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James C. Eisenach MD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentAnesthesiology
Address
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    R23GM035523     (EISENACH, JAMES C)Sep 1, 1985 - Aug 31, 1988
    NIH
    EPIDURAL CLONIDINE ANALGESIA IN OBSTETRICS
    Role: Principal Investigator
    R29GM035523     (EISENACH, JAMES C)Sep 1, 1985 - Aug 31, 1990
    NIH
    EPIDURAL CLONIDINE ANALGESIA IN OBSTETRICS
    Role: Principal Investigator
    R01GM035523     (EISENACH, JAMES)Sep 1, 1985 - Mar 31, 2008
    NIH
    Alpha2-Adrenergic Analgesia
    Role: Principal Investigator
    R01GM048085     (EISENACH, JAMES)Aug 1, 1992 - Feb 28, 2011
    NIH
    Receptor Selective Spinal Analgesia
    Role: Principal Investigator
    R37GM048085     (EISENACH, JAMES)Aug 1, 1992 - Feb 28, 2021
    NIH
    Receptor Selective Spinal Analgesia
    Role: Principal Investigator
    R01DA012367     (TOBIN, JOSEPH R)Sep 30, 1998 - Jun 30, 2002
    NIH
    SEX DIFFERENCES IN CHOLINERGIC MEDIATED ANALGESIA
    Role: Co-Principal Investigator
    P01NS041386     (EISENACH, JAMES)Feb 15, 2002 - Jan 31, 2008
    NIH
    Pharmacologic Plasticity in the Presence of Pain
    Role: Principal Investigator
    R01NS057594     (EISENACH, JAMES)Feb 1, 2008 - Jan 31, 2014
    NIH
    Spinal Noradrenergic Sprouting after Nerve Injury
    Role: Principal Investigator
    P01GM113852     (EISENACH, JAMES)Apr 1, 2016 - Mar 31, 2022
    NIH
    Recovery from Pain and Disability after Surgery
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ilfeld BM, Smith CR, Turan A, Mariano ER, Miller ME, Fisher RL, Trescot AM, Cohen SP, Eisenach JC, Sessler DI, Prologo JD, Mascha EJ, Liu L, Gabriel RA. Smallest Clinically Meaningful Improvement in Amputation-Related Pain and Brief Pain Inventory Scores as Defined by Patient Reports of Global Improvement After Cryoneurolysis: a Retrospective Analysis of a Randomized, Controlled Clinical Trial. Anesth Analg. 2024 Mar 14. PMID: 38478876.
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    2. Haroutounian S, Holzer KJ, Kerns RD, Veasley C, Dworkin RH, Turk DC, Carman KL, Chambers CT, Cowan P, Edwards RR, Eisenach JC, Farrar JT, Ferguson M, Forsythe LP, Freeman R, Gewandter JS, Gilron I, Goertz C, Grol-Prokopczyk H, Iyengar S, Jordan I, Kamp C, Kleykamp BA, Knowles RL, Langford DJ, Mackey S, Malamut R, Markman J, Martin KR, McNicol E, Patel KV, Rice ASC, Rowbotham M, Sandbrink F, Simon LS, Steiner DJ, Vollert J. Patient engagement in designing, conducting, and disseminating clinical pain research: IMMPACT recommended considerations. Pain. 2023 Dec 19. PMID: 38198239.
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    3. Henshaw DS, Khanna AK, Edwards CJ, Eisenach JC. Hypotension duration and vasopressor requirements following intrathecal oxytocin for Total hip arthroplasty: Secondary analysis of a randomized controlled trial. J Clin Anesth. 2023 Jun 23; 89:111189. PMID: 37356196.
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    4. Eisenach JC, Curry RS, Houle TT. Preliminary results from a randomized, controlled, cross-over trial of intrathecal oxytocin for neuropathic pain. Pain Med. 2023 Apr 21. PMID: 37084261.
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    5. Ilfeld BM, Khatibi B, Maheshwari K, Madison S, Ali Sakr Esa W, Mariano ER, Kent M, Hanling S, Sessler DI, Eisenach JC, Cohen SP, Mascha E, Li S, Turan A. Patient-centered results from a multicenter study of continuous peripheral nerve blocks and postamputation phantom and residual limb pain: secondary outcomes from a randomized, clinical trial. Reg Anesth Pain Med. 2023 Mar 09. PMID: 36894197.
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    6. Eisenach JC, Rice ASC. Improving Preclinical Development of Novel Interventions to Treat Pain: Insanity Is Doing the Same Thing Over and Over and Expecting Different Results. Anesth Analg. 2022 Dec 01; 135(6):1128-1136. PMID: 36384008.
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    7. Ilfeld BM, Smith CR, Turan A, Mariano ER, Miller ME, Fisher RL, Trescot AM, Cohen SP, Eisenach JC, Sessler DI, Prologo JD, Mascha EJ, Liu L, Gabriel RA. Ultrasound-Guided Percutaneous Cryoneurolysis to Treat Chronic Post-Amputation Phantom Limb Pain: A Multicenter, Randomized, Controlled Trial. Anesthesiology. 2022 Nov 10. PMID: 36512721.
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    8. Eisenach JC, Shields JS, Weller RS, Curry RS, Langfitt MK, Henshaw DS, Pollock DC, Edwards CJ, Houle TT. Randomized controlled trial of intrathecal oxytocin on speed of recovery after hip arthroplasty. Pain. 2022 Oct 19. PMID: 36448974.
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    9. Eisenach JC. Gadgeteering for Pain Relief: The 2021 John W. Severinghaus Lecture on Translational Science. Anesthesiology. 2022 Apr 29. PMID: 35482967.
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    10. Ilfeld BM, Plunkett A, Vijjeswarapu AM, Hackworth R, Dhanjal S, Turan A, Cohen SP, Eisenach JC, Griffith S, Hanling S, Sessler DI, Mascha EJ, Han Y, Boggs JW, Wongsarnpigoon A, Gelfand H. Percutaneous Neuromodulation of the Brachial Plexus and Sciatic Nerve for the Treatment of Acute Pain Following Surgery: Secondary Outcomes From a Multicenter, Randomized, Controlled Pilot Study. Neuromodulation. 2021 Aug 03. PMID: 34343394.
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    11. Ilfeld BM, Khatibi B, Maheshwari K, Madison SJ, Ali Sakr Esa W, Mariano ER, Kent ML, Hanling S, Sessler DI, Eisenach JC, Cohen SP, Mascha EJ, Yang D, Padwal JA, Turan A. Immediate Effects of a Continuous Peripheral Nerve Block on Postamputation Phantom and Residual Limb Pain: Secondary Outcomes From a Multicenter Randomized Controlled Clinical Trial. Anesth Analg. 2021 Jul 27. PMID: 34314392.
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    12. Sherman K, Woyach V, Eisenach JC, Hopp FA, Cao F, Hogan QH, Dean C. Heterogeneity in patterns of pain development after nerve injury in rats and the influence of sex. Neurobiol Pain. 2021 Aug-Dec; 10:100069. PMID: 34381929.
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    13. Ririe DG, Eisenach JC, Martin TJ. A Painful Beginning: Early Life Surgery Produces Long-Term Behavioral Disruption in the Rat. Front Behav Neurosci. 2021; 15:630889. PMID: 34025368.
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    14. Ilfeld BM, Plunkett A, Vijjeswarapu AM, Hackworth R, Dhanjal S, Turan A, Cohen SP, Eisenach JC, Griffith S, Hanling S, Sessler DI, Mascha EJ, Yang D, Boggs JW, Wongsarnpigoon A, Gelfand H. Percutaneous Peripheral Nerve Stimulation (Neuromodulation) for Postoperative Pain: A Randomized, Sham-controlled Pilot Study. Anesthesiology. 2021 04 15. PMID: 33856424.
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    15. Gewandter JS, Smith SM, Dworkin RH, Turk DC, Gan TJ, Gilron I, Hertz S, Katz NP, Markman JD, Raja SN, Rowbotham MC, Stacey BR, Strain EC, Ward DS, Farrar JT, Kroenke K, Rathmell JP, Rauck R, Brown C, Cowan P, Edwards RR, Eisenach JC, Ferguson M, Freeman R, Gray R, Giblin K, Grol-Prokopczyk H, Haythornthwaite J, Jamison RN, Martel M, McNicol E, Oshinsky M, Sandbrink F, Scholz J, Scranton R, Simon LS, Steiner D, Verburg K, Wasan AD, Wentworth K. Research approaches for evaluating opioid sparing in clinical trials of acute and chronic pain treatments: IMMPACT recommendations. Pain. 2021 Apr 08. PMID: 33863862.
