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Xiaoyan I. Leng MD, PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentPHS-Biostatistics and Data Science (Public Health Sciences)
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Nicklas BJ, Brinkley TE, Houston DK, Lyles MF, Hugenschmidt CE, Beavers KM, Leng X. Effects of Caloric Restriction on Cardiorespiratory Fitness, Fatigue, and Disability Responses to Aerobic Exercise in Older Adults With Obesity: A Randomized Controlled Trial. J Gerontol A Biol Sci Med Sci. 2019 06 18; 74(7):1084-1090. PMID: 29982294.
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    2. Hugenschmidt CE, Leng X, Lyles M, Michael L, Dougherty A, Babcock P, Baker LD, Brinkley TE, Nicklas BJ. Cognitive Effects of Adding Caloric Restriction to Aerobic Exercise Training in Older Adults with Obesity. Obesity (Silver Spring). 2019 08; 27(8):1266-1274. PMID: 31199592.
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    3. Arcury TA, Sandberg JC, Melius KP, Quandt SA, Leng X, Latulipe C, Miller DP, Smith DA, Bertoni AG. Older Adult Internet Use and eHealth Literacy. J Appl Gerontol. 2020 02; 39(2):141-150. PMID: 30353776.
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    4. Kim S, Neiberg R, Rejeski WJ, Marsh AP, Kritchevsky SB, Leng XI, Groban L. Self-reported mobility as a preoperative risk assessment tool in older surgical patients compared to the American College of Surgeons National Surgical Quality Improvement Program. Perioper Med (Lond). 2018; 7:12. PMID: 29951202.
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    5. Leng X, Espeland MA, Manson JE, Stefanick ML, Gower EW, Hayden KM, Limacher MC, Vaughan L, Robinson J, Wallace R, Wassertheil-Smoller S, Yaffe K, Shumaker SA. Cognitive Function and Changes in Cognitive Function as Predictors of Incident Cardiovascular Disease: The Women's Health Initiative Memory Study. J Gerontol A Biol Sci Med Sci. 2018 05 09; 73(6):779-785. PMID: 28977360.
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    6. Arcury TA, Quandt SA, Sandberg JC, Miller DP, Latulipe C, Leng X, Talton JW, Melius KP, Smith A, Bertoni AG. Patient Portal Utilization Among Ethnically Diverse Low Income Older Adults: Observational Study. JMIR Med Inform. 2017 Nov 14; 5(4):e47. PMID: 29138129.
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    7. Kim S, Leng XI, Kritchevsky SB. Body Composition and Physical Function in Older Adults with Various Comorbidities. Innov Aging. 2017 Mar 01; 1(1):igx008. PMID: 30480107.
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    8. Brinkley TE, Leng X, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG. Racial differences in circulating levels of the soluble receptor for advanced glycation endproducts in middle-aged and older adults. Metabolism. 2017 05; 70:98-106. PMID: 28403949.
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    9. Kim S, Marsh AP, Rustowicz L, Roach C, Leng XI, Kritchevsky SB, Rejeski WJ, Groban L. Self-reported Mobility in Older Patients Predicts Early Postoperative Outcomes after Elective Noncardiac Surgery. Anesthesiology. 2016 Apr; 124(4):815-25. PMID: 26978144.
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    10. Weaver KE, Leach CR, Leng X, Danhauer SC, Klepin HD, Vaughan L, Naughton M, Chlebowski RT, Vitolins MZ, Paskett E. Physical Functioning among Women 80 Years of Age and Older With and Without a Cancer History. J Gerontol A Biol Sci Med Sci. 2016 Mar; 71 Suppl 1:S23-30. PMID: 26858321.
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    11. Vaughan L, Leng X, La Monte MJ, Tindle HA, Cochrane BB, Shumaker SA. Functional Independence in Late-Life: Maintaining Physical Functioning in Older Adulthood Predicts Daily Life Function after Age 80. J Gerontol A Biol Sci Med Sci. 2016 Mar; 71 Suppl 1:S79-86. PMID: 26858328.
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    12. Ip EH, Leng X, Zhang Q, Schwartz R, Chen SH, Dai S, Labarthe D. Risk profiles of lipids, blood pressure, and anthropometric measures in childhood and adolescence: project heartBeat! BMC Obes. 2016; 3:9. PMID: 26929822.
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    13. Beavers DP, Pettinger M, Espeland MA, Snively BM, Leng X, Hunt JR, Tindle HA, Shumaker SA. The Evolution of the WHI 80+ Cohort. J Gerontol A Biol Sci Med Sci. 2016 Mar; 71 Suppl 1:S13-22. PMID: 25922347.
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    14. Chmelo EA, Crotts CI, Newman JC, Brinkley TE, Lyles MF, Leng X, Marsh AP, Nicklas BJ. Heterogeneity of physical function responses to exercise training in older adults. J Am Geriatr Soc. 2015 Mar; 63(3):462-9. PMID: 25752778.
