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David M.Kline PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentPHS-Biostatistics and Data Science (Public Health Sciences)
Address
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    Collapse Biography 
    Collapse education and training
    Messiah College, Grantham, PABA05/2010Mathematics
    The Ohio State University, Columbus, OHMS03/2012Statistics
    The Ohio State University, Columbus, OHPhD12/2015Biostatistics
    Collapse awards and honors
    2006Honors Program, Messiah College
    2010Department Honors, Messiah College Department of Mathematics
    2010Lubrizol Fellowship, The Ohio State University Department of Statistics
    2010University Fellowship, The Ohio State University
    2014Lester R. Curtin Award, American Statistical Association
    2015CSP Best Student Poster Runner-up, American Statistical Association
    2020Excellence in Teaching Award, The Ohio State University Department of Biomedical Informatics

    Collapse Overview 
    Collapse overview
    I am an Assistant Professor in the Department of Biostatistics and Data Science in the Division of Public Health Sciences at Wake Forest School of Medicine. Previously, I was an Assistant Professor in the Department of Biomedical Informatics and a member of the Center for Biostatistics at The Ohio State University. I earned my PhD in Biostatistics from The Ohio State University in 2015. I joined the faculty at Wake Forest School of Medicine in 2021.

    Public health surveillance involves the analysis and interpretation of health-related data essential to planning, implementation, and evaluation of public health policy and practice. My research is focused on developing biostatistical methodology to overcome challenges in public health surveillance and address key problems in population health and epidemiology. Specifically, I work on developing multivariate Bayesian hierarchical models for spatio-temporal disease mapping that leverage multiple sources of data to address complex, difficult to measure social and epidemiological problems, like the opioid epidemic. Through my research, I have developed expertise in small area estimation, spatio-temporal methods, multivariate modeling, and Bayesian methods. I am committed to collaborating with subject area experts so that we can leverage our collective expertise to best address challenging scientific questions of interest.

    Collapse Research 
    Collapse research activities and funding
    R21DA045236     (KLINE, DAVID M.)Sep 15, 2018 - Aug 31, 2021
    NIH
    A Bayesian Spatio-Temporal Approach for Estimating County-Level Opioid Misuse Rates in Ohio
    Role: Principal Investigator

    R01HS027200     (HEBERT, COURTNEY L.)Sep 30, 2019 - Aug 31, 2024
    NIH
    GeoHAI: A novel geographic tool for Hospital Acquired Infection visualization and assessment
    Role: Co-Investigator

    F30DA050423     (BROOK, DANIEL)Apr 1, 2020 - Mar 31, 2024
    NIH
    Buprenorphine, Hepatitis C Virus and Their Relationship in Rural US Populations
    Role: Co-Investigator

    R01NR019512     (RHODES, SCOTT D)Aug 27, 2020 - May 31, 2025
    NIH
    Harnessing the power of peer navigation and mHealth to reduce health disparities in Appalachia
    Role: Co-Investigator

    R01DA052214     (KLINE, DAVID M.)Sep 1, 2021 - Jun 30, 2025
    NIH
    Spatio-temporal Methods for Surveillance of the Opioid Syndemic
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Joseph JJ, Kluwe B, Echouffo-Tcheugui JB, Zhao S, Brock G, Kline D, Odei JB, Kalyani RR, Bradley DP, Hsueh WA, Sims M, Golden SH. Association of Adiposity With Incident Diabetes Among Black Adults in the Jackson Heart Study. J Am Heart Assoc. 2021 Sep 21; 10(18):e020716. PMID: 34493073.
      Citations:    
    2. Arnold WD, Severyn S, Zhao S, Kline D, Linsenmayer M, Kelly K, Tellez M, Bartlett A, Heintzman S, Reynolds J, Sterling G, Weaver T, Rajneesh K, Burghes AHM, Kolb SJ, Elsheikh B. Persistent neuromuscular junction transmission defects in adults with spinal muscular atrophy treated with nusinersen. BMJ Neurol Open. 2021; 3(2):e000164. PMID: 34466806.
      Citations:    
    3. Hill EB, Watson JR, Cohen DM, Kline D, Schwaderer AL, Spencer JD. Novel urine biomarkers to distinguish UTI from culture-negative pyuria. Pediatr Nephrol. 2021 Jul 16. PMID: 34272611.
