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Stephen J. Walker PhD

TitleProfessor
InstitutionWake Forest School of Medicine
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    TitleProfessor
    InstitutionWake Forest School of Medicine


    Collapse Research 
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    R21AA014984     (WALKER, STEPHEN)Apr 20, 2005 - Mar 31, 2008
    NIH
    Cerebellum Gene Expression Changes With Chronic Ethanol
    Role: Principal Investigator
    R21DK106554     (WALKER, STEPHEN)Aug 1, 2015 - Jul 31, 2018
    NIH
    Biomarkers for Molecular-Based Decision-Making in Diagnosis and Treatment of Inte
    Role: Principal Investigator
    R01DK124599     (WALKER, STEPHEN)May 1, 2020 - Apr 30, 2023
    NIH
    Molecular Characterization Of A Large Cross-Sectional And Longitudinal Collection of Patients To Investigate Disease Progression in IC/BPS
    Role: Principal Investigator
    R01DK128233     (WALKER, STEPHEN)Apr 1, 2022 - Mar 31, 2025
    NIH
    Investigation of Non-Invasive Pulsed Electromagnetic Field (PEMF) Therapy for Female Patients with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Stephens Shields AJ, Clemens JQ, Pontari MA, Lai HH, Moldwin R, Williams DA, Bradley CS, Farrar JT, Landis JR, Mullins C, Naliboff BD, Sutcliffe S, Walker SJ, Yang CC, Clauw DJ. Towards precision medicine in clinical trials for the treatment of urologic chronic pelvic pain syndrome: lessons from the MAPP Research Network. Nat Rev Urol. 2025 Apr 30. PMID: 40307537.
      Citations:    
    2. Sandberg M, Whitman W, Bissette R, Ross C, Tsivian M, Walker SJ. Pulsed Electromagnetic Field Therapy Alters the Genomic Profile of Bladder Cancer Cell Line HT-1197. J Pers Med. 2025 Apr 04; 15(4). PMID: 40278322.
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    3. El Haraki AS, Ritts R, Namugosa M, Regan J, Daniel B, Evans R, Walker SJ. Pelvic Venous Disorders are Associated with an Earlier Age-of-Onset in Females with Interstitial Cystitis/Bladder Pain Syndrome. Int Urogynecol J. 2025 Mar 01. PMID: 40025237.
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    4. Namugosa M, El Haraki A, Ritts R, Ferrara K, Badlani G, Evans R, Walker SJ. Prevalence and Clinical Correlates of Endometriosis in Patients With IC/BPS. Urogynecology (Phila). 2025 Feb 01; 31(2):131-138. PMID: 39423149.
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    5. Ritts R, Wolff D, Namugosa M, Hsu FC, Ferrara K, Evans R, Walker SJ. Symptomatic Autonomic Dysfunction in Interstitial Cystitis/Bladder Pain Syndrome. Urogynecology (Phila). 2024 Oct 01; 30(10):821-828. PMID: 38954605.
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    6. Lessey BA, Dong A, Deaton JL, Angress D, Savaris RF, Walker SJ. Inflammatory Changes after Medical Suppression of Suspected Endometriosis for Implantation Failure: Preliminary Results. Int J Mol Sci. 2024 Jun 22; 25(13). PMID: 38999962.
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    7. Rezapour M, Walker SJ, Ornelles DA, Niazi MKK, McNutt PM, Atala A, Gurcan MN. A comparative analysis of RNA-Seq and NanoString technologies in deciphering viral infection response in upper airway lung organoids. Front Genet. 2024; 15:1327984. PMID: 38957806.
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    8. Reeves KD, Figuereo YF, Weis VG, Hsu FC, Engevik MA, Krigsman A, Walker SJ. Mapping the geographical distribution of the mucosa-associated gut microbiome in GI-symptomatic children with autism spectrum disorder. Am J Physiol Gastrointest Liver Physiol. 2024 Aug 01; 327(2):G217-G234. PMID: 38887795.
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    9. Hazan S, Haroon J, Jordan S, Walker SJ. Improvements in Gut Microbiome Composition and Clinical Symptoms Following Familial Fecal Microbiota Transplantation in a Nineteen-Year-Old Adolescent With Severe Autism. J Med Cases. 2024 May; 15(4-5):82-91. PMID: 38715916.
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    10. Rezapour M, Walker SJ, Ornelles DA, McNutt PM, Atala A, Gurcan MN. Analysis of gene expression dynamics and differential expression in viral infections using generalized linear models and quasi-likelihood methods. Front Microbiol. 2024; 15:1342328. PMID: 38655085.
