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Tina E. Brinkley PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Gerontology & Geriatric Medicine
Address
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    K01AG033652     (BRINKLEY, TINA E)Sep 1, 2010 - May 31, 2016
    NIH
    Cardiac Imaging of Thoracic Fat and Aortic Stiffness in Older High Risk Patients
    Role: Principal Investigator
    R56HL134989     (BRINKLEY, TINA E)Sep 8, 2017 - Aug 31, 2020
    NIH
    Improving cardiac rehabilitation outcomes with evidence-based obesity treatment.
    Role: Principal Investigator
    R25AG060912     (BRINKLEY, TINA E)Jul 15, 2019 - Feb 29, 2024
    NIH
    Enhancing UNderGraduate Education and Research in AGing to Eliminate Health Disparities (ENGAGED)
    Role: Principal Investigator
    R01AG064014     (BRINKLEY, TINA E)Aug 15, 2019 - Apr 30, 2024
    NIH
    Dietary Effects on Imaging and Fluid-based Biomarkers of the Adipose-Brain Axis in Alzheimers Disease
    Role: Principal Investigator
    R01AG066910     (BRINKLEY, TINA E)Apr 15, 2020 - Dec 31, 2024
    NIH
    The POINTER Neurovascular Ancillary Study
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Brinkley TE, Semba RD, Kritchevsky SB, Houston DK. Dietary protein intake and circulating advanced glycation end product/receptor for advanced glycation end product concentrations in the Health, Aging, and Body Composition Study. Am J Clin Nutr. 2020 12 10; 112(6):1558-1565. PMID: 33301008.
      Citations:    
    2. Opina MTD, Brinkley TE, Gordon M, Lyles MF, Nicklas BJ. Association of Breathing Reserve at Peak Exercise With Body Composition and Physical Function in Older Adults With Obesity. J Gerontol A Biol Sci Med Sci. 2019 11 13; 74(12):1973-1979. PMID: 30535050.
      Citations:    
    3. Nicklas BJ, Brinkley TE, Houston DK, Lyles MF, Hugenschmidt CE, Beavers KM, Leng X. Effects of Caloric Restriction on Cardiorespiratory Fitness, Fatigue, and Disability Responses to Aerobic Exercise in Older Adults With Obesity: A Randomized Controlled Trial. J Gerontol A Biol Sci Med Sci. 2019 06 18; 74(7):1084-1090. PMID: 29982294.
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    4. Hugenschmidt CE, Leng X, Lyles M, Michael L, Dougherty A, Babcock P, Baker LD, Brinkley TE, Nicklas BJ. Cognitive Effects of Adding Caloric Restriction to Aerobic Exercise Training in Older Adults with Obesity. Obesity (Silver Spring). 2019 08; 27(8):1266-1274. PMID: 31199592.
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    5. Hugenschmidt CA, Leng X, Lyles M, Michael L, Doughtery A, Babcock P, Baker LD, Brinkley TE, Nicklas BJ. Cognitive effects of adding caloric restriction to aerobic exercise training in older adults with obesity. Obesity (Silver Spring). 2019.
    6. Opina MTD, Brinkley TE, Gordon M, Lyles MF, Nicklas BJ. Association of breathing reserve at peak exercise with body composition and physical function in older adults with obesity. J Gerontol A Biol Sci Med Sci. 2018.
    7. Brinkley TE, Berger M, Callahan KE, Fieo RA, Jennings LA, Morris JK, Wilkins HM, Kritchevsky SB. Workshop on Synergies Between Alzheimer's Research and Clinical Gerontology and Geriatrics: Current Status and Future Directions. J Gerontol A Biol Sci Med Sci. 2018 08 10; 73(9):1229-1237. PMID: 29982466.
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    8. Haykowsky MJ, Nicklas BJ, Brubaker PH, Hundley WG, Brinkley TE, Upadhya B, Becton JT, Nelson MD, Chen H, Kitzman DW. Regional Adipose Distribution and its Relationship to Exercise Intolerance in Older Obese Patients Who Have Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2018 08; 6(8):640-649. PMID: 30007558.
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    9. Patterson SA, Deep G, Brinkley TE. Detection of the receptor for advanced glycation endproducts in neuronally-derived exosomes in plasma. Biochem Biophys Res Commun. 2018 06 12; 500(4):892-896. PMID: 29702093.
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    10. Brinkley TE, Anderson A, Soliman EZ, Bertoni AG, Greenway F, Knowler WC, Glasser SP, Horton ES, Espeland MA. Long-Term Effects of an Intensive Lifestyle Intervention on Electrocardiographic Criteria for Left Ventricular Hypertrophy: The Look AHEAD Trial. Am J Hypertens. 2018 04 13; 31(5):541-548. PMID: 29324968.
