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Sean V. Murphy PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentWake Forest Institute for Regenerative Medicine
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentBiomedical Engineering


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    R56HL143076     (MURPHY, SEAN VINCENT)Sep 10, 2018 - Aug 31, 2019
    NIH
    Bioengineered Multi-Cell Type Organoids For Airways Disease Modeling
    Role: Principal Investigator
    R01HL143076     (MURPHY, SEAN VINCENT)Sep 1, 2019 - Jun 30, 2022
    NIH
    Bioengineered Multi-Cell Type Organoids For Airways Disease Modeling
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yoo KM, Murphy SV, Skardal A. A Rapid Crosslinkable Maleimide-Modified Hyaluronic Acid and Gelatin Hydrogel Delivery System for Regenerative Applications. Gels. 2021 Feb 01; 7(1). PMID: 33535669.
      Citations:    
    2. Nzou G, Wicks RT, VanOstrand NR, Mekky GA, Seale SA, El-Taibany A, Wicks EE, Nechtman CM, Marrotte EJ, Makani VS, Murphy SV, Seeds MC, Jackson JD, Atala AJ. Author Correction: Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction. Sci Rep. 2020 Nov 18; 10(1):20384. PMID: 33204010.
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    3. Nzou G, Wicks RT, VanOstrand NR, Mekky GA, Seale SA, El-Taibany A, Wicks EE, Nechtman CM, Marrotte EJ, Makani VS, Murphy SV, Seeds MC, Jackson JD, Atala AJ. Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction. Sci Rep. 2020 06 17; 10(1):9766. PMID: 32555384.
      Citations:    
    4. Jorgensen AM, Varkey M, Gorkun A, Clouse C, Xu L, Chou Z, Murphy SV, Molnar J, Lee SJ, Yoo JJ, Soker S, Atala A. Bioprinted Skin Recapitulates Normal Collagen Remodeling in Full-Thickness Wounds. Tissue Eng Part A. 2020 05; 26(9-10):512-526. PMID: 31861970.
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    5. Willson K, Ke D, Kengla C, Atala A, Murphy SV. Extrusion-Based Bioprinting: Current Standards and Relevancy for Human-Sized Tissue Fabrication. Methods Mol Biol. 2020; 2140:65-92. PMID: 32207106.
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    6. Ke D, Yi H, Est-Witte S, George S, Kengla C, Lee SJ, Atala A, Murphy SV. Bioprinted trachea constructs with patient-matched design, mechanical and biological properties. Biofabrication. 2019 12 31; 12(1):015022. PMID: 31671417.
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    7. Murphy SV, De Coppi P, Atala A. Opportunities and challenges of translational 3D bioprinting. Nat Biomed Eng. 2020 04; 4(4):370-380. PMID: 31695178.
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    8. Leung ST, Khoury O, Barrios C, Ortega VE, Atala A, Murphy SV. Immune and Cytokine Dysfunction in Cystic Fibrosis. Am J Respir Cell Mol Biol. 2019 11; 61(5):656-658. PMID: 31674827.
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    9. Khoury O, Atala A, Murphy SV. Stromal cells from perinatal and adult sources modulate the inflammatory immune response in vitro by decreasing Th1 cell proliferation and cytokine secretion. Stem Cells Transl Med. 2020 01; 9(1):61-73. PMID: 31638323.
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    10. Murphy SV, Ribeiro CMP. Cystic Fibrosis Inflammation: Hyperinflammatory, Hypoinflammatory, or Both? Am J Respir Cell Mol Biol. 2019 Sep; 61(3):273-274. PMID: 30951377.
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    11. Murphy SV, Skardal A, Nelson RA, Sunnon K, Reid T, Clouse C, Kock ND, Jackson J, Soker S, Atala A. Amnion membrane hydrogel and amnion membrane powder accelerate wound healing in a full thickness porcine skin wound model. Stem Cells Transl Med. 2020 01; 9(1):80-92. PMID: 31328435.
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    12. Gu X, Shi H, Matz E, Zhong L, Long T, Clouse C, Li W, Chen D, Chung H, Murphy S, Yoo J, Lin G, Lue T, Atala A, Jackson J, Zhang Y. Long-term therapeutic effect of cell therapy on improvement in erectile function in a rat model with pelvic neurovascular injury. BJU Int. 2019 07; 124(1):145-154. PMID: 30499626.
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    13. Albanna M, Binder KW, Murphy SV, Kim J, Qasem SA, Zhao W, Tan J, El-Amin IB, Dice DD, Marco J, Green J, Xu T, Skardal A, Holmes JH, Jackson JD, Atala A, Yoo JJ. In Situ Bioprinting of Autologous Skin Cells Accelerates Wound Healing of Extensive Excisional Full-Thickness Wounds. Sci Rep. 2019 02 12; 9(1):1856. PMID: 30755653.
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    14. Orlando G, Murphy SV, Bussolati B, Clancy M, Cravedi P, Migliaccio G, Murray P. Rethinking Regenerative Medicine From a Transplant Perspective (and Vice Versa). Transplantation. 2019 02; 103(2):237-249. PMID: 30028414.