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    11. Sandberg M, Whitman W, Rong A, Andres-Robusto B, Badlani G, Evans R, Walker SJ. Postsurgery Opiate Use Is Significantly Lower in Patients With Interstitial Cystitis/Bladder Pain Syndrome Following Cystectomy With Urinary Diversion. Urology. 2023 Oct; 180:86-92. PMID: 37482104.
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    12. Frankovich J, Nanda H, Mellins ED, Jyonouchi H, Boles RG, Walker SJ, Gaitanis J, Frye RE. Synchrony 2022: The Role of Neuroinflammation in Behavioral Exacerbations in Autism Spectrum Disorder. J Pers Med. 2023 Jul 13; 13(7). PMID: 37511746.
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    13. Wolfe AJ, Rademacher DJ, Mores CR, Evans RJ, Overholt T, Halverson T, Limeira R, Matthews C, Badlani G, Brubaker L, Walker SJ. Detection of Bacteria in Bladder Mucosa of Adult Females. J Urol. 2023 May; 209(5):937-949. PMID: 36657058.
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    14. Figuereo YF, Lewis J, Lee P, Walker SJ. Autism Spectrum Disorder in the Dominican Republic: A Mini Review of the Current Situation. Children (Basel). 2023 Jan 06; 10(1). PMID: 36670671.
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    15. Wolff DT, Xu R, Overholt T, Bassett EH, Ahn C, Simon T, Lee P, Badlani G, Matthews CA, Evans RJ, Walker SJ. Small-Fiber Polyneuropathy Is Prevalent in Patients With Interstitial Cystitis/Bladder Pain Syndrome. Urogynecology (Phila). 2022 Nov 01; 28(11):786-792. PMID: 36288118.
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    16. Wolff DT, Ross C, Lee P, Badlani G, Matthews CA, Evans RJ, Walker SJ. Pulsed Electromagnetic Field Therapy for Pain Management in Interstitial Cystitis/Bladder Pain Syndrome: A Proof-of-Concept Case Series. Urology. 2022 Sep; 167:96-101. PMID: 35636637.
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    17. Overholt T, Evans RJ, Badlani G, Matthews CA, Walker SJ. Functional genomic analyses of IC/BPS patient subgroups: a pilot study. Can J Urol. 2022 Feb; 29(1):11012-11019. PMID: 35150224.
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    18. Wolff DT, Walker SJ. Small Fiber Polyneuropathy May Be a Nexus Between Autonomic Nervous System Dysregulation and Pain in Interstitial Cystitis/Bladder Pain Syndrome. Front Pain Res (Lausanne). 2021; 2:810809. PMID: 35295485.
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    19. Krigsman A, Walker SJ. Gastrointestinal disease in children with autism spectrum disorders: Etiology or consequence? World J Psychiatry. 2021 Sep 19; 11(9):605-618. PMID: 34631464.
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    20. Plair A, Evans RJ, Langefeld CD, Matthews CA, Badlani G, Walker SJ. Anesthetic Bladder Capacity is a Clinical Biomarker for Interstitial Cystitis/Bladder Pain Syndrome Subtypes. Urology. 2021 Dec; 158:74-80. PMID: 34303757.
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    21. Ross C, Overholt T, Xu R, Badlani G, Evans RJ, Matthews CA, Walker SJ. Pulsed electromagnetic field (PEMF) as an adjunct therapy for pain management in interstitial cystitis/bladder pain syndrome. Int Urogynecol J. 2022 Mar; 33(3):487-491. PMID: 34100976.
      Citations:    
    22. Xu R, Schachar J, Evans RJ, Matthews CA, Badlani G, Walker SJ. Hydrodistention does not alter bladder gene expression profiles in patients with non-Hunner lesion interstitial cystitis/bladder pain syndrome. Neurourol Urodyn. 2021 May 04. PMID: 33942362.
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    23. Walker SJ, Wagoner AL, Leavitt D, Mack DL. A simplified approach for derivation of induced pluripotent stem cells from Epstein-Barr virus immortalized B-lymphoblastoid cell lines. Heliyon. 2021 Apr; 7(4):e06617. PMID: 33869861.
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    24. Asthana A, Tamburrini R, Chaimov D, Gazia C, Walker SJ, Van Dyke M, Tomei A, Lablanche S, Robertson J, Opara EC, Soker S, Orlando G. Comprehensive characterization of the human pancreatic proteome for bioengineering applications. Biomaterials. 2021 03; 270:120613. PMID: 33561625.