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    11. Shea MK, Booth SL, Weiner DE, Brinkley TE, Kanaya AM, Murphy RA, Simonsick EM, Wassel CL, Vermeer C, Kritchevsky SB. Circulating Vitamin K Is Inversely Associated with Incident Cardiovascular Disease Risk among Those Treated for Hypertension in the Health, Aging, and Body Composition Study (Health ABC). J Nutr. 2017 05; 147(5):888-895. PMID: 28356433.
      Citations:    
    12. Zhang T, Brinkley TE, Liu K, Feng X, Marsh AP, Kritchevsky S, Zhou X, Nicklas BJ. Circulating MiRNAs as biomarkers of gait speed responses to aerobic exercise training in obese older adults. Aging (Albany NY). 2017 03 15; 9(3):900-913. PMID: 28301325.
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    13. Brinkley TE, Leng X, Nicklas BJ, Kritchevsky SB, Ding J, Kitzman DW, Hundley WG. Racial differences in circulating levels of the soluble receptor for advanced glycation endproducts in middle-aged and older adults. Metabolism. 2017 05; 70:98-106. PMID: 28403949.
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    14. Henderson RM, Leng XI, Chmelo EA, Brinkley TE, Lyles MF, Marsh AP, Nicklas BJ. Gait speed response to aerobic versus resistance exercise training in older adults. Aging Clin Exp Res. 2017 Oct; 29(5):969-976. PMID: 27682435.
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    15. Hall ME, Brinkley TE, Chughtai H, Morgan TM, Hamilton CA, Jordan JH, Stacey RB, Soots S, Hundley WG. Adiposity Is Associated with Gender-Specific Reductions in Left Ventricular Myocardial Perfusion during Dobutamine Stress. PLoS One. 2016; 11(1):e0146519. PMID: 26751789.
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    16. Jefferson ME, Nicklas BJ, Chmelo EA, Crotts CI, Shaltout HA, Diz DI, Marsh AP, Brinkley TE. Effects of Resistance Training With and Without Caloric Restriction on Arterial Stiffness in Overweight and Obese Older Adults. Am J Hypertens. 2016 Apr; 29(4):494-500. PMID: 26297029.
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    17. Lazo M, Halushka MK, Shen L, Maruthur N, Rebholz CM, Rawlings AM, Hoogeveen RC, Brinkley TE, Ballantyne CM, Astor BC, Selvin E. Soluble receptor for advanced glycation end products and the risk for incident heart failure: The Atherosclerosis Risk in Communities Study. Am Heart J. 2015 Nov; 170(5):961-7. PMID: 26542505.
      Citations:    
    18. Chmelo EA, Crotts CI, Newman JC, Brinkley TE, Lyles MF, Leng X, Marsh AP, Nicklas BJ. Heterogeneity of physical function responses to exercise training in older adults. J Am Geriatr Soc. 2015 Mar; 63(3):462-9. PMID: 25752778.
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    19. Vaz Fragoso CA, Hsu FC, Brinkley T, Church T, Liu CK, Manini T, Newman AB, Stafford RS, McDermott MM, Gill TM. Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with functional limitations. J Am Med Dir Assoc. 2014 Sep; 15(9):665-70. PMID: 24973990.
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    20. Andersen MM, Kritchevsky SB, Morgan TM, Hire DG, Vasu S, Brinkley TE, Kitzman DW, Hamilton CA, Soots S, Hundley WG. Increased cardiovascular stiffness and impaired age-related functional status. J Gerontol A Biol Sci Med Sci. 2015 May; 70(5):545-53. PMID: 24963155.
      Citations:    
    21. Buford TW, Hsu FC, Brinkley TE, Carter CS, Church TS, Dodson JA, Goodpaster BH, McDermott MM, Nicklas BJ, Yank V, Johnson JA, Pahor M. Genetic influence on exercise-induced changes in physical function among mobility-limited older adults. Physiol Genomics. 2014 Mar 01; 46(5):149-58. PMID: 24423970.
      Citations:    
    22. Brinkley TE, Hsu FC, Beavers KM, Church TS, Goodpaster BH, Stafford RS, Pahor M, Kritchevsky SB, Nicklas BJ. Total and abdominal adiposity are associated with inflammation in older adults using a factor analysis approach. J Gerontol A Biol Sci Med Sci. 2012 Oct; 67(10):1099-106. PMID: 22451470.
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    23. Brinkley TE, Jerosch-Herold M, Folsom AR, Carr JJ, Hundley WG, Allison MA, Bluemke DA, Burke GL, Szklo M, Ding J. Pericardial fat and myocardial perfusion in asymptomatic adults from the Multi-Ethnic Study of Atherosclerosis. PLoS One. 2011; 6(12):e28410. PMID: 22174800.
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    24. Brinkley TE, Halverstadt A, Phares DA, Ferrell RE, Prigeon RL, Hagberg JM, Goldberg AP. Hepatic lipase gene -514C>T variant is associated with exercise training-induced changes in VLDL and HDL by lipoprotein lipase. J Appl Physiol (1985). 2011 Dec; 111(6):1871-6. PMID: 21960661.