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    16. Ilfeld BM, Khatibi B, Maheshwari K, Madison SJ, Esa WAS, Mariano ER, Kent ML, Hanling S, Sessler DI, Eisenach JC, Cohen SP, Mascha EJ, Ma C, Padwal JA, Turan A. Ambulatory continuous peripheral nerve blocks to treat postamputation phantom limb pain: a multicenter, randomized, quadruple-masked, placebo-controlled clinical trial. Pain. 2021 03 01; 162(3):938-955. PMID: 33021563.
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    17. Ilfeld BM, Eisenach JC, Gabriel RA. Clinical Effectiveness of Liposomal Bupivacaine Administered by Infiltration or Peripheral Nerve Block to Treat Postoperative Pain. Anesthesiology. 2021 02 01; 134(2):283-344. PMID: 33372949.
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    18. Arora V, Morado-Urbina CE, Gwak YS, Parker RA, Kittel CA, Munoz-Islas E, Miguel Jimenez-Andrade J, Romero-Sandoval EA, Eisenach JC, Peters CM. Systemic administration of a ß2-adrenergic receptor agonist reduces mechanical allodynia and suppresses the immune response to surgery in a rat model of persistent post-incisional hypersensitivity. Mol Pain. 2021 Jan-Dec; 17:1744806921997206. PMID: 33829907.
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    19. Gutierrez S, Eisenach JC, Boada MD. Seeding of breast cancer cell line (MDA-MB-231LUC+) to the mandible induces overexpression of substance P and CGRP throughout the trigeminal ganglion and widespread peripheral sensory neuropathy throughout all three of its divisions. Mol Pain. 2021 Jan-Dec; 17:17448069211024082. PMID: 34229504.
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    20. Ilfeld BM, Gelfand H, Dhanjal S, Hackworth R, Plunkett A, Turan A, Vijjeswarapu AM, Cohen SP, Eisenach JC, Griffith S, Hanling S, Mascha EJ, Sessler DI. Ultrasound-Guided Percutaneous Peripheral Nerve Stimulation: A Pragmatic Effectiveness Trial of a Nonpharmacologic Alternative for the Treatment of Postoperative Pain. Pain Med. 2020 12 12; 21(Suppl 2):S53-S61. PMID: 33313729.
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    21. Culley DJ, Kelz MB, Koch CG, Eisenach JC, Neuman MD, Whitlock EL, Robertson RM, Cooper T, Pomerantz P. Creation of the Anesthesia Research Council. Anesth Analg. 2020 10; 131(4):1300-1303. PMID: 32925351.
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    22. Boada MD, Martin TJ, Parker R, Houle TT, Eisenach JC, Ririe DG. Recovery from nerve injury induced behavioral hypersensitivity in rats parallels resolution of abnormal primary sensory afferent signaling. Pain. 2020 05; 161(5):949-959. PMID: 32040074.
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    23. Boada MD, Ririe DG, Martin CW, Martin SJ, Kim SA, Eisenach JC, Martin TJ. Nociceptive input after peripheral nerve injury results in cognitive impairment and alterations in primary afferent physiology in rats. Pain. 2020 05; 161(5):960-969. PMID: 32040075.
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    24. Sharpe EE, Booth JL, Houle TT, Pan PH, Harris LC, Aschenbrenner CA, Eisenach JC. Recovery of physical activity after cesarean delivery and its relationship with pain. Pain. 2019 10; 160(10):2350-2357. PMID: 31145215.
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    25. Hayashida KI, Eisenach JC, Kawatani M, Martin TJ. Peripheral nerve injury in rats induces alternations in choice behavior associated with food reinforcement. J Physiol Sci. 2019 Sep; 69(5):769-777. PMID: 31267368.
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    26. Boada MD, Gutierrez S, Eisenach JC. Peripheral oxytocin restores light touch and nociceptor sensory afferents towards normal after nerve injury. Pain. 2019 05; 160(5):1146-1155. PMID: 30920428.
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    27. Gutierrez S, Alvarado-Vázquez PA, Eisenach JC, Romero-Sandoval EA, Boada MD. Tachykinins modulate nociceptive responsiveness and sensitization: In vivo electrical characterization of primary sensory neurons in tachykinin knockout (Tac1 KO) mice. Mol Pain. 2019 Jan-Dec; 15:1744806919845750. PMID: 31012376.
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    28. Eisenach JC, Yaksh TL. Spinal Exparel®-an extended duration of preclinical study needed. Br J Anaesth. 2019 03; 122(3):298-300. PMID: 30770045.
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    29. Street LM, Harris L, Curry RS, Eisenach JC. Capsaicin-induced pain and sensitisation in the postpartum period. Br J Anaesth. 2019 Jan; 122(1):103-110. PMID: 30579387.
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    30. Ilfeld BM, Gabriel RA, Eisenach JC. Liposomal Bupivacaine Infiltration for Knee Arthroplasty: Significant Analgesic Benefits or Just a Bunch of Fat? Anesthesiology. 2018 10; 129(4):623-626. PMID: 30102616.
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    31. Ririe DG, Boada MD, MacGregor MK, Martin SJ, Strassburg TJ, Kim SA, Eisenach JC, Martin TJ. Incisional Nociceptive Input Impairs Attention-related Behavior and Is Associated with Reduced Neuronal Activity in the Prefrontal Cortex in Rats. Anesthesiology. 2018 10; 129(4):778-790. PMID: 29952818.
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    32. Booth JL, Sharpe EE, Houle TT, Harris L, Curry RS, Aschenbrenner CA, Eisenach JC. Patterns of recovery from pain after cesarean delivery. Pain. 2018 Oct; 159(10):2088-2096. PMID: 29905650.
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    33. Severino AL, Chen R, Hayashida K, Aschenbrenner CA, Sun H, Peters CM, Gutierrez S, Pan B, Eisenach JC. Plasticity and Function of Spinal Oxytocin and Vasopressin Signaling during Recovery from Surgery with Nerve Injury. Anesthesiology. 2018 09; 129(3):544-556. PMID: 29912007.
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    34. Eisenach JC, Brennan TJ. Pain after surgery. Pain. 2018 Jun; 159(6):1010-1011. PMID: 29768304.
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    35. Arora V, Martin TJ, Aschenbrenner CA, Hayashida K, Kim SA, Parker RA, Eisenach JC, Peters CM. Psychosocial Stress Delays Recovery of Postoperative Pain Following Incisional Surgery in the Rat. Neuroscience. 2018 07 01; 382:35-47. PMID: 29694918.
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    36. Street LM, Aschenbrenner CA, Houle TT, Pinyan CW, Eisenach JC. Gestational Obstructive Sleep Apnea: Biomarker Screening Models and Lack of Postpartum Resolution. J Clin Sleep Med. 2018 04 15; 14(4):549-555. PMID: 29609706.
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    37. Hayashida KI, Kimuram M, Eisenach JC. Blockade of a2-adrenergic or metabotropic glutamate receptors induces glutamate release in the locus coeruleus to activate descending inhibition in rats with chronic neuropathic hypersensitivity. Neurosci Lett. 2018 05 29; 676:41-45. PMID: 29627342.
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    38. Hayashida KI, Eisenach JC. Descending Noradrenergic Inhibition: An Important Mechanism of Gabapentin Analgesia in Neuropathic Pain. Adv Exp Med Biol. 2018; 1099:93-100. PMID: 30306517.
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    39. Houle TT, Miller S, Lang JE, Booth JL, Curry RS, Harris L, Aschenbrenner CA, Eisenach JC. Day-to-day experience in resolution of pain after surgery. Pain. 2017 Nov; 158(11):2147-2154. PMID: 28708763.
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    40. Gewandter JS, Eisenach JC, Gross RA, Jensen MP, Keefe FJ, Lee DA, Turk DC. Checklist for the preparation and review of pain clinical trial publications: a pain-specific supplement to CONSORT. Pain Rep. 2019 May-Jun; 4(3):e621. PMID: 28989992.
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    41. Martin TJ, Strassburg TJ, Grigg AL, Kim SA, Ririe DG, Eisenach JC. Assessment of Behavioral Disruption in Rats with Abdominal Inflammation Using Visual Cue Titration and the Five-choice Serial-reaction Time Task. Anesthesiology. 2017 08; 127(2):372-381. PMID: 28542002.
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    42. Booth JL, Ross VH, Nelson KE, Harris L, Eisenach JC, Pan PH. Epidural Neostigmine versus Fentanyl to Decrease Bupivacaine Use in Patient-controlled Epidural Analgesia during Labor: A Randomized, Double-blind, Controlled Study. Anesthesiology. 2017 07; 127(1):50-57. PMID: 28475555.
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    43. Eisenach JC. Ketamine fails to prevent postoperative delirium. Lancet. 2017 07 15; 390(10091):206-208. PMID: 28576283.
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    44. Eisenach JC, Curry R, Aschenbrenner CA, Coghill RC, Houle TT. Pupil responses and pain ratings to heat stimuli: Reliability and effects of expectations and a conditioning pain stimulus. J Neurosci Methods. 2017 03 01; 279:52-59. PMID: 28089758.