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    25. Hazan S, Spradling-Reeves KD, Papoutsis A, Walker SJ. Shotgun Metagenomic Sequencing Identifies Dysbiosis in Triplet Sibling with Gastrointestinal Symptoms and ASD. Children (Basel). 2020 Nov 25; 7(12). PMID: 33255785.
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    26. Overholt TL, Matthews CA, Evans RJ, Badlani G, Ahn C, Simon T, Walker SJ. Small Fiber Polyneuropathy Is Associated With Non-Bladder-Centric Interstitial Cystitis/Bladder Pain Syndrome Patients. Female Pelvic Med Reconstr Surg. 2020 Oct 26. PMID: 33109931.
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    27. Matz EL, Thakker PU, Gu X, Terlecki RP, Dou L, Walker SJ, Lue T, Lin G, Atala A, Yoo JJ, Zhang Y, Jackson JD. Administration of secretome from human placental stem cell-conditioned media improves recovery of erectile function in the pelvic neurovascular injury model. J Tissue Eng Regen Med. 2020 10; 14(10):1394-1402. PMID: 32652851.
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    28. Overholt TL, Evans RJ, Lessey BA, Matthews CA, Hines KN, Badlani G, Walker SJ. Non-bladder centric interstitial cystitis/bladder pain syndrome phenotype is significantly associated with co-occurring endometriosis. Can J Urol. 2020 06; 27(3):10257-10262. PMID: 32544050.
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    29. Orlando G, Danger R, Okut H, Edgar L, Bussolati B, Gall E, Bergman CR, Tamburrini R, Gazia C, Farney AC, Freedman BI, McPherson G, Rogers J, Stratta RJ, Brouard S, Walker SJ. Molecular Pathways Underlying Adaptive Repair of the Injured Kidney: Novel Donation After Cardiac Death and Acute Kidney Injury Platforms. Ann Surg. 2020 02; 271(2):383-390. PMID: 30048305.
      Citations:    
    30. Evans RJ, Overholt T, Colaco M, Walker SJ. Injection location does not impact botulinum toxin A efficacy in interstitial cystitis/bladder pain syndrome patients. Can J Urol. 2020 02; 27(1):10125-10129. PMID: 32065870.
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    31. Overholt TL, Ross C, Evans RJ, Walker SJ. Pulsed Electromagnetic Field Therapy as a Complementary Alternative for Chronic Pelvic Pain Management in an Interstitial Cystitis/Bladder Pain Syndrome Patient. Case Rep Urol. 2019; 2019:5767568. PMID: 31949970.
      Citations:    
    32. Walker SJ, Plair A, Hemal K, Langefeld CD, Matthews C, Badlani G, Zambon J, Heath H, Evans RJ. Bladder Hydrodistention Does Not Result in a Significant Change in Bladder Capacity for Interstitial Cystitis/Bladder Pain Syndrome Patients. Urology. 2019 Oct; 132:81-86. PMID: 31299328.
      Citations:    
    33. Schachar JS, Evans RJ, Parks GE, Zambon J, Badlani G, Walker SJ. Histological evidence supports low anesthetic bladder capacity as a marker of a bladder-centric disease subtype in interstitial cystitis/bladder pain syndrome. Int Urogynecol J. 2019 11; 30(11):1863-1870. PMID: 31254048.
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    34. Matthews CA, Deveshwar SP, Evans RJ, Badlani G, Walker SJ. Small fiber polyneuropathy as a potential therapeutic target in interstitial cystitis/bladder pain syndrome. Int Urogynecol J. 2019 11; 30(11):1817-1820. PMID: 31240362.
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    35. Walker SJ, Langefeld CD, Zimmerman K, Schwartz MZ, Krigsman A. A molecular biomarker for prediction of clinical outcome in children with ASD, constipation, and intestinal inflammation. Sci Rep. 2019 04 12; 9(1):5987. PMID: 30979947.
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    36. Almeida-Porada G, Rodman C, Kuhlman B, Brudvik E, Moon J, George S, Guida P, Sajuthi SP, Langefeld CD, Walker SJ, Wilson PF, Porada CD. Exposure of the Bone Marrow Microenvironment to Simulated Solar and Galactic Cosmic Radiation Induces Biological Bystander Effects on Human Hematopoiesis. Stem Cells Dev. 2018 09 15; 27(18):1237-1256. PMID: 29698131.
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    37. Walker SJ, Zambon J, Andersson KE, Langefeld CD, Matthews CA, Badlani G, Bowman H, Evans RJ. Bladder Capacity is a Biomarker for a Bladder Centric versus Systemic Manifestation in Interstitial Cystitis/Bladder Pain Syndrome. J Urol. 2017 08; 198(2):369-375. PMID: 28202356.
