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David M. Kline PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentPHS-Biostatistics and Data Science (Public Health Sciences)
Address
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentEpidemiology & Prevention (Public Health Sciences)


    Collapse Biography 
    Collapse education and training
    Messiah College, Grantham, PABA05/2010Mathematics
    The Ohio State University, Columbus, OHMS03/2012Statistics
    The Ohio State University, Columbus, OHPhD12/2015Biostatistics
    Collapse awards and honors
    2006Honors Program, Messiah College
    2010Department Honors, Messiah College Department of Mathematics
    2010Lubrizol Fellowship, The Ohio State University Department of Statistics
    2010University Fellowship, The Ohio State University
    2014Lester R. Curtin Award, American Statistical Association
    2015CSP Best Student Poster Runner-up, American Statistical Association
    2020Excellence in Teaching Award, The Ohio State University Department of Biomedical Informatics
    2022Top 10 Research Paper, Wake Forest University School of Medicine Division of Public Health Sciences
    2023Top 10 Research Paper, Wake Forest University School of Medicine Division of Public Health Sciences

    Collapse Overview 
    Collapse overview
    I am an Associate Professor and Interim Vice Chair in the Department of Biostatistics and Data Science in the Division of Public Health Sciences at Wake Forest University School of Medicine. I am secondary faculty in the Department of Epidemiology and Prevention and Affiliate Faculty in the Department of Statistical Sciences. Previously, I was an Assistant Professor in the Department of Biomedical Informatics and a member of the Center for Biostatistics at The Ohio State University. I earned my PhD in Biostatistics from The Ohio State University in 2015. I joined the faculty at Wake Forest University School of Medicine in 2021.

    Public health surveillance involves the analysis and interpretation of health-related data essential to planning, implementation and evaluation of public health policy and practice. My research is focused on developing biostatistical methodology to overcome challenges in public health surveillance and address key problems in population health and epidemiology. Specifically, I work on developing multivariate Bayesian hierarchical models for spatio-temporal disease mapping, leveraging multiple sources of data to address complex social and epidemiological problems, like the opioid epidemic. I am committed to collaborating with subject area experts so that we can leverage our collective expertise to best address challenging scientific questions of interest.

    Collapse Research 
    Collapse research activities and funding
    R21DA045236     (KLINE, DAVID M.)Sep 15, 2018 - Aug 31, 2021
    NIH
    A Bayesian Spatio-Temporal Approach for Estimating County-Level Opioid Misuse Rates in Ohio
    Role: Principal Investigator
    R01HS027200     (HEBERT, COURTNEY L.)Sep 30, 2019 - Aug 31, 2024
    NIH
    GeoHAI: A novel geographic tool for Hospital Acquired Infection visualization and assessment
    Role: Co-Investigator
    F30DA050423     (BROOK, DANIEL)Apr 1, 2020 - Mar 31, 2024
    NIH
    Buprenorphine, Hepatitis C Virus and Their Relationship in Rural US Populations
    Role: Mentor
    R01NR019512     (RHODES, SCOTT D)Aug 27, 2020 - May 31, 2025
    NIH
    Harnessing the power of peer navigation and mHealth to reduce health disparities in Appalachia
    Role: Co-Investigator
    R01DA052214     (KLINE, DAVID M.)Sep 1, 2021 - Jun 30, 2025
    NIH
    Spatio-temporal Methods for Surveillance of the Opioid Syndemic
    Role: Principal Investigator
    LDRD 3T06A-XXH6     (KAUFELD, KIMBERLY)Oct 1, 2021 - Sep 30, 2024
    Los Alamos National Laboratory
    Assessing environmental and health impacts of airborne particles
    Role: Co-Investigator
    F31DA054752     (ESTADT, ANGELA T)May 3, 2022 - May 2, 2025
    NIH
    The effect of opioids, stimulants, and the simultaneous use of both on the hepatitis C virus (HCV) cascade of care in rural communities in the United States
    Role: Mentor
    U24DA057612     (ADAMS, MEREDITH C. B.)Sep 30, 2022 - Aug 31, 2027
    NIH
    WF DISC: Navigating Data Solutions for Chronic Pain and Opioid Use Disorder
    Role: Consultant
         (JENSEN, ELIZABETH)Jan 1, 2023 - Dec 31, 2024
    The Duke Endowment
    Assessment of a postpartum, remote blood pressure monitoring intervention for reduction in disparities hypertensive-associated readmissions and healthcare costs
    Role: Co-Investigator
         (JENSEN, ELIZABETH)Jan 1, 2024 - Dec 31, 2026
    The Duke Endowment
    Evaluation of a Health System Integrated Model for Postpartum Education and Support in Rural Populations – NEST Rural
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Estadt AT, Kline D, Miller WC, Feinberg J, Hurt CB, Mixson LS, Friedmann PD, Lowe K, Tsui JI, Young AM, Cooper H, Korthuis PT, Pho MT, Jenkins W, Westergaard RP, Go VF, Brook D, Smith G, Rice DR, Lancaster KE. Differences in hepatitis C virus (HCV) testing and treatment by opioid, stimulant, and polysubstance use among people who use drugs in rural U.S. communities. Harm Reduct J. 2024 Nov 29; 21(1):214. PMID: 39614319.
      Citations:    
    2. Chakraborty P, Ning X, McNeill M, Kline DM, Shoben AB, Miller WC, Norris Turner A. Analysis of 2019 Ohio Disease Intervention Specialist (DIS) Records for Syphilis Cases Using Clustering Algorithms. Sex Transm Dis. 2024 Oct 31. PMID: 39481010.
