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Yuanyuan Zhang MD, PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentWake Forest Institute for Regenerative Medicine
Address
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    Collapse Research 
    Collapse research overview
    3D Organoids for Drug-Induced Mitochondrial Toxicity Testing and Nephrotoxicity Testing

    Cell Therapy for Renal Dysfunction, Vesicoureteral Reflux, Stress Urinary Incontinence and Erectile Dysfunction

    Controlled Release of Growth Factors

    Kidney Tissue Regeneration

    Stem Cells

    Tissue Specific Extracellular Matrix

    Treatment and Biomarkers for Diabetic Nephropathy
    Collapse research activities and funding
    R21DK071791     (PI: Zhang, Yuanyuan)Jan 4, 2006 - Jan 3, 2009
    NIH/HIDDK
    Use of Bone Marrow Stromal Cells for Bladder Tissue Engineering.
    R56DK100669     (PI: Zhang, Yuanyuan)Jul 10, 2014 - Jul 9, 2015
    NIH/NIDDK
    Stem Cell Therapy Combined with Growth Factors for Stress Urinary Incontinence
    U01 DK103225     (PI: FELDMAN, HAROLD; Pilot Grant Site-PI: Zhang Yuanyuan)Apr 15, 2018 - Jun 30, 2019
    NIH/NIDDK
    Micro-RNA from Urine-derived Stem Cells as a Novel Biomarker for Diabetic Nephropathy
    R21AI152832     (PI: Zhang, Yuanyuan)Oct 7, 2020 - Sep 7, 2022
    NIH/NIAID
    3D Culture Systems of Urine-Derived Stem Cell for NTRI-Induced Mitotoxicity Assessment
    R03AI165170     (PI: Zhang, Yuanyuan)Jun 10, 2021 - Jun 9, 2023
    NIH/NIAID
    Silk Fibers-Assisted 3D System for Large-Scale Culture of Human Urine-Derived Stem Cells Suitable for Late Mitotoxicity Testing

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yu P, Zhu H, Bosholm CC, Beiner D, Duan Z, Shetty AK, Mou SS, Kramer PA, Barroso LF, Liu H, Cheng K, Ihnat M, Gorris MA, Aloi JA, Woldemichael JA, Bleyer A, Zhang Y. Precision nephrotoxicity testing using 3D in vitro models. Cell Biosci. 2023 Dec 21; 13(1):231. PMID: 38129901.
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    2. Wang Y, Liu Z, Pan C, Zheng Y, Chen Y, Lian X, Jiang Y, Chen C, Xue K, Zhang Y, Xu P, Liu K. Ultrasound-Driven Healing: Unleashing the Potential of Chondrocyte-Derived Extracellular Vesicles for Chondrogenesis in Adipose-Derived Stem Cells. Biomedicines. 2023 Oct 19; 11(10). PMID: 37893208.
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    3. Feloney MP, Klock JA, Zhang Y. Dual balloon adjustable continence therapy for urinary incontinence. Am J Clin Exp Urol. 2023; 11(4):334-338. PMID: 37645611.
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    4. Huang RL, Li Q, Ma JX, Atala A, Zhang Y. Body fluid-derived stem cells - an untapped stem cell source in genitourinary regeneration. Nat Rev Urol. 2023 Dec; 20(12):739-761. PMID: 37414959.
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    5. Zhang W, Zheng Z, Wang K, Mao W, Li X, Wang G, Zhang Y, Huang J, Zhang N, Wu P, Liu J, Zhang H, Che J, Peng B, Zheng J, Li W, Yao X. piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination. Exp Mol Med. 2023 Jun; 55(6):1258-1271. PMID: 37332045.
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    6. Bosholm CC, Zhu H, Yu P, Cheng K, Murphy SV, McNutt PM, Zhang Y. Therapeutic Benefits of Stem Cells and Exosomes for Sulfur-Mustard-Induced Tissue Damage. Int J Mol Sci. 2023 Jun 09; 24(12). PMID: 37373093.
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    7. Shan S, Li Q, Criswell T, Atala A, Zhang Y. Stem cell therapy combined with controlled release of growth factors for the treatment of sphincter dysfunction. Cell Biosci. 2023 Mar 16; 13(1):56. PMID: 36927578.
