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Poole, Leslie
One or more keywords matched the following items that are connected to Poole, Leslie
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Academic Article Activity of one of two engineered heterodimers of AhpF, the NADH:peroxiredoxin oxidoreductase from Salmonella typhimurium, reveals intrasubunit electron transfer between domains.
Academic Article Identification of cysteine sulfenic acid in AhpC of alkyl hydroperoxide reductase.
Academic Article Identification of a peroxide-sensitive redox switch at the CXXC motif in the human mitochondrial branched chain aminotransferase.
Academic Article Human mitochondrial branched chain aminotransferase: structural basis for substrate specificity and role of redox active cysteines.
Academic Article Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling.
Academic Article Protein sulfenic acids in redox signaling.
Academic Article Analysis of the link between enzymatic activity and oligomeric state in AhpC, a bacterial peroxiredoxin.
Academic Article Synthesis of chemical probes to map sulfenic acid modifications on proteins.
Academic Article Isotope-coded, iodoacetamide-based reagent to determine individual cysteine pK(a) values by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Academic Article Discovering mechanisms of signaling-mediated cysteine oxidation.
Academic Article Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2).
Academic Article Conformational and oligomeric effects on the cysteine pK(a) of tryparedoxin peroxidase.
Academic Article Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins.
Academic Article Use of dimedone-based chemical probes for sulfenic acid detection methods to visualize and identify labeled proteins.
Academic Article Structural evidence that peroxiredoxin catalytic power is based on transition-state stabilization.
Academic Article Cysteine-based redox switches in enzymes.
Academic Article Reactive oxygen species mediate lysophosphatidic acid induced signaling in ovarian cancer cells.
Academic Article Formation and functions of protein sulfenic acids.
Academic Article Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.
Academic Article Analysis of the peroxiredoxin family: using active-site structure and sequence information for global classification and residue analysis.
Academic Article Conformational studies of the robust 2-Cys peroxiredoxin Salmonella typhimurium AhpC by solution phase hydrogen/deuterium (H/D) exchange monitored by electrospray ionization mass spectrometry.
Academic Article Crystal structure of alkyl hydroperoxidase D like protein PA0269 from Pseudomonas aeruginosa: homology of the AhpD-like structural family.
Academic Article Overview of peroxiredoxins in oxidant defense and redox regulation.
Academic Article Peroxiredoxins in parasites.
Academic Article Structural and electrostatic asymmetry at the active site in typical and atypical peroxiredoxin dimers.
Academic Article Peroxiredoxin II regulates effector and secondary memory CD8+ T cell responses.
Academic Article AhpF can be dissected into two functional units: tandem repeats of two thioredoxin-like folds in the N-terminus mediate electron transfer from the thioredoxin reductase-like C-terminus to AhpC.
Academic Article An NADH-dependent bacterial thioredoxin reductase-like protein in conjunction with a glutaredoxin homologue form a unique peroxiredoxin (AhpC) reducing system in Clostridium pasteurianum.
Academic Article Dimers to doughnuts: redox-sensitive oligomerization of 2-cysteine peroxiredoxins.
Academic Article An iron-binding protein, Dpr, from Streptococcus mutans prevents iron-dependent hydroxyl radical formation in vitro.
Academic Article Catalytic mechanism of thiol peroxidase from Escherichia coli. Sulfenic acid formation and overoxidation of essential CYS61.
Academic Article Structure, mechanism and regulation of peroxiredoxins.
Academic Article Hydroxyapatite chromatography: altering the phosphate-dependent elution profile of protein as a function of pH.
Academic Article Roles for cysteine residues in the regulatory CXXC motif of human mitochondrial branched chain aminotransferase enzyme.
Academic Article Bacterial defenses against oxidants: mechanistic features of cysteine-based peroxidases and their flavoprotein reductases.
Academic Article Structural basis for the retroreduction of inactivated peroxiredoxins by human sulfiredoxin.
Academic Article Oxidized and synchrotron cleaved structures of the disulfide redox center in the N-terminal domain of Salmonella typhimurium AhpF.
