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Michael Olivier PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Molecular Medicine
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    Other Positions
    TitleDirector
    InstitutionWake Forest School of Medicine
    DepartmentCenter for Precision Medicine (CPM)

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentPHS-Biostatistics and Data Science (Public Health Sciences)

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentWake Forest Institute for Regenerative Medicine


    Collapse Biography 
    Collapse education and training
    University of Cologne, Cologne, GermanyM.S.Chemistry
    Cornell University, Ithaca, NYPh.D.Physiology and Molecular Genetics
    Stanford Human Genome Center, Stanford, CAHuman Genetics and Genomics
    Collapse awards and honors
    2005Charles J. Epstein Research Award, National Down Syndrome Society, New York, NY
    2008Faculty Vitality Award, Medical College of Wisconsin, Milwaukee, WI
    2014 - 2017Maddux Chair of Genetics, Texas Biomedical research Institute
    2019Research Excellence Award, Wake Forest University School of Medicine
    2021Research Excellence Award, Wake Forest University School of Medicine

    Collapse Overview 
    Collapse overview
    My laboratory uses a wide range of genomics, proteomics, metabolomics and bioinformatics tools to study the molecular basis of common human diseases. We routinely use next generation sequencing, gene expression analysis, and mass spectrometry to profile cells and tissues from human patients and animal models to identify early molecular changes that happen in target tissues and organs during the initial development of diseases such as obesity, cardiovascular diseases, or dylipidemias and fatty liver disease. Our lab group has been developing novel methodologies to functionally study human genome variation, and to help understand how mutations and sequence variants that have been identified in large scale genetic studies (e.g. genome-wide association studies) actually affect the normal function of cells. Work in our lab ranges from basic molecular biology to tissue culture, high-end sequencing and mass spectrometry, and computational data analysis.

    Collapse Research 
    Collapse research activities and funding
    N01HV28182     Sep 30, 2002 - Sep 29, 2009
    NIH
    National Heart, Lung, and Blood Institute Proteomics Initiative
    Role: Co-Investigator
    R01HL074168     (OLIVIER, MICHAEL)Jul 10, 2003 - Jun 30, 2009
    NIH
    Genomic dissection of a QTL affecting the lipid profile
    Role: Principal Investigator
    R01DK071895     (SILVERSTEIN, ROY L)Jul 1, 2007 - Jun 30, 2013
    NIH
    Candidate Genes Affecting Adolescent Metabolic Syndrome
    Role: Co-Investigator
    R01DK080007     (WILKE, RUSSELL A.)Aug 1, 2009 - Jun 30, 2013
    NIH
    Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Role: Co-Investigator
    P50HG004952     (OLIVIER, MICHAEL)Aug 12, 2009 - Jun 30, 2016
    NIH
    Wisconsin Center of Excellence in Genomics Science
    Role: Principal Investigator
    R01GM109099     (OLIVIER, MICHAEL)Jul 24, 2014 - Jun 30, 2019
    NIH
    Functional characterization of regulatory sequence variants in complex diseases
    Role: Principal Investigator
    R01AG061805     (Molina)Dec 1, 2017 - Nov 30, 2022
    NIH/NIA
    Exosome-mediated alterations in cellular metabolism in the pathogenesis and progression of Alzheimer’s Disease
    Role: Co-Investigator
    R01HL136724     (ROHATGI, ANAND KUMAR)Dec 15, 2017 - Nov 30, 2022
    NIH
    The Genetic and Molecular Basis of Cholesterol Efflux
    Role: Co-Investigator
    R01GM118741     (OLIVIER, MICHAEL)Sep 18, 2018 - Aug 31, 2022
    NIH
    HyCCAPP: A new method for the functional analysis of regulatory SNPs
    Role: Principal Investigator
    U19AG057758     (NATHANIELSZ, PETER W.)Sep 30, 2018 - May 31, 2023
    NIH
    Womb to Tomb: Developmental Programming and Aging Interactions in Primates
    Role: Co-Principal Investigator
    U54DA049113     (OLIVIER, MICHAEL)Sep 1, 2019 - Jul 31, 2023
    NIH
    Integrated Omics Analysis of Pain: Omics Data Generation Center
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cox LA, Chan J, Rao P, Hamid Z, Glenn JP, Jadhav A, Das V, Karere GM, Quillen E, Kavanagh K, Olivier M. Integrated omics analysis reveals sirtuin signaling is central to hepatic response to a high fructose diet. BMC Genomics. 2021 Dec 03; 22(1):870. PMID: 34861817.