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    8. Yu Y, Chen M, Guo Q, Shen L, Liu X, Pan J, Zhang Y, Xu T, Zhang D, Wei G. Human umbilical cord mesenchymal stem cell exosome-derived miR-874-3p targeting RIPK1/PGAM5 attenuates kidney tubular epithelial cell damage. Cell Mol Biol Lett. 2023 Feb 07; 28(1):12. PMID: 36750776.
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    9. Qu Q, Park K, Zhou K, Wassel D, Farjo R, Criswell T, Ma JX, Zhang Y. Sustained therapeutic effect of an anti-inflammatory peptide encapsulated in nanoparticles on ocular vascular leakage in diabetic retinopathy. Front Cell Dev Biol. 2022; 10:1049678. PMID: 36589744.
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    10. Chen M, Yu Y, Mi T, Guo Q, Xiang B, Tian X, Jin L, Long C, Shen L, Liu X, Pan J, Zhang Y, Xu T, Zhang D, Wei G. MK-2206 Alleviates Renal Fibrosis by Suppressing the Akt/mTOR Signaling Pathway In Vivo and In Vitro. Cells. 2022 Nov 05; 11(21). PMID: 36359901.
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    11. Li Q, Qi G, Lutter D, Beard W, Souza CRS, Highland MA, Wu W, Li P, Zhang Y, Atala A, Sun X. Injectable Peptide Hydrogel Encapsulation of Mesenchymal Stem Cells Improved Viability, Stemness, Anti-Inflammatory Effects, and Early Stage Wound Healing. Biomolecules. 2022 Sep 17; 12(9). PMID: 36139156.
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    12. Mao W, Wang K, Zhang W, Chen S, Xie J, Zheng Z, Li X, Zhang N, Zhang Y, Zhang H, Peng B, Yao X, Che J, Zheng J, Chen M, Li W. Transfection with Plasmid-Encoding lncRNA-SLERCC nanoparticle-mediated delivery suppressed tumor progression in renal cell carcinoma. J Exp Clin Cancer Res. 2022 Aug 19; 41(1):252. PMID: 35986402.
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    13. Yin X, Li Q, McNutt PM, Zhang Y. Urine-Derived Stem Cells for Epithelial Tissues Reconstruction and Wound Healing. Pharmaceutics. 2022 Aug 11; 14(8). PMID: 36015295.
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    14. Ding, Huifen; George, Sunil; Leng, Xiaoyan Iris; Ihnat, Michael; Ma, Jian-Xing; Jiang, Guochun; Margolis, Dumond, Julie; Zhang, Yuanyuan. Silk fibers assisted long-term 3D culture of human primary urinary stem cells via inhibition of senescence-associated genes: Potential use in the assessment of chronic mitochondrial toxicity. Materials Today Advances. 2022; 15. View Publication.
    15. Canning P, Alwan A, Khalil F, Zhang Y, Opara EC. Perspectives and Challenges on the Potential Use of Exosomes in Bioartificial Pancreas Engineering. Ann Biomed Eng. 2022 Jul 08. PMID: 35804253.
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    16. Ding H, George S, Leng XI, Ihnat M, Ma JX, Jiang G, Margolis D, Dumond J, Zhang Y. Silk fibers assisted long-term 3D culture of human primary urinary stem cells via inhibition of senescence-associated genes: Potential use in the assessment of chronic mitochondrial toxicity. Mater Today Adv. 2022 Aug; 15. PMID: 36212078.
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    17. Shi Y, Liu G, Wu R, Mack DL, Sun XS, Maxwell J, Guan X, Atala A, Zhang Y. Differentiation Capacity of Human Urine-Derived Stem Cells to Retain Telomerase Activity. Front Cell Dev Biol. 2022; 10:890574. PMID: 35693947.
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    18. Ding H, Jambunathan K, Jiang G, Margolis DM, Leng I, Ihnat M, Ma JX, Mirsalis J, Zhang Y. 3D Spheroids of Human Primary Urine-Derived Stem Cells in the Assessment of Drug-Induced Mitochondrial Toxicity. Pharmaceutics. 2022 May 11; 14(5). PMID: 35631624.
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    19. Fan J, Dai J, Lu F, Zhang Y. Editorial: Regulation Mechanism of Adipose-Derived Stem Cells in Differentiation and Translation. Front Physiol. 2022; 13:852275. PMID: 35283758.
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    20. Liu C, Pei M, Li Q, Zhang Y. Decellularized extracellular matrix mediates tissue construction and regeneration. Front Med. 2021 Dec 28. PMID: 34962624.