      Citations:    
    3. Wang J, Kline DM, White LF. On the estimation of population size-A comparison of capture-recapture and multiplier-benchmark methods. Stat Methods Med Res. 2024 Sep 30; 9622802241275413. PMID: 39350602.
      Citations:    
    4. Kline D, Hepler SA, Krawczyk N, Rivera-Aguirre A, Waller LA, Cerdá M. A state-level history of opioid overdose deaths in the United States: 1999-2021. PLoS One. 2024; 19(9):e0309938. PMID: 39240938.
      Citations:    
    5. Hostettler LD, Kline DM, Moore JB, Nightingale CL, Miller PR, Nunn AM, Carmichael SP. Evaluation of a Novel Emergency General Surgery Handover: A Prospective Feasibility Study. J Surg Res. 2024 Aug 29; 302:715-723. PMID: 39214063.
      Citations:    
    6. Carmichael SP, Chandra PK, Vaughan JW, Kline DM, Ip EH, Holcomb JB, Atala AJ. A Scoping Review of Animal Models for Development of Abdominal Adhesion Prevention Strategies. J Surg Res. 2024 Aug 16; 302:364-375. PMID: 39153357.
      Citations:    
    7. Kline DM, Santaella-Tenorio J, Ariadne RA, Hepler S, Cerda M. Kline et al. respond to "Motivating better methods-and better data collection-for measuring prevalence of drug misuse". Am J Epidemiol. 2024 Aug 06. PMID: 39108163.
      Citations:    
    8. Hepler SA, Kaufeld KA, Kline D, Greene A, Gorris ME. Estimating coccidioidomycosis endemicity while accounting for imperfect detection using spatio - temporal occupancy modeling. Am J Epidemiol. 2024 Jul 16. PMID: 39013787.
      Citations:    
    9. South AM, Giammattei VC, Bagley KW, Bakhoum CY, Beasley WH, Bily MB, Biswas S, Bridges AM, Byfield RL, Campbell JF, Chanchlani R, Chen A, D'Agostino McGowan L, Downs SM, Fergeson GM, Greenberg JH, Hill-Horowitz TA, Jensen ET, Kallash M, Kamel M, Kiessling SG, Kline DM, Laisure JR, Liu G, Londeree J, Lucas CB, Mannemuddhu SS, Mao KR, Misurac JM, Murphy MO, Nugent JT, Onugha EA, Pudupakkam A, Redmond KM, Riar S, Sethna CB, Siddiqui S, Thumann AL, Uss SR, Vincent CL, Viviano IV, Walsh MJ, White BD, Woroniecki RP, Wu M, Yamaguchi I, Yun E, Weaver DJ. The Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): Rationale and Methods. Am J Epidemiol. 2024 Jun 17. PMID: 38881045.
      Citations:    
    10. Carmichael SP, Chandra PK, Vaughan JW, Kline DM, Ip EH, Holcomb JB, Atala A. Prevention of post-operative adhesions: Model development and pilot outcomes of human placental stem cell-based interventions. Transfusion. 2024 May 01. PMID: 38693056.
      Citations:    
    11. Kline DM. Strengthening a solid foundation: The role of spatial epidemiology within contemporary epidemiology. Epidemiology. 2024 Mar 22. PMID: 38534154.
      Citations:    
    12. Wang J, Bernson D, Erdman EA, Villani J, Chandler R, Kline D, White LF, Barocas JA. Intersectional inequities and longitudinal prevalence estimates of opioid use disorder in Massachusetts 2014-2020: a multi-sample capture-recapture analysis. Lancet Reg Health Am. 2024 Apr; 32:100709. PMID: 38510791.
      Citations:    
    13. Santaella-Tenorio J, Hepler SA, Rivera-Aguirre A, Kline DM, Cerda M. Estimation of opioid misuse prevalence in New York State counties, 2007-2018. A Bayesian spatio-temporal abundance model approach. Am J Epidemiol. 2024 Mar 06. PMID: 38456752.
      Citations:    
    14. Kegelmeyer DA, Minarsch R, Kostyk SK, Kline D, Smith R, Kloos AD. Use of a Robotic Walking Device for Home and Community Mobility in Parkinson Disease: A Randomized Controlled Trial. J Neurol Phys Ther. 2024 Mar 04. PMID: 38441461.
      Citations:    
    15. Ortiz R, Kershaw KN, Zhao S, Kline D, Brock G, Jaffee S, Golden SH, Ogedegbe G, Carroll J, Seeman TE, Joseph JJ. Evidence for the Association Between Adverse Childhood Family Environment, Child Abuse, and Caregiver Warmth and Cardiovascular Health Across the Lifespan: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Circ Cardiovasc Qual Outcomes. 2024 Jan 23; e009794. PMID: 38258561.
      Citations:    
    16. Bulthuis MS, van Leeuwen SJM, Thomas RZ, van Gennip LLA, Whiteside HM, Isom S, Kline DM, Laheij AMGA, Raber-Durlacher JE, Hasséus B, Johansson JE, Hovan AJ, Brennan MT, von Bültzingslöwen I, Huysmans MDNJM, Blijlevens NMA. Subjective oral dryness following haematopoietic cell transplantation: a report from the Orastem study. Transplant Cell Ther. 2024 Jan 17. PMID: 38242439.