Academic Article Novel organic hydroperoxide-sensing and responding mechanisms for OhrR, a major bacterial sensor and regulator of organic hydroperoxide stress.
Academic Article Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recovery.
Academic Article Cysteine reactivity and thiol-disulfide interchange pathways in AhpF and AhpC of the bacterial alkyl hydroperoxide reductase system.
Academic Article The requirement of reversible cysteine sulfenic acid formation for T cell activation and function.
Academic Article Fluorescent and affinity-based tools to detect cysteine sulfenic acid formation in proteins.
Academic Article The catalytic mechanism of peroxiredoxins.
Academic Article Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin.
Academic Article Mutant AhpC peroxiredoxins suppress thiol-disulfide redox deficiencies and acquire deglutathionylating activity.
Academic Article Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid.
Academic Article Cysteine pK(a) values for the bacterial peroxiredoxin AhpC.
Academic Article Redox regulation and trapping sulfenic acid in the peroxide-sensitive human mitochondrial branched chain aminotransferase.
Academic Article Redox-dependent dynamics of a dual thioredoxin fold protein: evolution of specialized folds.
Academic Article Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.
Academic Article Structural changes common to catalysis in the Tpx peroxiredoxin subfamily.
Academic Article Water-soluble triarylphosphines as biomarkers for protein S-nitrosation.
Academic Article Broad specificity AhpC-like peroxiredoxin and its thioredoxin reductant in the sparse antioxidant defense system of Treponema pallidum.
Academic Article Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice.
Academic Article Engineering of fluorescent reporters into redox domains to monitor electron transfers.
Academic Article Measurement of protein sulfenic acid content.
Academic Article PREX: PeroxiRedoxin classification indEX, a database of subfamily assignments across the diverse peroxiredoxin family.
Academic Article Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species.
Academic Article Simple synthesis of 1,3-cyclopentanedione derived probes for labeling sulfenic acid proteins.
Academic Article Localized cysteine sulfenic acid formation by vascular endothelial growth factor: role in endothelial cell migration and angiogenesis.
Academic Article Kinetic and thermodynamic features reveal that Escherichia coli BCP is an unusually versatile peroxiredoxin.
Academic Article Peroxiredoxins as molecular triage agents, sacrificing themselves to enhance cell survival during a peroxide attack.
Academic Article A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of ß-ketoesters as cleavable probes.
Academic Article A new family of membrane electron transporters and its substrates, including a new cell envelope peroxiredoxin, reveal a broadened reductive capacity of the oxidative bacterial cell envelope.
Academic Article A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target.
Academic Article The reversible formation of cysteine sulfenic acid promotes B-cell activation and proliferation.
Academic Article Electrostatics of cysteine residues in proteins: parameterization and validation of a simple model.
Academic Article Mapping the active site helix-to-strand conversion of CxxxxC peroxiredoxin Q enzymes.
Academic Article Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry.
Academic Article Attachment of the N-terminal domain of Salmonella typhimurium AhpF to Escherichia coli thioredoxin reductase confers AhpC reductase activity but does not affect thioredoxin reductase activity.
Academic Article AhpF and other NADH:peroxiredoxin oxidoreductases, homologues of low Mr thioredoxin reductase.
Academic Article Essential thioredoxin-dependent peroxiredoxin system from Helicobacter pylori: genetic and kinetic characterization.
