3):221-9. PMID: 9598869.
      Citations:    
    183. Tansey G, Hughes CL, Cline JM, Krümmer A, Walmer DK, Schmoltzer S. Effects of dietary soybean estrogens on the reproductive tract in female rats. Proc Soc Exp Biol Med. 1998 Mar; 217(3):340-4. PMID: 9492345.
      Citations:    
    184. Clarkson TB, Anthony MS, Williams JK, Honoré EK, Cline JM. The potential of soybean phytoestrogens for postmenopausal hormone replacement therapy. Proc Soc Exp Biol Med. 1998 Mar; 217(3):365-8. PMID: 9492349.
      Citations:    
    185. Cline JM, Hughes CL. Phytochemicals for the prevention of breast and endometrial cancer. Cancer Treat Res. 1998; 94:107-34. PMID: 9587685.
      Citations:    
    186. Obasanjo IO, Cline JM, Schmotzer S, Weaver DS. Nandrolone decanoate causes pathologic changes in the uterus of surgically postmenopausal female cynomolgus macaques. Menopause. 1998; 5(3):163-8. PMID: 9774762.
      Citations:    
    187. Clarkson TB, Cline JM, Williams JK, Anthony MS. Gonadal hormone substitutes: effects on the cardiovascular system. Osteoporos Int. 1997; 7 Suppl 1:S43-51. PMID: 9205646.
      Citations:    
    188. Cline JM, Söderqvist G, von Schoultz B, Skoog L. Regional distribution of proliferating cells and hormone receptors in the mammary gland of surgically postmenopausal macaques. Gynecol Obstet Invest. 1997; 44(1):41-6. PMID: 9251953.
      Citations:    
    189. Washburn SA, Honoré EK, Cline JM, Helman M, Wagner JD, Adelman SJ, Clarkson TB. Effects of 17 alpha-dihydroequilenin sulfate on atherosclerotic male and female rhesus monkeys. Am J Obstet Gynecol. 1996 Aug; 175(2):341-9; discussion 349-51. PMID: 8765251.
      Citations:    
    190. Cline JM, Soderqvist G, von Schoultz E, Skoog L, von Schoultz B. Effects of hormone replacement therapy on the mammary gland of surgically postmenopausal cynomolgus macaques. Am J Obstet Gynecol. 1996 Jan; 174(1 Pt 1):93-100. PMID: 8572040.
      Citations:    
    191. Cline JM, Thrall DE, Rosner GL, Raleigh JA. Distribution of the hypoxia marker CCI-103F in canine tumors. Int J Radiat Oncol Biol Phys. 1994 Mar 1; 28(4):921-33. PMID: 8138446.
      Citations:    
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