Item Type | Name |
Academic Article
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Phase I safety assessment of intrathecal injection of an American formulation of adenosine in humans.
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Academic Article
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Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans.
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Academic Article
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Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding.
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Academic Article
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Peripheral nerve injury alters the alpha2 adrenoceptor subtype activated by clonidine for analgesia.
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Academic Article
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Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury.
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Academic Article
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Phase I safety assessment of intrathecal ketorolac.
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Academic Article
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Intrathecal ketorolac enhances antinociception from clonidine.
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Academic Article
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Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis.
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Academic Article
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Intrathecal clonidine reduces hypersensitivity after nerve injury by a mechanism involving spinal m4 muscarinic receptors.
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Academic Article
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Individual differences in pain sensitivity: implications for treatment decisions.
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Academic Article
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Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain.
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Academic Article
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Age-dependent responses to thermal hyperalgesia and mechanical allodynia in a rat model of acute postoperative pain.
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Academic Article
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Intrathecal, but not intravenous adenosine reduces allodynia in patients with neuropathic pain.
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Academic Article
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Four PGE2 EP receptors are up-regulated in injured nerve following partial sciatic nerve ligation.
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Academic Article
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Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury.
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Academic Article
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Cystatin C in cerebrospinal fluid is not a diagnostic test for pain in humans.
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Academic Article
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Did experimenter bias conceal the efficacy of spinal opioids in previous studies with the spinal nerve ligation model of neuropathic pain?
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Academic Article
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Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain.
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Academic Article
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The monoamine reuptake inhibitor milnacipran does not affect nociception to acute visceral distension in rats.
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Academic Article
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Peripheral nerve injury sensitizes the response to visceral distension but not its inhibition by the antidepressant milnacipran.
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Academic Article
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Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury.
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Academic Article
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Polyanalgesic Consensus Conference 2003: an update on the management of pain by intraspinal drug delivery-- report of an expert panel.
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Academic Article
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Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain.
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Academic Article
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Intrathecal clonidine for postoperative analgesia in elderly patients: the influence of baricity on hemodynamic and analgesic effects.
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Academic Article
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Preoperative sciatic nerve block decreases mechanical allodynia more in young rats: is preemptive analgesia developmentally modulated?
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Academic Article
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Effect of pregnancy and pain on cerebrospinal fluid immunoreactive enkephalins and norepinephrine in healthy humans.
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Academic Article
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Effect of cyclooxygenase-1 inhibition in postoperative pain is developmentally regulated.
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Academic Article
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The antinociceptive effects of spinal cyclooxygenase inhibitors on uterine cervical distension.
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Academic Article
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Intrathecal morphine and ketorolac analgesia after surgery: comparison of spontaneous and elicited responses in rats.
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Academic Article
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Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased alpha2C-adrenoceptor co-expression and functional inhibition by clonidine.
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Academic Article
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Intrathecal morphine reduces allodynia after peripheral nerve injury in rats via activation of a spinal A1 adenosine receptor.
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Academic Article
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Spinal nerve ligation increases alpha2-adrenergic receptor G-protein coupling in the spinal cord.
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Academic Article
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Intravenous butorphanol, meperidine, and their combination relieve pain and distress in women in labor.
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Academic Article
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Peripheral block of the hyperpolarization-activated cation current (Ih) reduces mechanical allodynia in animal models of postoperative and neuropathic pain.
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Academic Article
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Abdominal surgery decreases food-reinforced operant responding in rats: relevance of incisional pain.
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Academic Article
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Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain.
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Academic Article
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Age-dependent responses to nerve injury-induced mechanical allodynia.
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Academic Article
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Spinal cord dynorphin expression increases, but does not drive microglial prostaglandin production or mechanical hypersensitivity after incisional surgery in rats.
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Academic Article
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Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation.
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Academic Article
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Perineural clonidine reduces p38 mitogen-activated protein kinase activation in sensory neurons.
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Academic Article
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Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis.
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Academic Article
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Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics.
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Academic Article
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Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery.
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Academic Article
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Estrogen amplifies pain responses to uterine cervical distension in rats by altering transient receptor potential-1 function.
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Academic Article
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Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats.
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Academic Article
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Neostigmine decreases bupivacaine use by patient-controlled epidural analgesia during labor: a randomized controlled study.
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Academic Article
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Epidural neostigmine: will it replace lipid soluble opioids for postoperative and labor analgesia?
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Academic Article
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Science marches forward: a new tool to study the progress of labor.
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Academic Article
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Role of spinal cyclooxygenase in human postoperative and chronic pain.
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Academic Article
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Effects of intrathecal ketorolac on human experimental pain.
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Academic Article
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Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming.