      Citations:    
    17. Estadt AT, White BN, Ricks JM, Lancaster KE, Hepler S, Miller WC, Kline D. The impact of fentanyl on state- and county-level psychostimulant and cocaine overdose death rates by race in Ohio from 2010 to 2020: a time series and spatiotemporal analysis. Harm Reduct J. 2024 Jan 17; 21(1):13. PMID: 38233924.
      Citations:    
    18. Joseph JJ, Williams A, Azap RA, Zhao S, Brock G, Kline D, Odei JB, Foraker R, Sims M, Brewer LC, Gray DM, Nolan TS. Role of Sex in the Association of Socioeconomic Status With Cardiovascular Health in Black Americans: The Jackson Heart Study. J Am Heart Assoc. 2023 Dec 05; 12(23):e030695. PMID: 38038179.
      Citations:    
    19. Sucaldito AD, Tanner AE, Mann-Jackson L, Alonzo J, Garcia M, Chaffin JW, Faller R, McGuire T, Jibriel M, Mertus S, Kline DM, Russell L, Stafford J, Aviles LR, Weil PH, Wilkin AM, Rhodes SD. Exploring Individual and Contextual Factors Associated With Sexual Risk and Substance Use Among Underserved GBQMSM and Transgender and Nonbinary Persons in South Central Appalachia. AIDS Educ Prev. 2023 Dec; 35(6):495-506. PMID: 38096454.
      Citations:    
    20. Stino AM, Bumma N, Smith R, Davalos L, Allen J, Ye JC, Pianko M, Campagnaro E, Fierro C, Awad A, Murdock B, Pietrzak M, Loszanski G, Kline DM, Efebera Y, Elsheikh B. Lenalidomide in the treatment of anti-myelin-associated glycoprotein neuropathy: A phase 1 study to identify the maximum tolerated dose. Eur J Neurol. 2023 Nov 28. PMID: 38015467.
      Citations:    
    21. Lang K, Atchison TJ, Singh P, Kline DM, Odei JB, Martin JL, Smyer JF, Day SR, Hebert CL. Describing the monthly variability of hospital-onset Clostridioides difficile during early coronavirus disease 2019 (COVID-19) using electronic health record data. Infect Control Hosp Epidemiol. 2023 Oct 09; 1-6. PMID: 37807908.
      Citations:    
    22. Estadt AT, Miller WC, Kline D, Whitney BM, Young AM, Todd Korthuis P, Stopka TJ, Feinberg J, Zule WA, Pho MT, Friedmann PD, Westergaard RP, Eagen KV, Seaman A, Ma J, Go VF, Lancaster KE. Associations of hepatitis C virus (HCV) antibody positivity with opioid, stimulant, and polysubstance injection among people who inject drugs (PWID) in rural U.S. communities. Int J Drug Policy. 2023 Oct 06; 104222. PMID: 37806839.
      Citations:    
    23. Wang J, Doogan N, Thompson K, Bernson D, Feaster D, Villani J, Chandler R, White LF, Kline D, Barocas JA. Massachusetts Prevalence of Opioid Use Disorder Estimation Revisited: Comparing a Bayesian Approach to Standard Capture-Recapture Methods. Epidemiology. 2023 Nov 01; 34(6):841-849. PMID: 37757873.
      Citations:    
    24. Kline D, Bunting AM, Hepler SA, Rivera-Aguirre A, Krawczyk N, Cerda M. State-Level History of Overdose Deaths Involving Stimulants in the United States, 1999?2020. Am J Public Health. 2023 Sep; 113(9):991-999. PMID: 37556789.
      Citations:    
    25. Rayo MF, Faulkner D, Kline D, Thornhill Iv T, Malloy S, Della Vella D, Morey DA, Zhang N, Gonsalves G. Using Bandit Algorithms to Maximize SARS-CoV-2 Case-Finding: Evaluation and Feasibility Study. JMIR Public Health Surveill. 2023 Aug 15; 9:e39754. PMID: 37581924.
      Citations:    
    26. Dong Q, Kline D, Hepler SA. A Bayesian Spatio-temporal Model to Optimize Allocation of Buprenorphine in North Carolina. Stat Public Policy (Phila). 2023; 10(1). PMID: 37545670.
      Citations:    
    27. Kwon J, Kline DM, Hepler SA. A spatio-temporal hierarchical model to account for temporal misalignment in American Community Survey explanatory variables. Spat Spatiotemporal Epidemiol. 2023 Aug; 46:100593. PMID: 37500228.
      Citations:    
    28. Kline D, Waller LA, McKnight E, Bonny A, Miller WC, Hepler SA. A Dynamic Spatial Factor Model to Describe the Opioid Syndemic in Ohio. Epidemiology. 2023 May 05. PMID: 37155617.
      Citations:    
    29. Joseph JJ, Kluwe B, Zhao S, Kline D, Nedungadi D, Brock G, Hsueh WA, Golden SH. The association of aldosterone and endothelin-1 with incident diabetes among African Americans: The Jackson Heart Study. Endocr Metab Sci. 2023 Jun 30; 11. PMID: 37475850.
      Citations:    
    30. Lee G, Kluwe B, Zhao S, Kline D, Nedungadi D, Brock GN, Odei JB, Kesireddy V, Pohlman N, Sims M, Effoe VS, Wu WC, Kalyani RR, Wand GS, Echouffo-Tcheugui J, Golden SH, Joseph JJ. Adiposity, aldosterone and plasma renin activity among African Americans: The Jackson Heart Study. Endocr Metab Sci. 2023 Jun 30; 11. PMID: 37475849.
