A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the p-glycoprotein family of proteins.

Descriptor ID	D027425
MeSH Number(s)	D12.776.157.530.100.304 D12.776.157.530.450.074.500.500.500 D12.776.543.585.100.304 D12.776.543.585.450.074.500.500.500
Concept/Terms	Multidrug Resistance-Associated Proteins Multidrug Resistance-Associated Proteins Multidrug Resistance Associated Proteins Multispecific Organic Anion Transporter Multidrug Resistance-Associated Protein Multidrug Resistance Associated Protein Resistance-Associated Protein, Multidrug Multispecific Organic Anion Transport Proteins ATP-Binding Cassette, Sub-Family C Proteins ATP Binding Cassette, Sub Family C Proteins MOAT Protein

Below are MeSH descriptors whose meaning is more general than "Multidrug Resistance-Associated Proteins".

Below are MeSH descriptors whose meaning is related to "Multidrug Resistance-Associated Proteins".

Below are MeSH descriptors whose meaning is more specific than "Multidrug Resistance-Associated Proteins".