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    21. Yu P, Duan Z, Liu S, Pachon I, Ma J, Hemstreet GP, Zhang Y. Drug-Induced Nephrotoxicity Assessment in 3D Cellular Models. Micromachines (Basel). 2021 Dec 21; 13(1). PMID: 35056167.
      Citations:    
    22. Zhang Z, Zhu X, Wang Y, Chen D, Fan J, Deng C, Liu G, Yang L, Feloney M, Wang X, Zhang Y. Sexual dysfunction associated with chronic retention of foreign bodies in the low urinary tract. Andrologia. 2021 Dec 06; e14346. PMID: 34873749.
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    23. Tao W, Ming X, Zang Y, Zhu J, Zhang Y, Sun C, Xue B. The clinical outcomes of flexible ureteroscopy and laser lithotripsy (FURSL) for treatment of the upper urinary tract calculi. J Xray Sci Technol. 2021 Oct 24. PMID: 34719474.
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    24. Gong ZC, Wu ZL, Wen YA, Zou JP, Wang X, Leng X, Bleyer AJ, Deng C, Feloney MP, Zhang Y, Zhao SC. Sexual Dysfunction in Patients With Urinary Bladder Stones but no Bladder Outlet Obstruction. Front Med (Lausanne). 2021; 8:704360. PMID: 34604254.
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    25. Wu R, Soland M, Liu G, Shi Y, Zhang C, Tang Y, Almeida-Porada G, Zhang Y. Functional characterization of the immunomodulatory properties of human urine-derived stem cells. Transl Androl Urol. 2021 Sep; 10(9):3566-3578. PMID: 34733653.
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    26. Sun B, Luo X, Yang C, Liu P, Yang Y, Dong X, Yang Z. Corrigendum to "Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro". Stem Cells Int. 2021; 2021:9789181. PMID: 33981344.
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    27. Luo S, Shao L, Geng R, Liu Q, Jiang W, Gong M, Zhang Y, He Y. Identification and biological characteristics of clear cell renal cell carcinoma associated urine-derived stem cells. Am J Transl Res. 2021; 13(4):2143-2162. PMID: 34017380.
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    28. Hu C, He Y, Fang S, Tian N, Gong M, Xu X, Zhao L, Wang Y, He TC, Zhang Y, Bi Y. Erratum: Urine-derived stem cells accelerate the recovery of injured mouse hepatic tissue. Am J Transl Res. 2021; 13(3):1904. PMID: 33841718.
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    29. Vasyutin I, Butnaru D, Lyundup A, Timashev P, Vinarov A, Kuznetsov S, Atala A, Zhang Y. Frontiers in urethra regeneration: current state and future perspective. Biomed Mater. 2021 Mar 09; 16(4). PMID: 32503009.
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    30. Zhang Z, Fang L, Chen D, Li W, Peng N, Thakker PU, Zhang Y, Wang X. A Modified Endoscopic Primary Realignment of Severe Bulbar Urethral Injury. J Endourol. 2021 03; 35(3):335-341. PMID: 33040587.
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    31. Wang X, Zhang Z, Zhu X, Cheng W, Fang J, Cai Y, Li W, Thakker PU, Zhang Y. A rare case of a cystic renal mass with heterotopic ossification and a mini literature review. J Xray Sci Technol. 2021; 29(3):541-549. PMID: 33749630.
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    32. Zhang Z, Chen D, Deng L, Li W, Wang X, Zhang Y, Liekui F, Feloney MP, Zhang Y. Iatrogenic ureteral injury during retroperitoneal laparoscopy for large renal cysts: What we learned and a review of the literature. J Xray Sci Technol. 2021; 29(1):185-196. PMID: 33459688.
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    33. Guo H, Deng N, Dou L, Ding H, Criswell T, Atala A, Furdui CM, Zhang Y. 3-D Human Renal Tubular Organoids Generated from Urine-Derived Stem Cells for Nephrotoxicity Screening. ACS Biomater Sci Eng. 2020 12 14; 6(12):6701-6709. PMID: 33320634.
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    34. Qiao B, Luo Y, Cheng HB, Ren J, Cao J, Yang C, Liang B, Yang A, Yuan X, Li J, Deng L, Li P, Ran HT, Hao L, Zhou Z, Li M, Zhang Y, Timashev PS, Liang XJ, Wang Z. Artificial Nanotargeted Cells with Stable Photothermal Performance for Multimodal Imaging-Guided Tumor-Specific Therapy. ACS Nano. 2020 10 27; 14(10):12652-12667. PMID: 32986406.