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    45. Boada MD, Ririe DG, Eisenach JC. Post-discharge hyperpolarization is an endogenous modulatory factor limiting input from fast-conducting nociceptors (AHTMRs). Mol Pain. 2017 Jan-Dec; 13:1744806917726255. PMID: 28825337.
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    46. Eisenach JC. In Reply. Anesthesiology. 2016 11; 125(5):1074-1075. PMID: 27755040.
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    47. Kimura M, Eisenach JC, Hayashida KI. Gabapentin loses efficacy over time after nerve injury in rats: role of glutamate transporter-1 in the locus coeruleus. Pain. 2016 09; 157(9):2024-2032. PMID: 27315512.
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    48. Eisenach JC, Yaksh TL. Ethical Concerns Regarding Human Study. CNS Neurosci Ther. 2016 10; 22(10):866. PMID: 27577599.
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    49. Eisenach JC. Without Science There Is Little Art in Anesthesiology: 2015 Rovenstine Lecture. Anesthesiology. 2016 06; 124(6):1205-7. PMID: 27028472.
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    50. Eisenach JC, Kheterpal S, Houle TT. Reporting of Observational Research in ANESTHESIOLOGY: The Importance of the Analysis Plan. Anesthesiology. 2016 May; 124(5):998-1000. PMID: 26933796.
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    51. Andrews NA, Latrémolière A, Basbaum AI, Mogil JS, Porreca F, Rice ASC, Woolf CJ, Currie GL, Dworkin RH, Eisenach JC, Evans S, Gewandter JS, Gover TD, Handwerker H, Huang W, Iyengar S, Jensen MP, Kennedy JD, Lee N, Levine J, Lidster K, Machin I, McDermott MP, McMahon SB, Price TJ, Ross SE, Scherrer G, Seal RP, Sena ES, Silva E, Stone L, Svensson CI, Turk DC, Whiteside G. Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations. Pain. 2016 Apr; 157(4):901-909. PMID: 26683237.
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    52. Booth JL, Harris LC, Eisenach JC, Pan PH. A Randomized Controlled Trial Comparing Two Multimodal Analgesic Techniques in Patients Predicted to Have Severe Pain After Cesarean Delivery. Anesth Analg. 2016 Apr; 122(4):1114-9. PMID: 25806400.
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    53. Eisenach JC, Warner DS, Houle TT. Reporting of Preclinical Research in Anesthesiology: Transparency and Enforcement. Anesthesiology. 2016 Apr; 124(4):763-5. PMID: 26845144.
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    54. Zeidan F, Adler-Neal AL, Wells RE, Stagnaro E, May LM, Eisenach JC, McHaffie JG, Coghill RC. Mindfulness-Meditation-Based Pain Relief Is Not Mediated by Endogenous Opioids. J Neurosci. 2016 Mar 16; 36(11):3391-7. PMID: 26985045.
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    55. Kharasch ED, Eisenach JC. Wherefore Gabapentinoids?: Was There Rush Too Soon to Judgment? Anesthesiology. 2016 Jan; 124(1):10-2. PMID: 26528777.
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    56. Eisenach JC. Can a Blood Test of Immune Responsiveness Predict Speed of Recovery from Pain and Dysfunction after Surgery? Anesthesiology. 2015 Dec; 123(6):1221-3. PMID: 26655307.
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    57. Boada MD, Eisenach JC, Ririe DG. Mechanical sensibility of nociceptive and non-nociceptive fast-conducting afferents is modulated by skin temperature. J Neurophysiol. 2016 Jan 01; 115(1):546-53. PMID: 26581873.
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    58. Arora V, Morado-Urbina CE, Aschenbrenner CA, Hayashida K, Wang F, Martin TJ, Eisenach JC, Peters CM. Disruption of Spinal Noradrenergic Activation Delays Recovery of Acute Incision-Induced Hypersensitivity and Increases Spinal Glial Activation in the Rat. J Pain. 2016 Feb; 17(2):190-202. PMID: 26545342.
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    59. Kimura M, Suto T, Eisenach JC, Hayashida K. Down-regulation of astroglial glutamate transporter-1 in the locus coeruleus impairs pain-evoked endogenous analgesia in rats. Neurosci Lett. 2015 Nov 03; 608:18-22. PMID: 26450532.
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    60. Kimura M, Suto T, Morado-Urbina CE, Peters CM, Eisenach JC, Hayashida K. Impaired Pain-evoked Analgesia after Nerve Injury in Rats Reflects Altered Glutamate Regulation in the Locus Coeruleus. Anesthesiology. 2015 Oct; 123(4):899-908. PMID: 26244888.
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    61. Eisenach JC. Anesthesiology: Attracting the Best New Science in the Specialty. Anesthesiology. 2015 Jun; 122(6):1198-200. PMID: 25844842.
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    62. Peters CM, Hayashida K, Suto T, Houle TT, Aschenbrenner CA, Martin TJ, Eisenach JC. Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat. Anesthesiology. 2015 Apr; 122(4):895-907. PMID: 25581910.
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    63. Tedeschi V, Rathmell JP, Eisenach JC. Finding and getting what you want when you want it just got easier at ANESTHESIOLOGY. Anesthesiology. 2015 Mar; 122(3):491-4. PMID: 25603458.
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    64. Eisenach JC, Tong C, Curry R. Phase 1 safety assessment of intrathecal oxytocin. Anesthesiology. 2015 Feb; 122(2):407-13. PMID: 25502065.
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    65. Eisenach JC, Tong C, Curry RS. Failure of intrathecal ketorolac to reduce remifentanil-induced postinfusion hyperalgesia in humans. Pain. 2015 Jan; 156(1):81-87. PMID: 25599304.
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    66. Rauck RL, North J, Eisenach JC. Intrathecal clonidine and adenosine: effects on pain and sensory processing in patients with chronic regional pain syndrome. Pain. 2015 Jan; 156(1):88-95. PMID: 25599305.
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    67. Martin TJ, Grigg A, Kim SA, Ririe DG, Eisenach JC. Assessment of attention threshold in rats by titration of visual cue duration during the five choice serial reaction time task. J Neurosci Methods. 2015 Feb 15; 241:37-43. PMID: 25528113.
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    68. Aschenbrenner CA, Houle TT, Gutierrez S, Eisenach JC. Modeling individual recovery after peripheral nerve injury in rats and the effects of parturition. Anesthesiology. 2014 Nov; 121(5):1056-67. PMID: 24979387.
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    69. Boada MD, Gutierrez S, Aschenbrenner CA, Houle TT, Hayashida K, Ririe DG, Eisenach JC. Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents. J Neurophysiol. 2015 Jan 01; 113(1):100-9. PMID: 25274350.
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    70. Boada DM, Martin TJ, Peters CM, Hayashida K, Harris MH, Houle TT, Boyden ES, Eisenach JC, Ririe DG. Fast-conducting mechanoreceptors contribute to withdrawal behavior in normal and nerve injured rats. Pain. 2014 Dec; 155(12):2646-2655. PMID: 25267211.
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    71. Eisenach JC. In reply. Anesthesiology. 2014 Aug; 121(2):433. PMID: 25050508.
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    72. Eisenach JC, Houle TT. Replication to advance science: changes in ANESTHESIOLOGY. Anesthesiology. 2014 Aug; 121(2):209-11. PMID: 24895916.
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    73. Suto T, Eisenach JC, Hayashida K. Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain. Pain. 2014 Oct; 155(10):1935-42. PMID: 24837843.
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    74. Yaksh TL, Hobo S, Peters C, Osborn KG, Richter PJ, Rossi SS, Grafe MR, Eisenach JC. Preclinical toxicity screening of intrathecal oxytocin in rats and dogs. Anesthesiology. 2014 Apr; 120(4):951-61. PMID: 24492326.
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    75. Peters CM, Ririe D, Houle TT, Aschenbrenner CA, Eisenach JC. Nociceptor-selective peripheral nerve block induces delayed mechanical hypersensitivity and neurotoxicity in rats. Anesthesiology. 2014 Apr; 120(4):976-86. PMID: 24296762.
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    76. Wang L, Bauer M, Curry R, Larsson A, Sessler DI, Eisenach JC. Intrathecal ketorolac does not improve acute or chronic pain after hip arthroplasty: a randomized controlled trial. J Anesth. 2014 Oct; 28(5):790-3. PMID: 24535482.
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    77. Suto T, Severino AL, Eisenach JC, Hayashida K. Gabapentin increases extracellular glutamatergic level in the locus coeruleus via astroglial glutamate transporter-dependent mechanisms. Neuropharmacology. 2014 Jun; 81:95-100. PMID: 24495399.
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    78. Eisenach JC, Rathmell JP. In reply. Anesthesiology. 2014 Jan; 120(1):238-9. PMID: 24398737.
