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Christopher L. Schaich PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentSurgery, Hypertension
Address
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    Other Positions
    TitleClinical Adjunct Faculty
    InstitutionWake Forest School of Medicine
    DepartmentOphthalmology, Head & Neck Surgery


    Collapse Biography 
    Collapse education and training
    Wake Forest University, Winston-Salem, NCMS05/2019Clinical and Population Translational Sciences
    Wake Forest University, Winston-Salem, NCPhD05/2014Physiology and Pharmacology
    University of Connecticut, Storrs, CTBA05/2006Psychology

    Collapse Research 
    Collapse research activities and funding
    R01AG054069     (HUGHES, TIMOTHY M.)Sep 1, 2016 - May 31, 2021
    NIH
    The Macrovascular and Microvascular Contributions to Alzheimer's Disease: MESA VASCAD
    Role: Co-Investigator
    F32HL146075     (SCHAICH, CHRISTOPHER)Jun 1, 2019 - May 31, 2020
    NIH
    Heart Rate Variability as a Predictor of Cognitive Performance in the Multi-Ethnic Study of Atherosclerosis
    Role: Principal Investigator
    R03AG064569     (SCHAICH, CHRISTOPHER)Jul 15, 2019 - Apr 30, 2021
    NIH
    Heart Rate Variability, Cognitive Performance, and Alzheimer Disease-related Pathology in the Multi-Ethnic Study of Atherosclerosis
    Role: Principal Investigator
    K01AG073581     (SCHAICH, CHRISTOPHER)Aug 15, 2021 - Apr 30, 2025
    NIH
    Cardiac Autonomic Function, Cognitive Performance, and Neurocognitive Outcomes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chappell MC, Schaich CL, Busse LW, Martin GS, Sevransky JE, Hinson JK, Khanna AK. Stronger association of intact angiotensinogen with mortality than lactate or renin in critical illness: post-hoc analysis from the VICTAS trial. Crit Care. 2024 Oct 14; 28(1):333. PMID: 39402593.
      Citations:    
    2. Kazibwe R, Schaich CL, Muhammad AI, Epiu I, Namutebi JH, Chevli PA, Kazibwe J, Hughes T, Rikhi RR, Shapiro MD, Yeboah J. Effect of vigorous-intensity physical activity on incident cognitive impairment in high-risk hypertension. Alzheimers Dement. 2024 Jun 06. PMID: 38842100.
      Citations:    
    3. Schaich CL, Leisman DE, Goldberg MB, Filbin MR, Khanna AK, Chappell MC. Dysfunction of the renin-angiotensin-aldosterone system in human septic shock. Peptides. 2024 Mar 29; 176:171201. PMID: 38555976.
      Citations:    
    4. Hughes TM, Tanley J, Chen H, Schaich CL, Yeboah J, Espeland MA, Lima JAC, Ambale-Venkatesh B, Michos ED, Ding J, Hayden K, Casanova R, Craft S, Rapp SR, Luchsinger JA, Fitzpatrick AL, Heckbert SR, Post WS, Burke GL. Subclinical vascular composites predict clinical cardiovascular disease, stroke, and dementia: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2024 Mar 15; 392:117521. PMID: 38552474.
      Citations:    
    5. Teixeira JP, Perez Ingles D, Barton JB, Dean JT, Garcia P, Kunkel SJ, Sarangarm P, Weiss NK, Schaich CL, Busse LW, Nielsen ND. The scientific rationale and study protocol for the DPP3, Angiotensin II, and Renin Kinetics in Sepsis (DARK-Sepsis) randomized controlled trial: serum biomarkers to predict response to angiotensin II versus standard-of-care vasopressor therapy in the treatment of septic shock. Trials. 2024 Mar 12; 25(1):182. PMID: 38475822.
      Citations:    
    6. El Husseini N, Schaich CL, Craft S, Rapp SR, Hayden KM, Sharrett R, Cotch MF, Wong TY, Luchsinger JA, Espeland MA, Baker LD, Bertoni AG, Hughes TM. Retinal vessel caliber and cognitive performance: the multi-ethnic study of atherosclerosis (MESA). Sci Rep. 2024 Feb 19; 14(1):4120. PMID: 38374377.
      Citations:    
    7. Rikhi R, Schaich CL, Hafzalla GW, Patel NA, Tannenbaum JE, German CA, Polonsky T, Tsai MY, Ahmad MI, Islam T, Chevli PA, Shapiro MD. Small Dense Low-Density Lipoprotein Cholesterol and Coronary Artery Calcification in the Multi-Ethnic Study of Atherosclerosis. Eur J Prev Cardiol. 2024 Feb 07. PMID: 38323698.
