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Sean L. Simpson PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentOtolaryngology
Address
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    K25EB012236     (SIMPSON, SEAN L)Sep 1, 2012 - Apr 30, 2018
    NIH
    Statistical Methods for Whole-Brain Connectivety Networks
    Role: Principal Investigator
    R01EB024559     (SIMPSON, SEAN L)Jun 15, 2018 - Feb 28, 2022
    NIH
    Analytical Tools for Complex Brain Networks: Fusing Novel Statistical Methods and Network Science to Understand Brain Function
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Boyd MC, Burdette JH, Miller ME, Lyday RG, Hugenschmidt CE, Jack Rejeski W, Simpson SL, Baker LD, Tomlinson CE, Kritchevsky SB, Laurienti PJ. Association of physical function with connectivity in the sensorimotor and dorsal attention networks: why examining specific components of physical function matters. Geroscience. 2024 Oct; 46(5):4987-5002. PMID: 38967698.
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    2. Gregorich M, Simpson SL, Heinze G. Flexible parametrization of graph-theoretical features from individual-specific networks for prediction. Stat Med. 2024 Jun 15; 43(13):2592-2606. PMID: 38664934.
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    3. Kirse HA, Bahrami M, Lyday RG, Simpson SL, Peterson-Sockwell H, Burdette JH, Laurienti PJ. Differences in Brain Network Topology Based on Alcohol Use History in Adolescents. Brain Sci. 2023 Dec 05; 13(12). PMID: 38137124.
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    4. Simpson SL, Shappell HM, Bahrami M. Statistical Brain Network Analysis. Annu Rev Stat Appl. 2024; 11:505-531. PMID: 39184922.
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    5. Khodaei M, Dobbins DL, Laurienti PJ, Simpson SL, Arcury TA, Quandt SA, Anderson KA, Scott RP, Burdette JH. Neuroanatomical differences in Latinx children from rural farmworker families and urban non-farmworker families and related associations with pesticide exposure. Heliyon. 2023 Nov; 9(11):e21929. PMID: 38027758.
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    6. Peterson-Sockwell H, Veach LJ, Simpson SL, Fanning J, Laurienti PJ, Gauvin L. Desire and craving measured using behavioral ratings and brain network topology differ significantly among moderate to heavy alcohol consumers. Alcohol Clin Exp Res (Hoboken). 2023 May; 47(5):893-907. PMID: 36997344.
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    7. Laurienti PJ, Miller ME, Lyday RG, Boyd MC, Tanase AD, Burdette JH, Hugenschmidt CE, Rejeski WJ, Simpson SL, Baker LD, Tomlinson CE, Kritchevsky SB. Associations of physical function and body mass index with functional brain networks in community-dwelling older adults. Neurobiol Aging. 2023 Jul; 127:43-53. PMID: 37054493.
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    8. Khodaei M, Laurienti PJ, Dagenbach D, Simpson SL. Brain working memory network indices as landmarks of intelligence. Neuroimage Rep. 2023 Jun; 3(2). PMID: 37425210.
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    9. Tegeler CL, Munger Clary H, Shaltout HA, Simpson SL, Gerdes L, Tegeler CH. Cereset Research Standard Operating Procedures for Insomnia: A Randomized, Controlled Clinical Trial. Glob Adv Integr Med Health. 2023; 12:27536130221147475. PMID: 36816469.
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    10. Tomlinson CE, Laurienti PJ, Lyday RG, Simpson SL. 3M_BANTOR: A regression framework for multitask and multisession brain network distance metrics. Netw Neurosci. 2023; 7(1):1-21. PMID: 37334005.
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    11. Bahrami M, Laurienti PJ, Shappell HM, Simpson SL. Brain Network Analysis: A Review on Multivariate Analytical Methods. Brain Connect. 2023 Mar; 13(2):64-79. PMID: 36006366.
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    12. Rejeski WJ, Laurienti PJ, Bahrami M, Fanning J, Simpson SL, Burdette JH. Aging and Neural Vulnerabilities in Overeating: A Conceptual Overview and Model to Guide Treatment. PCN Rep. 2022 Sep; 1(3). PMID: 36589860.
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    13. Bahrami M, Laurienti PJ, Shappell HM, Dagenbach D, Simpson SL. A mixed-modeling framework for whole-brain dynamic network analysis. Netw Neurosci. 2022 Jun; 6(2):591-613. PMID: 35733427.