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    79. Eisenach JC. Fraud in anesthesia - an editor's perspective. Rev Esp Anestesiol Reanim. 2013 Dec; 60(10):547-8. PMID: 25493303.
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    80. Eisenach JC. Patient safety: anesthesiology contributions and supplements to the American Society of Anesthesiologists' Annual Meeting. Anesthesiology. 2013 Oct; 119(4):745-6. PMID: 23924681.
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    81. Yoshizumi M, Eisenach JC, Hayashida K. Valproate prevents dysregulation of spinal glutamate and reduces the development of hypersensitivity in rats after peripheral nerve injury. J Pain. 2013 Nov; 14(11):1485-91. PMID: 24021575.
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    82. Pan PH, Tonidandel AM, Aschenbrenner CA, Houle TT, Harris LC, Eisenach JC. Predicting acute pain after cesarean delivery using three simple questions. Anesthesiology. 2013 May; 118(5):1170-9. PMID: 23485992.
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    83. Eisenach JC. Case reports are leaving Anesthesiology, but not the specialty. Anesthesiology. 2013 Mar; 118(3):479-80. PMID: 23299365.
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    84. Gutierrez S, Liu B, Hayashida K, Houle TT, Eisenach JC. Reversal of peripheral nerve injury-induced hypersensitivity in the postpartum period: role of spinal oxytocin. Anesthesiology. 2013 Jan; 118(1):152-9. PMID: 23249932.
      Citations:    
    85. Kimura M, Hayashida K, Eisenach JC, Saito S, Obata H. Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic and ?-aminobutyric acid mechanisms. Anesthesiology. 2013 Jan; 118(1):173-80. PMID: 23221863.
      Citations:    
    86. Eisenach JC, Pan P, Smiley RM, Lavand'homme P, Landau R, Houle TT. Resolution of pain after childbirth. Anesthesiology. 2013 Jan; 118(1):143-51. PMID: 23249931.
      Citations:    
    87. Gutierrez S, Hayashida K, Eisenach JC. The puerperium alters spinal cord plasticity following peripheral nerve injury. Neuroscience. 2013 Jan 03; 228:301-8. PMID: 23103215.
      Citations:    
    88. Hayashida K, Kimura M, Yoshizumi M, Hobo S, Obata H, Eisenach JC. Ondansetron reverses antihypersensitivity from clonidine in rats after peripheral nerve injury: role of ?-aminobutyric acid in a2-adrenoceptor and 5-HT3 serotonin receptor analgesia. Anesthesiology. 2012 Aug; 117(2):389-98. PMID: 22722575.
      Citations:    
    89. Boada MD, Gutierrez S, Giffear K, Eisenach JC, Ririe DG. Skin incision-induced receptive field responses of mechanosensitive peripheral neurons are developmentally regulated in the rat. J Neurophysiol. 2012 Aug; 108(4):1122-9. PMID: 22673323.
      Citations:    
    90. Yoshizumi M, Parker RA, Eisenach JC, Hayashida K. Gabapentin inhibits ?-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats. Anesthesiology. 2012 Jun; 116(6):1347-53. PMID: 22487864.
      Citations:    
    91. Devereaux PJ, Chan MT, Eisenach J, Schricker T, Sessler DI. The need for large clinical studies in perioperative medicine. Anesthesiology. 2012 Jun; 116(6):1169-75. PMID: 22415390.
      Citations:    
    92. Martucci KT, Eisenach JC, Tong C, Coghill RC. Opioid-independent mechanisms supporting offset analgesia and temporal sharpening of nociceptive information. Pain. 2012 Jun; 153(6):1232-1243. PMID: 22503222.
      Citations:    
    93. Turner DP, Smitherman TA, Eisenach JC, Penzien DB, Houle TT. Predictors of headache before, during, and after pregnancy: a cohort study. Headache. 2012 Mar; 52(3):348-62. PMID: 22268840.
      Citations:    
    94. Yoshizumi M, Eisenach JC, Hayashida K. Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes. Eur J Pharmacol. 2012 Feb 29; 677(1-3):87-92. PMID: 22206816.
      Citations:    
    95. Hayashida K, Peters CM, Gutierrez S, Eisenach JC. Depletion of endogenous noradrenaline does not prevent spinal cord plasticity following peripheral nerve injury. J Pain. 2012 Jan; 13(1):49-57. PMID: 22155404.
      Citations:    
    96. Eisenach JC. Washington University and the why of anesthesiology. Anesthesiology. 2011 Dec; 115(6):1145-6. PMID: 21993156.
      Citations:    
    97. Hobo S, Hayashida K, Eisenach JC. Oxytocin inhibits the membrane depolarization-induced increase in intracellular calcium in capsaicin sensitive sensory neurons: a peripheral mechanism of analgesic action. Anesth Analg. 2012 Feb; 114(2):442-9. PMID: 22104073.
      Citations:    
    98. Hains LE, Loram LC, Taylor FR, Strand KA, Wieseler JL, Barrientos RM, Young JJ, Frank MG, Sobesky J, Martin TJ, Eisenach JC, Maier SF, Johnson JD, Fleshner M, Watkins LR. Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors. J Neuroimmunol. 2011 Oct 28; 239(1-2):53-60. PMID: 21907418.
      Citations:    
    99. Eisenach JC. Note of editorial concern. Anesthesiology. 2011 09; 115(3):463. PMID: 21716090.
      Citations:    
    100. Boada MD, Gutierrez S, Houle T, Eisenach JC, Ririe DG. Developmental differences in peripheral glabrous skin mechanosensory nerve receptive field and intracellular electrophysiologic properties: phenotypic characterization in infant and juvenile rats. Int J Dev Neurosci. 2011 Dec; 29(8):847-54. PMID: 21856407.
      Citations:    
    101. Hobo S, Eisenach JC, Hayashida K. Up-regulation of spinal glutamate transporters contributes to anti-hypersensitive effects of valproate in rats after peripheral nerve injury. Neurosci Lett. 2011 Sep 08; 502(1):52-5. PMID: 21802494.
      Citations:    
    102. Eisenach JC. It's a bright and sunny day: Anesthesiology in 2011. Anesthesiology. 2011 Jan; 114(1):24. PMID: 21150573.
      Citations:    
    103. Hayashida K, Eisenach JC. A tropomyosine receptor kinase inhibitor blocks spinal neuroplasticity essential for the anti-hypersensitivity effects of gabapentin and clonidine in rats with peripheral nerve injury. J Pain. 2011 Jan; 12(1):94-100. PMID: 20638911.
      Citations:    
    104. Eisenach JC. Why is Karolinska on the cover of an American journal? Anesthesiology. 2010 Dec; 113(6):1257. PMID: 21042198.
      Citations:    
    105. Boada MD, Houle TT, Eisenach JC, Ririe DG. Differing neurophysiologic mechanosensory input from glabrous and hairy skin in juvenile rats. J Neurophysiol. 2010 Dec; 104(6):3568-75. PMID: 20926608.
      Citations:    
    106. Hains LE, Loram LC, Weiseler JL, Frank MG, Bloss EB, Sholar P, Taylor FR, Harrison JA, Martin TJ, Eisenach JC, Maier SF, Watkins LR. Pain intensity and duration can be enhanced by prior challenge: initial evidence suggestive of a role of microglial priming. J Pain. 2010 Oct; 11(10):1004-14. PMID: 20434956.
      Citations:    
    107. Hayashida K, Eisenach JC. Spinal alpha 2-adrenoceptor-mediated analgesia in neuropathic pain reflects brain-derived nerve growth factor and changes in spinal cholinergic neuronal function. Anesthesiology. 2010 Aug; 113(2):406-12. PMID: 20613480.
      Citations:    
    108. Peters CM, Hayashida K, Ewan EE, Nakajima K, Obata H, Xu Q, Yaksh TL, Eisenach JC. Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain Res. 2010 Sep 17; 1352:83-93. PMID: 20637741.
      Citations:    
    109. Eisenach JC, Sumikawa K, Makita T, Cho S. Anesthesiology and the Japanese Society of Anesthesiologists: the science is amazing. Anesthesiology. 2010 Jun; 112(6):1301-2. PMID: 20502110.
      Citations:    
    110. Eisenach JC, Curry R, Rauck R, Pan P, Yaksh TL. Role of spinal cyclooxygenase in human postoperative and chronic pain. Anesthesiology. 2010 May; 112(5):1225-33. PMID: 20395820.
      Citations:    
    111. Peters CM, Eisenach JC. Contribution of the chemokine (C-C motif) ligand 2 (CCL2) to mechanical hypersensitivity after surgical incision in rats. Anesthesiology. 2010 May; 112(5):1250-8. PMID: 20395830.