      Citations:    
    31. Kluwe B, Pohlman N, Kesireddy V, Zhao S, Tan Y, Kline D, Brock G, Odei JB, Effoe VS, Tcheugui JBE, Kalyani RR, Sims M, Taylor HA, Mongraw-Chaffin M, Akhabue E, Joseph JJ. The role of aldosterone and ideal cardiovascular health in incident cardiovascular disease: The Jackson heart study. Am J Prev Cardiol. 2023 Jun; 14:100494. PMID: 37114212.
      Citations:    
    32. Carmichael SP, Kline DA. Categories of Evidence and Methods in Surgical Decision-Making. Surg Clin North Am. 2023 Apr; 103(2):233-245. PMID: 36948715.
      Citations:    
    33. McKnight ER, Dong Q, Brook DL, Hepler SA, Kline DM, Bonny AE. A Descriptive Study on Opioid Misuse Prevalence and Office-Based Buprenorphine Access in Ohio Prior to the Removal of the Drug Addiction Treatment Act of 2000 Waiver. Cureus. 2023 Mar; 15(3):e36903. PMID: 37139287.
      Citations:    
    34. Carmichael SP, Kline DM, Mowery NT, Miller PR, Meredith JW, Hanchate AD. Geographic Variation in Operative Management of Adhesive Small Bowel Obstruction. J Surg Res. 2023 Feb 06; 286:57-64. PMID: 36753950.
      Citations:    
    35. Hepler SA, Kline DM, Bonny A, McKnight E, Waller LA. An integrated abundance model for estimating county-level prevalence of opioid misuse in Ohio. J R Stat Soc Ser A Stat Soc. 2023 Jan; 186(1):43-60. PMID: 37261313.
      Citations:    
    36. Kesireddy V, Kluwe B, Pohlman N, Zhao S, Tan Y, Kline D, Brock G, Odei JB, Effoe VS, Echouffo-Tcheugui JB, Kalyani RR, Sims M, Taylor HA, Mongraw-Chaffin M, Akhabue E, Joseph JJ. The role of aldosterone and ideal cardiovascular health in incident diabetes: The Jackson Heart Study. Am J Prev Cardiol. 2023 Mar; 13:100466. PMID: 36798725.
      Citations:    
    37. Belany P, Kackley ML, Zhao S, Kluwe B, Buga A, Crabtree C, Nedungadi D, Kline D, Brock G, Simonetti OP, Volek JS, Joseph JJ. Effects of Hypocaloric Low-Fat, Ketogenic and Ketogenic & Ketone Supplement diets on Aldosterone and Renin. J Clin Endocrinol Metab. 2023 Jan 11. PMID: 36629058.
      Citations:    
    38. Ortiz R, Zhao S, Kline DM, Brock G, Carroll JE, Seeman TE, Jaffee SR, Berger JS, Golden SH, Carnethon MR, Joseph JJ. Childhood environment early life stress, caregiver warmth, and associations with the cortisol diurnal curve in adulthood: The coronary artery risk development in young adults (CARDIA) study. Psychoneuroendocrinology. 2022 Dec 22; 149:106008. PMID: 36599226.
      Citations:    
    39. Bressler CJ, Malthaner L, Pondel N, Letson MM, Kline D, Leonard JC. Identifying Children at Risk for Maltreatment Using Emergency Medical Services' Data: An Exploratory Study. Child Maltreat. 2022 Oct 07; 10775595221127925. PMID: 36205182.
      Citations:    
    40. Hu J, Kline DM, Tan A, Zhao S, Brock G, Mion LC, Efird JT, Wang D, Sims M, Wu B, Mongraw-Chaffin M, Joseph JJ. Association Between Social Determinants of Health and Glycemic Control Among African American People with Type 2 diabetes: The Jackson Heart Study. Ann Behav Med. 2022 Oct 05. PMID: 36197118.
      Citations:    
    41. Joseph JJ, Rajwani A, Roper D, Zhao S, Kline D, Odei J, Brock G, Echouffo-Tcheugui JB, Kalyani RR, Bertoni AG, Effoe VS, Sims M, Wu WC, Wand GS, Golden SH. Associations of Cardiometabolic Multimorbidity With All-Cause and Coronary Heart Disease Mortality Among Black Adults in the Jackson Heart Study. JAMA Netw Open. 2022 Oct 03; 5(10):e2238361. PMID: 36282500.
      Citations:    
    42. Williams A, Zhao S, Brock G, Kline D, Echouffo-Tcheugui JB, Effoe VS, Bertoni AG, Michos ED, de Boer IH, Kestenbaum B, Golden SH, Joseph JJ. Vitamin D, parathyroid hormone, glucose metabolism and incident diabetes in the multiethnic study of atherosclerosis. BMJ Open Diabetes Res Care. 2022 Sep; 10(5). PMID: 36162866.
      Citations:    
    43. Moore T, Kline D, Palettas M, Bodine T. Fall Prevention With the Smart Socks System Reduces Hospital Fall Rates. J Nurs Care Qual. 2022 Aug 19. PMID: 35984693.
      Citations:    
    44. Williams A, Shrodes JC, Radabaugh JN, Braun A, Kline D, Zhao S, Brock G, Nolan TS, Garner JA, Spees CK, Joseph JJ. Outcomes of Cooking Matters for Diabetes: A 6-week Randomized, Controlled Cooking and Diabetes Self-Management Education Intervention. J Acad Nutr Diet. 2022 Aug 09. PMID: 35961614.