      Citations:    
    8. Schaich CL, Hughes TM, Kitzman DW, Jung Y, Chen H, Nicklas BJ, Houston DK, Brubaker PH, Molina AJA, Hugenschmidt CE. Neurocognitive Impairments and Their Improvement Following Exercise and Dietary Interventions in Older Patients With Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2023 Dec 01; e011134. PMID: 38037817.
      Citations:    
    9. Heckbert SR, Jensen PN, Erus G, Nasrallah IM, Rashid T, Habes M, Austin TR, Floyd JS, Schaich CL, Redline S, Bryan RN, Costa MD. Heart rate fragmentation and brain MRI markers of small vessel disease in MESA. Alzheimers Dement. 2023 Nov 27. PMID: 38009395.
      Citations:    
    10. Busse LW, Schaich CL, Chappell MC, McCurdy MT, Staples EM, Ten Lohuis CC, Hinson JS, Sevransky JE, Rothman RE, Wright DW, Martin GS, Khanna AK. Association of Active Renin Content With Mortality in Critically Ill Patients: A Post hoc Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Trial. Crit Care Med. 2023 Nov 10. PMID: 37947484.
      Citations:    
    11. Schaich CL, Bancks MP, Hayden KM, Ding J, Rapp SR, Bertoni AG, Heckbert SR, Hughes TM, Mongraw-Chaffin M. Visit-to-Visit Glucose Variability, Cognition, and Global Cognitive Decline: The Multi-Ethnic Study of Atherosclerosis. J Clin Endocrinol Metab. 2023 Jul 27. PMID: 37497618.
      Citations:    
    12. Hughes TM, Tanley J, Chen H, Schaich CL, Yeboah J, Espeland MA, Lima JAC, Ambale-Venkatesh B, Michos ED, Ding J, Hayden K, Casanova R, Craft S, Rapp SR, Luchsinger JA, Fitzpatrick AL, Heckbert SR, Post WS, Burke GL. Subclinical Vascular Composites Predict Clinical Cardiovascular Disease, Stroke, and Dementia: The Multi-Ethnic Study of Atherosclerosis (MESA). medRxiv. 2023 May 02. PMID: 37205504.
      Citations:    
    13. Rikhi R, Bhatia HS, Schaich CL, Ashburn N, Tsai MY, Michos ED, Chevli PA, Herrington DM, Tsimikas S, Shapiro MD. Association of Lp(a) (Lipoprotein[a]) and Hypertension in Primary Prevention of Cardiovascular Disease: The MESA. Hypertension. 2022 Dec 13. PMID: 36511156.
      Citations:    
    14. Chappell MC, Duncan AV, Melo AC, Schaich CL, Pirro NT, Diz DI, Tallant EA, Gallagher PE. Targeted UHPLC-MS Analysis Reveals Disparate Polyphenol Composition and Concentration in Muscadine Grape Supplements with Proportional Antioxidant Activity. Antioxidants (Basel). 2022 Oct 27; 11(11). PMID: 36358490.
      Citations:    
    15. Christopher L Schaich, Michael Bancks, Kathleen Hayden, Jingzhong Ding, Steve Rapp, Alain G Bertoni, Annette L Fitzpatrick, Susan R Heckbert, Timothy M Hughes and Morgana Mongraw-Chaffin. Higher Visit-to-Visit Variability in Fasting Glucose and HbA1c is Associated with Decline in Global Cognitive Performance: The Multi-Ethnic Study of Atherosclerosis (MESA). Circulation. 2022; 145(Suppl_1):A063. View Publication.
    16. Tim M. Hughes, Christopher L. Schaich, Samuel N. Lockhart, Kevin Hiatt, Christopher T. Whitlow, Youngkyoo Jung, Alain Bertoni, Gregory L. Burke, Kiran K. Solingapuram Sai, Susan Heckbert, Suzanne Craft, Stephen R. Rapp, Kathleen M. Hayden. Racial differences in dementia-related pathology underlying cognitive decline: The Multi-Ethnic Study of Atherosclerosis (MESA). Alzheimer’s Dement. 2022; 17(S4):e054482. View Publication.
    17. Sebastian L. Sandler, Samuel N. Lockhart, Kevin Hiatt, Christopher T. Whitlow, Stephen R. Rapp, Bonnie C. Sachs, Elsayed Z. Soliman, Alain Bertoni, Susan Heckbert, Tim M. Hughes, Christopher L. Schaich. Association of lower heart rate variability with neuroimaging markers for dementia-related pathology: The Multi-Ethnic Study of Atherosclerosis (MESA). Alzheimer’s Dement. 2022; 17(S4):e054094. View Publication.