      Citations:    
    112. Eisenach JC, Curry R, Tong C, Houle TT, Yaksh TL. Effects of intrathecal ketorolac on human experimental pain. Anesthesiology. 2010 May; 112(5):1216-24. PMID: 20395821.
      Citations:    
    113. Yaksh TL, Eisenach JC, Shafer SL. Consent contraindicated? Science. 2010 Apr 02; 328(5974):45; author reply 45. PMID: 20360092.
      Citations:    
    114. Eisenach JC, Shafer SL, Yaksh T. The need for a journal policy on intrathecal, epidural, and perineural administration of non-approved drugs. Pain. 2010 Jun; 149(3):417-419. PMID: 20227830.
      Citations:    
    115. Hayashida K, Parker RA, Eisenach JC. Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats. Brain Res. 2010 Mar 04; 1317:80-6. PMID: 20059984.
      Citations:    
    116. Nelson KE, Houle TT, Eisenach JC. Blood pressure, but not cerebrospinal fluid fentanyl concentration, predicts duration of labor analgesia from spinal fentanyl. Anesthesiology. 2010 Jan; 112(1):174-80. PMID: 19996953.
      Citations:    
    117. Eisenach JC. To our readers: an experiment in education. Anesthesiology. 2010 Jan; 112(1):1-2. PMID: 19952721.
      Citations:    
    118. Eisenach JC. To our authors. Anesthesiology. 2009 Dec; 111(6):1189-91. PMID: 19934860.
      Citations:    
    119. Fisher DM, Eisenach JC. Science marches forward: a new tool to study the progress of labor. Anesthesiology. 2009 Nov; 111(5):936-7. PMID: 19786860.
      Citations:    
    120. Eisenach JC. Epidural neostigmine: will it replace lipid soluble opioids for postoperative and labor analgesia? Anesth Analg. 2009 Aug; 109(2):293-5. PMID: 19608792.
      Citations:    
    121. Eisenach JC. Data fabrication and article retraction: how not to get lost in the woods. Anesthesiology. 2009 May; 110(5):955-6. PMID: 19262370.
      Citations:    
    122. Gurun MS, Parker R, Eisenach JC, Vincler M. The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of alpha7 nicotinic acetylcholine receptor. Anesth Analg. 2009 May; 108(5):1680-7. PMID: 19372354.
      Citations:    
    123. Ross VH, Pan PH, Owen MD, Seid MH, Harris L, Clyne B, Voltaire M, Eisenach JC. Neostigmine decreases bupivacaine use by patient-controlled epidural analgesia during labor: a randomized controlled study. Anesth Analg. 2009 Aug; 109(2):524-31. PMID: 19377050.
      Citations:    
    124. Eisenach JC. Curiosity, discipline, and joy; and the greatest of these is joy. Anesthesiology. 2009 Apr; 110(4):712-3. PMID: 19276963.
      Citations:    
    125. Hayashida K, Obata H, Nakajima K, Eisenach JC. Gabapentin acts within the locus coeruleus to alleviate neuropathic pain. Anesthesiology. 2008 Dec; 109(6):1077-84. PMID: 19034104.
      Citations:    
    126. Eisenach JC, Borgeat A, Bosnjak ZJ, Brennan TJ, Kersten JR, Kochs E, Lerman J, Warner DS, Wiener-Kronish JP. 2008 in review: advancing medicine in anesthesiology. Anesthesiology. 2008 Dec; 109(6):962-72. PMID: 19034092.
      Citations:    
    127. Eisenach JC, Pan PH, Smiley R, Lavand'homme P, Landau R, Houle TT. Severity of acute pain after childbirth, but not type of delivery, predicts persistent pain and postpartum depression. Pain. 2008 Nov 15; 140(1):87-94. PMID: 18818022.
      Citations:    
    128. Rice ASC, Cimino-Brown D, Eisenach JC, Kontinen VK, Lacroix-Fralish ML, Machin I, Mogil JS, Stöhr T. Animal models and the prediction of efficacy in clinical trials of analgesic drugs: a critical appraisal and call for uniform reporting standards. Pain. 2008 Oct 15; 139(2):243-247. PMID: 18814968.
      Citations:    
    129. Hayashida K, Eisenach JC. Multiplicative interactions to enhance gabapentin to treat neuropathic pain. Eur J Pharmacol. 2008 Nov 19; 598(1-3):21-6. PMID: 18822281.
      Citations:    
    130. Lerman J, Kharasch ED, Eisenach JC, Warner MA, Jevtovic-Todorovic V, Patel PM, Sun LS. Journal-related and other special activities at the 2008 American Society of Anesthesiologists Annual Meeting. Anesthesiology. 2008 Sep; 109(3):365. PMID: 18754137.
      Citations:    
    131. Eisenach JC. Regional anesthesia: advancing the practice of medicine; the 2008 Gaston Labat Award lecture. Reg Anesth Pain Med. 2008 Sep-Oct; 33(5):463-9. PMID: 18774516.
      Citations:    
    132. Ririe DG, Liu B, Clayton B, Tong C, Eisenach JC. Electrophysiologic characteristics of large neurons in dorsal root ganglia during development and after hind paw incision in the rat. Anesthesiology. 2008 Jul; 109(1):111-7. PMID: 18580180.
      Citations:    
    133. Eisenach JC, Kersten J. Science and the mission of anesthesiology. Anesthesiology. 2008 Jul; 109(1):1-2. PMID: 18580163.
      Citations:    
    134. Liu B, Tong C, Eisenach JC. Pregnancy increases excitability of mechanosensitive afferents innervating the uterine cervix. Anesthesiology. 2008 Jun; 108(6):1087-92. PMID: 18497610.
      Citations:    
    135. Tong C, Conklin DR, Liu B, Ririe DG, Eisenach JC. Assessment of behavior during labor in rats and effect of intrathecal morphine. Anesthesiology. 2008 Jun; 108(6):1081-6. PMID: 18497609.
      Citations:    
    136. Yaksh TL, Tozier N, Horais KA, Malkmus S, Rathbun M, Lafranco L, Eisenach J. Toxicology profile of N-methyl-D-aspartate antagonists delivered by intrathecal infusion in the canine model. Anesthesiology. 2008 May; 108(5):938-49. PMID: 18431131.
      Citations:    
    137. Deer T, Krames ES, Hassenbusch S, Burton A, Caraway D, Dupen S, Eisenach J, Erdek M, Grigsby E, Kim P, Levy R, McDowell G, Mekhail N, Panchal S, Prager J, Rauck R, Saulino M, Sitzman T, Staats P, Stanton-Hicks M, Stearns L, Dean Willis K, Witt W, Follett K, Huntoon M, Liem L, Rathmell J, Wallace M, Buchser E, Cousins M, Ver Donck A. Management of intrathecal catheter-tip inflammatory masses: an updated 2007 consensus statement from an expert panel. Neuromodulation. 2008 Apr; 11(2):77-91. PMID: 22151039.
      Citations:    
    138. Deer T, Krames ES, Hassenbusch S, Burton A, Caraway D, Dupen S, Eisenach J, Erdek M, Grigsby E, Kim P, Levy R, McDowell G, Mekhail N, Panchal S, Prager J, Rauck R, Saulino M, Sitzman T, Staats P, Stanton-Hicks M, Stearns L, Dean Willis K, Witt W, Follett K, Huntoon M, Liem L, Rathmell J, Wallace M, Buchser E, Cousins M, Ver Donck A. Future directions for intrathecal pain management: a review and update from the interdisciplinary polyanalgesic consensus conference 2007. Neuromodulation. 2008 Apr; 11(2):92-7. PMID: 22151040.
      Citations:    
    139. Eisenach JC, Borgeat A, Bosnjak ZJ, Brennan TJ, Kersten JR, Kochs EF, Wiener-Kronish JP. 2007 in review: a dozen steps forward in Anesthesiology. Anesthesiology. 2008 Jan; 108(1):149-55. PMID: 18156893.
      Citations:    
    140. Deer T, Krames ES, Hassenbusch SJ, Burton A, Caraway D, Dupen S, Eisenach J, Erdek M, Grigsby E, Kim P, Levy R, McDowell G, Mekhail N, Panchal S, Prager J, Rauck R, Saulino M, Sitzman T, Staats P, Stanton-Hicks M, Stearns L, Willis KD, Witt W, Follett K, Huntoon M, Liem L, Rathmell J, Wallace M, Buchser E, Cousins M, Ver Donck A. Polyanalgesic consensus conference 2007: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation. 2007 Oct; 10(4):300-28. PMID: 22150890.
      Citations:    
    141. Stone LS, Kitto KF, Eisenach JC, Fairbanks CA, Wilcox GL. ST91 [2-(2,6-diethylphenylamino)-2-imidazoline hydrochloride]-mediated spinal antinociception and synergy with opioids persists in the absence of functional alpha-2A- or alpha-2C-adrenergic receptors. J Pharmacol Exp Ther. 2007 Dec; 323(3):899-906. PMID: 17855473.