      Citations:    
    2. Chan J, Yao W, Howard TD, Hawkins GA, Olivier M, Jorgensen MJ, Cheeseman IH, Cole SA, Cox LA. Efficiency of whole-exome sequencing in old world and new world primates using human capture reagents. J Med Primatol. 2021 Jun; 50(3):176-181. PMID: 33876458.
      Citations:    
    3. Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, Karaderi T, Barber TM, McCarthy MI, Franks S, Lindgren CM, Welt CK, Diamanti-Kandarakis E, Panidis D, Goodarzi MO, Azziz R, Zhang Y, James RG, Olivier M, Kissebah AH, Stener-Victorin E, Legro RS, Dunaif A. Publisher Correction: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun. 2020 04 28; 11(1):2158. PMID: 32345980.
      Citations:    
    4. Misra BB, Olivier M. High Resolution GC-Orbitrap-MS Metabolomics Using Both Electron Ionization and Chemical Ionization for Analysis of Human Plasma. J Proteome Res. 2020 07 02; 19(7):2717-2731. PMID: 31978300.
      Citations:    
    5. Olivier M, Asmis R, Hawkins GA, Howard TD, Cox LA. The Need for Multi-Omics Biomarker Signatures in Precision Medicine. Int J Mol Sci. 2019 Sep 26; 20(19). PMID: 31561483.
      Citations:    
    6. Jimenez H, Wang M, Zimmerman JW, Pennison MJ, Sharma S, Surratt T, Xu ZX, Brezovich I, Absher D, Myers RM, DeYoung B, Caudell DL, Chen D, Lo HW, Lin HK, Godwin DW, Olivier M, Ghanekar A, Chen K, Miller LD, Gong Y, Capstick M, D'Agostino RB, Munden R, Merle P, Barbault A, Blackstock AW, Bonkovsky HL, Yang GY, Jin G, Liu L, Zhang W, Watabe K, Blackman CF, Pasche BC. Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2?T-type voltage-gated calcium channels and Ca2+ influx. EBioMedicine. 2019 Jun; 44:209-224. PMID: 31160272.
      Citations:    
    7. Misra BB, Puppala SR, Comuzzie AG, Mahaney MC, VandeBerg JL, Olivier M, Cox LA. Analysis of serum changes in response to a high fat high cholesterol diet challenge reveals metabolic biomarkers of atherosclerosis. PLoS One. 2019; 14(4):e0214487. PMID: 30951537.
      Citations:    
    8. Misra BB, Bassey E, Bishop AC, Kusel DT, Cox LA, Olivier M. High-resolution gas chromatography/mass spectrometry metabolomics of non-human primate serum. Rapid Commun Mass Spectrom. 2018 Sep 15; 32(17):1497-1506. PMID: 29874398.
      Citations:    
    9. Misra BB, Langefeld CD, Olivier M, Cox LA. Integrated Omics: Tools, Advances, and Future Approaches. J Mol Endocrinol. 2018 Jul 13. PMID: 30006342.
      Citations:    
    10. Guillen-Ahlers H, Rao PK, Perumalla DS, Montoya MJ, Jadhav AYL, Shortreed MR, Smith LM, Olivier M. Adaptation of Hybridization Capture of Chromatin-associated Proteins for Proteomics to Mammalian Cells. J Vis Exp. 2018 06 01; (136). PMID: 29912191.