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    35. Li F, Chen J, Gong M, Bi Y, Hu C, Zhang Y, Li M. Isolation and Characterization of Human Synovial Fluid-Derived Mesenchymal Stromal Cells from Popliteal Cyst. Stem Cells Int. 2020; 2020:7416493. PMID: 33014069.
      Citations:    
    36. Hu C, He Y, Fang S, Tian N, Gong M, Xu X, Zhao L, Wang Y, He T, Zhang Y, Bi Y. Urine-derived stem cells accelerate the recovery of injured mouse hepatic tissue. Am J Transl Res. 2020; 12(9):5131-5150. PMID: 33042410.
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    37. Duan H, Zhang X, Song R, Liu T, Zhang Y, Yu A. Upregulation of miR-133a by adiponectin inhibits pyroptosis pathway and rescues acute aortic dissection. Acta Biochim Biophys Sin (Shanghai). 2020 Sep 08; 52(9):988-997. PMID: 32634201.
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    38. Chen K, Sinelnikov MY, Reshetov IV, Timashev P, Gu Y, Mu L, Lu P, Zhang Y. Therapeutic Potential of Mesenchymal Stem Cells for Postmastectomy Lymphedema: A Literature Review. Clin Transl Sci. 2021 01; 14(1):54-61. PMID: 33460321.
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    39. Matz EL, Thakker PU, Gu X, Terlecki RP, Dou L, Walker SJ, Lue T, Lin G, Atala A, Yoo JJ, Zhang Y, Jackson JD. Administration of secretome from human placental stem cell-conditioned media improves recovery of erectile function in the pelvic neurovascular injury model. J Tissue Eng Regen Med. 2020 10; 14(10):1394-1402. PMID: 32652851.
      Citations:    
    40. Kosheleva NV, Efremov YM, Shavkuta BS, Zurina IM, Zhang D, Zhang Y, Minaev NV, Gorkun AA, Wei S, Shpichka AI, Saburina IN, Timashev PS. Cell spheroid fusion: beyond liquid drops model. Sci Rep. 2020 07 28; 10(1):12614. PMID: 32724115.
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    41. Yu Y, Hu D, Zhou Y, Xiang H, Liu B, Shen L, Long C, Liu X, Lin T, He D, Zhang Y, Xu T, Zhang D, Wei G. Human umbilical cord mesenchymal stem cell attenuates renal fibrosis via TGF-ß/Smad signaling pathways in vivo and in vitro. Eur J Pharmacol. 2020 Sep 15; 883:173343. PMID: 32629029.
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    42. Zhou C, Wu XR, Liu HS, Liu XH, Liu GH, Zheng XB, Hu T, Liang ZX, He XW, Wu XJ, Smith LC, Zhang Y, Lan P. Immunomodulatory Effect of Urine-derived Stem Cells on Inflammatory Bowel Diseases via Downregulating Th1/Th17 Immune Responses in a PGE2-dependent Manner. J Crohns Colitis. 2020 Jun 19; 14(5):654-668. PMID: 31841595.
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    43. Huang Q, Zhang J, Zhang Y, Timashev P, Ma X, Liang XJ. Adaptive changes induced by noble-metal nanostructures in vitro and in vivo. Theranostics. 2020; 10(13):5649-5670. PMID: 32483410.
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    44. Liu Y, Huang L, Yuan W, Zhang D, Gu Y, Huang J, Murphy S, Ali M, Zhang Y, Song L. Sustained release of stromal cell-derived factor-1 alpha from silk fibroin microfiber promotes urethral reconstruction in rabbits. J Biomed Mater Res A. 2020 08 01; 108(8):1760-1773. PMID: 32276293.
      Citations:    
    45. Hu D, Zhang D, Liu B, Liu Y, Zhou Y, Yu Y, Shen L, Long C, Zhang D, Liu X, Lin T, He D, Xu T, Timashev P, Butnaru D, Zhang Y, Wei G. Insights Image for "Human ucMSCs seeded in a decellularized kidney scaffold attenuate renal fibrosis by reducing epithelial-mesenchymal transition via the TGF-ß/Smad signaling pathway". Pediatr Res. 2020 08; 88(2):336. PMID: 32305994.
      Citations:    
    46. Sui Y, Zhang S, Li Y, Zhang X, Hu W, Feng Y, Xiong J, Zhang Y, Wei S. Generation of functional salivary gland tissue from human submandibular gland stem/progenitor cells. Stem Cell Res Ther. 2020 03 20; 11(1):127. PMID: 32197647.