Concept MAP Kinase Signaling System
Concept Oxidative Stress
Concept Transgenes
Concept S-Nitrosoglutathione
Concept Superoxide Dismutase
Concept High-Throughput Screening Assays
Concept Reactive Oxygen Species
Concept Protein Structure, Tertiary
Concept Myocytes, Smooth Muscle
Concept Genes, Bacterial
Concept Sulfur Compounds
Concept Genes, Reporter
Concept Catalytic Domain
Concept Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Concept Enzyme Stability
Concept Streptococcus mutans
Concept Protein Stability
Concept Sequence Alignment
Concept Synchrotrons
Concept Protein Structure, Quaternary
Concept Binding Sites
Concept Saccharomyces cerevisiae Proteins
Concept Amino Acid Substitution
Concept Computer Simulation
Concept Database Management Systems
Concept Molecular Dynamics Simulation
Concept Amino Acid Sequence
Concept src-Family Kinases
Concept Spectrophotometry, Ultraviolet
Concept Oxidoreductases Acting on Sulfur Group Donors
Concept Streptococcus pneumoniae
Concept Genetic Loci
Concept Stroke Volume
Concept Spectrometry, Mass, Electrospray Ionization
Concept Serum
Concept Static Electricity
Concept Molecular Structure
Concept Sulfenic Acids
Concept Schizosaccharomyces pombe Proteins
Concept Retrospective Studies
Concept Signal Transduction
Concept Spectrophotometry
Concept Protein Structure, Secondary
Concept Tandem Mass Spectrometry
Concept Muscle, Smooth, Vascular
Concept Protein Subunits
Concept Sulfinic Acids
Concept Sequence Analysis, DNA
Concept RNA, Small Interfering
Concept Data Interpretation, Statistical
Concept Mass Spectrometry
Concept Neoplastic Stem Cells
Concept Multigene Family
Concept Magnetic Resonance Spectroscopy
Concept Sulfhydryl Compounds
Concept Mutagenesis, Site-Directed
Concept Genome, Bacterial
Concept Tandem Repeat Sequences
Concept Cell Survival
Concept Sirtuins
Concept Genes, Essential
Concept Case-Control Studies
Concept Spectrometry, Fluorescence
Concept Extracellular Signal-Regulated MAP Kinases
Concept S-Nitrosothiols
Concept Sulfhydryl Reagents
Concept Sequence Homology, Amino Acid
Concept Staining and Labeling
Concept Substrate Specificity
Concept Sulfones
Concept Schizosaccharomyces
Concept Rats, Sprague-Dawley
Concept Serine
Concept Structure-Activity Relationship
Concept Sequence Analysis, Protein
Concept Base Sequence
Concept Salmonella typhimurium
Concept Molecular Sequence Data
Academic Article Evaluating peroxiredoxin sensitivity toward inactivation by peroxide substrates.
Academic Article D-alanine modification of a protease-susceptible outer membrane component by the Bordetella pertussis dra locus promotes resistance to antimicrobial peptides and polymorphonuclear leukocyte-mediated killing.
Academic Article Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids.
Academic Article The sensitive balance between the fully folded and locally unfolded conformations of a model peroxiredoxin.
Academic Article Chemical approaches to detect and analyze protein sulfenic acids.
Academic Article Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling.
Academic Article Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase.
Academic Article Strained cycloalkynes as new protein sulfenic acid traps.
Academic Article Tuning of peroxiredoxin catalysis for various physiological roles.
Academic Article Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC.
Academic Article Introduction: What we do and do not know regarding redox processes of thiols in signaling pathways.
Academic Article The basics of thiols and cysteines in redox biology and chemistry.
Academic Article Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling.
Academic Article Au-ACRAMTU-PEt3 Alters Redox Balance To Inhibit T Cell Proliferation and Function.
Academic Article Relation of Pre-anthracycline Serum Bilirubin Levels to Left Ventricular Ejection Fraction After Chemotherapy.
Academic Article Cysteine-Mediated Redox Regulation of Cell Signaling in Chondrocytes Stimulated With Fibronectin Fragments.
Academic Article Distribution and Features of the Six Classes of Peroxiredoxins.
Academic Article X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action.
Academic Article Backbone chemical shift assignments for Xanthomonas campestris peroxiredoxin Q in the reduced and oxidized states: a dramatic change in backbone dynamics.
Academic Article Structural changes upon peroxynitrite-mediated nitration of peroxiredoxin 2; nitrated Prx2 resembles its disulfide-oxidized form.
Academic Article Oxidative Stress Promotes Peroxiredoxin Hyperoxidation and Attenuates Pro-survival Signaling in Aging Chondrocytes.
Academic Article Peroxiredoxin Catalysis at Atomic Resolution.
Academic Article An Atlas of Peroxiredoxins Created Using an Active Site Profile-Based Approach to Functionally Relevant Clustering of Proteins.