      Citations:    
    4. Kline D, Li Z, Chu Y, Wakefield J, Miller WC, Norris Turner A, Clark SJ. Estimating seroprevalence of SARS-CoV-2 in Ohio: A Bayesian multilevel poststratification approach with multiple diagnostic tests. Proc Natl Acad Sci U S A. 2021 06 29; 118(26). PMID: 34172581.
      Citations:    
    5. Gonsalves GS, Copple JT, Paltiel AD, Fenichel EP, Bayham J, Abraham M, Kline D, Malloy S, Rayo MF, Zhang N, Faulkner D, Morey DA, Wu F, Thornhill T, Iloglu S, Warren JL. Maximizing the Efficiency of Active Case Finding for SARS-CoV-2 Using Bandit Algorithms. Med Decis Making. 2021 11; 41(8):970-977. PMID: 34120510.
      Citations:    
    6. Sotos-Prieto M, Zhao S, Kline D, Brock G, Gooding H, Mattei J, Rodriguez-Artalejo F, Min YI, Rimm EB, Tucker KL, Joseph JJ. Application of a Lifestyle-Based Score to Predict Cardiovascular Risk in African Americans: The Jackson Heart Study. J Clin Med. 2021 May 22; 10(11). PMID: 34067473.
      Citations:    
    7. Elsheikh B, Severyn S, Zhao S, Kline D, Linsenmayer M, Kelly K, Tellez M, Bartlett A, Heintzman S, Reynolds J, Sterling G, Weaver T, Rajneesh K, Kolb SJ, Arnold WD. Safety, Tolerability, and Effect of Nusinersen Treatment in Ambulatory Adults With 5q-SMA. Front Neurol. 2021; 12:650535. PMID: 34093395.
      Citations:    
    8. Brook DL, Hetrick AT, Chettri SR, Schalkoff CA, Sibley AL, Lancaster KE, Go VF, Miller WC, Kline DM. The Relationship Between Hepatitis C Virus Rates and Office-Based Buprenorphine Access in Ohio. Open Forum Infect Dis. 2021 Jun; 8(6):ofab242. PMID: 34159217.
      Citations:    
    9. Schoenfield L, Janse S, Kline D, Aronow ME, Singh AD, Craven C, Abdel-Rahman M, Cebulla CM. Estrogen Receptor Is Expressed in Uveal Melanoma: A Potential Target for Therapy. Ocul Oncol Pathol. 2021 Sep; 7(4):303-310. PMID: 34604204.
      Citations:    
    10. Elsheikh B, Severyn S, Zhao S, Kline D, Linsenmayer M, Kelly K, Tellez M, Bartlett A, Heintzman S, Reynolds J, Sterling G, Weaver T, Rajneesh K, Kolb SJ, Arnold WD. Safety, Tolerability, and Effect of Nusinersen in Non-ambulatory Adults With Spinal Muscular Atrophy. Front Neurol. 2021; 12:650532. PMID: 33935949.
      Citations:    
    11. Kline D, Pan Y, Hepler SA. Spatiotemporal Trends in Opioid Overdose Deaths by Race for Counties in Ohio. Epidemiology. 2021 03 01; 32(2):295-302. PMID: 33394810.
      Citations:    
    12. Joseph JJ, Pohlman NK, Zhao S, Kline D, Brock G, Echouffo-Tcheugui JB, Sims M, Effoe VS, Wu WC, Kalyani RR, Wand GS, Kluwe B, Hsueh WA, Abdalla M, Shimbo D, Golden SH. Association of Serum Aldosterone and Plasma Renin Activity With Ambulatory Blood Pressure in African Americans: The Jackson Heart Study. Circulation. 2021 Jun 15; 143(24):2355-2366. PMID: 33605160.
      Citations:    
    13. Kluwe B, Zhao S, Kline D, Ortiz R, Brock G, Echouffo-Tcheugui JB, Sims M, Kalyani RR, Golden SH, Joseph JJ. Adiposity Measures and Morning Serum Cortisol in African Americans: Jackson Heart Study. Obesity (Silver Spring). 2021 02; 29(2):418-427. PMID: 33491313.
      Citations:    
    14. Linakis SW, Lloyd JK, Kline D, Holmes JF, Stanley RM, Leonard JC. Field triage of children with abdominal trauma. Trauma. 2021; 23(1):55-63.