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Academic Article
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Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function.
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Academic Article
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Differing neurophysiologic mechanosensory input from glabrous and hairy skin in juvenile rats.
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Academic Article
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Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury.
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Academic Article
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Polyanalgesic consensus conference 2007: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel.
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Academic Article
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Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of ?-aminobutyric acid in a2-adrenoceptor and 5-HT3 serotonin receptor analgesia.
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Academic Article
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Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain.
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Academic Article
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Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats.
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Academic Article
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Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain.
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Academic Article
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Dose response of intrathecal adenosine in experimental pain and allodynia.
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Academic Article
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Pharmacology of opioid inhibition to noxious uterine cervical distension.
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Academic Article
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Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac.
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Academic Article
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Chronic constriction injury of sciatic nerve induces the up-regulation of descending inhibitory noradrenergic innervation to the lumbar dorsal horn of mice.
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Academic Article
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Spinal adrenergic and cholinergic receptor interactions activated by clonidine in postincisional pain.
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Academic Article
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Intrathecal morphine reduces the visceromotor response to acute uterine cervical distension in an estrogen-independent manner.
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Academic Article
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Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury.
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Academic Article
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Intravenous remifentanil produces withdrawal hyperalgesia in volunteers with capsaicin-induced hyperalgesia.
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Academic Article
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Systemic, but not intrathecal ketorolac is antinociceptive to uterine cervical distension in rats.
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Academic Article
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Epidural neostigmine produces analgesia but also sedation in women after cesarean delivery.
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Academic Article
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Intrathecal but not intravenous opioids release adenosine from the spinal cord.
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Academic Article
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Fishing for genes: practical ways to study genetic polymorphisms for pain.
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Academic Article
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Knock down of the alpha 5 nicotinic acetylcholine receptor in spinal nerve-ligated rats alleviates mechanical allodynia.
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Academic Article
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Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats.
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Academic Article
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alpha2-Adrenoceptor activation by clonidine enhances stimulation-evoked acetylcholine release from spinal cord tissue after nerve ligation in rats.
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Academic Article
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Preoperative inhibition of cyclooxygenase-1 in the spinal cord reduces postoperative pain.
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Academic Article
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Preventing chronic pain after surgery: who, how, and when?
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Academic Article
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Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury.
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Academic Article
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Multifactorial preoperative predictors for postcesarean section pain and analgesic requirement.
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Academic Article
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Treating and preventing chronic pain: a view from the spinal cord--Bonica Lecture, ASRA Annual Meeting, 2005.
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Academic Article
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Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats.
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Academic Article
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A pain model after gynecologic surgery: the effect of intrathecal and systemic morphine.
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Academic Article
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Spinal glial activation contributes to postoperative mechanical hypersensitivity in the rat.
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Academic Article
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Analgesia induced by perineural clonidine is enhanced in persistent neuritis.
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Academic Article
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Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision.
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Academic Article
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Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism.
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Academic Article
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Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil.
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Academic Article
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ST91 [2-(2,6-diethylphenylamino)-2-imidazoline hydrochloride]-mediated spinal antinociception and synergy with opioids persists in the absence of functional alpha-2A- or alpha-2C-adrenergic receptors.
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Academic Article
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Assessment of behavior during labor in rats and effect of intrathecal morphine.
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Academic Article
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Electrophysiologic characteristics of large neurons in dorsal root ganglia during development and after hind paw incision in the rat.
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Academic Article
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Regional anesthesia: advancing the practice of medicine; the 2008 Gaston Labat Award lecture.
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Academic Article
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Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards.
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Academic Article
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Severity of acute pain after childbirth, but not type of delivery, predicts persistent pain and postpartum depression.
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Academic Article
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Multiplicative interactions to enhance gabapentin to treat neuropathic pain.
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Academic Article
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Gabapentin acts within the locus coeruleus to alleviate neuropathic pain.
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Academic Article
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The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of alpha7 nicotinic acetylcholine receptor.
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Academic Article
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Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats.
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Academic Article
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The need for a journal policy on intrathecal, epidural, and perineural administration of non-approved drugs.
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Academic Article
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Contribution of the chemokine (C-C motif) ligand 2 (CCL2) to mechanical hypersensitivity after surgical incision in rats.
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Academic Article
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Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat.
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Academic Article
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A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury.
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Academic Article
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Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors.
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Academic Article
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Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury.
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Academic Article
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Opioid-independent mechanisms supporting offset analgesia and temporal sharpening of nociceptive information.
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Academic Article
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Skin incision-induced receptive field responses of mechanosensitive peripheral neurons are developmentally regulated in the rat.
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Academic Article
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Resolution of pain after childbirth.