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    14. Peterson H, Mayhugh RE, Bahrami M, Rejeski WJ, Simpson SL, Heilman K, Porges SW, Laurienti PJ. Correction: Peterson et al. Influence of Heart Rate Variability on Abstinence-Related Changes in Brain State in Everyday Drinkers. Brain Sci. 2021, 11, 817. Brain Sci. 2022 May 10; 12(5). PMID: 35625069.
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    15. Bahrami M, Simpson SL, Burdette JH, Lyday RG, Quandt SA, Chen H, Arcury TA, Laurienti PJ. Altered default mode network associated with pesticide exposure in Latinx children from rural farmworker families. Neuroimage. 2022 Apr 14; 256:119179. PMID: 35429626.
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    16. Burdette JH, Bahrami M, Laurienti PJ, Simpson SL, Nicklas BJ, Fanning J, Rejeski WJ. Longitudinal relationship of baseline functional brain networks with intentional weight loss in older adults. Obesity (Silver Spring). 2022 04; 30(4):902-910. PMID: 35333443.
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    17. Shappell H, Simpson SL. Discussion on "Distributional independent component analysis for diverse neuroimaging modalities" by Ben Wu, Subhadip Pal, Jian Kang, and Ying Guo. Biometrics. 2022 Sep; 78(3):1106-1108. PMID: 35290677.
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    18. Tomlinson CE, Laurienti PJ, Lyday RG, Simpson SL. A regression framework for brain network distance metrics. Netw Neurosci. 2022 Feb; 6(1):49-68. PMID: 35350586.
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    19. Simpson SL. Mixed Modeling Frameworks for Analyzing Whole-Brain Network Data. Methods Mol Biol. 2022; 2393:571-595. PMID: 34837200.
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    20. Casanova R, Lyday RG, Bahrami M, Burdette JH, Simpson SL, Laurienti PJ. Embedding Functional Brain Networks in Low Dimensional Spaces Using Manifold Learning Techniques. Front Neuroinform. 2021; 15:740143. PMID: 35002665.
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    21. Peterson H, Mayhugh RE, Bahrami M, Rejeski WJ, Simpson SL, Heilman K, Porges SW, Laurienti PJ. Influence of Heart Rate Variability on Abstinence-Related Changes in Brain State in Everyday Drinkers. Brain Sci. 2021 Jun 20; 11(6). PMID: 34203005.
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    22. Dagenbach DE, Tegeler CH, Morgan AR, Laurienti PJ, Tegeler CL, Lee SW, Gerdes L, Simpson SL. Effects of an Allostatic Closed-Loop Neurotechnology (HIRREM) on Brain Functional Connectivity Laterality in Military-Related Traumatic Stress. J Neuroimaging. 2021 03; 31(2):287-296. PMID: 33406294.
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    23. Burdette JH, Laurienti PJ, Miron LL, Bahrami M, Simpson SL, Nicklas BJ, Fanning J, Rejeski WJ. Functional Brain Networks: Unique Patterns with Hedonic Appetite and Confidence to Resist Eating in Older Adults with Obesity. Obesity (Silver Spring). 2020 12; 28(12):2379-2388. PMID: 33135364.
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    24. Garg RK, Khan J, Dawe RJ, Conners J, John S, Prabhakaran S, Kocak M, Bhabad S, Simpson SL, Ouyang B, Jhaveri M, Bleck TP. The Influence of Diffusion Weighted Imaging Lesions on Outcomes in Patients with Acute Spontaneous Intracerebral Hemorrhage. Neurocrit Care. 2020 10; 33(2):552-564. PMID: 32072457.
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    25. Tegeler CL, Shaltout HA, Lee SW, Simpson SL, Gerdes L, Tegeler CH. High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM) improves symptoms and autonomic function for insomnia: A randomized, placebo-controlled clinical trial. Brain Behav. 2020 11; 10(11):e01826. PMID: 32940419.
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    26. Tegeler CL, Shaltout HA, Lee SW, Simpson SL, Gerdes L, Tegeler CH. Pilot Trial of a Noninvasive Closed-Loop Neurotechnology for Stress-Related Symptoms in Law Enforcement: Improvements in Self-Reported Symptoms and Autonomic Function. Glob Adv Health Med. 2020; 9:2164956120923288. PMID: 32426179.
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    27. Bahrami M, Lyday RG, Casanova R, Burdette JH, Simpson SL, Laurienti PJ. Using Low-Dimensional Manifolds to Map Relationships Between Dynamic Brain Networks. Front Hum Neurosci. 2019; 13:430. PMID: 31920590.