      Citations:    
    47. Zhong L, Ding W, Zeng Q, He B, Zhang H, Wang L, Fan J, He S, Zhang Y, Wei A. Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia. Oxid Med Cell Longev. 2020; 2020:7286958. PMID: 32215177.
      Citations:    
    48. Yang X, Xiong X, Zhou W, Feng G, Zhang Y, Dai H, Zhou J. Effects of human urine-derived stem cells on the cementogenic differentiation of indirectly-cocultured periodontal ligament stem cells. Am J Transl Res. 2020; 12(2):361-378. PMID: 32194889.
      Citations:    
    49. Liu G, Wu R, Yang B, Shi Y, Deng C, Atala A, Mou S, Criswell T, Zhang Y. A cocktail of growth factors released from a heparin hyaluronic-acid hydrogel promotes the myogenic potential of human urine-derived stem cells in vivo. Acta Biomater. 2020 04 15; 107:50-64. PMID: 32044457.
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    50. Gu X, Thakker PU, Matz EL, Terlecki RP, Marini FC, Allickson JG, Lue TF, Lin G, Atala A, Yoo JJ, Zhang Y, Jackson JD. Dynamic Changes in Erectile Function and Histological Architecture After Intracorporal Injection of Human Placental Stem Cells in a Pelvic Neurovascular Injury Rat Model. J Sex Med. 2020 03; 17(3):400-411. PMID: 32001204.
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    51. Hu D, Zhang D, Liu B, Liu Y, Zhou Y, Yu Y, Shen L, Long C, Zhang D, Liu X, Lin T, He D, Xu T, Timashev P, Butnaru D, Zhang Y, Wei G. Human ucMSCs seeded in a decellularized kidney scaffold attenuate renal fibrosis by reducing epithelial-mesenchymal transition via the TGF-ß/Smad signaling pathway. Pediatr Res. 2020 08; 88(2):192-201. PMID: 31896126.
      Citations:    
    52. Tao W, Sun C, Yao Q, Fu K, Shan Y, Zhang Y, Xue B, Yang D. The clinical study of en bloc transurethral resection with 980?nm laser for treatment of primary non-muscle invasive bladder cancer. J Xray Sci Technol. 2020; 28(3):563-571. PMID: 32224536.
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    53. Zhang Z, Zhang Y, Wang X, Fang L, Chen D, Peng N, Thakker P, Wang Q, Zhang Y. Challenges in the diagnosis of severe renal trauma in child: A case report and literature review. J Xray Sci Technol. 2020; 28(2):357-367. PMID: 32039882.
      Citations:    
    54. Zhang C, George SK, Wu R, Thakker PU, Abolbashari M, Kim TH, Ko IK, Zhang Y, Sun Y, Jackson J, Lee SJ, Yoo JJ, Atala A. Reno-protection of Urine-derived Stem Cells in A Chronic Kidney Disease Rat Model Induced by Renal Ischemia and Nephrotoxicity. Int J Biol Sci. 2020; 16(3):435-446. PMID: 32015680.
      Citations:    
    55. Wang X, Zhang Z, Fang LK, Chen D, Peng N, Thakker PU, Schwartz MZ, Zhang Y. Challenges in the diagnosis of testicular infarction in the presence of prolonged epididymitis: Three cases report and literature review. J Xray Sci Technol. 2020; 28(4):809-819. PMID: 32474478.
      Citations:    
    56. Zhang Z, Wang X, Chen D, Peng N, Chen J, Wang Q, Yang M, Zhang Y. Minimally invasive management of acute ureteral obstruction and severe infection caused by upper urinary tract calculi. J Xray Sci Technol. 2020; 28(1):125-135. PMID: 31796723.
      Citations:    
    57. Zhang S, Sui Y, Fu X, Feng Y, Luo Z, Zhang Y, Wei S. Specific complexes derived from extracellular matrix facilitate generation of structural and drug-responsive human salivary gland microtissues through maintenance stem cell homeostasis. J Tissue Eng Regen Med. 2020 02; 14(2):284-294. PMID: 31833667.
      Citations:    
    58. Xiong X, Yang X, Dai H, Feng G, Zhang Y, Zhou J, Zhou W. Extracellular matrix derived from human urine-derived stem cells enhances the expansion, adhesion, spreading, and differentiation of human periodontal ligament stem cells. Stem Cell Res Ther. 2019 12 18; 10(1):396. PMID: 31852539.