Grant Mechanistic Studies of Alkyl Hydroperoxide Reductase and Related Redox Proteins
Grant REVERSION MUTAGENESIS OF ACTIVE-SITE MUTANTS OF NUCLEASE
Grant New Reagents for Tracking Protein Oxidation in Cells by MS and Imaging Methods
Grant 2012 Thiol-based Redox Regulation &Signaling GRC and GRS
Grant Proteomic Profiling of Cancer-Related Redox Signaling Pathways
Grant 2010 Thiol-based Redox Regulation &Signaling Gordon Research Conference
Grant Profiling of Redox-Sensitive Signaling Proteins
Grant Structural and Computational Biophysics Training Program
Grant Mechanisms and Regulation of Peroxiredoxins
Academic Article The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch.
Academic Article Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.
Academic Article Discovery of Heteroaromatic Sulfones As a New Class of Biologically Compatible Thiol-Selective Reagents.
Academic Article The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat.
Academic Article Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals.
Grant Redox Biology and Medicine Training Program
Academic Article SVM-SulfoSite: A support vector machine based predictor for sulfenylation sites.
Academic Article Novel hyperoxidation resistance motifs in 2-Cys peroxiredoxins.
Academic Article Differential Kinetics of Two-Cysteine Peroxiredoxin Disulfide Formation Reveal a Novel Model for Peroxide Sensing.
Academic Article Mitochondria-targeted Probes for Imaging Protein Sulfenylation.
Academic Article Chaperone activation and client binding of a 2-cysteine peroxiredoxin.
Academic Article NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase d-Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion.
Academic Article Redox proteins.
Academic Article H2O2 oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes.
Academic Article Triphenylphosphonium-Derived Protein Sulfenic Acid Trapping Agents: Synthesis, Reactivity, and Effect on Mitochondrial Function.
Academic Article Unraveling the effects of peroxiredoxin 2 nitration; role of C-terminal tyrosine 193.
Academic Article Differential peroxiredoxin hyperoxidation regulates MAP kinase signaling in human articular chondrocytes.
Grant Redox Regulation of Cysteine-Dependent Peroxidases and Signal Transduction Pathways
Academic Article Discovery of Spilanthol Endoperoxide as a Redox Natural Compound Active against Mammalian Prx3 and Chlamydiatrachomatis Infection.
Academic Article Identification of sulfenylation patterns in trophozoite stage Plasmodium falciparum using a non-dimedone based probe.
Academic Article Introduction to approaches and tools for the evaluation of protein cysteine oxidation.
Academic Article Sirtuin 6 (SIRT6) regulates redox homeostasis and signaling events in human articular chondrocytes.
Academic Article Acyl-lipid desaturases and Vipp1 cooperate in cyanobacteria to produce novel omega-3 PUFA-containing glycolipids.
Academic Article [18F]Fluoro-DCP, a first generation PET radiotracer for monitoring protein sulfenylation in vivo.
Academic Article Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition.
Academic Article Bioinformatic Analyses of Peroxiredoxins and RF-Prx: A Random Forest-Based Predictor and Classifier for Prxs.
Academic Article Mitigation of doxorubicin-induced cardiotoxicity with an H2O2-Activated, H2S-Donating hybrid prodrug.
Academic Article Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis.
Academic Article Native state fluctuations in a peroxiredoxin active site match motions needed for catalysis.
Academic Article Nuclear-localized, iron-bound superoxide dismutase-2 antagonizes epithelial lineage programs to promote stemness of breast cancer cells via a histone demethylase activity.
Academic Article Hydrogen peroxide-dependent oxidation of ERK2 within its D-recruitment site alters its substrate selection.
Academic Article Glutathionylation of pyruvate dehydrogenase complex E2 and inflammatory cytokine production during acute inflammation are magnified by mitochondrial oxidative stress.
Academic Article Glutathionylation of Pyruvate Dehydrogenase Complex E2 and Inflammatory Cytokine Production During Acute Inflammation Are Magnified By Mitochondrial Oxidative Stress.
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