      Citations:    
    45. Shrodes JC, Williams A, Nolan TS, Radabaugh JN, Braun A, Kline D, Zhao S, Brock G, Garner JA, Spees CK, Joseph JJ. Feasibility of Cooking Matters for Diabetes: A 6-week Randomized, Controlled Cooking and Diabetes Self-Management Education Intervention. J Acad Nutr Diet. 2022 Aug 06. PMID: 35944873.
      Citations:    
    46. Townsend TN, Hamilton LK, Rivera-Aguirre A, Davis CS, Pamplin Ii JR, Kline D, Rudolph KE, Cerdá M. Using an Inverted Synthetic Control Method to Estimate Effects of Recent Overdose Good Samaritan Laws, Overall and by Black/White Race. Am J Epidemiol. 2022 Jul 22. PMID: 35872589.
      Citations:    
    47. Hepler SA, Kaufeld KA, Benedict K, Toda M, Jackson BR, Liu X, Kline D. Integrating Public Health Surveillance and Environmental Data to Model Presence of Histoplasma in the United States. Epidemiology. 2022 May 05. PMID: 35545229.
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    48. Coccaro EF, Drossos T, Kline D, Lazarus S, Joseph JJ, de Groot M. Diabetes distress, emotional regulation, HbA1c in people with diabetes and A controlled pilot study of an emotion-focused behavioral therapy intervention in adults with type 2 diabetes. Prim Care Diabetes. 2022 Mar 11. PMID: 35288059.
      Citations:    
    49. Kline D, Hyder A, Liu E, Rayo M, Malloy S, Root E. A Bayesian spatio-temporal nowcasting model for public health decision-making and surveillance. Am J Epidemiol. 2022 Feb 28. PMID: 35225333.
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    50. Townsend T, Kline D, Rivera-Aguirre A, Bunting AM, Mauro PM, Marshall BDL, Martins SS, Cerdá M. Racial/Ethnic and Geographic Trends in Combined Stimulant/Opioid Overdoses, 2007-2019. Am J Epidemiol. 2022 Feb 08. PMID: 35142341.
      Citations:    
    51. Turner AN, Kline D, Norris A, Phillips WG, Root E, Wakefield J, Li ZR, Lemeshow S, Spahnie M, Luff A, Chu Y, Francis MK, Gallo M, Chakraborty P, Lindstrom M, Lozanski G, Miller W, Clark S. Prevalence of current and past COVID-19 in Ohio adults. Ann Epidemiol. 2021 Dec 15. PMID: 34921991.
      Citations:    
    52. Donneyong MM, Fischer MA, Langston MA, Joseph JJ, Juarez PD, Zhang P, Kline DM. Examining the Drivers of Racial/Ethnic Disparities in Non-Adherence to Antihypertensive Medications and Mortality Due to Heart Disease and Stroke: A County-Level Analysis. Int J Environ Res Public Health. 2021 12 02; 18(23). PMID: 34886429.
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    53. Hepler SA, Waller LA, Kline DM. A MULTIVARIATE SPATIOTEMPORAL CHANGE-POINT MODEL OF OPIOID OVERDOSE DEATHS IN OHIO. Ann Appl Stat. 2021 Sep; 15(3):1329-1342. PMID: 34721750.
      Citations:    
    54. Joseph JJ, Kluwe B, Echouffo-Tcheugui JB, Zhao S, Brock G, Kline D, Odei JB, Kalyani RR, Bradley DP, Hsueh WA, Sims M, Golden SH. Association of Adiposity With Incident Diabetes Among Black Adults in the Jackson Heart Study. J Am Heart Assoc. 2021 Sep 21; 10(18):e020716. PMID: 34493073.
      Citations:    
    55. Arnold WD, Severyn S, Zhao S, Kline D, Linsenmayer M, Kelly K, Tellez M, Bartlett A, Heintzman S, Reynolds J, Sterling G, Weaver T, Rajneesh K, Burghes AHM, Kolb SJ, Elsheikh B. Persistent neuromuscular junction transmission defects in adults with spinal muscular atrophy treated with nusinersen. BMJ Neurol Open. 2021; 3(2):e000164. PMID: 34466806.
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    56. Hill EB, Watson JR, Cohen DM, Kline D, Schwaderer AL, Spencer JD. Novel urine biomarkers to distinguish UTI from culture-negative pyuria. Pediatr Nephrol. 2021 Jul 16. PMID: 34272611.
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    57. Kline D, Li Z, Chu Y, Wakefield J, Miller WC, Norris Turner A, Clark SJ. Estimating seroprevalence of SARS-CoV-2 in Ohio: A Bayesian multilevel poststratification approach with multiple diagnostic tests. Proc Natl Acad Sci U S A. 2021 06 29; 118(26). PMID: 34172581.
      Citations:    
    58. Gonsalves GS, Copple JT, Paltiel AD, Fenichel EP, Bayham J, Abraham M, Kline D, Malloy S, Rayo MF, Zhang N, Faulkner D, Morey DA, Wu F, Thornhill T, Iloglu S, Warren JL. Maximizing the Efficiency of Active Case Finding for SARS-CoV-2 Using Bandit Algorithms. Med Decis Making. 2021 11; 41(8):970-977. PMID: 34120510.