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    28. Peterson H, Simpson SL, Laurienti PJ. Wake Forest Alcohol Imagery Set: Development and Validation of a Large Standardized Alcohol Imagery Dataset. Alcohol Clin Exp Res. 2019 12; 43(12):2559-2567. PMID: 31595975.
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    29. Bahrami M, Laurienti PJ, Simpson SL. Analysis of brain subnetworks within the context of their whole-brain networks. Hum Brain Mapp. 2019 12 01; 40(17):5123-5141. PMID: 31441167.
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    30. Echouffo-Tcheugui JB, Chen H, Kalyani RR, Sims M, Simpson S, Effoe VS, Correa A, Bertoni AG, Golden SH. Glycemic Markers and Subclinical Cardiovascular Disease: The Jackson Heart Study. Circ Cardiovasc Imaging. 2019 03; 12(3):e008641. PMID: 30879330.
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    31. Mokhtari F, Akhlaghi MI, Simpson SL, Wu G, Laurienti PJ. Sliding window correlation analysis: Modulating window shape for dynamic brain connectivity in resting state. Neuroimage. 2019 04 01; 189:655-666. PMID: 30721750.
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    32. Simpson SL, Bahrami M, Laurienti PJ. A mixed-modeling framework for analyzing multitask whole-brain network data. Netw Neurosci. 2019; 3(2):307-324. PMID: 30793084.
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    33. Lee SW, Laurienti PJ, Burdette JH, Tegeler CL, Morgan AR, Simpson SL, Gerdes L, Tegeler CH. Functional Brain Network Changes Following Use of an Allostatic, Closed-Loop, Acoustic Stimulation Neurotechnology for Military-Related Traumatic Stress. J Neuroimaging. 2019 01; 29(1):70-78. PMID: 30302866.
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    34. Bahrami M, Laurienti PJ, Simpson SL. A MATLAB toolbox for multivariate analysis of brain networks. Hum Brain Mapp. 2019 01; 40(1):175-186. PMID: 30256496.
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    35. Solo V, Poline JB, Lindquist MA, Simpson SL, Bowman FD, Chung MK, Cassidy B. Connectivity in fMRI: Blind Spots and Breakthroughs. IEEE Trans Med Imaging. 2018 07; 37(7):1537-1550. PMID: 29969406.
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    36. Shaltout HA, Lee SW, Tegeler CL, Hirsch JR, Simpson SL, Gerdes L, Tegeler CH. Improvements in Heart Rate Variability, Baroreflex Sensitivity, and Sleep After Use of Closed-Loop Allostatic Neurotechnology by a Heterogeneous Cohort. Front Public Health. 2018; 6:116. PMID: 29922641.
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    37. Mokhtari F, Rejeski WJ, Zhu Y, Wu G, Simpson SL, Burdette JH, Laurienti PJ. Dynamic fMRI networks predict success in a behavioral weight loss program among older adults. Neuroimage. 2018 06; 173:421-433. PMID: 29471100.
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    38. Tegeler CL, Gerdes L, Shaltout HA, Cook JF, Simpson SL, Lee SW, Tegeler CH. Successful use of closed-loop allostatic neurotechnology for post-traumatic stress symptoms in military personnel: self-reported and autonomic improvements. Mil Med Res. 2017 12 22; 4(1):38. PMID: 29502530.
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    39. McCrory MC, Spaeder MC, Gower EW, Nakagawa TA, Simpson SL, Coleman MA, Morris PE. Time of Admission to the PICU and Mortality. Pediatr Crit Care Med. 2017 Oct; 18(10):915-923. PMID: 28737595.
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    40. Bahrami M, Laurienti PJ, Quandt SA, Talton J, Pope CN, Summers P, Burdette JH, Chen H, Liu J, Howard TD, Arcury TA, Simpson SL. The impacts of pesticide and nicotine exposures on functional brain networks in Latino immigrant workers. Neurotoxicology. 2017 Sep; 62:138-150. PMID: 28583619.
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    41. Tegeler CH, Cook JF, Tegeler CL, Hirsch JR, Shaltout HA, Simpson SL, Fidali BC, Gerdes L, Lee SW. Clinical, hemispheric, and autonomic changes associated with use of closed-loop, allostatic neurotechnology by a case series of individuals with self-reported symptoms of post-traumatic stress. BMC Psychiatry. 2017 04 19; 17(1):141. PMID: 28420362.