    18. Lockhart SN, Schaich CL, Craft S, Sachs BC, Rapp SR, Jung Y, Whitlow CT, Solingapuram Sai KK, Cleveland M, Williams BJ, Burke GL, Bertoni A, Hayden KM, Hughes TM. Associations among vascular risk factors, neuroimaging biomarkers, and cognition: Preliminary analyses from the Multi-Ethnic Study of Atherosclerosis (MESA). Alzheimers Dement. 2021 Sep 05. PMID: 34482601.
      Citations:    
    19. Schaich CL, Yeboah J, Espeland MA, Baker LD, Ding J, Hayden KM, Sachs BC, Craft S, Rapp SR, Luchsinger JA, Fitzpatrick AL, Heckbert SR, Post WS, Burke GL, Allen NB, Hughes TM. Association of Vascular Risk Scores and Cognitive Performance in a Diverse Cohort: The Multi-Ethnic Study of Atherosclerosis. J Gerontol A Biol Sci Med Sci. 2021 Jul 03. PMID: 34216214.
      Citations:    
    20. Files DC, Gibbs KW, Schaich CL, Collins SP, Gwathmey TM, Casey JD, Self WH, Chappell MC. A Pilot Study to Assess the Circulating Renin-Angiotensin-System in COVID-19 Acute Respiratory Failure. Am J Physiol Lung Cell Mol Physiol. 2021 05 19. PMID: 34009036.
      Citations:    
    21. Mary Branch, Christopher L Schaich, Daniel Beavers, Elsayed Z Soliman, Kerryn Reding, Aladdin Shadyab, Tochi M OKWUOSA, Gretchen L Wells, Celina Valencia, Ana Barac, Mara Vitolins. Association Between Breast Cancer and Cardiac Autonomic Function as Measured by Heart Rate Variability in the Women’s Health Initiative. Circulation. 2020; 142(Suppl_3):A13500. View Publication.
    22. Schaich CL, Malaver D, Chen H, Shaltout HA, Zeki Al Hazzouri A, Herrington DM, Hughes TM. Association of Heart Rate Variability With Cognitive Performance: The Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2020 04 07; 9(7):e013827. PMID: 32200711.
      Citations:    
    23. Schaich CL ,Bancks M, Ding J, Kathleen M Hayden KM, Heckbert S, Hughes TM, Rapp SR, Fitzpatrick AL, Bertoni AG, Mongraw-Chaffin M. Association of Lower Fasting Glucose and Visit-to-visit Glucose Variability With Cognitive Performance: The Multi-ethnic Study of Atherosclerosis. Circulation. 2020; 141(Suppl_1):AP349. View Publication.
    24. Schaich CL, Maurer MS, Nadkarni NK. Amyloidosis of the Brain and Heart: Two Sides of the Same Coin? JACC Heart Fail. 2019 02; 7(2):129-131. PMID: 30704604.
      Citations:    
    25. Nada K El Husseini, Chris L. Schaich, Suzanne Craft, Steve Rapp, Annette Fitzpatrick, A. Richey Sharrett, Ronald Klein, Barbara Klein, Mary Frances Cotch, Tien Y Wong, Jose A Luchsinger, Timothy M Hughes . Retinal Vessel Caliber is Associated With Cognitive Function Independent of Cerebrovascular and Renal Disease: The Multi-Ethnic Study of Atherosclerosis (MESA). Stroke. 2019; 50(Suppl_1):AWP562. View Publication.
    26. Chris Schaich, Diego Malaver, Hossam A Shaltout, Adina Zeki Al Hazzouri, David M Herrington, Timothy M Hughes . Heart Rate Variability is Associated with Future Global Cognitive Performance: the Multi-Ethnic Study of Atherosclerosis. Hypertension. 2018; 72(1):AP301. View Publication.
    27. Schaich CL, Wellman TL, Einwag Z, Dutko RA, Erdos B. Inhibition of BDNF signaling in the paraventricular nucleus of the hypothalamus lowers acute stress-induced pressor responses. J Neurophysiol. 2018 08 01; 120(2):633-643. PMID: 29694277.
      Citations:    
    28. Chris L. Schaich, Hossam A. Shaltout, Alex Kovach, Megan Grabenauer, Brian F. Thomas, Tina E. Brinkley, Barbara J. Nicklas, Debra I. Diz. Gender-specific Relationships Between Plasma Levels of Endocannabinoids and Vagal and Sympathetic Control of Heart Rate in Normotensive Obese Older Adults. Hypertension. 2017; 70(Suppl_1):AP204. View Publication.