      Citations:    
    59. Sun B, Dong X, Zhao J, Yang Z, Zhang Y, Li L. Differentiation of human urine-derived stem cells into interstitial cells of Cajal-like cells by exogenous gene modification: A preliminary study. Biochem Biophys Res Commun. 2020 02 26; 523(1):10-17. PMID: 31831171.
      Citations:    
    60. Sun B, Luo X, Yang C, Liu P, Yang Y, Dong X, Yang Z, Xu J, Zhang Y, Li L. Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro. Stem Cells Int. 2019; 2019:8035076. PMID: 31885626.
      Citations:    
    61. Dou L, Matz EL, Gu X, Shu F, Paxton J, Song J, Yoo J, Atala A, Jackson J, Zhang Y. Non-Invasive Cell Tracking with Brighter and Red-Transferred Luciferase for Potential Application in Stem Cell Therapy. Cell Transplant. 2019 12; 28(12):1542-1551. PMID: 31684762.
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    62. Zhang C, Luo D, Li T, Yang Q, Xie Y, Chen H, Lv L, Yao J, Deng C, Liang X, Wu R, Sun X, Zhang Y, Deng C, Liu G. Transplantation of Human Urine-Derived Stem Cells Ameliorates Erectile Function and Cavernosal Endothelial Function by Promoting Autophagy of Corpus Cavernosal Endothelial Cells in Diabetic Erectile Dysfunction Rats. Stem Cells Int. 2019; 2019:2168709. PMID: 31582984.
      Citations:    
    63. Deng C, Xie Y, Zhang C, Ouyang B, Chen H, Lv L, Yao J, Liang X, Zhang Y, Sun X, Deng C, Liu G. Urine-Derived Stem Cells Facilitate Endogenous Spermatogenesis Restoration of Busulfan-Induced Nonobstructive Azoospermic Mice by Paracrine Exosomes. Stem Cells Dev. 2019 10 01; 28(19):1322-1333. PMID: 31311428.
      Citations:    
    64. Li XY, Zhou LY, Luo H, Zhu Q, Zuo L, Liu GY, Feng C, Zhao JY, Zhang YY, Li X. The long noncoding RNA MIR210HG promotes tumor metastasis by acting as a ceRNA of miR-1226-3p to regulate mucin-1c expression in invasive breast cancer. Aging (Albany NY). 2019 08 10; 11(15):5646-5665. PMID: 31399552.
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    65. Zhou Y, Zhang D, Hu D, Liu B, Peng J, Shen L, Long C, Yu Y, Zhang Y, Liu X, Tao X, Timashev P, Lin T, He D, Wei G. Retinoic acid: A potential therapeutic agent for cryptorchidism infertility based on investigation of flutamide-induced cryptorchid rats in vivo and in vitro. Reprod Toxicol. 2019 08; 87:108-117. PMID: 31170451.
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    66. Xiong G, Tang W, Zhang D, He D, Wei G, Atala A, Liang XJ, Bleyer AJ, Bleyer ME, Yu J, Aloi JA, Ma JX, Furdui CM, Zhang Y. Impaired Regeneration Potential in Urinary Stem Cells Diagnosed from the Patients with Diabetic Nephropathy. Theranostics. 2019; 9(14):4221-4232. PMID: 31281543.
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    67. Ouyang B, Xie Y, Zhang C, Deng C, Lv L, Yao J, Zhang Y, Liu G, Deng J, Deng C. Extracellular Vesicles From Human Urine-Derived Stem Cells Ameliorate Erectile Dysfunction in a Diabetic Rat Model by Delivering Proangiogenic MicroRNA. Sex Med. 2019 Jun; 7(2):241-250. PMID: 30910509.
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    68. Shpichka A, Butnaru D, Bezrukov EA, Sukhanov RB, Atala A, Burdukovskii V, Zhang Y, Timashev P. Skin tissue regeneration for burn injury. Stem Cell Res Ther. 2019 03 15; 10(1):94. PMID: 30876456.
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    69. Gu X, Shi H, Matz E, Zhong L, Long T, Clouse C, Li W, Chen D, Chung H, Murphy S, Yoo J, Lin G, Lue T, Atala A, Jackson J, Zhang Y. Long-term therapeutic effect of cell therapy on improvement in erectile function in a rat model with pelvic neurovascular injury. BJU Int. 2019 07; 124(1):145-154. PMID: 30499626.