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    15. Houston DK, Leng X, Bray GA, Hergenroeder AL, Hill JO, Jakicic JM, Johnson KC, Neiberg RH, Marsh AP, Rejeski WJ, Kritchevsky SB. A long-term intensive lifestyle intervention and physical function: the look AHEAD Movement and Memory Study. Obesity (Silver Spring). 2015 Jan; 23(1):77-84. PMID: 25452229.
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    16. Nicklas BJ, Gaukstern JE, Beavers KM, Newman JC, Leng X, Rejeski WJ. Self-monitoring of spontaneous physical activity and sedentary behavior to prevent weight regain in older adults. Obesity (Silver Spring). 2014 Jun; 22(6):1406-12. PMID: 24585701.
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    17. Sawaki L, Butler AJ, Leng X, Wassenaar PA, Mohammad YM, Blanton S, Sathian K, Nichols-Larsen DS, Wolf SL, Good DC, Wittenberg GF. Differential patterns of cortical reorganization following constraint-induced movement therapy during early and late period after stroke: A preliminary study. NeuroRehabilitation. 2014; 35(3):415-26. PMID: 25227542.
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    18. Butler SG, Clark H, Baginski SG, Todd JT, Lintzenich C, Leng X. Computed tomography pulmonary findings in healthy older adult aspirators versus nonaspirators. Laryngoscope. 2014 Feb; 124(2):494-7. PMID: 23832617.
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    19. Stehle JR, Leng X, Kitzman DW, Nicklas BJ, Kritchevsky SB, High KP. Lipopolysaccharide-binding protein, a surrogate marker of microbial translocation, is associated with physical function in healthy older adults. J Gerontol A Biol Sci Med Sci. 2012 Nov; 67(11):1212-8. PMID: 22960476.
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    20. Arcury TA, Savoca MR, Anderson AM, Chen H, Gilbert GH, Bell RA, Leng X, Reynolds T, Quandt SA. Dental care utilization among North Carolina rural older adults. J Public Health Dent. 2012; 72(3):190-7. PMID: 22536828.
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    21. Butler SG, Lintzenich CR, Leng X, Stuart A, Feng X, Carr JJ, Kritchevsky SB. Tongue adiposity and strength in healthy older adults. Laryngoscope. 2012 Jul; 122(7):1600-4. PMID: 22522371.
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    22. Loeser RF, Olex AL, McNulty MA, Carlson CS, Callahan MF, Ferguson CM, Chou J, Leng X, Fetrow JS. Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice. Arthritis Rheum. 2012 Mar; 64(3):705-17. PMID: 21972019.
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    23. Butler SG, Maslan J, Stuart A, Leng X, Wilhelm E, Lintzenich CR, Williamson J, Kritchevsky SB. Factors influencing bolus dwell times in healthy older adults assessed endoscopically. Laryngoscope. 2011 Dec; 121(12):2526-34. PMID: 22081498.
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    24. Arcury TA, Chen H, Savoca MR, Anderson AM, Leng X, Bell RA, Quandt SA. Ethnic variation in oral health and social integration among older rural adults. J Appl Gerontol. 2013 Apr; 32(3):302-23. PMID: 23788829.
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    25. Chapman DB, French CC, Leng X, Browne JD, Waltonen JD, Sullivan CA. Parathyroid hormone early percent change: an individualized approach to predict postthyroidectomy hypocalcemia. Am J Otolaryngol. 2012 Mar-Apr; 33(2):216-20. PMID: 21899924.
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    26. Darcy JM, Grzywacz JG, Stephens RL, Leng I, Clinch CR, Arcury TA. Maternal depressive symptomatology: 16-month follow-up of infant and maternal health-related quality of life. J Am Board Fam Med. 2011 May-Jun; 24(3):249-57. PMID: 21551396.
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    27. Maslan J, Leng X, Rees C, Blalock D, Butler SG. Maximum phonation time in healthy older adults. J Voice. 2011 Nov; 25(6):709-13. PMID: 21439778.
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    28. Quandt SA, Savoca MR, Leng X, Chen H, Bell RA, Gilbert GH, Anderson AM, Kohrman T, Arcury TA. Dry mouth and dietary quality in older adults in north Carolina. J Am Geriatr Soc. 2011 Mar; 59(3):439-45. PMID: 21391935.
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    29. Butler SG, Stuart A, Leng X, Wilhelm E, Rees C, Williamson J, Kritchevsky SB. The relationship of aspiration status with tongue and handgrip strength in healthy older adults. J Gerontol A Biol Sci Med Sci. 2011 Apr; 66(4):452-8. PMID: 21300744.
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    30. Butler SG, Stuart A, Leng X, Rees C, Williamson J, Kritchevsky SB. Factors influencing aspiration during swallowing in healthy older adults. Laryngoscope. 2010 Nov; 120(11):2147-52. PMID: 20938951.
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    31. Helderman JB, Welch CD, Leng X, O'Shea TM. Sepsis-associated electroencephalographic changes in extremely low gestational age neonates. Early Hum Dev. 2010 Aug; 86(8):509-13. PMID: 20708356.