      Citations:    
    142. Hayashida KI, Clayton BA, Johnson JE, Eisenach JC. Brain derived nerve growth factor induces spinal noradrenergic fiber sprouting and enhances clonidine analgesia following nerve injury in rats. Pain. 2008 Jun; 136(3):348-355. PMID: 17822849.
      Citations:    
    143. Eisenach JC, Brennan TJ. Anesthesiology and the press. Anesthesiology. 2007 Jul; 107(1):8. PMID: 17585209.
      Citations:    
    144. Hayashida K, Parker R, Eisenach JC. Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil. Anesthesiology. 2007 Jun; 106(6):1213-9. PMID: 17525597.
      Citations:    
    145. Yan T, Liu B, Du D, Eisenach JC, Tong C. Estrogen amplifies pain responses to uterine cervical distension in rats by altering transient receptor potential-1 function. Anesth Analg. 2007 May; 104(5):1246-50, tables of contents. PMID: 17456681.
      Citations:    
    146. Clayton BA, Hayashida K, Childers SR, Xiao R, Eisenach JC. Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism. Anesthesiology. 2007 May; 106(5):1019-25. PMID: 17457135.
      Citations:    
    147. Romero-Sandoval A, Eisenach JC. Spinal cannabinoid receptor type 2 activation reduces hypersensitivity and spinal cord glial activation after paw incision. Anesthesiology. 2007 Apr; 106(4):787-94. PMID: 17413917.
      Citations:    
    148. Hayashida K, DeGoes S, Curry R, Eisenach JC. Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery. Anesthesiology. 2007 Mar; 106(3):557-62. PMID: 17325515.
      Citations:    
    149. Martin TJ, Kim SA, Buechler NL, Porreca F, Eisenach JC. Opioid self-administration in the nerve-injured rat: relevance of antiallodynic effects to drug consumption and effects of intrathecal analgesics. Anesthesiology. 2007 Feb; 106(2):312-22. PMID: 17264726.
      Citations:    
    150. Romero-Sandoval A, Bynum T, Eisenach JC. Analgesia induced by perineural clonidine is enhanced in persistent neuritis. Neuroreport. 2007 Jan 08; 18(1):67-71. PMID: 17259863.
      Citations:    
    151. Ma W, Eisenach JC. Neuronal nitric oxide synthase is upregulated in a subset of primary sensory afferents after nerve injury which are necessary for analgesia from alpha2-adrenoceptor stimulation. Brain Res. 2007 Jan 05; 1127(1):52-8. PMID: 17113051.
      Citations:    
    152. Obata H, Eisenach JC, Hussain H, Bynum T, Vincler M. Spinal glial activation contributes to postoperative mechanical hypersensitivity in the rat. J Pain. 2006 Nov; 7(11):816-22. PMID: 17074623.
      Citations:    
    153. Tong C, Conklin D, Eisenach JC. A pain model after gynecologic surgery: the effect of intrathecal and systemic morphine. Anesth Analg. 2006 Nov; 103(5):1288-93. PMID: 17056971.
      Citations:    
    154. Romero-Sandoval A, Eisenach JC. Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis. Brain Behav Immun. 2007 Jul; 21(5):569-80. PMID: 17079113.
      Citations:    
    155. Martin TJ, Eisenach JC, Misler J, Childers SR. Chronic activation of spinal adenosine A1 receptors results in hypersensitivity. Neuroreport. 2006 Oct 23; 17(15):1619-22. PMID: 17001280.
      Citations:    
    156. Martin TJ, Buechler NL, Eisenach JC. Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats. Anesth Analg. 2006 Sep; 103(3):690-5. PMID: 16931682.
      Citations:    
    157. Liu B, Eisenach JC. Perineural clonidine reduces p38 mitogen-activated protein kinase activation in sensory neurons. Neuroreport. 2006 Aug 21; 17(12):1313-7. PMID: 16951576.
      Citations:    
    158. Martin TJ, Kim SA, Eisenach JC. Clonidine maintains intrathecal self-administration in rats following spinal nerve ligation. Pain. 2006 Dec 05; 125(3):257-263. PMID: 16806709.
      Citations:    
    159. Zhu X, Vincler MA, Parker R, Eisenach JC. Spinal cord dynorphin expression increases, but does not drive microglial prostaglandin production or mechanical hypersensitivity after incisional surgery in rats. Pain. 2006 Nov; 125(1-2):43-52. PMID: 16740361.
      Citations:    
    160. Tong C, Conklin D, Clyne BB, Stanislaus JD, Eisenach JC. Uterine cervical afferents in thoracolumbar dorsal root ganglia express transient receptor potential vanilloid type 1 channel and calcitonin gene-related peptide, but not P2X3 receptor and somatostatin. Anesthesiology. 2006 Apr; 104(4):651-7. PMID: 16571958.
      Citations:    
    161. Eisenach JC. Treating and preventing chronic pain: a view from the spinal cord--Bonica Lecture, ASRA Annual Meeting, 2005. Reg Anesth Pain Med. 2006 Mar-Apr; 31(2):146-51. PMID: 16543101.
      Citations:    
    162. Ririe DG, Prout HD, Barclay D, Tong C, Lin M, Eisenach JC. Developmental differences in spinal cyclooxygenase 1 expression after surgical incision. Anesthesiology. 2006 Mar; 104(3):426-31. PMID: 16508388.
      Citations:    
    163. Pan PH, Coghill R, Houle TT, Seid MH, Lindel WM, Parker RL, Washburn SA, Harris L, Eisenach JC. Multifactorial preoperative predictors for postcesarean section pain and analgesic requirement. Anesthesiology. 2006 Mar; 104(3):417-25. PMID: 16508387.
      Citations:    
    164. Ririe DG, Eisenach JC. Age-dependent responses to nerve injury-induced mechanical allodynia. Anesthesiology. 2006 Feb; 104(2):344-50. PMID: 16436855.
      Citations:    
    165. Romero-Sandoval A, Eisenach JC. Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury. Anesthesiology. 2006 Feb; 104(2):351-5. PMID: 16436856.
      Citations:    
    166. Eisenach JC. Preventing chronic pain after surgery: who, how, and when? Reg Anesth Pain Med. 2006 Jan-Feb; 31(1):1-3. PMID: 16418016.
      Citations:    
    167. Li X, Eisenach JC. Adenosine reduces glutamate release in rat spinal synaptosomes. Anesthesiology. 2005 Nov; 103(5):1060-5. PMID: 16249681.
      Citations:    
    168. Liu B, Eisenach JC. Hyperexcitability of axotomized and neighboring unaxotomized sensory neurons is reduced days after perineural clonidine at the site of injury. J Neurophysiol. 2005 Nov; 94(5):3159-67. PMID: 16222073.
      Citations:    
    169. Romero-Sandoval EA, McCall C, Eisenach JC. Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain. J Neurosci. 2005 Sep 28; 25(39):8988-94. PMID: 16192389.
      Citations:    
    170. Martin TJ, Kahn WR, Eisenach JC. Abdominal surgery decreases food-reinforced operant responding in rats: relevance of incisional pain. Anesthesiology. 2005 Sep; 103(3):629-37. PMID: 16129990.
      Citations:    
    171. Zhu X, Conklin DR, Eisenach JC. Preoperative inhibition of cyclooxygenase-1 in the spinal cord reduces postoperative pain. Anesth Analg. 2005 May; 100(5):1390-3, table of contents. PMID: 15845692.
      Citations:    
    172. Dalle C, Eisenach JC. Peripheral block of the hyperpolarization-activated cation current (Ih) reduces mechanical allodynia in animal models of postoperative and neuropathic pain. Reg Anesth Pain Med. 2005 May-Jun; 30(3):243-8. PMID: 15898027.
      Citations:    
    173. Nelson KE, Eisenach JC. Intravenous butorphanol, meperidine, and their combination relieve pain and distress in women in labor. Anesthesiology. 2005 May; 102(5):1008-13. PMID: 15851889.
      Citations:    
    174. Childers SR, Li X, Xiao R, Eisenach JC. Allosteric modulation of adenosine A1 receptor coupling to G-proteins in brain. J Neurochem. 2005 May; 93(3):715-23. PMID: 15836630.
      Citations:    
    175. Liu B, Eisenach JC, Tong C. Chronic estrogen sensitizes a subset of mechanosensitive afferents innervating the uterine cervix. J Neurophysiol. 2005 Apr; 93(4):2167-73. PMID: 15774714.
      Citations:    
    176. Bantel C, Eisenach JC, Duflo F, Tobin JR, Childers SR. Spinal nerve ligation increases alpha2-adrenergic receptor G-protein coupling in the spinal cord. Brain Res. 2005 Mar 15; 1038(1):76-82. PMID: 15748875.