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    70. Tao W, Sun C, Yang D, Zang Y, Zhu J, Zhang Y, Wang G, Xue B. Application of 180W XPS GreenLight laser vaporization of the prostate for treatment of benign prostatic hyperplasia. J Xray Sci Technol. 2019; 27(6):1121-1129. PMID: 31498146.
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    71. Zhang Z, Zhang Y, Wang X, Chen D, Peng N, Chen J, Bleyer A, Wang Q, Liu Y, Zhang Y. Challenges in the diagnosis of calyceal diverticulum: A report of two cases and review of the literature. J Xray Sci Technol. 2019; 27(6):1155-1167. PMID: 31476195.
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    72. Glybochko PV, Alyaev YG, Khokhlachev SB, Fiev DN, Shpot EV, Petrovsky NV, Zhang D, Proskura AV, Yurova M, Matz EL, Wang X, Atala A, Zhang Y, Butnaru DV. 3D reconstruction of CT scans aid in preoperative planning for sarcomatoid renal cancer: A case report and mini-review. J Xray Sci Technol. 2019; 27(2):389-395. PMID: 30689600.
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    73. Tao W, Xue B, Sun C, Yang D, Zhang Y, Shan Y. Comparison of vaporization using 120-W GreenLight laser versus 2-micrometer continuous laser for treating benign prostatic hyperplasia: A 24-month follow-up study of a single center. J Xray Sci Technol. 2019; 27(4):755-764. PMID: 31256112.
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    74. Wan Q, Xiong G, Liu G, Shupe TD, Wei G, Zhang D, Liang D, Lu X, Atala A, Zhang Y. Urothelium with barrier function differentiated from human urine-derived stem cells for potential use in urinary tract reconstruction. Stem Cell Res Ther. 2018 11 08; 9(1):304. PMID: 30409188.
      Citations:    
    75. Qiao H, Zhang Y, Lin W, Wang YF, Furdui CM, Jiang Q, Li X, Long T, Wang Y, Qin DN. Decreased expression of pigment epithelium-derived factor within the penile tissues contributes to erectile dysfunction in diabetic rats. Clin Sci (Lond). 2018 10 31; 132(20):2175-2188. PMID: 30232174.
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    76. Liu B, Ding FX, Liu Y, Xiong G, Lin T, He DW, Zhang YY, Zhang DY, Wei GH. Human umbilical cord-derived mesenchymal stem cells conditioned medium attenuate interstitial fibrosis and stimulate the repair of tubular epithelial cells in an irreversible model of unilateral ureteral obstruction. Nephrology (Carlton). 2018 Aug; 23(8):728-736. PMID: 28667820.
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    77. Yang H, Chen B, Deng J, Zhuang G, Wu S, Liu G, Deng C, Yang G, Qiu X, Wei P, Wang X, Zhang Y. Characterization of rabbit urine-derived stem cells for potential application in lower urinary tract tissue regeneration. Cell Tissue Res. 2018 Nov; 374(2):303-315. PMID: 30066105.
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    169. Tian H, Bharadwaj S, Liu Y, Ma H, Ma PX, Atala A, Zhang Y. Myogenic differentiation of human bone marrow mesenchymal stem cells on a 3D nano fibrous scaffold for bladder tissue engineering. Biomaterials. 2010 Feb; 31(5):870-7. PMID: 19853294.
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    170. Liu Y, Bharadwaj S, Lee SJ, Atala A, Zhang Y. Optimization of a natural collagen scaffold to aid cell-matrix penetration for urologic tissue engineering. Biomaterials. 2009 Aug; 30(23-24):3865-73. PMID: 19427687.
      Citations:    
    171. Zhang Y, He Y, Bharadwaj S, Hammam N, Carnagey K, Myers R, Atala A, Van Dyke M. Tissue-specific extracellular matrix coatings for the promotion of cell proliferation and maintenance of cell phenotype. Biomaterials. 2009 Aug; 30(23-24):4021-8. PMID: 19410290.
      Citations:    
    172. Zhang Y, McNeill E, Tian H, Soker S, Andersson KE, Yoo JJ, Atala A. Urine derived cells are a potential source for urological tissue reconstruction. J Urol. 2008 Nov; 180(5):2226-33. PMID: 18804817.
      Citations:    
    173. Zhang Y. Bladder reconstruction by tissue engineering--with or without cells? J Urol. 2008 Jul; 180(1):10-1. PMID: 18485386.