      Citations:    
    11. Misra BB, Upadhayay RP, Cox LA, Olivier M. Optimized GC-MS metabolomics for the analysis of kidney tissue metabolites. Metabolomics. 2018 05 25; 14(6):75. PMID: 30830353.
      Citations:    
    12. Rao PK, Merath K, Drigalenko E, Jadhav AYL, Komorowski RA, Goldblatt MI, Rohatgi A, Sarzynski MA, Gawrieh S, Olivier M. Proteomic characterization of high-density lipoprotein particles in patients with non-alcoholic fatty liver disease. Clin Proteomics. 2018; 15:10. PMID: 29527140.
      Citations:    
    13. Cox LA, Olivier M, Spradling-Reeves K, Karere GM, Comuzzie AG, VandeBerg JL. Nonhuman Primates and Translational Research-Cardiovascular Disease. ILAR J. 2017 12 01; 58(2):235-250. PMID: 28985395.
      Citations:    
    14. Proffitt JM, Glenn J, Cesnik AJ, Jadhav A, Shortreed MR, Smith LM, Kavanagh K, Cox LA, Olivier M. Proteomics in non-human primates: utilizing RNA-Seq data to improve protein identification by mass spectrometry in vervet monkeys. BMC Genomics. 2017 Nov 13; 18(1):877. PMID: 29132314.
      Citations:    
    15. Chu AY, Deng X, Fisher VA, Drong A, Zhang Y, Feitosa MF, Liu CT, Weeks O, Choh AC, Duan Q, Dyer TD, Eicher JD, Guo X, Heard-Costa NL, Kacprowski T, Kent JW, Lange LA, Liu X, Lohman K, Lu L, Mahajan A, O'Connell JR, Parihar A, Peralta JM, Smith AV, Zhang Y, Homuth G, Kissebah AH, Kullberg J, Laqua R, Launer LJ, Nauck M, Olivier M, Peyser PA, Terry JG, Wojczynski MK, Yao J, Bielak LF, Blangero J, Borecki IB, Bowden DW, Carr JJ, Czerwinski SA, Ding J, Friedrich N, Gudnason V, Harris TB, Ingelsson E, Johnson AD, Kardia SL, Langefeld CD, Lind L, Liu Y, Mitchell BD, Morris AP, Mosley TH, Rotter JI, Shuldiner AR, Towne B, Völzke H, Wallaschofski H, Wilson JG, Allison M, Lindgren CM, Goessling W, Cupples LA, Steinhauser ML, Fox CS. Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Nat Genet. 2017 01; 49(1):125-130. PMID: 27918534.
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    16. Runge CL, Indap A, Zhou Y, Kent JW, King E, Erbe CB, Cole R, Littrell J, Merath K, James R, Rüschendorf F, Kerschner JE, Marth G, Hübner N, Göring HH, Friedland DR, Kwok WM, Olivier M. Association of TMTC2 With Human Nonsyndromic Sensorineural Hearing Loss. JAMA Otolaryngol Head Neck Surg. 2016 09 01; 142(9):866-72. PMID: 27311106.
      Citations:    
    17. Guillen-Ahlers H, Rao PK, Levenstein ME, Kennedy-Darling J, Perumalla DS, Jadhav AY, Glenn JP, Ludwig-Kubinski A, Drigalenko E, Montoya MJ, Göring HH, Anderson CD, Scalf M, Gildersleeve HI, Cole R, Greene AM, Oduro AK, Lazarova K, Cesnik AJ, Barfknecht J, Cirillo LA, Gasch AP, Shortreed MR, Smith LM, Olivier M. HyCCAPP as a tool to characterize promoter DNA-protein interactions in Saccharomyces cerevisiae. Genomics. 2016 06; 107(6):267-73. PMID: 27184763.
      Citations:    
    18. Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, Karaderi T, Barber TM, McCarthy MI, Franks S, Lindgren CM, Welt CK, Diamanti-Kandarakis E, Panidis D, Goodarzi MO, Azziz R, Zhang Y, James RG, Olivier M, Kissebah AH, Stener-Victorin E, Legro RS, Dunaif A. Corrigendum: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun. 2016 Feb 12; 7:10762. PMID: 26867975.