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    59. Sotos-Prieto M, Zhao S, Kline D, Brock G, Gooding H, Mattei J, Rodriguez-Artalejo F, Min YI, Rimm EB, Tucker KL, Joseph JJ. Application of a Lifestyle-Based Score to Predict Cardiovascular Risk in African Americans: The Jackson Heart Study. J Clin Med. 2021 May 22; 10(11). PMID: 34067473.
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    60. Elsheikh B, Severyn S, Zhao S, Kline D, Linsenmayer M, Kelly K, Tellez M, Bartlett A, Heintzman S, Reynolds J, Sterling G, Weaver T, Rajneesh K, Kolb SJ, Arnold WD. Safety, Tolerability, and Effect of Nusinersen Treatment in Ambulatory Adults With 5q-SMA. Front Neurol. 2021; 12:650535. PMID: 34093395.
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    61. Brook DL, Hetrick AT, Chettri SR, Schalkoff CA, Sibley AL, Lancaster KE, Go VF, Miller WC, Kline DM. The Relationship Between Hepatitis C Virus Rates and Office-Based Buprenorphine Access in Ohio. Open Forum Infect Dis. 2021 Jun; 8(6):ofab242. PMID: 34159217.
      Citations:    
    62. Schoenfield L, Janse S, Kline D, Aronow ME, Singh AD, Craven C, Abdel-Rahman M, Cebulla CM. Estrogen Receptor Is Expressed in Uveal Melanoma: A Potential Target for Therapy. Ocul Oncol Pathol. 2021 Sep; 7(4):303-310. PMID: 34604204.
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    63. Elsheikh B, Severyn S, Zhao S, Kline D, Linsenmayer M, Kelly K, Tellez M, Bartlett A, Heintzman S, Reynolds J, Sterling G, Weaver T, Rajneesh K, Kolb SJ, Arnold WD. Safety, Tolerability, and Effect of Nusinersen in Non-ambulatory Adults With Spinal Muscular Atrophy. Front Neurol. 2021; 12:650532. PMID: 33935949.
      Citations:    
    64. Kline D, Pan Y, Hepler SA. Spatiotemporal Trends in Opioid Overdose Deaths by Race for Counties in Ohio. Epidemiology. 2021 03 01; 32(2):295-302. PMID: 33394810.
      Citations:    
    65. Joseph JJ, Pohlman NK, Zhao S, Kline D, Brock G, Echouffo-Tcheugui JB, Sims M, Effoe VS, Wu WC, Kalyani RR, Wand GS, Kluwe B, Hsueh WA, Abdalla M, Shimbo D, Golden SH. Association of Serum Aldosterone and Plasma Renin Activity With Ambulatory Blood Pressure in African Americans: The Jackson Heart Study. Circulation. 2021 Jun 15; 143(24):2355-2366. PMID: 33605160.
      Citations:    
    66. Kluwe B, Zhao S, Kline D, Ortiz R, Brock G, Echouffo-Tcheugui JB, Sims M, Kalyani RR, Golden SH, Joseph JJ. Adiposity Measures and Morning Serum Cortisol in African Americans: Jackson Heart Study. Obesity (Silver Spring). 2021 02; 29(2):418-427. PMID: 33491313.
      Citations:    
    67. Linakis SW, Lloyd JK, Kline D, Holmes JF, Stanley RM, Leonard JC. Field triage of children with abdominal trauma. Trauma. 2021; 23(1):55-63.
    68. Jamieson N, Akande M, Karsies T, Smith RM, Kline D, Spencer SP. Respiratory Pathogen Detection in Pediatric Patients Intubated for Presumed Infection. Pediatr Emerg Care. 2020 Nov 16. PMID: 33201137.
      Citations:    
    69. Kline D, Ji Y, Hepler S. A multivariate spatio-temporal model of the opioid epidemic in Ohio: A factor model approach. Health Serv Outcomes Res Methodol. 2021 Mar; 21:42-53. PMID: 34305443.
      Citations:    
    70. Kluwe B, Ortiz R, Odei JB, Zhao S, Kline D, Brock G, Echouffo-Tcheugui JB, Lee JM, Lazarus S, Seeman T, Greenland P, Needham B, Carnethon MR, Golden SH, Joseph JJ. The association of cortisol curve features with incident diabetes among whites and African Americans: The CARDIA study. Psychoneuroendocrinology. 2021 01; 123:105041. PMID: 33227536.
      Citations:    
    71. Moberly AC, Vasil K, Baxter J, Klamer B, Kline D, Ray C. Comprehensive auditory rehabilitation in adults receiving cochlear implants: A pilot study. Laryngoscope Investig Otolaryngol. 2020 Oct; 5(5):911-918. PMID: 33134539.
      Citations:    
    72. Dias JP, Joseph JJ, Kluwe B, Zhao S, Shardell M, Seeman T, Needham BL, Wand GS, Kline D, Brock G, Castro-Diehl C, Golden SH. The longitudinal association of changes in diurnal cortisol features with fasting glucose: MESA. Psychoneuroendocrinology. 2020 09; 119:104698. PMID: 32674946.
      Citations:    
    73. Meyer AP, Roggenbuck J, LoRusso S, Kissel J, Smith RM, Kline D, Arnold WD. Genotype-Phenotype Correlations and Characterization of Medication Use in Inherited Myotonic Disorders. Front Neurol. 2020; 11:593. PMID: 32670189.