      Citations:    
    174. Zhang Y, Frimberger D, Cheng EY, Lin HK, Kropp BP. Challenges in a larger bladder replacement with cell-seeded and unseeded small intestinal submucosa grafts in a subtotal cystectomy model. BJU Int. 2006 Nov; 98(5):1100-5. PMID: 17034611.
      Citations:    
    175. Mondalek FG, Zhang YY, Kropp B, Kopke RD, Ge X, Jackson RL, Dormer KJ. The permeability of SPION over an artificial three-layer membrane is enhanced by external magnetic field. J Nanobiotechnology. 2006 Apr 07; 4:4. PMID: 16603066.
      Citations:    
    176. Zhang Y, Lin HK, Frimberger D, Epstein RB, Kropp BP. Growth of bone marrow stromal cells on small intestinal submucosa: an alternative cell source for tissue engineered bladder. BJU Int. 2005 Nov; 96(7):1120-5. PMID: 16225540.
      Citations:    
    177. Raghavan D, Kropp BP, Lin HK, Zhang Y, Cowan R, Madihally SV. Physical characteristics of small intestinal submucosa scaffolds are location-dependent. J Biomed Mater Res A. 2005 Apr 01; 73(1):90-6. PMID: 15693016.
      Citations:    
    178. Kropp BP, Cheng EY, Lin HK, Zhang Y. Reliable and reproducible bladder regeneration using unseeded distal small intestinal submucosa. J Urol. 2004 Oct; 172(4 Pt 2):1710-3. PMID: 15371796.
      Citations:    
    179. Lin HK, Cowan R, Moore P, Zhang Y, Yang Q, Peterson JA, Tomasek JJ, Kropp BP, Cheng E. Characterization of neuropathic bladder smooth muscle cells in culture. J Urol. 2004 Mar; 171(3):1348-52. PMID: 14767346.
      Citations:    
    180. Zhang Y, Kropp BP, Lin HK, Cowan R, Cheng EY. Bladder regeneration with cell-seeded small intestinal submucosa. Tissue Eng. 2004 Jan-Feb; 10(1-2):181-7. PMID: 15009944.
      Citations:    
    181. Zhang YY, Frey P. Growth of cultured human urothelial cells into stratified urothelial sheet suitable for autografts. Adv Exp Med Biol. 2003; 539(Pt B):907-20. PMID: 15176333.
      Citations:    
    182. Zhang YY, Ludwikowski B, Hurst R, Frey P. Expansion and long-term culture of differentiated normal rat urothelial cells in vitro. In Vitro Cell Dev Biol Anim. 2001 Jul-Aug; 37(7):419-29. PMID: 11573816.
      Citations:    
    183. Sugasi S, Lesbros Y, Bisson I, Zhang YY, Kucera P, Frey P. In vitro engineering of human stratified urothelium: analysis of its morphology and function. J Urol. 2000 Sep; 164(3 Pt 2):951-7. PMID: 10958715.
      Citations:    
    184. Zhang Y, Kropp BP, Moore P, Cowan R, Furness PD, Kolligian ME, Frey P, Cheng EY. Coculture of bladder urothelial and smooth muscle cells on small intestinal submucosa: potential applications for tissue engineering technology. J Urol. 2000 Sep; 164(3 Pt 2):928-34; discussion 934-5. PMID: 10958711.
      Citations:    
    185. Kropp BP, Zhang Y, Tomasek JJ, Cowan R, Furness PD, Vaughan MB, Parizi M, Cheng EY. Characterization of cultured bladder smooth muscle cells: assessment of in vitro contractility. J Urol. 1999 Nov; 162(5):1779-84. PMID: 10524934.
      Citations:    
    186. Ludwikowski B, Zhang YY, Frey P. The long-term culture of porcine urothelial cells and induction of urothelial stratification. BJU Int. 1999 Sep; 84(4):507-14. PMID: 10468771.
      Citations:    
    187. Zhang YY, Bailey RR. A model of sterile vesicoureteric reflux in the sheep. Pediatr Nephrol. 1998 Apr; 12(3):190-6; discussion 189. PMID: 9630035.
      Citations:    
    188. Zhang YY, Bailey RR. Treatment of vesicoureteric reflux in a sheep model using subureteric injection of cultured fetal-bladder tissue. Pediatr Surg Int. 1998 Jan; 13(1):32-6. PMID: 9391201.
      Citations:    
    189. Zhang Y, Bailey RR. A long term follow up of adults with reflux nephropathy. N Z Med J. 1995 Apr 26; 108(998):142-4. PMID: 7761049.
      Citations:    
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