Enzyme that is a major constituent of kidney brush-border membranes and is also present to a lesser degree in the brain and other tissues. It preferentially catalyzes cleavage at the amino group of hydrophobic residues of the B-chain of insulin as well as opioid peptides and other biologically active peptides. The enzyme is inhibited primarily by EDTA, phosphoramidon, and thiorphan and is reactivated by zinc. Neprilysin is identical to common acute lymphoblastic leukemia antigen (CALLA Antigen), an important marker in the diagnosis of human acute lymphocytic leukemia. There is no relationship with CALLA PLANT.

Descriptor ID	D015260
MeSH Number(s)	D08.811.277.656.300.480.600 D08.811.277.656.675.374.600 D23.050.285.550 D23.050.301.264.035.550 D23.101.100.110.550 D23.101.840.500
Concept/Terms	Neprilysin Neprilysin CALLA Antigen Enkephalinase Enkephalinase-24.11 Enkephalinase 24.11 Kidney-Brush-Border Neutral Proteinase Kidney Brush Border Neutral Proteinase Neutral Proteinase, Kidney-Brush-Border Membrane Metallo-Endopeptidase Membrane Metallo Endopeptidase Metallo-Endopeptidase, Membrane Neutral Endopeptidase Endopeptidase, Neutral Neutral Endopeptidase 24.11 Endopeptidase 24.11, Neutral Thermolysin-Like Metalloendopeptidase Metalloendopeptidase, Thermolysin-Like Thermolysin Like Metalloendopeptidase YGG-Forming Enzyme Enzyme, YGG-Forming YGG Forming Enzyme Common Acute Lymphoblastic Leukemia Antigens Antigens, Leukemia, Common Acute Lymphoblastic Atriopeptidase CD10 Antigen Antigen, CD10 Antigens, CD10 CD10 Antigens Endopeptidase-24.11 Endopeptidase 24.11 Enkephalin Dipeptidyl Carboxypeptidase Carboxypeptidase, Enkephalin Dipeptidyl Dipeptidyl Carboxypeptidase, Enkephalin

Below are MeSH descriptors whose meaning is more general than "Neprilysin".

Below are MeSH descriptors whose meaning is related to "Neprilysin".

Below are MeSH descriptors whose meaning is more specific than "Neprilysin".