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    15. Ke D, Murphy SV. Current Challenges of Bioprinted Tissues Toward Clinical Translation. Tissue Eng Part B Rev. 2019 02; 25(1):1-13. PMID: 30129878.
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    16. Nzou G, Wicks RT, Wicks EE, Seale SA, Sane CH, Chen A, Murphy SV, Jackson JD, Atala AJ. Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling. Sci Rep. 2018 05 09; 8(1):7413. PMID: 29743549.
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    17. Khoury O, Barrios C, Ortega V, Atala A, Murphy SV. Immunomodulatory Cell Therapy to Target Cystic Fibrosis Inflammation. Am J Respir Cell Mol Biol. 2018 Jan; 58(1):12-20. PMID: 28707978.
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    18. Murphy SV, Skardal A, Song L, Sutton K, Haug R, Mack DL, Jackson J, Soker S, Atala A. Solubilized Amnion Membrane Hyaluronic Acid Hydrogel Accelerates Full-Thickness Wound Healing. Stem Cells Transl Med. 2017 11; 6(11):2020-2032. PMID: 28941321.
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    19. Skardal A, Murphy SV, Devarasetty M, Mead I, Kang HW, Seol YJ, Shrike Zhang Y, Shin SR, Zhao L, Aleman J, Hall AR, Shupe TD, Kleensang A, Dokmeci MR, Jin Lee S, Jackson JD, Yoo JJ, Hartung T, Khademhosseini A, Soker S, Bishop CE, Atala A. Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform. Sci Rep. 2017 08 18; 7(1):8837. PMID: 28821762.
      Citations:    
    20. Skardal A, Murphy SV, Crowell K, Mack D, Atala A, Soker S. A tunable hydrogel system for long-term release of cell-secreted cytokines and bioprinted in situ wound cell delivery. . 2017 10; 105(7):1986-2000. PMID: 27351939.
      Citations:    
    21. Konar D, Devarasetty M, Yildiz DV, Atala A, Murphy SV. Lung-On-A-Chip Technologies for Disease Modeling and Drug Development. Biomed Eng Comput Biol. 2016; 7(Suppl 1):17-27. PMID: 27127414.
      Citations:    
    22. Sean V Murphy, Mohammad Z Albanna. Cutaneous Applications of Stem Cells for Skin Tissue Engineering. Skin Tissue Engineering and Regenerative Medicine. 2016.
    23. Sean V Murphy, Anthony Atala. Regenerative Medicine Technology: On-a-Chip Applications for Disease Modeling, Drug Discovery and Personalized Medicine. 2016. View Publication.
    24. Murphy SV, Atala A. New Government Accountability Office Report on Regenerative Medicine Provides an Excellent Assessment of the Field. Stem Cells Transl Med. 2015 Dec; 4(12):1371-2. PMID: 26518238.
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    25. Mohiti-Asli M, Saha S, Murphy SV, Gracz H, Pourdeyhimi B, Atala A, Loboa EG. Ibuprofen loaded PLA nanofibrous scaffolds increase proliferation of human skin cells in vitro and promote healing of full thickness incision wounds in vivo. . 2017 02; 105(2):327-339. PMID: 26509902.
      Citations:    
    26. Huang JW, Xu YM, Li ZB, Murphy SV, Zhao W, Liu QQ, Zhu WD, Fu Q, Zhang YP, Song LJ. Tissue performance of bladder following stretched electrospun silk fibroin matrix and bladder acellular matrix implantation in a rabbit model. J Biomed Mater Res A. 2016 Jan; 104(1):9-16. PMID: 26148477.
      Citations:    
    27. Niclis JC, Murphy SV, Parkinson DY, Zedan A, Sathananthan AH, Cram DS, Heraud P. Three-dimensional imaging of human stem cells using soft X-ray tomography. J R Soc Interface. 2015 Jul 06; 12(108):20150252. PMID: 26063819.
      Citations:    
    28. Atala A, Murphy S. Regenerative medicine. JAMA. 2015 Apr 14; 313(14):1413-4. PMID: 25871665.
      Citations:    
    29. Peloso A, Katari R, Murphy SV, Zambon JP, DeFrancesco A, Farney AC, Rogers J, Stratta RJ, Manzia TM, Orlando G. Prospect for kidney bioengineering: shortcomings of the status quo. Expert Opin Biol Ther. 2015 Apr; 15(4):547-58. PMID: 25640286.
      Citations:    
    30. Amritha Kidiyoor, Anthony Atala, Sean V. Murphy. Gene and Cell Therapy Therapeutic Mechanisms and Strategies. Adult lung stem cells. 2015; 4:757–772.
    31. Murphy SV, Kidyoor A, Reid T, Atala A, Wallace EM, Lim R. Isolation, cryopreservation and culture of human amnion epithelial cells for clinical applications. J Vis Exp. 2014 Dec 21; (94). PMID: 25548905.
      Citations:    
    32. Lim R, Zavou MJ, Milton PL, Chan ST, Tan JL, Dickinson H, Murphy SV, Jenkin G, Wallace EM. Measuring respiratory function in mice using unrestrained whole-body plethysmography. J Vis Exp. 2014 Aug 12; (90):e51755. PMID: 25146417.