      Citations:    
    74. Kline D, Hepler SA. Estimating the burden of the opioid epidemic for adults and adolescents in Ohio counties. Biometrics. 2021 06; 77(2):765-775. PMID: 32413155.
      Citations:    
    75. Battisti KA, Cohen DM, Bourgeois T, Kline D, Zhao S, Iyer MS. A Paucity of Code Status Documentation Despite Increasing Complex Chronic Disease in Pediatrics. J Palliat Med. 2020 11; 23(11):1452-1459. PMID: 32213109.
      Citations:    
    76. Karamians R, Proffitt R, Kline D, Gauthier LV. Effectiveness of Virtual Reality- and Gaming-Based Interventions for Upper Extremity Rehabilitation Poststroke: A Meta-analysis. Arch Phys Med Rehabil. 2020 05; 101(5):885-896. PMID: 31821799.
      Citations:    
    77. Saba K, Hossieny ZS, Arnold WD, Elsheikh B, Palettas M, Kline D, Stino AM. CSF Protein Level and Short-Term Prognosis in Guillain-Barré Syndrome. J Clin Neuromuscul Dis. 2019 Dec; 21(2):118-119. PMID: 31743257.
      Citations:    
    78. Young NA, Brown MP, Peng J, Kline D, Reider C, Deogaonkar M. Predicting extended hospital stay after deep brain stimulation surgery in Parkinson's patients. J Clin Neurosci. 2019 Nov; 69:241-244. PMID: 31431404.
      Citations:    
    79. Liu A, Kline DM, Brock GN, Bonsu BK. Multistate model of the patient flow process in the pediatric emergency department. PLoS One. 2019; 14(7):e0219514. PMID: 31291345.
      Citations:    
    80. Gillespie SL, Anderson CM, Zhao S, Tan Y, Kline D, Brock G, Odei J, O'Brien E, Sims M, Lazarus SA, Hood DB, Williams KP, Joseph JJ. Allostatic load in the association of depressive symptoms with incident coronary heart disease: The Jackson Heart Study. Psychoneuroendocrinology. 2019 11; 109:104369. PMID: 31307010.
      Citations:    
    81. Hepler S, McKnight E, Bonny A, Kline D. A Latent Spatial Factor Approach for Synthesizing Opioid-Associated Deaths and Treatment Admissions in Ohio Counties. Epidemiology. 2019 05; 30(3):365-370. PMID: 30882402.
      Citations:    
    82. Kesireddy V, Tan Y, Kline D, Brock G, Odei JB, Kluwe B, Effoe VS, Echouffo Tcheugui JB, Kalyani RR, Sims M, Taylor HA, Mongraw-Chaffin M, Akhabue E, Joseph JJ. The Association of Life's Simple 7 with Aldosterone among African Americans in the Jackson Heart Study. Nutrients. 2019 Apr 26; 11(5). PMID: 31035479.
      Citations:    
    83. La Count S, Lovett ME, Zhao S, Kline D, O'Brien NF, Hall MW, Sribnick EA. Factors Associated With Poor Outcome in Pediatric Near-Hanging Injuries. J Emerg Med. 2019 Jul; 57(1):21-28. PMID: 31031070.
      Citations:    
    84. Suarez-Kelly LP, Yu L, Kline D, Schneider EB, Agnese DM, Carson WE. Increased breast cancer risk in women with neurofibromatosis type 1: a meta-analysis and systematic review of the literature. Hered Cancer Clin Pract. 2019; 17:12. PMID: 30962859.
      Citations:    
    85. Kloos AD, Kegelmeyer DA, Ambrogi K, Kline D, McCormack-Mager M, Schroeder B, Kostyk SK. The Step Test Evaluation of Performance on Stairs (STEPS): Validation and reliability in a neurological disorder. PLoS One. 2019; 14(3):e0213698. PMID: 30897107.
      Citations:    
    86. Kline D, Hepler S, Bonny A, McKnight E. A joint spatial model of opioid-associated deaths and treatment admissions in Ohio. Ann Epidemiol. 2019 05; 33:19-23. PMID: 30948153.
      Citations:    
    87. Wang H, Hecht S, Kline D, Leber AL. Staphylococcus aureus and methicillin resistance detection directly from pediatric samples using PCR assays with differential cycle threshold values for corroboration of methicillin resistance. J Microbiol Methods. 2019 04; 159:167-173. PMID: 30826439.
      Citations:    
    88. Bressler CJ, Letson MM, Kline D, McCarthy T, Davis J, Leonard JC. Characteristics of Neighborhoods Where Emergency Medical Services Encounter Children at Risk for Maltreatment. Prehosp Emerg Care. 2019 Sep-Oct; 23(5):672-682. PMID: 30703337.
      Citations:    
    89. Yackey K, Stukus K, Cohen D, Kline D, Zhao S, Stanley R. Off-label Medication Prescribing Patterns in Pediatrics: An Update. Hosp Pediatr. 2019 03; 9(3):186-193. PMID: 30745323.
      Citations:    
    90. Grisanti K, Martorano L, Redmond M, Scherzer R, Strothman K, Malthaner L, Davis J, Zhao S, Kline D, Leonard JC. Emergency Call Characteristics and EMS Dispatcher Protocol Adherence for Possible Anaphylaxis. Prehosp Emerg Care. 2019 Sep-Oct; 23(5):691-699. PMID: 30526221.
