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alpha2-Adrenoceptor activation by clonidine enhances stimulation-evoked acetylcholine release from spinal cord tissue after nerve ligation in rats.
Gabapentin acts within the locus coeruleus to alleviate neuropathic pain.
Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism.
Spinal cord dynorphin expression increases, but does not drive microglial prostaglandin production or mechanical hypersensitivity after incisional surgery in rats.
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Gabapentin acts within the locus coeruleus to alleviate neuropathic pain.
Hayashida K, Obata H, Nakajima K, Eisenach JC. Gabapentin acts within the locus coeruleus to alleviate neuropathic pain. Anesthesiology. 2008 Dec; 109(6):1077-84.
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PubMed
subject areas
Amines
Animals
Cyclohexanecarboxylic Acids
gamma-Aminobutyric Acid
Locus Coeruleus
Male
Neuralgia
Norepinephrine
Rats
Rats, Sprague-Dawley
authors with profiles
James C. Eisenach MD