      Citations:    
    177. Obata H, Li X, Eisenach JC. alpha2-Adrenoceptor activation by clonidine enhances stimulation-evoked acetylcholine release from spinal cord tissue after nerve ligation in rats. Anesthesiology. 2005 Mar; 102(3):657-62. PMID: 15731607.
      Citations:    
    178. Obata H, Conklin D, Eisenach JC. Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats. Pain. 2005 Feb; 113(3):271-276. PMID: 15661433.
      Citations:    
    179. Zhang Y, Conklin DR, Li X, Eisenach JC. Intrathecal morphine reduces allodynia after peripheral nerve injury in rats via activation of a spinal A1 adenosine receptor. Anesthesiology. 2005 Feb; 102(2):416-20. PMID: 15681960.
      Citations:    
    180. Martin TJ, Zhang Y, Buechler N, Conklin DR, Eisenach JC. Intrathecal morphine and ketorolac analgesia after surgery: comparison of spontaneous and elicited responses in rats. Pain. 2005 Feb; 113(3):376-385. PMID: 15661447.
      Citations:    
    181. Ma W, Zhang Y, Bantel C, Eisenach JC. Medium and large injured dorsal root ganglion cells increase TRPV-1, accompanied by increased alpha2C-adrenoceptor co-expression and functional inhibition by clonidine. Pain. 2005 Feb; 113(3):386-394. PMID: 15661448.
      Citations:    
    182. Vincler MA, Eisenach JC. Knock down of the alpha 5 nicotinic acetylcholine receptor in spinal nerve-ligated rats alleviates mechanical allodynia. Pharmacol Biochem Behav. 2005 Jan; 80(1):135-43. PMID: 15652389.
      Citations:    
    183. Du D, Eisenach JC, Ririe DG, Tong C. The antinociceptive effects of spinal cyclooxygenase inhibitors on uterine cervical distension. Brain Res. 2004 Oct 22; 1024(1-2):130-6. PMID: 15451374.
      Citations:    
    184. Ririe DG, Prout HM, Eisenach JC. Effect of cyclooxygenase-1 inhibition in postoperative pain is developmentally regulated. Anesthesiology. 2004 Oct; 101(4):1031-5. PMID: 15448542.
      Citations:    
    185. Martin TJ, Buechler NL, Kahn W, Crews JC, Eisenach JC. Effects of laparotomy on spontaneous exploratory activity and conditioned operant responding in the rat: a model for postoperative pain. Anesthesiology. 2004 Jul; 101(1):191-203. PMID: 15220791.
      Citations:    
    186. Baker A, Klimscha W, Eisenach JC, Li XH, Wildling E, Menth-Chiari WA, Chiari AI. Intrathecal clonidine for postoperative analgesia in elderly patients: the influence of baricity on hemodynamic and analgesic effects. Anesth Analg. 2004 Jul; 99(1):128-34. PMID: 15281518.
      Citations:    
    187. Ririe DG, Barclay D, Prout H, Tong C, Tobin JR, Eisenach JC. Preoperative sciatic nerve block decreases mechanical allodynia more in young rats: is preemptive analgesia developmentally modulated? Anesth Analg. 2004 Jul; 99(1):140-5. PMID: 15281520.
      Citations:    
    188. Hassenbusch SJ, Portenoy RK, Cousins M, Buchser E, Deer TR, Du Pen SL, Eisenach J, Follett KA, Hildebrand KR, Krames ES, Levy RM, Palmer PP, Rathmell JP, Rauck RL, Staats PS, Stearns L, Willis KD. Polyanalgesic Consensus Conference 2003: an update on the management of pain by intraspinal drug delivery-- report of an expert panel. J Pain Symptom Manage. 2004 Jun; 27(6):540-63. PMID: 15165652.
      Citations:    
    189. Eisenach JC. Fishing for genes: practical ways to study genetic polymorphisms for pain. Anesthesiology. 2004 Jun; 100(6):1343-4. PMID: 15166551.
      Citations:    
    190. Yaksh TL, Horais KA, Tozier N, Rathbun M, Richter P, Rossi S, Grafe M, Tong C, Meschter C, Cline JM, Eisenach J. Intrathecal ketorolac in dogs and rats. Toxicol Sci. 2004 Aug; 80(2):322-34. PMID: 15141096.
      Citations:    
    191. Obata H, Li X, Eisenach JC. Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury. Anesthesiology. 2004 May; 100(5):1258-62. PMID: 15114225.
      Citations:    
    192. Shin SW, Eisenach JC, Rao SG, Tong C. The monoamine reuptake inhibitor milnacipran does not affect nociception to acute visceral distension in rats. Anesth Analg. 2004 May; 98(5):1365-9, table of contents. PMID: 15105216.
      Citations:    
    193. Li X, Bantel C, Conklin D, Childers SR, Eisenach JC. Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain. Anesthesiology. 2004 Apr; 100(4):956-61. PMID: 15087633.
      Citations:    
    194. Eisenach JC, Lindner MD. Did experimenter bias conceal the efficacy of spinal opioids in previous studies with the spinal nerve ligation model of neuropathic pain? Anesthesiology. 2004 Apr; 100(4):765-7. PMID: 15087608.
      Citations:    
    195. Duflo F, Zhang Y, Eisenach JC. Electrical field stimulation to study inhibitory mechanisms in individual sensory neurons in culture. Anesthesiology. 2004 Mar; 100(3):740-3. PMID: 15108995.
      Citations:    
    196. Shin SW, Eisenach JC. Peripheral nerve injury sensitizes the response to visceral distension but not its inhibition by the antidepressant milnacipran. Anesthesiology. 2004 Mar; 100(3):671-5. PMID: 15108984.
      Citations:    
    197. Kaya FN, Sahin S, Owen MD, Eisenach JC. Epidural neostigmine produces analgesia but also sedation in women after cesarean delivery. Anesthesiology. 2004 Feb; 100(2):381-5. PMID: 14739815.
      Citations:    
    198. Vincler M, Eisenach JC. Plasticity of spinal nicotinic acetylcholine receptors following spinal nerve ligation. Neurosci Res. 2004 Feb; 48(2):139-45. PMID: 14741388.
      Citations:    
    199. Eisenach JC, Hood DD, Curry R, Sawynok J, Yaksh TL, Li X. Intrathecal but not intravenous opioids release adenosine from the spinal cord. J Pain. 2004 Feb; 5(1):64-8. PMID: 14975380.
      Citations:    
    200. Eisenach JC, Thomas JA, Rauck RL, Curry R, Li X. Cystatin C in cerebrospinal fluid is not a diagnostic test for pain in humans. Pain. 2004 Feb; 107(3):207-212. PMID: 14736582.
      Citations:    
    201. Zhu X, Eisenach JC. Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury. Anesthesiology. 2003 Nov; 99(5):1175-9. PMID: 14576556.
      Citations:    
    202. Ma W, Hatzis C, Eisenach JC. Intrathecal injection of cAMP response element binding protein (CREB) antisense oligonucleotide attenuates tactile allodynia caused by partial sciatic nerve ligation. Brain Res. 2003 Oct 24; 988(1-2):97-104. PMID: 14519530.
      Citations:    
    203. Ma W, Eisenach JC. Four PGE2 EP receptors are up-regulated in injured nerve following partial sciatic nerve ligation. Exp Neurol. 2003 Oct; 183(2):581-92. PMID: 14552899.
      Citations:    
    204. Hood DD, Curry R, Eisenach JC. Intravenous remifentanil produces withdrawal hyperalgesia in volunteers with capsaicin-induced hyperalgesia. Anesth Analg. 2003 Sep; 97(3):810-5. PMID: 12933407.
      Citations:    
    205. Eisenach JC, Rauck RL, Curry R. Intrathecal, but not intravenous adenosine reduces allodynia in patients with neuropathic pain. Pain. 2003 Sep; 105(1-2):65-70. PMID: 14499421.
      Citations:    
    206. Shin SW, Sandner-Kiesling A, Eisenach JC. Systemic, but not intrathecal ketorolac is antinociceptive to uterine cervical distension in rats. Pain. 2003 Sep; 105(1-2):109-14. PMID: 14499426.
      Citations:    
    207. Ririe DG, Vernon TL, Tobin JR, Eisenach JC. Age-dependent responses to thermal hyperalgesia and mechanical allodynia in a rat model of acute postoperative pain. Anesthesiology. 2003 Aug; 99(2):443-8. PMID: 12883418.
      Citations:    
    208. Eisenach JC, Hood DD, Curry R, Shafer SL. Cephalad movement of morphine and fentanyl in humans after intrathecal injection. Anesthesiology. 2003 Jul; 99(1):166-73. PMID: 12826857.
      Citations:    
    209. Paqueron X, Conklin D, Eisenach JC. Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury. Anesthesiology. 2003 Jul; 99(1):199-204. PMID: 12826860.