    15. Jamieson N, Akande M, Karsies T, Smith RM, Kline D, Spencer SP. Respiratory Pathogen Detection in Pediatric Patients Intubated for Presumed Infection. Pediatr Emerg Care. 2020 Nov 16. PMID: 33201137.
      Citations:    
    16. Kline D, Ji Y, Hepler S. A multivariate spatio-temporal model of the opioid epidemic in Ohio: A factor model approach. Health Serv Outcomes Res Methodol. 2021 Mar; 21:42-53. PMID: 34305443.
      Citations:    
    17. Kluwe B, Ortiz R, Odei JB, Zhao S, Kline D, Brock G, Echouffo-Tcheugui JB, Lee JM, Lazarus S, Seeman T, Greenland P, Needham B, Carnethon MR, Golden SH, Joseph JJ. The association of cortisol curve features with incident diabetes among whites and African Americans: The CARDIA study. Psychoneuroendocrinology. 2021 01; 123:105041. PMID: 33227536.
      Citations:    
    18. Moberly AC, Vasil K, Baxter J, Klamer B, Kline D, Ray C. Comprehensive auditory rehabilitation in adults receiving cochlear implants: A pilot study. Laryngoscope Investig Otolaryngol. 2020 Oct; 5(5):911-918. PMID: 33134539.
      Citations:    
    19. Dias JP, Joseph JJ, Kluwe B, Zhao S, Shardell M, Seeman T, Needham BL, Wand GS, Kline D, Brock G, Castro-Diehl C, Golden SH. The longitudinal association of changes in diurnal cortisol features with fasting glucose: MESA. Psychoneuroendocrinology. 2020 09; 119:104698. PMID: 32674946.
      Citations:    
    20. Meyer AP, Roggenbuck J, LoRusso S, Kissel J, Smith RM, Kline D, Arnold WD. Genotype-Phenotype Correlations and Characterization of Medication Use in Inherited Myotonic Disorders. Front Neurol. 2020; 11:593. PMID: 32670189.
      Citations:    
    21. Kline D, Hepler SA. Estimating the burden of the opioid epidemic for adults and adolescents in Ohio counties. Biometrics. 2021 06; 77(2):765-775. PMID: 32413155.
      Citations:    
    22. Battisti KA, Cohen DM, Bourgeois T, Kline D, Zhao S, Iyer MS. A Paucity of Code Status Documentation Despite Increasing Complex Chronic Disease in Pediatrics. J Palliat Med. 2020 11; 23(11):1452-1459. PMID: 32213109.
      Citations:    
    23. Karamians R, Proffitt R, Kline D, Gauthier LV. Effectiveness of Virtual Reality- and Gaming-Based Interventions for Upper Extremity Rehabilitation Poststroke: A Meta-analysis. Arch Phys Med Rehabil. 2020 05; 101(5):885-896. PMID: 31821799.
      Citations:    
    24. Saba K, Hossieny ZS, Arnold WD, Elsheikh B, Palettas M, Kline D, Stino AM. CSF Protein Level and Short-Term Prognosis in Guillain-Barré Syndrome. J Clin Neuromuscul Dis. 2019 Dec; 21(2):118-119. PMID: 31743257.
      Citations:    
    25. Young NA, Brown MP, Peng J, Kline D, Reider C, Deogaonkar M. Predicting extended hospital stay after deep brain stimulation surgery in Parkinson's patients. J Clin Neurosci. 2019 Nov; 69:241-244. PMID: 31431404.
      Citations:    
    26. Liu A, Kline DM, Brock GN, Bonsu BK. Multistate model of the patient flow process in the pediatric emergency department. PLoS One. 2019; 14(7):e0219514. PMID: 31291345.
      Citations:    
    27. Gillespie SL, Anderson CM, Zhao S, Tan Y, Kline D, Brock G, Odei J, O'Brien E, Sims M, Lazarus SA, Hood DB, Williams KP, Joseph JJ. Allostatic load in the association of depressive symptoms with incident coronary heart disease: The Jackson Heart Study. Psychoneuroendocrinology. 2019 11; 109:104369. PMID: 31307010.
      Citations:    
    28. Hepler S, McKnight E, Bonny A, Kline D. A Latent Spatial Factor Approach for Synthesizing Opioid-Associated Deaths and Treatment Admissions in Ohio Counties. Epidemiology. 2019 05; 30(3):365-370. PMID: 30882402.