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    25. Chughtai HL, Morgan TM, Hamilton CA, Charoenpanichkit C, Ding J, Brinkley TE, Hundley WG. Intraperitoneal fat is associated with thickening of the thoracic aorta in individuals at high risk for cardiovascular events. Obesity (Silver Spring). 2011 Sep; 19(9):1784-90. PMID: 21720433.
      Citations:    
    26. Brinkley TE, Ding J, Carr JJ, Nicklas BJ. Pericardial fat loss in postmenopausal women under conditions of equal energy deficit. Med Sci Sports Exerc. 2011 May; 43(5):808-14. PMID: 20881884.
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    27. Brinkley TE, Wang X, Kume N, Mitsuoka H, Nicklas BJ. . Caloric restriction, aerobic exercise training, and soluble lectin-like oxidized LDL receptor-1 levels in overweight and obese postmenopausal women. Int J Obesity. 2011; 6(35):793-799.
    28. Chughtai HL, Morgan TM, Rocco M, Stacey B, Brinkley TE, Ding J, Nicklas B, Hamilton C, Hundley WG. Renal sinus fat and poor blood pressure control in middle-aged and elderly individuals at risk for cardiovascular events. Hypertension. 2010 Nov; 56(5):901-6. PMID: 20837881.
      Citations:    
    29. Beavers KM, Brinkley TE, Nicklas BJ. Effect of exercise training on chronic inflammation. Clin Chim Acta. 2010 Jun 03; 411(11-12):785-93. PMID: 20188719.
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    30. Brinkley TE, Lovato JF, Arnold AM, Furberg CD, Kuller LH, Burke GL, Nahin RL, Lopez OL, Yasar S, Williamson JD. Effect of Ginkgo biloba on blood pressure and incidence of hypertension in elderly men and women. Am J Hypertens. 2010 May; 23(5):528-33. PMID: 20168306.
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    31. Brinkley TE, Fenty-Stewart NM, Park JY, Brown MD, Hagberg JM. Plasma nitrate/nitrite levels are unchanged after long-term aerobic exercise training in older adults. Nitric Oxide. 2009 Nov-Dec; 21(3-4):234-8. PMID: 19825427.
      Citations:    
    32. Nicklas BJ, Brinkley TE. Exercise training as a treatment for chronic inflammation in the elderly. Exerc Sport Sci Rev. 2009 Oct; 37(4):165-70. PMID: 19955865.
      Citations:    
    33. Feairheller DL, Brown MD, Park JY, Brinkley TE, Basu S, Hagberg JM, Ferrell RE, Fenty-Stewart NM. Exercise training, NADPH oxidase p22phox gene polymorphisms, and hypertension. Med Sci Sports Exerc. 2009 Jul; 41(7):1421-8. PMID: 19516159.
      Citations:    
    34. Brinkley TE, Nicklas BJ, Kanaya AM, Satterfield S, Lakatta EG, Simonsick EM, Sutton-Tyrrell K, Kritchevsky SB. Plasma oxidized low-density lipoprotein levels and arterial stiffness in older adults: the health, aging, and body composition study. Hypertension. 2009 May; 53(5):846-52. PMID: 19332658.
      Citations:    
    35. Brinkley TE, Leng X, Miller ME, Kitzman DW, Pahor M, Berry MJ, Marsh AP, Kritchevsky SB, Nicklas BJ. Chronic inflammation is associated with low physical function in older adults across multiple comorbidities. J Gerontol A Biol Sci Med Sci. 2009 Apr; 64(4):455-61. PMID: 19196644.
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    36. Sturgeon KM, Fenty-Stewart NM, Diaz KM, Brinkley TE, Dowling TC, Brown MD. The relationship of oxidative stress and cholesterol with dipping status before and after aerobic exercise training. Blood Press. 2009; 18(4):171-9. PMID: 19544106.
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    37. Nicklas BJ, Hsu FC, Brinkley TJ, Church T, Goodpaster BH, Kritchevsky SB, Pahor M. Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc. 2008 Nov; 56(11):2045-52. PMID: 19016938.
      Citations:    
    38. Brinkley TE, Kume N, Mitsuoka H, Brown MD, Phares DA, Ferrell RE, Kita T, Hagberg JM. Variation in the human lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) gene is associated with plasma soluble LOX-1 levels. Exp Physiol. 2008 Sep; 93(9):1085-90. PMID: 18469066.
      Citations:    
    39. Brinkley TE, Kume N, Mitsuoka H, Phares DA, Hagberg JM. Elevated soluble lectin-like oxidized LDL receptor-1 (sLOX-1) levels in obese postmenopausal women. Obesity (Silver Spring). 2008 Jun; 16(6):1454-6. PMID: 18388896.
      Citations:    
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