      Citations:    
    33. Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol. 2014 Aug; 32(8):773-85. PMID: 25093879.
      Citations:    
    34. Zhang C, Murphy SV, Atala A. Regenerative medicine in urology. Semin Pediatr Surg. 2014 Jun; 23(3):106-11. PMID: 24994523.
      Citations:    
    35. Anthony Atala, Sean V Murphy. Perinatal Stem Cells. 2014. View Publication.
    36. A Kidiyoor, SV Murphy, A Atala. Stem Cells from the Amniotic Fluid and Placenta. Cell and Molecular Biology and Imaging of Stem Cells. 2014.
    37. Wood MW, Murphy SV, Feng X, Wright SC. Tracheal reconstruction in a canine model. Otolaryngol Head Neck Surg. 2014 Mar; 150(3):428-33. PMID: 24367052.
      Citations:    
    38. Song L, Murphy SV, Yang B, Xu Y, Zhang Y, Atala A. Bladder acellular matrix and its application in bladder augmentation. Tissue Eng Part B Rev. 2014 Apr; 20(2):163-72. PMID: 23895225.
      Citations:    
    39. Murphy SV, Atala A. Cell therapy for cystic fibrosis. J Tissue Eng Regen Med. 2015 Mar; 9(3):210-23. PMID: 23894126.
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    40. Lim R, Chan ST, Tan JL, Mockler JC, Murphy SV, Wallace EM. Preterm human amnion epithelial cells have limited reparative potential. Placenta. 2013 Jun; 34(6):486-92. PMID: 23597502.
      Citations:    
    41. Murphy SV, Atala A. Amniotic fluid and placental membranes: unexpected sources of highly multipotent cells. Semin Reprod Med. 2013 Jan; 31(1):62-8. PMID: 23329638.
      Citations:    
    42. Sean Vincent Murphy, Anthony Atala. Perinatal Stem Cells, KJ Cetrulo, CL Cetrulo Jr. and RR Taghizadeh. Amniotic Fluid Stem Cells. 2013.
    43. Lim R, Milton P, Murphy SV, Dickinson H, Chan ST, Jenkin G. Human mesenchymal stem cells reduce lung injury in immunocompromised mice but not in immunocompetent mice. Respiration. 2013; 85(4):332-41. PMID: 23207668.
      Citations:    
    44. Murphy SV, Lim R, Heraud P, Cholewa M, Le Gros M, de Jonge MD, Howard DL, Paterson D, McDonald C, Atala A, Jenkin G, Wallace EM. Human amnion epithelial cells induced to express functional cystic fibrosis transmembrane conductance regulator. PLoS One. 2012; 7(9):e46533. PMID: 23029546.
      Citations:    
    45. Murphy SV, Atala A. Organ engineering--combining stem cells, biomaterials, and bioreactors to produce bioengineered organs for transplantation. Bioessays. 2013 Mar; 35(3):163-72. PMID: 22996568.
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    46. Murphy SV, Skardal A, Atala A. Evaluation of hydrogels for bio-printing applications. J Biomed Mater Res A. 2013 Jan; 101(1):272-84. PMID: 22941807.
      Citations:    
    47. Murphy SV, Shiyun SC, Tan JL, Chan S, Jenkin G, Wallace EM, Lim R. Human amnion epithelial cells do not abrogate pulmonary fibrosis in mice with impaired macrophage function. Cell Transplant. 2012; 21(7):1477-92. PMID: 22507554.
      Citations:    
    48. A Park, L Chan, MDI Gohel, S Murphy, U Manuelpillai, A Chidgey, R Boyd. Perinatal Stem Cells, KJ Cetrulo, CL Cetrulo Jr. and RR Taghizadeh. Newborn stem cells: Identity, Function and Clinical Potential. 2012.
    49. Sean Murphy, Euan Wallace, Graham Jenkin. Placental-derived stem cells: potential clinical applications. 2011.
    50. Sean Vincent Murphy. Placental Stem Cells as a Treatment for Lung Disease. 2011.
    51. Murphy S, Lim R, Dickinson H, Acharya R, Rosli S, Jenkin G, Wallace E. Human amnion epithelial cells prevent bleomycin-induced lung injury and preserve lung function. Cell Transplant. 2011; 20(6):909-23. PMID: 21092408.
      Citations:    
    52. Murphy S, Rosli S, Acharya R, Mathias L, Lim R, Wallace E, Jenkin G. Amnion epithelial cell isolation and characterization for clinical use. Curr Protoc Stem Cell Biol. 2010 Apr; Chapter 1:Unit 1E.6. PMID: 20373516.
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    53. Evan Ingley, Christine J. Payne, Sean V. Murphy, Jessica R. Schnieder, David J. McCarthy, Amy Samuels, Peter S. Klinken. The SH2 interactome: Development and utility of a phosphotyrosine-specific yeast two-hybrid system to identify and analyse signalling pathways. The Journal of the Federation of American Societies for Experimental Biology. 2007; 21(5).
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