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    42. 3. Bowman FD, Simpson SL, Drake DF . Handbook of Modern Statistical Methods: Handbook of Neuroimaging Data Analysis. Joint fMRI and DTI Models for Brain Connectivity. 2017; 495-516.
    43. Casanova R, Saldana S, Simpson SL, Lacy ME, Subauste AR, Blackshear C, Wagenknecht L, Bertoni AG. Prediction of Incident Diabetes in the Jackson Heart Study Using High-Dimensional Machine Learning. PLoS One. 2016; 11(10):e0163942. PMID: 27727289.
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    44. Tegeler CH, Tegeler CL, Cook JF, Lee SW, Gerdes L, Shaltout HA, Miles CM, Simpson SL. A Preliminary Study of the Effectiveness of an Allostatic, Closed-Loop, Acoustic Stimulation Neurotechnology in the Treatment of Athletes with Persisting Post-concussion Symptoms. Sports Med Open. 2016 Dec; 2(1):39. PMID: 27747793.
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    45. Mayhugh RE, Moussa MN, Simpson SL, Lyday RG, Burdette JH, Porrino LJ, Laurienti PJ. Moderate-Heavy Alcohol Consumption Lifestyle in Older Adults Is Associated with Altered Central Executive Network Community Structure during Cognitive Task. PLoS One. 2016; 11(8):e0160214. PMID: 27494180.
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    46. Simpson SL, Laurienti PJ. Disentangling Brain Graphs: A Note on the Conflation of Network and Connectivity Analyses. Brain Connect. 2016 Mar; 6(2):95-8. PMID: 26414952.
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    47. Ip EH, Zhang Q, Sowinski T, Simpson SL. Analysis of Feedback Mechanisms with Unknown Delay Using Sparse Multivariate Autoregressive Method. PLoS One. 2015; 10(8):e0131371. PMID: 26252637.
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    48. Simpson S, Burdette J, Laurienti P. The brain science interface. Signif (Oxf). 2015 Aug; 12(4):34-39. PMID: 27441037.
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    49. Telesford QK, Simpson SL, Kolaczyk ED. Editorial: Complexity and emergence in brain network analyses. Front Comput Neurosci. 2015; 9:65. PMID: 26082712.
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    50. Paolini BM, Laurienti PJ, Simpson SL, Burdette JH, Lyday RG, Rejeski WJ. Global integration of the hot-state brain network of appetite predicts short term weight loss in older adult. Front Aging Neurosci. 2015; 7:70. PMID: 25999855.
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    51. Stanley ML, Simpson SL, Dagenbach D, Lyday RG, Burdette JH, Laurienti PJ. Changes in brain network efficiency and working memory performance in aging. PLoS One. 2015; 10(4):e0123950. PMID: 25875001.
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    52. Simpson SL, Laurienti PJ. A two-part mixed-effects modeling framework for analyzing whole-brain network data. Neuroimage. 2015 Jun; 113:310-9. PMID: 25796135.
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    53. Moussa MN, Simpson SL, Mayhugh RE, Grata ME, Burdette JH, Porrino LJ, Laurienti PJ. Long-term moderate alcohol consumption does not exacerbate age-related cognitive decline in healthy, community-dwelling older adults. Front Aging Neurosci. 2014; 6:341. PMID: 25601835.
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    54. McCrory MC, Gower EW, Simpson SL, Nakagawa TA, Mou SS, Morris PE. Off-hours admission to pediatric intensive care and mortality. Pediatrics. 2014 Nov; 134(5):e1345-53. PMID: 25287463.
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    55. Fetterhoff D, Opris I, Simpson SL, Deadwyler SA, Hampson RE, Kraft RA. Multifractal analysis of information processing in hippocampal neural ensembles during working memory under ??-tetrahydrocannabinol administration. J Neurosci Methods. 2015 Apr 15; 244:136-53. PMID: 25086297.
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    56. Edwards LJ, Simpson SL. An analysis of 24-h ambulatory blood pressure monitoring data using orthonormal polynomials in the linear mixed model. Blood Press Monit. 2014 Jun; 19(3):153-63. PMID: 24667908.
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    57. Simpson SL, Edwards LJ, Styner MA, Muller KE. Kronecker product linear exponent AR(1) correlation structures for multivariate repeated measures. PLoS One. 2014; 9(2):e88864. PMID: 24586419.
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    58. Simpson SL, Edwards LJ, Styner MA, Muller KE. Separability tests for high-dimensional, low sample size multivariate repeated measures data. J Appl Stat. 2014; 41(11):2450-2461. PMID: 25342869.