      Citations:    
    19. Sunwook K, Nussbaum MA, Quandt SA, Laurienti PJ, Arcury TA. Effects of Lifetime Occupational Pesticide Exposure on Postural Control Among Farmworkers and Non-Farmworkers. J Occup Environ Med. 2016 Feb; 58(2):133-9. PMID: 29671961.
      Citations:    
    20. Hayes MG, Urbanek M, Ehrmann DA, Armstrong LL, Lee JY, Sisk R, Karaderi T, Barber TM, McCarthy MI, Franks S, Lindgren CM, Welt CK, Diamanti-Kandarakis E, Panidis D, Goodarzi MO, Azziz R, Zhang Y, James RG, Olivier M, Kissebah AH, Stener-Victorin E, Legro RS, Dunaif A. Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations. Nat Commun. 2015 Aug 18; 6:7502. PMID: 26284813.
      Citations:    
    21. Kennedy-Darling J, Guillen-Ahlers H, Shortreed MR, Scalf M, Frey BL, Kendziorski C, Olivier M, Gasch AP, Smith LM. Discovery of Chromatin-Associated Proteins via Sequence-Specific Capture and Mass Spectrometric Protein Identification in Saccharomyces cerevisiae. J Proteome Res. 2014 Aug 01; 13(8):3810-25. PMID: 24999558.
      Citations:    
    22. Guillen-Ahlers H, Shortreed MR, Smith LM, Olivier M. Advanced methods for the analysis of chromatin-associated proteins. Physiol Genomics. 2014 Jul 01; 46(13):441-7. PMID: 24803678.
      Citations:    
    23. Indap AR, Cole R, Runge CL, Marth GT, Olivier M. Variant discovery in targeted resequencing using whole genome amplified DNA. BMC Genomics. 2013 Jul 10; 14:468. PMID: 23837845.
      Citations:    
    24. Martin LJ, Ding L, Zhang X, Kissebah AH, Olivier M, Benson DW. A novel method, the Variant Impact On Linkage Effect Test (VIOLET), leads to improved identification of causal variants in linkage regions. Eur J Hum Genet. 2014 Feb; 22(2):243-7. PMID: 23736220.
      Citations:    
    25. Zhang Y, Kent JW, Olivier M, Ali O, Cerjak D, Broeckel U, Abdou RM, Dyer TD, Comuzzie A, Curran JE, Carless MA, Rainwater DL, Göring HH, Blangero J, Kissebah AH. A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inflammation. BMC Med Genomics. 2013 Apr 29; 6:14. PMID: 23628382.
      Citations:    
    26. Zhang Y, Kent JW, Lee A, Cerjak D, Ali O, Diasio R, Olivier M, Blangero J, Carless MA, Kissebah AH. Fatty acid binding protein 3 (fabp3) is associated with insulin, lipids and cardiovascular phenotypes of the metabolic syndrome through epigenetic modifications in a Northern European family population. BMC Med Genomics. 2013 Mar 19; 6:9. PMID: 23510163.
      Citations:    
    27. Bienengraeber M, Pellitteri-Hahn M, Hirata N, Baye TM, Bosnjak ZJ, Olivier M. Quantitative characterization of changes in the cardiac mitochondrial proteome during anesthetic preconditioning and ischemia. Physiol Genomics. 2013 Mar 01; 45(5):163-70. PMID: 23300156.
      Citations:    
    28. Li W, Olivier M. Current analysis platforms and methods for detecting copy number variation. Physiol Genomics. 2013 Jan 07; 45(1):1-16. PMID: 23132758.
      Citations:    
    29. Olivier M. Body fat distribution, lipoprotein metabolism, and insulin resistance: a lifetime of research on the pathophysiology of the human metabolic syndrome. J Clin Lipidol. 2012 Nov-Dec; 6(6):601-3. PMID: 23312057.
