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Does the angiotensin-converting enzyme (ACE)/ACE2 balance contribute to the fate of angiotensin peptides in programmed hypertension?
Primary role of angiotensin-converting enzyme-2 in cardiac production of angiotensin-(1-7) in transgenic Ren-2 hypertensive rats.
Principal Investigator
Localization of the novel angiotensin peptide, angiotensin-(1-12), in heart and kidney of hypertensive and normotensive rats.
Divergent pathways for the angiotensin-(1-12) metabolism in the rat circulation and kidney.
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Divergent pathways for the angiotensin-(1-12) metabolism in the rat circulation and kidney.
Westwood BM, Chappell MC. Divergent pathways for the angiotensin-(1-12) metabolism in the rat circulation and kidney. Peptides. 2012 Jun; 35(2):190-5.
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PubMed
subject areas
Angiotensin I
Angiotensin II
Angiotensin-Converting Enzyme Inhibitors
Angiotensinogen
Angiotensins
Animals
Hypertension
Kidney
Lisinopril
Male
Neprilysin
Peptide Fragments
Peptidyl-Dipeptidase A
Rats
Rats, Inbred Lew
Renin
authors with profiles
Mark C. Chappell PhD