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    59. Vaughan L, Leng I, Dagenbach D, Resnick SM, Rapp SR, Jennings JM, Brunner RL, Simpson SL, Beavers DP, Coker LH, Gaussoin SA, Sink KM, Espeland MA. Intraindividual variability in domain-specific cognition and risk of mild cognitive impairment and dementia. Curr Gerontol Geriatr Res. 2013; 2013:495793. PMID: 24454359.
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    60. Simpson SL, Lyday RG, Hayasaka S, Marsh AP, Laurienti PJ. A permutation testing framework to compare groups of brain networks. Front Comput Neurosci. 2013; 7:171. PMID: 24324431.
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    61. Bruce MA, Beech BM, Crook ED, Sims M, Griffith DM, Simpson SL, Ard J, Norris KC. Sex, weight status, and chronic kidney disease among African Americans: the Jackson Heart Study. J Investig Med. 2013 Apr; 61(4):701-7. PMID: 23524947.
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    62. Simpson SL, Bowman FD, Laurienti PJ. Analyzing complex functional brain networks: Fusing statistics and network science to understand the brain*† Stat Surv. 2013; 7:1-36. PMID: 25309643.
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    63. Simpson SL, Moussa MN, Laurienti PJ. An exponential random graph modeling approach to creating group-based representative whole-brain connectivity networks. Neuroimage. 2012 Apr 02; 60(2):1117-26. PMID: 22281670.
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    64. Simpson SL, Hayasaka S, Laurienti PJ. Exponential random graph modeling for complex brain networks. PLoS One. 2011; 6(5):e20039. PMID: 21647450.
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    65. Webb BC, Simpson SL, Hairston KG. From politics to parity: using a health disparities index to guide legislative efforts for health equity. Am J Public Health. 2011 Mar; 101(3):554-60. PMID: 21233445.
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    66. Simpson SL, Edwards LJ. A circular LEAR correlation structure for cyclical longitudinal data. Stat Methods Med Res. 2013 Jun; 22(3):296-306. PMID: 21216801.
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    67. Telesford QK, Simpson SL, Burdette JH, Hayasaka S, Laurienti PJ. The brain as a complex system: using network science as a tool for understanding the brain. Brain Connect. 2011; 1(4):295-308. PMID: 22432419.
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    68. Telesford QK, Morgan AR, Hayasaka S, Simpson SL, Barret W, Kraft RA, Mozolic JL, Laurienti PJ. Reproducibility of graph metrics in FMRI networks. Front Neuroinform. 2010; 4:117. PMID: 21165174.
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    69. Simpson, Sean L. An adjusted likelihood ratio test for separability in unbalanced multivariate repeated measures data. Statistical Methodology. 2010; 7(5):511-519.
    70. Simpson SL, Edwards LJ, Muller KE, Sen PK, Styner MA. A linear exponent AR(1) family of correlation structures. Stat Med. 2010 Jul 30; 29(17):1825-38. PMID: 20658550.
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    71. Slager RE, Simpson SL, Levan TD, Poole JA, Sandler DP, Hoppin JA. Rhinitis associated with pesticide use among private pesticide applicators in the agricultural health study. J Toxicol Environ Health A. 2010; 73(20):1382-93. PMID: 20818537.
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    72. Johnson JL, Muller KE, Slaughter JC, Gurka MJ, Gribbin MJ, Simpson SL. POWERLIB: SAS/IML Software for Computing Power in Multivariate Linear Models. J Stat Softw. 2009 Apr 01; 30(5). PMID: 25400516.
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    73. Thomas KB, Simpson SL, Tarver WL, Gwede CK. Is social support from family associated with PSA testing? An exploratory analysis using the Health Information National Trends Survey (HINTS) 2005. Am J Mens Health. 2010 Mar; 4(1):50-9. PMID: 19477731.
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    74. Muller KE, Edwards LJ, Simpson SL, Taylor DJ. Statistical tests with accurate size and power for balanced linear mixed models. Stat Med. 2007 Aug 30; 26(19):3639-60. PMID: 17394132.
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    75. Lark RK, Williams CL, Stadler D, Simpson SL, Henderson RC, Samson-Fang L, Worley G. Serum prealbumin and albumin concentrations do not reflect nutritional state in children with cerebral palsy. J Pediatr. 2005 Nov; 147(5):695-7. PMID: 16291366.
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