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    30. Martin LJ, Kissebah AH, Olivier M. Accounting for a quantitative trait locus for plasma triglyceride levels: utilization of variants in multiple genes. PLoS One. 2012; 7(4):e34614. PMID: 22485179.
      Citations:    
    31. Gawrieh S, Marion MC, Komorowski R, Wallace J, Charlton M, Kissebah A, Langefeld CD, Olivier M. Genetic variation in the peroxisome proliferator activated receptor-gamma gene is associated with histologically advanced NAFLD. Dig Dis Sci. 2012 Apr; 57(4):952-7. PMID: 22160635.
      Citations:    
    32. Wu CH, Chen S, Shortreed MR, Kreitinger GM, Yuan Y, Frey BL, Zhang Y, Mirza S, Cirillo LA, Olivier M, Smith LM. Sequence-specific capture of protein-DNA complexes for mass spectrometric protein identification. PLoS One. 2011; 6(10):e26217. PMID: 22028835.
      Citations:    
    33. Chesnik M, Halligan B, Olivier M, Mirza SP. Sequential abundant ion fragmentation analysis (SAIFA): an alternative approach for phosphopeptide identification using an ion trap mass spectrometer. Anal Biochem. 2011 Nov 15; 418(2):197-203. PMID: 21855524.
      Citations:    
    34. Smith LM, Shortreed MR, Olivier M. To understand the whole, you must know the parts: unraveling the roles of protein-DNA interactions in genome regulation. Analyst. 2011 Aug 07; 136(15):3060-5. PMID: 21629937.
      Citations:    
    35. Gawrieh S, Baye TM, Carless M, Wallace J, Komorowski R, Kleiner DE, Andris D, Makladi B, Cole R, Charlton M, Curran J, Dyer TD, Charlesworth J, Wilke R, Blangero J, Kissebah AH, Olivier M. Hepatic gene networks in morbidly obese patients with nonalcoholic fatty liver disease. Obes Surg. 2010 Dec; 20(12):1698-709. PMID: 20473581.
      Citations:    
    36. Collins LA, Olivier M. Quantitative comparison of lipoprotein fractions derived from human plasma and serum by liquid chromatography-tandem mass spectrometry. Proteome Sci. 2010 Jul 29; 8:42. PMID: 20670422.
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    37. Zhang Y, Sonnenberg GE, Baye TM, Littrell J, Gunnell J, DeLaForest A, MacKinney E, Hillard CJ, Kissebah AH, Olivier M, Wilke RA. Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent. Pharmacogenomics. 2009 Dec; 10(12):1929-39. PMID: 19958092.
      Citations:    
    38. Collins LA, Mirza SP, Kissebah AH, Olivier M. Integrated approach for the comprehensive characterization of lipoproteins from human plasma using FPLC and nano-HPLC-tandem mass spectrometry. Physiol Genomics. 2010 Feb 04; 40(3):208-15. PMID: 19903763.
      Citations:    
    39. Baye TM, Wilke RA, Olivier M. Genomic and geographic distribution of private SNPs and pathways in human populations. Per Med. 2009 Nov 01; 6(6):623-641. PMID: 20352079.
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    40. Runge-Samuelson C, Olivier M. The rocky road toward clinical genetic testing: insights into the physio-genetic basis of hearing loss. Physiol Genomics. 2009 Oct 07; 39(2):83-4. PMID: 19706690.
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    41. Zhang Y, Smith E, Olivier M. Putting the Invader assay to work: laboratory application and data management. Methods Mol Biol. 2009; 578:363-77. PMID: 19768605.
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    42. Baye TM, Zhang Y, Smith E, Hillard CJ, Gunnell J, Myklebust J, James R, Kissebah AH, Olivier M, Wilke RA. Genetic variation in cannabinoid receptor 1 (CNR1) is associated with derangements in lipid homeostasis, independent of body mass index. Pharmacogenomics. 2008 Nov; 9(11):1647-56. PMID: 19018721.