      Citations:    
    29. Kesireddy V, Tan Y, Kline D, Brock G, Odei JB, Kluwe B, Effoe VS, Echouffo Tcheugui JB, Kalyani RR, Sims M, Taylor HA, Mongraw-Chaffin M, Akhabue E, Joseph JJ. The Association of Life's Simple 7 with Aldosterone among African Americans in the Jackson Heart Study. Nutrients. 2019 Apr 26; 11(5). PMID: 31035479.
      Citations:    
    30. La Count S, Lovett ME, Zhao S, Kline D, O'Brien NF, Hall MW, Sribnick EA. Factors Associated With Poor Outcome in Pediatric Near-Hanging Injuries. J Emerg Med. 2019 Jul; 57(1):21-28. PMID: 31031070.
      Citations:    
    31. Suarez-Kelly LP, Yu L, Kline D, Schneider EB, Agnese DM, Carson WE. Increased breast cancer risk in women with neurofibromatosis type 1: a meta-analysis and systematic review of the literature. Hered Cancer Clin Pract. 2019; 17:12. PMID: 30962859.
      Citations:    
    32. Kloos AD, Kegelmeyer DA, Ambrogi K, Kline D, McCormack-Mager M, Schroeder B, Kostyk SK. The Step Test Evaluation of Performance on Stairs (STEPS): Validation and reliability in a neurological disorder. PLoS One. 2019; 14(3):e0213698. PMID: 30897107.
      Citations:    
    33. Kline D, Hepler S, Bonny A, McKnight E. A joint spatial model of opioid-associated deaths and treatment admissions in Ohio. Ann Epidemiol. 2019 05; 33:19-23. PMID: 30948153.
      Citations:    
    34. Wang H, Hecht S, Kline D, Leber AL. Staphylococcus aureus and methicillin resistance detection directly from pediatric samples using PCR assays with differential cycle threshold values for corroboration of methicillin resistance. J Microbiol Methods. 2019 04; 159:167-173. PMID: 30826439.
      Citations:    
    35. Bressler CJ, Letson MM, Kline D, McCarthy T, Davis J, Leonard JC. Characteristics of Neighborhoods Where Emergency Medical Services Encounter Children at Risk for Maltreatment. Prehosp Emerg Care. 2019 Sep-Oct; 23(5):672-682. PMID: 30703337.
      Citations:    
    36. Yackey K, Stukus K, Cohen D, Kline D, Zhao S, Stanley R. Off-label Medication Prescribing Patterns in Pediatrics: An Update. Hosp Pediatr. 2019 03; 9(3):186-193. PMID: 30745323.
      Citations:    
    37. Grisanti K, Martorano L, Redmond M, Scherzer R, Strothman K, Malthaner L, Davis J, Zhao S, Kline D, Leonard JC. Emergency Call Characteristics and EMS Dispatcher Protocol Adherence for Possible Anaphylaxis. Prehosp Emerg Care. 2019 Sep-Oct; 23(5):691-699. PMID: 30526221.
      Citations:    
    38. Echouffo-Tcheugui JB, Zhao S, Brock G, Matsouaka RA, Kline D, Joseph JJ. Visit-to-Visit Glycemic Variability and Risks of Cardiovascular Events and All-Cause Mortality: The ALLHAT Study. Diabetes Care. 2019 03; 42(3):486-493. PMID: 30659073.
      Citations:    
    39. Lorusso S, Kline D, Bartlett A, Freimer M, Agriesti J, Hawash AA, Rich MM, Kissel JT, David Arnold W. Open-label trial of ranolazine for the treatment of paramyotonia congenita. Muscle Nerve. 2019 02; 59(2):240-243. PMID: 30390395.
      Citations:    
    40. Wier CG, Crum AE, Reynolds AB, Iyer CC, Chugh D, Palettas MS, Heilman PL, Kline DM, Arnold WD, Kolb SJ. Muscle contractility dysfunction precedes loss of motor unit connectivity in SOD1(G93A) mice. Muscle Nerve. 2019 02; 59(2):254-262. PMID: 30370671.
      Citations:    
    41. Stino AM, Atway S, Anthony M, Kline D, Kissel JT. Foot measures in patients with pes cavus with and without charcot-marie-tooth disease: A pilot study. Muscle Nerve. 2019 01; 59(1):122-125. PMID: 30039580.