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Academic Article
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Predicting acute pain after cesarean delivery using three simple questions.
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Academic Article
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Epidural clonidine analgesia for intractable cancer pain. The Epidural Clonidine Study Group.
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Academic Article
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Relative potency of epidural to intrathecal clonidine differs between acute thermal pain and capsaicin-induced allodynia.
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Concept
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Pain Measurement
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Concept
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Pain Threshold
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Concept
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Abdominal Pain
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Concept
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Pain, Intractable
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Concept
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Complex Regional Pain Syndromes
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Concept
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Labor Pain
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Concept
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Back Pain
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Concept
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Pain
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Concept
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Pain, Postoperative
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Academic Article
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Future directions for intrathecal pain management: a review and update from the interdisciplinary polyanalgesic consensus conference 2007.
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Academic Article
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Valproate prevents dysregulation of spinal glutamate and reduces the development of hypersensitivity in rats after peripheral nerve injury.
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Academic Article
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Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats.
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Academic Article
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Intrathecal ketorolac does not improve acute or chronic pain after hip arthroplasty: a randomized controlled trial.
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Academic Article
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Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain.
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Academic Article
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Modeling individual recovery after peripheral nerve injury in rats and the effects of parturition.
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Academic Article
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Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats.
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Academic Article
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Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents.
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Academic Article
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Phase 1 safety assessment of intrathecal oxytocin.
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Academic Article
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Failure of intrathecal ketorolac to reduce remifentanil-induced postinfusion hyperalgesia in humans.
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Academic Article
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Intrathecal clonidine and adenosine: effects on pain and sensory processing in patients with chronic regional pain syndrome.
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Academic Article
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Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat.
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Academic Article
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Impaired Pain-evoked Analgesia after Nerve Injury in Rats Reflects Altered Glutamate Regulation in the Locus Coeruleus.
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Academic Article
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Down-regulation of astroglial glutamate transporter-1 in the locus coeruleus impairs pain-evoked endogenous analgesia in rats.
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Academic Article
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Wherefore Gabapentinoids?: Was There Rush Too Soon to Judgment?
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Academic Article
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Can a Blood Test of Immune Responsiveness Predict Speed of Recovery from Pain and Dysfunction after Surgery?
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Academic Article
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A Randomized Controlled Trial Comparing Two Multimodal Analgesic Techniques in Patients Predicted to Have Severe Pain After Cesarean Delivery.
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Academic Article
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Mindfulness-Meditation-Based Pain Relief Is Not Mediated by Endogenous Opioids.
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Academic Article
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Disruption of Spinal Noradrenergic Activation Delays Recovery of Acute Incision-Induced Hypersensitivity and Increases Spinal Glial Activation in the Rat.
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Academic Article
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Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations.
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Academic Article
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Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus.
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Academic Article
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Ethical Concerns Regarding Human Study.
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Academic Article
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Pupil responses and pain ratings to heat stimuli: Reliability and effects of expectations and a conditioning pain stimulus.
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Grant
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EPIDURAL CLONIDINE ANALGESIA IN OBSTETRICS
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Grant
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Receptor Selective Spinal Analgesia
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Grant
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Spinal Noradrenergic Sprouting after Nerve Injury
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Grant
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Recovery from Pain and Disability after Surgery
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Grant
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EPIDURAL CLONIDINE ANALGESIA IN OBSTETRICS
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Grant
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SEX DIFFERENCES IN CHOLINERGIC MEDIATED ANALGESIA
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Grant
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Receptor Selective Spinal Analgesia
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Grant
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Pharmacologic Plasticity in the Presence of Pain
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Grant
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Alpha2-Adrenergic Analgesia
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Academic Article
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Assessment of Behavioral Disruption in Rats with Abdominal Inflammation Using Visual Cue Titration and the Five-choice Serial-reaction Time Task.
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Academic Article
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Day-to-day experience in resolution of pain after surgery.
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Academic Article
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Post-discharge hyperpolarization is an endogenous modulatory factor limiting input from fast-conducting nociceptors (AHTMRs).
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Academic Article
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Blockade of a2-adrenergic or metabotropic glutamate receptors induces glutamate release in the locus coeruleus to activate descending inhibition in rats with chronic neuropathic hypersensitivity.
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Academic Article
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Plasticity and Function of Spinal Oxytocin and Vasopressin Signaling during Recovery from Surgery with Nerve Injury.
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Academic Article
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Incisional Nociceptive Input Impairs Attention-related Behavior and Is Associated with Reduced Neuronal Activity in the Prefrontal Cortex in Rats.
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Academic Article
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Psychosocial Stress Delays Recovery of Postoperative Pain Following Incisional Surgery in the Rat.