      Citations:    
    43. Duffy KJ, Littrell J, Locke A, Sherman SL, Olivier M. A novel procedure for genotyping of single nucleotide polymorphisms in trisomy with genomic DNA and the invader assay. Nucleic Acids Res. 2008 Dec; 36(22):e145. PMID: 18940863.
      Citations:    
    44. Lee JE, Mirza SP, Didier DN, Scalf M, Olivier M, Greene AS, Smith LM. Identification of cell surface markers to differentiate rat endothelial and fibroblast cells using lectin arrays and LC-ESI-MS/MS. Anal Chem. 2008 Nov 01; 80(21):8269-75. PMID: 18821777.
      Citations:    
    45. Mirza SP, Greene AS, Olivier M. 18O labeling over a coffee break: a rapid strategy for quantitative proteomics. J Proteome Res. 2008 Jul; 7(7):3042-8. PMID: 18510357.
      Citations:    
    46. Mirza SP, Olivier M. Methods and approaches for the comprehensive characterization and quantification of cellular proteomes using mass spectrometry. Physiol Genomics. 2008 Mar 14; 33(1):3-11. PMID: 18162499.
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    47. Smith EM, Littrell J, Olivier M. Automated SNP genotype clustering algorithm to improve data completeness in high-throughput SNP genotyping datasets from custom arrays. Genomics Proteomics Bioinformatics. 2007 Dec; 5(3-4):256-9. PMID: 18267308.
      Citations:    
    48. Smith JR, Olivier M, Greene AS. Relative quantification of peptide phosphorylation in a complex mixture using 18O labeling. Physiol Genomics. 2007 Oct 22; 31(2):357-63. PMID: 17684036.
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    49. Lee JE, Didier DN, Lockett MR, Scalf M, Greene AS, Olivier M, Smith LM. Characterization of vascular endothelial growth factor receptors on the endothelial cell surface during hypoxia using whole cell binding arrays. Anal Biochem. 2007 Oct 15; 369(2):241-7. PMID: 17624292.
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    50. Kerns JA, Cargill EJ, Clark LA, Candille SI, Berryere TG, Olivier M, Lust G, Todhunter RJ, Schmutz SM, Murphy KE, Barsh GS. Linkage and segregation analysis of black and brindle coat color in domestic dogs. Genetics. 2007 Jul; 176(3):1679-89. PMID: 17483404.
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    51. Mirza SP, Halligan BD, Greene AS, Olivier M. Improved method for the analysis of membrane proteins by mass spectrometry. Physiol Genomics. 2007 Jun 19; 30(1):89-94. PMID: 17341690.
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    52. Skelton JA, DeMattia L, Miller L, Olivier M. Obesity and its therapy: from genes to community action. Pediatr Clin North Am. 2006 Aug; 53(4):777-94. PMID: 16873005.
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    53. Indap AR, Marth GT, Struble CA, Tonellato P, Olivier M. Analysis of concordance of different haplotype block partitioning algorithms. BMC Bioinformatics. 2005 Dec 15; 6:303. PMID: 16356172.
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    54. Olivier M. The Invader assay for SNP genotyping. Mutat Res. 2005 Jun 03; 573(1-2):103-10. PMID: 15829241.
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    55. Chen Y, Shortreed MR, Olivier M, Smith LM. Parallel single nucleotide polymorphism genotyping by surface invasive cleavage with universal detection. Anal Chem. 2005 Apr 15; 77(8):2400-5. PMID: 15828773.
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    56. Hicks WA, Halligan BD, Slyper RY, Twigger SN, Greene AS, Olivier M. Simultaneous quantification and identification using 18O labeling with an ion trap mass spectrometer and the analysis software application "ZoomQuant". J Am Soc Mass Spectrom. 2005 Jun; 16(6):916-25. PMID: 15907706.