      Citations:    
    42. Caterino JM, Kline DM, Leininger R, Southerland LT, Carpenter CR, Baugh CW, Pallin DJ, Hunold KM, Stevenson KB. Nonspecific Symptoms Lack Diagnostic Accuracy for Infection in Older Patients in the Emergency Department. J Am Geriatr Soc. 2019 03; 67(3):484-492. PMID: 30467825.
      Citations:    
    43. Kelly KM, Borstad AL, Kline D, Gauthier LV. Improved quality of life following constraint-induced movement therapy is associated with gains in arm use, but not motor improvement. Top Stroke Rehabil. 2018 10; 25(7):467-474. PMID: 30246613.
      Citations:    
    44. Mundy-Bosse B, Denlinger N, McLaughlin E, Chakravarti N, Hwang S, Chen L, Mao HC, Kline D, Youssef Y, Kohnken R, Lee DA, Lozanski G, Freud AG, Porcu P, William B, Caligiuri MA, Mishra A. Highly cytotoxic natural killer cells are associated with poor prognosis in patients with cutaneous T-cell lymphoma. Blood Adv. 2018 08 14; 2(15):1818-1827. PMID: 30054309.
      Citations:    
    45. Prior DE, Nurre E, Roller SL, Kline D, Panara R, Stino AM, Davis JA, Freimer ML, Arnold WD. Infections and the relationship to treatment in neuromuscular autoimmunity. Muscle Nerve. 2018 06; 57(6):927-931. PMID: 29211921.
      Citations:    
    46. Vaughn JL, Kline D, Denlinger NM, Andritsos LA, Exline MC, Walker AR. Predictive performance of early warning scores in acute leukemia patients receiving induction chemotherapy. Leuk Lymphoma. 2018 06; 59(6):1498-1500. PMID: 28901797.
      Citations:    
    47. Arnold WD, Kline D, Sanderson A, Hawash AA, Bartlett A, Novak KR, Rich MM, Kissel JT. Open-label trial of ranolazine for the treatment of myotonia congenita. Neurology. 2017 Aug 15; 89(7):710-713. PMID: 28710329.
      Citations:    
    48. Makki N, Kline DM, Kanmanthareddy A, Mathelier H, Shreenivas S, Lilly SM. Procedure utilization, latency and mortality: Weekend versus Weekday admission for Myocardial Infarction. Journal of Cardiology and Cardiovascular Medicine. 2017; 2(1):020-025.
    49. Caterino JM, Leininger R, Kline DM, Southerland LT, Khaliqdina S, Baugh CW, Pallin DJ, Stevenson KB. Accuracy of Current Diagnostic Criteria for Acute Bacterial Infection in Older Adults in the Emergency Department. J Am Geriatr Soc. 2017 Aug; 65(8):1802-1809. PMID: 28440855.
      Citations:    
    50. McKnight ER, Bonny AE, Lange HLH, Kline DM, Abdel-Rasoul M, Gay JR, Matson SC. Statewide opioid prescriptions and the prevalence of adolescent opioid misuse in Ohio. Am J Drug Alcohol Abuse. 2017 05; 43(3):299-305. PMID: 27646841.
      Citations:    
    51. Kline D, Andridge R, Kaizar E. Comparing multiple imputation methods for systematically missing subject-level data. Res Synth Methods. 2017 Jun; 8(2):136-148. PMID: 26679326.
      Citations:    
    52. Wang H, Schwaderer AL, Kline J, Spencer JD, Kline D, Hains DS. Contribution of structural domains to the activity of ribonuclease 7 against uropathogenic bacteria. Antimicrob Agents Chemother. 2013 Feb; 57(2):766-74. PMID: 23183439.
      Citations:    
    53. Carpenter A, Paulus A, Robinson M, Bates CM, Robinson ML, Hains D, Kline D, McHugh KM. 3-Dimensional morphometric analysis of murine bladder development and dysmorphogenesis. Dev Dyn. 2012 Mar; 241(3):522-33. PMID: 22275180.
      Citations:    
    54. Seibert SM, King TS, Kline D, Mende C, Craig T. Reliability of skin test results when read at different time points. Allergy Asthma Proc. 2011 May-Jun; 32(3):203-5. PMID: 21703100.
      Citations:    
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