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    32. Olex AL, Hiltbold EM, Leng X, Fetrow JS. Dynamics of dendritic cell maturation are identified through a novel filtering strategy applied to biological time-course microarray replicates. BMC Immunol. 2010 Aug 03; 11:41. PMID: 20682054.
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    33. Van Ness PH, Charpentier PA, Ip EH, Leng X, Murphy TE, Tooze JA, Allore HG. Gerontologic biostatistics: the statistical challenges of clinical research with older study participants. J Am Geriatr Soc. 2010 Jul; 58(7):1386-92. PMID: 20533963.
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    34. Savoca MR, Arcury TA, Leng X, Chen H, Bell RA, Anderson AM, Kohrman T, Gilbert GH, Quandt SA. Association between dietary quality of rural older adults and self-reported food avoidance and food modification due to oral health problems. J Am Geriatr Soc. 2010 Jul; 58(7):1225-32. PMID: 20533966.
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    35. Reddix RN, Leng XI, Woodall J, Jackson B, Dedmond B, Webb LX. The effect of incisional negative pressure therapy on wound complications after acetabular fracture surgery. J Surg Orthop Adv. 2010; 19(2):91-7. PMID: 20727304.
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    36. Puntawangkoon C, Kitzman DW, Kritchevsky SB, Hamilton CA, Nicklas B, Leng X, Brubaker PH, Hundley WG. Reduced peripheral arterial blood flow with preserved cardiac output during submaximal bicycle exercise in elderly heart failure. J Cardiovasc Magn Reson. 2009 Nov 18; 11:48. PMID: 19922666.
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    37. Savoca MR, Arcury TA, Leng X, Chen H, Bell RA, Anderson AM, Kohrman T, Frazier RJ, Gilbert GH, Quandt SA. Severe tooth loss in older adults as a key indicator of compromised dietary quality. Public Health Nutr. 2010 Apr; 13(4):466-74. PMID: 19691903.
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    38. Sink KM, Leng X, Williamson J, Kritchevsky SB, Yaffe K, Kuller L, Yasar S, Atkinson H, Robbins M, Psaty B, Goff DC. Angiotensin-converting enzyme inhibitors and cognitive decline in older adults with hypertension: results from the Cardiovascular Health Study. Arch Intern Med. 2009 Jul 13; 169(13):1195-202. PMID: 19597068.
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    39. Quandt SA, Chen H, Bell RA, Savoca MR, Anderson AM, Leng X, Kohrman T, Gilbert GH, Arcury TA. Food avoidance and food modification practices of older rural adults: association with oral health status and implications for service provision. Gerontologist. 2010 Feb; 50(1):100-11. PMID: 19574543.
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    40. Hartmann EL, Kitzman D, Rocco M, Leng X, Klepin H, Gordon M, Rejeski J, Berry M, Kritchevsky S. Physical function in older candidates for renal transplantation: an impaired population. Clin J Am Soc Nephrol. 2009 Mar; 4(3):588-94. PMID: 19261824.
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    41. Brinkley TE, Leng X, Miller ME, Kitzman DW, Pahor M, Berry MJ, Marsh AP, Kritchevsky SB, Nicklas BJ. Chronic inflammation is associated with low physical function in older adults across multiple comorbidities. J Gerontol A Biol Sci Med Sci. 2009 Apr; 64(4):455-61. PMID: 19196644.
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    42. Sawaki L, Butler AJ, Leng X, Wassenaar PA, Mohammad YM, Blanton S, Sathian K, Nichols-Larsen DS, Wolf SL, Good DC, Wittenberg GF. Constraint-induced movement therapy results in increased motor map area in subjects 3 to 9 months after stroke. Neurorehabil Neural Repair. 2008 Sep-Oct; 22(5):505-13. PMID: 18780885.
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    43. Grant KA, Leng X, Green HL, Szeliga KT, Rogers LS, Gonzales SW. Drinking typography established by scheduled induction predicts chronic heavy drinking in a monkey model of ethanol self-administration. Alcohol Clin Exp Res. 2008 Oct; 32(10):1824-38. PMID: 18702645.
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    44. Nicklas BJ, Leng I, Delbono O, Kitzman DW, Marsh AP, Hundley WG, Lyles MF, O'Rourke KS, Annex BH, Kraus WE. Relationship of physical function to vastus lateralis capillary density and metabolic enzyme activity in elderly men and women. Aging Clin Exp Res. 2008 Aug; 20(4):302-9. PMID: 18852542.
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    45. Müller HG, Chiou JM, Leng X. Inferring gene expression dynamics via functional regression analysis. BMC Bioinformatics. 2008 Jan 28; 9:60. PMID: 18226220.
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    46. Leng X, Müller HG. Time ordering of gene coexpression. Biostatistics. 2006 Oct; 7(4):569-84. PMID: 16495429.
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    47. Leng X, Müller HG. Classification using functional data analysis for temporal gene expression data. Bioinformatics. 2006 Jan 01; 22(1):68-76. PMID: 16257986.
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