    29. Benedek Erdos, Nick C. Cruickshank, Zachary D. Einwag, Chris L. Schaich, Theresa L. Wellman . Increased BDNF Expression in the Paraventricular Nucleus of the Hypothalamus (PVN) Abolishes Hypotensive Actions of Nucleus of the Solitary Tract (NTS) Catecholaminergic Neurons. FASEB J. 2017; 31(1):866.7. View Publication.
    30. Schaich CL, Grabenauer M, Thomas BF, Shaltout HA, Gallagher PE, Howlett AC, Diz DI. Medullary Endocannabinoids Contribute to the Differential Resting Baroreflex Sensitivity in Rats with Altered Brain Renin-Angiotensin System Expression. Front Physiol. 2016; 7:207. PMID: 27375489.
      Citations:    
    31. Benedek Erdos, Chris L. Schaich, Nicholas C. Cruickshank, Theresa L. Wellman . Brain-derived neurotrophic factor (BDNF) acting within the paraventricular nucleus induces blood pressure elevations under permissive control of angiotensin II and mediates pressor responses to acute stress. FASEB J. 2016; 30(1):955.6. View Publication.
    32. Schaich CL, Wellman TL, Koi B, Erdos B. BDNF acting in the hypothalamus induces acute pressor responses under permissive control of angiotensin II. Auton Neurosci. 2016 05; 197:1-8. PMID: 26948539.
      Citations:    
    33. Schaich CL, Shaltout HA, Grabenauer M, Thomas BF, Gallagher PE, Howlett AC, Diz DI. Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity. J Cardiovasc Pharmacol. 2015 May; 65(5):473-9. PMID: 25636077.
      Citations:    
    34. Chris Schaich, George Wellman, Benedek Erdos . Novel Method for Investigating Impaired Blood Pressure Regulation Following Subarachnoid Hemorrhage in Conscious Rats. FASEB J. 2015; 29(1):831.6. View Publication.
    35. Schaich CL, Shaltout HA, Brosnihan KB, Howlett AC, Diz DI. Acute and chronic systemic CB1 cannabinoid receptor blockade improves blood pressure regulation and metabolic profile in hypertensive (mRen2)27 rats. Physiol Rep. 2014 Aug 01; 2(8). PMID: 25168868.
      Citations:    
    36. Chris Schaich, Brian Thomas, Megan Grabenauer, Allyn Howlett, Debra Diz . Blockade of CB1 receptors reveals that elevated medullary endocannabinoids contribute to age-related impairment of baroreflex sensitivity in Sprague-Dawley rats. FASEB J. 2014; 28(1):681.4. View Publication.
    37. Chris Schaich, Allyn Howlett, K. Brosnihan, Debra Diz . Differential blood pressure response in normotensive rats and rats with angiotensin II-dependent hypertension following systemic cannabinoid CB1 receptor blockade. FASEB J. 2014; 28(1):1140.11. View Publication.
    38. Chris L. Schaich, Hossam A. Shaltout, Allyn C. Howlett, Debra I. Diz . Chronic Systemic CB1 Cannabinoid Receptor Blockade Reduces Blood Pressure and Weight Gain and Improves Baroreflex Function and Heart Rate Variability in Hypertensive (mRen2)27 Rats. Hypertension. 2013; 62(Suppl_1):A183. View Publication.
    39. Chris Schaich, Manisha Nautiyal, Allyn Howlett, Mark Chappell, Debra Diz . Enhanced CB1 Cannabinoid Receptor Tone Contributes to Impaired Baroreflex Sensitivity in Hypertensive (mRen2)27 Transgenic Rats. FASEB J. 2013; 27(1). View Publication.
    40. Chris L Schaich, Allyn C Howlett, Brian F Thomas, Megan A Grabenauer, Debra I Diz . Medullary Endocannabinoid Content Contributes to the Differential Resting Baroreflex Sensitivity in Rats with Altered Brain Renin-Angiotensin System Expression. Hypertension. 2013; 62(Suppl_1):A182. View Publication.
    41. Chris L. Schaich, Allyn C. Howlett, Debra I. Diz . Contribution of Endocannabinoids via CB1 Receptors to the Impaired Baroreflex Sensitivity in (mRen2)27 Transgenic Hypertensive Rats. Hypertension. 2012; 60(Suppl_1):A117. View Publication.
    42. Chris L. Schaich, Allyn C. Howlett, Debra I. Diz. Dose-Related Biphasic Modulation of Baroreflex Sensitivity by the CB1 Receptor in Rat Solitary Tract Nucleus. Hypertension. 2011; 58(5):e105. View Publication.
    43. Chris L. Schaich, Allyn C. Howlett, Debra I. Diz. Attenuation of Baroreflex Sensitivity by Cannabinoid Receptor Activation in Rat Solitary Tract Nucleus. Hypertension. 2010; 56(5):e106. View Publication.
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