      Citations:    
    57. Halligan BD, Slyper RY, Twigger SN, Hicks W, Olivier M, Greene AS. ZoomQuant: an application for the quantitation of stable isotope labeled peptides. J Am Soc Mass Spectrom. 2005 Mar; 16(3):302-6. PMID: 15734322.
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    58. Baessler A, Hasinoff MJ, Fischer M, Reinhard W, Sonnenberg GE, Olivier M, Erdmann J, Schunkert H, Doering A, Jacob HJ, Comuzzie AG, Kissebah AH, Kwitek AE. Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity. Diabetes. 2005 Jan; 54(1):259-67. PMID: 15616037.
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    59. Huang J, Lin A, Narasimhan B, Quertermous T, Hsiung CA, Ho LT, Grove JS, Olivier M, Ranade K, Risch NJ, Olshen RA. Tree-structured supervised learning and the genetics of hypertension. Proc Natl Acad Sci U S A. 2004 Jul 20; 101(29):10529-34. PMID: 15249660.
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    60. Olivier M, Hsiung CA, Chuang LM, Ho LT, Ting CT, Bustos VI, Lee TM, De Witte A, Chen YD, Olshen R, Rodriguez B, Wen CC, Cox DR. Single nucleotide polymorphisms in protein tyrosine phosphatase 1beta (PTPN1) are associated with essential hypertension and obesity. Hum Mol Genet. 2004 Sep 01; 13(17):1885-92. PMID: 15229188.
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    61. Olivier M, Wang X, Cole R, Gau B, Kim J, Rubin EM, Pennacchio LA. Haplotype analysis of the apolipoprotein gene cluster on human chromosome 11. Genomics. 2004 May; 83(5):912-23. PMID: 15081120.
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    62. Sonnenberg GE, Krakower GR, Martin LJ, Olivier M, Kwitek AE, Comuzzie AG, Blangero J, Kissebah AH. Genetic determinants of obesity-related lipid traits. J Lipid Res. 2004 Apr; 45(4):610-5. PMID: 14754912.
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    63. Olivier M. From SNPs to function: the effect of sequence variation on gene expression. Focus on "a survey of genetic and epigenetic variation affecting human gene expression". Physiol Genomics. 2004 Jan 15; 16(2):182-3. PMID: 14726602.
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    64. Olivier M, Brady S, Cox DR. Radiation hybrid mapping with BAC ends. Methods Mol Biol. 2004; 255:163-9. PMID: 15020823.
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    65. Eichenbaum-Voline S, Olivier M, Jones EL, Naoumova RP, Jones B, Gau B, Patel HN, Seed M, Betteridge DJ, Galton DJ, Rubin EM, Scott J, Shoulders CC, Pennacchio LA. Linkage and association between distinct variants of the APOA1/C3/A4/A5 gene cluster and familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol. 2004 Jan; 24(1):167-74. PMID: 14551155.
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    66. Olivier M. A haplotype map of the human genome. Physiol Genomics. 2003 Mar 18; 13(1):3-9. PMID: 12644628.
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    67. Liang M, Yuan B, Rute E, Greene AS, Olivier M, Cowley AW. Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expression. Physiol Genomics. 2003 Feb 06; 12(3):229-37. PMID: 12488510.
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    68. Yuan B, Liang M, Yang Z, Rute E, Taylor N, Olivier M, Cowley AW. Gene expression reveals vulnerability to oxidative stress and interstitial fibrosis of renal outer medulla to nonhypertensive elevations of ANG II. . 2003 May; 284(5):R1219-30. PMID: 12676744.
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    69. Kerns JA, Olivier M, Lust G, Barsh GS. Exclusion of melanocortin-1 receptor (mc1r) and agouti as candidates for dominant black in dogs. J Hered. 2003 Jan-Feb; 94(1):75-9. PMID: 12692166.
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    70. Talmud PJ, Hawe E, Martin S, Olivier M, Miller GJ, Rubin EM, Pennacchio LA, Humphries SE. Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides. Hum Mol Genet. 2002 Nov 15; 11(24):3039-46. PMID: 12417525.