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Academic Article
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Pain after surgery.
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Academic Article
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Patterns of recovery from pain after cesarean delivery.
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Academic Article
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Peripheral oxytocin restores light touch and nociceptor sensory afferents towards normal after nerve injury.
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Academic Article
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Spinal Exparel®-an extended duration of preclinical study needed.
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Academic Article
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Recovery of physical activity after cesarean delivery and its relationship with pain.
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Academic Article
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Tachykinins modulate nociceptive responsiveness and sensitization: In vivo electrical characterization of primary sensory neurons in tachykinin knockout (Tac1 KO) mice.
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Academic Article
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Descending Noradrenergic Inhibition: An Important Mechanism of Gabapentin Analgesia in Neuropathic Pain.
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Academic Article
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Checklist for the preparation and review of pain clinical trial publications: a pain-specific supplement to CONSORT.
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Academic Article
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Peripheral nerve injury in rats induces alternations in choice behavior associated with food reinforcement.
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Academic Article
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Nociceptive input after peripheral nerve injury results in cognitive impairment and alterations in primary afferent physiology in rats.
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Academic Article
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Recovery from nerve injury induced behavioral hypersensitivity in rats parallels resolution of abnormal primary sensory afferent signaling.
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Academic Article
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Capsaicin-induced pain and sensitisation in the postpartum period.
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Academic Article
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Ambulatory continuous peripheral nerve blocks to treat postamputation phantom limb pain: a multicenter, randomized, quadruple-masked, placebo-controlled clinical trial.
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Academic Article
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Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Pragmatic Effectiveness Trial of a Nonpharmacologic Alternative for the Treatment of Postoperative Pain.
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Academic Article
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Research approaches for evaluating opioid sparing in clinical trials of acute and chronic pain treatments: IMMPACT recommendations.
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Academic Article
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Systemic administration of a ß2-adrenergic receptor agonist reduces mechanical allodynia and suppresses the immune response to surgery in a rat model of persistent post-incisional hypersensitivity.
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Academic Article
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Percutaneous Neuromodulation of the Brachial Plexus and Sciatic Nerve for the Treatment of Acute Pain Following Surgery: Secondary Outcomes From a Multicenter, Randomized, Controlled Pilot Study.
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Academic Article
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Immediate Effects of a Continuous Peripheral Nerve Block on Postamputation Phantom and Residual Limb Pain: Secondary Outcomes From a Multicenter Randomized Controlled Clinical Trial.
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Academic Article
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Seeding of breast cancer cell line (MDA-MB-231LUC+) to the mandible induces overexpression of substance P and CGRP throughout the trigeminal ganglion and widespread peripheral sensory neuropathy throughout all three of its divisions.
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Academic Article
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Heterogeneity in patterns of pain development after nerve injury in rats and the influence of sex.
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Academic Article
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Gadgeteering for Pain Relief: The 2021 John W. Severinghaus Lecture on Translational Science.
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Academic Article
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Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Chronic Post-Amputation Phantom Limb Pain: A Multicenter, Randomized, Controlled Trial.
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Academic Article
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Randomized controlled trial of intrathecal oxytocin on speed of recovery after hip arthroplasty.
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Academic Article
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Improving Preclinical Development of Novel Interventions to Treat Pain: Insanity Is Doing the Same Thing Over and Over and Expecting Different Results.
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Academic Article
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Preliminary results from a randomized, controlled, cross-over trial of intrathecal oxytocin for neuropathic pain.
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Academic Article
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Patient-centered results from a multicenter study of continuous peripheral nerve blocks and postamputation phantom and residual limb pain: secondary outcomes from a randomized, clinical trial.
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Academic Article
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Patient engagement in designing, conducting, and disseminating clinical pain research: IMMPACT recommended considerations.
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Academic Article
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Smallest Clinically Meaningful Improvement in Amputation-Related Pain and Brief Pain Inventory Scores as Defined by Patient Reports of Global Improvement After Cryoneurolysis: a Retrospective Analysis of a Randomized, Controlled Clinical Trial.
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Academic Article
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Clinical Effectiveness of Liposomal Bupivacaine Administered by Infiltration or Peripheral Nerve Block to Treat Postoperative Pain.
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Academic Article
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Percutaneous Peripheral Nerve Stimulation (Neuromodulation) for Postoperative Pain: A Randomized, Sham-controlled Pilot Study.
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Academic Article
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Effects of systemic oxytocin administration on ultraviolet B-induced nociceptive hypersensitivity and tactile hyposensitivity in mice.
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Academic Article
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Effect of surgical approach to hip arthroplasty on postoperative pain and mobilization and on efficacy of intrathecal oxytocin for pain.
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