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    38. Walker SJ, Beavers DP, Fortunato J, Krigsman A. A Putative Blood-Based Biomarker for Autism Spectrum Disorder-Associated Ileocolitis. Sci Rep. 2016 10 21; 6:35820. PMID: 27767057.
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    39. Matthews CA, Eschenroeder A, Badlani G, Evans R, Walker SJ. Evaluation of the efficacy of postmortem human bladder tissue as a normal comparator for case-controlled gene expression studies in urology. Neurourol Urodyn. 2017 04; 36(4):1076-1080. PMID: 27541974.
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    40. Mack DL, Guan X, Wagoner A, Walker SJ, Childers MK. Disease-in-a-dish: the contribution of patient-specific induced pluripotent stem cell technology to regenerative rehabilitation. Am J Phys Med Rehabil. 2014 Nov; 93(11 Suppl 3):S155-68. PMID: 25122102.
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    41. Walker SJ, Colaco M, Koslov DS, Keys T, Evans RJ, Badlani GH, Andersson KE. Transcriptome analysis of bladder biopsy from interstitial cystitis/bladder pain syndrome patients. Genom Data. 2014 Dec; 2:366-8. PMID: 26484132.
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    42. Colaco M, Koslov DS, Keys T, Evans RJ, Badlani GH, Andersson KE, Walker SJ. Correlation of gene expression with bladder capacity in interstitial cystitis/bladder pain syndrome. J Urol. 2014 Oct; 192(4):1123-9. PMID: 24840534.
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    43. Walker SJ, Fortunato J, Gonzalez LG, Krigsman A. Identification of unique gene expression profile in children with regressive autism spectrum disorder (ASD) and ileocolitis. PLoS One. 2013; 8(3):e58058. PMID: 23520485.
      Citations:    
    44. Ramos PS, Sajuthi S, Langefeld CD, Walker SJ. Immune function genes CD99L2, JARID2 and TPO show association with autism spectrum disorder. Mol Autism. 2012 Jun 09; 3(1):4. PMID: 22681640.
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    45. Walker SJ, Segal J, Aschner M. Cultured lymphocytes from autistic children and non-autistic siblings up-regulate heat shock protein RNA in response to thimerosal challenge. Neurotoxicology. 2006 Sep; 27(5):685-92. PMID: 16870260.
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    46. Walker SJ, Grant KA. Peripheral blood alpha-synuclein mRNA levels are elevated in cynomolgus monkeys that chronically self-administer ethanol. Alcohol. 2006 Jan; 38(1):1-4. PMID: 16762686.
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    47. Walker SJ, Wang Y, Grant KA, Chan F, Hellmann GM. Long versus short oligonucleotide microarrays for the study of gene expression in nonhuman primates. J Neurosci Methods. 2006 Apr 15; 152(1-2):179-89. PMID: 16253343.
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    48. Walker SJ, Xu A. Biomarker discovery using molecular profiling approaches. Int Rev Neurobiol. 2004; 61:1-30. PMID: 15482809.
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    49. Walker SJ, Worst TJ, Freeman WM, Vrana KE. Functional genomic analysis in pain research using hybridization arrays. Methods Mol Med. 2004; 99:239-53. PMID: 15131342.
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    50. Vrana KE, Hipp JD, Goss AM, McCool BA, Riddle DR, Walker SJ, Wettstein PJ, Studer LP, Tabar V, Cunniff K, Chapman K, Vilner L, West MD, Grant KA, Cibelli JB. Nonhuman primate parthenogenetic stem cells. Proc Natl Acad Sci U S A. 2003 Sep 30; 100 Suppl 1:11911-6. PMID: 14504386.
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    51. Walker SJ, Worst TJ, Vrana KE. Semiquantitative real-time PCR for analysis of mRNA levels. Methods Mol Med. 2003; 79:211-27. PMID: 12506699.
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    52. Worst TJ, Freeman WM, Walker SJ, Vrana KE. Systematic screening of gene expression using a cDNA macroarray. Methods Mol Med. 2003; 79:243-59. PMID: 12506701.
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    53. Shanker G, Mutkus LA, Walker SJ, Aschner M. Methylmercury enhances arachidonic acid release and cytosolic phospholipase A2 expression in primary cultures of neonatal astrocytes. Brain Res Mol Brain Res. 2002 Oct 15; 106(1-2):1-11. PMID: 12393259.
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