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    71. Pennacchio LA, Olivier M, Hubacek JA, Krauss RM, Rubin EM, Cohen JC. Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. Hum Mol Genet. 2002 Nov 15; 11(24):3031-8. PMID: 12417524.
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    72. Olivier M, Chuang LM, Chang MS, Chen YT, Pei D, Ranade K, de Witte A, Allen J, Tran N, Curb D, Pratt R, Neefs H, de Arruda Indig M, Law S, Neri B, Wang L, Cox DR. High-throughput genotyping of single nucleotide polymorphisms using new biplex invader technology. Nucleic Acids Res. 2002 Jun 15; 30(12):e53. PMID: 12060691.
      Citations:    
    73. Olivier M, Aggarwal A, Allen J, Almendras AA, Bajorek ES, Beasley EM, Brady SD, Bushard JM, Bustos VI, Chu A, Chung TR, De Witte A, Denys ME, Dominguez R, Fang NY, Foster BD, Freudenberg RW, Hadley D, Hamilton LR, Jeffrey TJ, Kelly L, Lazzeroni L, Levy MR, Lewis SC, Liu X, Lopez FJ, Louie B, Marquis JP, Martinez RA, Matsuura MK, Misherghi NS, Norton JA, Olshen A, Perkins SM, Perou AJ, Piercy C, Piercy M, Qin F, Reif T, Sheppard K, Shokoohi V, Smick GA, Sun WL, Stewart EA, Fernando J, Tran NM, Trejo T, Vo NT, Yan SC, Zierten DL, Zhao S, Sachidanandam R, Trask BJ, Myers RM, Cox DR. A high-resolution radiation hybrid map of the human genome draft sequence. Science. 2001 Feb 16; 291(5507):1298-302. PMID: 11181994.
      Citations:    
    74. Cheung VG, Nowak N, Jang W, Kirsch IR, Zhao S, Chen XN, Furey TS, Kim UJ, Kuo WL, Olivier M, Conroy J, Kasprzyk A, Massa H, Yonescu R, Sait S, Thoreen C, Snijders A, Lemyre E, Bailey JA, Bruzel A, Burrill WD, Clegg SM, Collins S, Dhami P, Friedman C, Han CS, Herrick S, Lee J, Ligon AH, Lowry S, Morley M, Narasimhan S, Osoegawa K, Peng Z, Plajzer-Frick I, Quade BJ, Scott D, Sirotkin K, Thorpe AA, Gray JW, Hudson J, Pinkel D, Ried T, Rowen L, Shen-Ong GL, Strausberg RL, Birney E, Callen DF, Cheng JF, Cox DR, Doggett NA, Carter NP, Eichler EE, Haussler D, Korenberg JR, Morton CC, Albertson D, Schuler G, de Jong PJ, Trask BJ. Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature. 2001 Feb 15; 409(6822):953-8. PMID: 11237021.
      Citations:    
    75. Olivier M, Breen M, Binns MM, Lust G. Localization and characterization of nucleotide sequences from the canine Y chromosome. Chromosome Res. 1999; 7(3):223-33. PMID: 10421382.
      Citations:    
    76. Todhunter RJ, Acland GM, Olivier M, Williams AJ, Vernier-Singer M, Burton-Wurster N, Farese JP, Gröhn YT, Gilbert RO, Dykes NL, Lust G. An outcrossed canine pedigree for linkage analysis of hip dysplasia. J Hered. 1999 Jan-Feb; 90(1):83-92. PMID: 9987910.
      Citations:    
    77. Olivier M, Meehl MA, Lust G. Random amplified polymorphic DNA (RAPD) sequences as markers for canine genetic studies. J Hered. 1999 Jan-Feb; 90(1):78-82. PMID: 9987909.
      Citations:    
    78. Olivier M, Lust G. Two DNA sequences specific for the canine Y chromosome. Anim Genet. 1998 Apr; 29(2):146-9. PMID: 9699278.
      Citations:    
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