      Citations:    
    91. Echouffo-Tcheugui JB, Zhao S, Brock G, Matsouaka RA, Kline D, Joseph JJ. Visit-to-Visit Glycemic Variability and Risks of Cardiovascular Events and All-Cause Mortality: The ALLHAT Study. Diabetes Care. 2019 03; 42(3):486-493. PMID: 30659073.
      Citations:    
    92. Lorusso S, Kline D, Bartlett A, Freimer M, Agriesti J, Hawash AA, Rich MM, Kissel JT, David Arnold W. Open-label trial of ranolazine for the treatment of paramyotonia congenita. Muscle Nerve. 2019 02; 59(2):240-243. PMID: 30390395.
      Citations:    
    93. Wier CG, Crum AE, Reynolds AB, Iyer CC, Chugh D, Palettas MS, Heilman PL, Kline DM, Arnold WD, Kolb SJ. Muscle contractility dysfunction precedes loss of motor unit connectivity in SOD1(G93A) mice. Muscle Nerve. 2019 02; 59(2):254-262. PMID: 30370671.
      Citations:    
    94. Stino AM, Atway S, Anthony M, Kline D, Kissel JT. Foot measures in patients with pes cavus with and without charcot-marie-tooth disease: A pilot study. Muscle Nerve. 2019 01; 59(1):122-125. PMID: 30039580.
      Citations:    
    95. Caterino JM, Kline DM, Leininger R, Southerland LT, Carpenter CR, Baugh CW, Pallin DJ, Hunold KM, Stevenson KB. Nonspecific Symptoms Lack Diagnostic Accuracy for Infection in Older Patients in the Emergency Department. J Am Geriatr Soc. 2019 03; 67(3):484-492. PMID: 30467825.
      Citations:    
    96. Kelly KM, Borstad AL, Kline D, Gauthier LV. Improved quality of life following constraint-induced movement therapy is associated with gains in arm use, but not motor improvement. Top Stroke Rehabil. 2018 10; 25(7):467-474. PMID: 30246613.
      Citations:    
    97. Mundy-Bosse B, Denlinger N, McLaughlin E, Chakravarti N, Hwang S, Chen L, Mao HC, Kline D, Youssef Y, Kohnken R, Lee DA, Lozanski G, Freud AG, Porcu P, William B, Caligiuri MA, Mishra A. Highly cytotoxic natural killer cells are associated with poor prognosis in patients with cutaneous T-cell lymphoma. Blood Adv. 2018 08 14; 2(15):1818-1827. PMID: 30054309.
      Citations:    
    98. Prior DE, Nurre E, Roller SL, Kline D, Panara R, Stino AM, Davis JA, Freimer ML, Arnold WD. Infections and the relationship to treatment in neuromuscular autoimmunity. Muscle Nerve. 2018 06; 57(6):927-931. PMID: 29211921.
      Citations:    
    99. Vaughn JL, Kline D, Denlinger NM, Andritsos LA, Exline MC, Walker AR. Predictive performance of early warning scores in acute leukemia patients receiving induction chemotherapy. Leuk Lymphoma. 2018 06; 59(6):1498-1500. PMID: 28901797.
      Citations:    
    100. Arnold WD, Kline D, Sanderson A, Hawash AA, Bartlett A, Novak KR, Rich MM, Kissel JT. Open-label trial of ranolazine for the treatment of myotonia congenita. Neurology. 2017 Aug 15; 89(7):710-713. PMID: 28710329.
      Citations:    
    101. Makki N, Kline DM, Kanmanthareddy A, Mathelier H, Shreenivas S, Lilly SM. Procedure utilization, latency and mortality: Weekend versus Weekday admission for Myocardial Infarction. Journal of Cardiology and Cardiovascular Medicine. 2017; 2(1):020-025.
    102. Caterino JM, Leininger R, Kline DM, Southerland LT, Khaliqdina S, Baugh CW, Pallin DJ, Stevenson KB. Accuracy of Current Diagnostic Criteria for Acute Bacterial Infection in Older Adults in the Emergency Department. J Am Geriatr Soc. 2017 Aug; 65(8):1802-1809. PMID: 28440855.
      Citations:    
    103. McKnight ER, Bonny AE, Lange HLH, Kline DM, Abdel-Rasoul M, Gay JR, Matson SC. Statewide opioid prescriptions and the prevalence of adolescent opioid misuse in Ohio. Am J Drug Alcohol Abuse. 2017 05; 43(3):299-305. PMID: 27646841.
      Citations:    
    104. Kline D, Andridge R, Kaizar E. Comparing multiple imputation methods for systematically missing subject-level data. Res Synth Methods. 2017 Jun; 8(2):136-148. PMID: 26679326.
      Citations:    
    105. Wang H, Schwaderer AL, Kline J, Spencer JD, Kline D, Hains DS. Contribution of structural domains to the activity of ribonuclease 7 against uropathogenic bacteria. Antimicrob Agents Chemother. 2013 Feb; 57(2):766-74. PMID: 23183439.
      Citations:    
    106. Carpenter A, Paulus A, Robinson M, Bates CM, Robinson ML, Hains D, Kline D, McHugh KM. 3-Dimensional morphometric analysis of murine bladder development and dysmorphogenesis. Dev Dyn. 2012 Mar; 241(3):522-33. PMID: 22275180.
      Citations:    
    107. Seibert SM, King TS, Kline D, Mende C, Craig T. Reliability of skin test results when read at different time points. Allergy Asthma Proc. 2011 May-Jun; 32(3):203-5. PMID: 21703100.
      Citations:    
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