      Citations:    
    210. Zhu X, Conklin D, Eisenach JC. Cyclooxygenase-1 in the spinal cord plays an important role in postoperative pain. Pain. 2003 Jul; 104(1-2):15-23. PMID: 12855310.
      Citations:    
    211. Tong C, Ma W, Shin SW, James RL, Eisenach JC. Uterine cervical distension induces cFos expression in deep dorsal horn neurons of the rat spinal cord. Anesthesiology. 2003 Jul; 99(1):205-11. PMID: 12826861.
      Citations:    
    212. Vincler MA, Eisenach JC. Immunocytochemical localization of the alpha3, alpha4, alpha5, alpha7, beta2, beta3 and beta4 nicotinic acetylcholine receptor subunits in the locus coeruleus of the rat. Brain Res. 2003 Jun 06; 974(1-2):25-36. PMID: 12742621.
      Citations:    
    213. Coghill RC, Eisenach J. Individual differences in pain sensitivity: implications for treatment decisions. Anesthesiology. 2003 Jun; 98(6):1312-4. PMID: 12766637.
      Citations:    
    214. Shin SW, Eisenach JC. Intrathecal morphine reduces the visceromotor response to acute uterine cervical distension in an estrogen-independent manner. Anesthesiology. 2003 Jun; 98(6):1467-71; discussion 6A. PMID: 12766659.
      Citations:    
    215. Bantel C, Li X, Eisenach JC. Intraspinal adenosine induces spinal cord norepinephrine release in spinal nerve-ligated rats but not in normal or sham controls. Anesthesiology. 2003 Jun; 98(6):1461-6. PMID: 12766658.
      Citations:    
    216. Duflo F, Conklin D, Li X, Eisenach JC. Spinal adrenergic and cholinergic receptor interactions activated by clonidine in postincisional pain. Anesthesiology. 2003 May; 98(5):1237-42. PMID: 12717147.
      Citations:    
    217. Kang YJ, Eisenach JC. Intrathecal clonidine reduces hypersensitivity after nerve injury by a mechanism involving spinal m4 muscarinic receptors. Anesth Analg. 2003 May; 96(5):1403-8, table of contents. PMID: 12707142.
      Citations:    
    218. Ma W, Eisenach JC. Chronic constriction injury of sciatic nerve induces the up-regulation of descending inhibitory noradrenergic innervation to the lumbar dorsal horn of mice. Brain Res. 2003 Apr 25; 970(1-2):110-8. PMID: 12706252.
      Citations:    
    219. Pancaro C, Ma W, Vincler M, Duflo F, Eisenach JC. Clonidine-induced neuronal activation in the spinal cord is altered after peripheral nerve injury. Anesthesiology. 2003 Mar; 98(3):748-53. PMID: 12606922.
      Citations:    
    220. Li X, Conklin D, Pan HL, Eisenach JC. Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism. J Pharmacol Exp Ther. 2003 Jun; 305(3):950-5. PMID: 12606636.
      Citations:    
    221. Eisenach JC, Yaksh TL. Epidural ketamine in healthy children--what's the point? Anesth Analg. 2003 Feb; 96(2):626; author reply 626-7. PMID: 12538224.
      Citations:    
    222. Ma W, Du W, Eisenach JC. Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac. Anesthesiology. 2003 Jan; 98(1):203-8. PMID: 12502998.
      Citations:    
    223. Eisenach JC, Carpenter R, Curry R. Analgesia from a peripherally active kappa-opioid receptor agonist in patients with chronic pancreatitis. Pain. 2003 Jan; 101(1-2):89-95. PMID: 12507703.
      Citations:    
    224. Conklin DR, Eisenach JC. Intrathecal ketorolac enhances antinociception from clonidine. Anesth Analg. 2003 Jan; 96(1):191-4, table of contents. PMID: 12505951.
      Citations:    
    225. Kang YJ, Vincler M, Li X, Conklin D, Eisenach JC. Intrathecal ketorolac reverses hypersensitivity following acute fentanyl exposure. Anesthesiology. 2002 Dec; 97(6):1641-4. PMID: 12459700.
      Citations:    
    226. Eisenach JC, Yaksh TL. Safety in numbers: how do we study toxicity of spinal analgesics? Anesthesiology. 2002 Nov; 97(5):1047-9. PMID: 12411784.
      Citations:    
    227. Eisenach JC, Curry R, Hood DD. Dose response of intrathecal adenosine in experimental pain and allodynia. Anesthesiology. 2002 Oct; 97(4):938-42. PMID: 12357162.
      Citations:    
    228. Lavand'homme PM, Ma W, De Kock M, Eisenach JC. Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury. Anesthesiology. 2002 Oct; 97(4):972-80. PMID: 12357167.
      Citations:    
    229. Sandner-Kiesling A, Eisenach JC. Pharmacology of opioid inhibition to noxious uterine cervical distension. Anesthesiology. 2002 Oct; 97(4):966-71. PMID: 12357166.
      Citations:    
    230. Eisenach JC, Curry R, Hood DD, Yaksh TL. Phase I safety assessment of intrathecal ketorolac. Pain. 2002 Oct; 99(3):599-604. PMID: 12406536.
      Citations:    
    231. Duflo F, Li X, Bantel C, Pancaro C, Vincler M, Eisenach JC. Peripheral nerve injury alters the alpha2 adrenoceptor subtype activated by clonidine for analgesia. Anesthesiology. 2002 Sep; 97(3):636-41. PMID: 12218531.
      Citations:    
    232. Zhu X, Li X, Eisenach JC. Spinal norepinephrine release from nitric oxide species is not increased following peripheral nerve injury in rats. Brain Res. 2002 Aug 30; 947(2):199-203. PMID: 12176161.
      Citations:    
    233. Li X, Eisenach JC. Nicotinic acetylcholine receptor regulation of spinal norepinephrine release. Anesthesiology. 2002 Jun; 96(6):1450-6. PMID: 12170059.
      Citations:    
    234. Bantel C, Childers SR, Eisenach JC. Role of adenosine receptors in spinal G-protein activation after peripheral nerve injury. Anesthesiology. 2002 Jun; 96(6):1443-9. PMID: 12170058.
      Citations:    
    235. Ma W, Du W, Eisenach JC. Role for both spinal cord COX-1 and COX-2 in maintenance of mechanical hypersensitivity following peripheral nerve injury. Brain Res. 2002 May 24; 937(1-2):94-9. PMID: 12020867.
      Citations:    
    236. Li X, Conklin D, Ma W, Zhu X, Eisenach JC. Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain. Pain. 2002 May; 97(1-2):117-25. PMID: 12031785.
      Citations:    
    237. Ma W, Eisenach JC. Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain. Eur J Neurosci. 2002 Mar; 15(6):1037-47. PMID: 11918652.
      Citations:    
    238. Sandner-Kiesling A, Pan HL, Chen SR, James RL, DeHaven-Hudkins DL, Dewan DM, Eisenach JC. Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats. Pain. 2002 Mar; 96(1-2):13-22. PMID: 11932057.
      Citations:    
    239. Sandner-Kiesling A, Eisenach JC. Estrogen reduces efficacy of mu- but Not kappa-opioid agonist inhibition in response to uterine cervical distension. Anesthesiology. 2002 Feb; 96(2):375-9. PMID: 11818771.
      Citations:    
    240. Eisenach JC, Hood DD, Curry R. Preliminary efficacy assessment of intrathecal injection of an American formulation of adenosine in humans. Anesthesiology. 2002 Jan; 96(1):29-34. PMID: 11752998.
      Citations:    
    241. Eisenach JC, Hood DD, Curry R. Phase I safety assessment of intrathecal injection of an American formulation of adenosine in humans. Anesthesiology. 2002 Jan; 96(1):24-8. PMID: 11752997.
      Citations:    
    242. Bantel C, Tobin JR, Li X, Childers SR, Chen SR, Eisenach JC. Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding. Anesthesiology. 2002 Jan; 96(1):103-8. PMID: 11753009.
      Citations:    
    243. Eisenach JC, Hood DD, Curry R. Relative potency of epidural to intrathecal clonidine differs between acute thermal pain and capsaicin-induced allodynia. Pain. 2000 Jan; 84(1):57-64. PMID: 10601673.
      Citations:    
    244. Eisenach JC, DuPen S, Dubois M, Miguel R, Allin D. Epidural clonidine analgesia for intractable cancer pain. The Epidural Clonidine Study Group. Pain. 1995 Jun; 61(3):391-399. PMID: 7478682.
      Citations:    
    245. Eisenach JC, Dobson CE, Inturrisi CE, Hood DD, Agner PB. Effect of pregnancy and pain on cerebrospinal fluid immunoreactive enkephalins and norepinephrine in healthy humans. Pain. 1990 Nov; 43(2):149-154. PMID: 2087327.
      Citations:    
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