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Jessica A. Palakshappa MD, MS

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Pulmonary, Critical Care, Allergy and Immunologic Diseases
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentEpidemiology & Prevention (Public Health Sciences)


    Collapse Biography 
    Collapse education and training
    University of Pennsylvania , Philadelphia MD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Palakshappa JA, Russell GB, Gibbs KW, Kloefkorn C, Hayden D, Moss M, Hough CL, Files DC. Association of early sedation level with patient outcomes in moderate-to-severe acute respiratory distress syndrome: Propensity-score matched analysis. J Crit Care. 2022 Jul 26; 71:154118. PMID: 35905586.
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    2. Palakshappa JA, Gibbs KW, Lannan MT, Cranford AR, Taylor SP. Systematic Review of the "Pragmatism" of Pragmatic Critical Care Trials. Crit Care Explor. 2022 Jul; 4(7):e0738. PMID: 35923590.
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    3. Gibbs KW, Forbes JL, O'Connell NS, Martin RS, Bakhru RN, Palakshappa JA, Files DC. Excess Tidal Volume Ventilation in Critically Ill Adults Receiving Adaptive Pressure Control: A Cohort Study. Ann Am Thorac Soc. 2022 May 27. PMID: 35622413.
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    4. Valley TS, Schutz A, Peltan ID, Vranas KC, Mathews KS, Jolley SE, Palakshappa JA, Hough CL. Organization of Outpatient Care After COVID-19 Hospitalization. Chest. 2022 06; 161(6):1485-1489. PMID: 35108571.
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    5. Palakshappa JA, Hough CL. How We Prevent and Treat Delirium in the ICU. Chest. 2021 10; 160(4):1326-1334. PMID: 34102141.
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    6. Palakshappa JA, Krall JTW, Belfield LT, Files DC. Long-Term Outcomes in Acute Respiratory Distress Syndrome: Epidemiology, Mechanisms, and Patient Evaluation. Crit Care Clin. 2021 Oct; 37(4):895-911. PMID: 34548140.
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    7. Palakshappa JA, Callahan KE, Pajewski NM, Files DC, Willard JJ, Williamson JD. Detection of Cognitive Impairment Following Critical Illness with the Medicare Annual Wellness Visit: A Cohort Study. Ann Am Thorac Soc. 2021 Mar 18. PMID: 33735597.
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    8. Nagawa CS, Palakshappa JA, Sadasivam RS, Houston TK. Herbal or Dietary Supplement Use and Hypertensive Medications: Does the Combination Relate to Medication Adherence and Blood Pressure Control? J Altern Complement Med. 2021 Feb; 27(2):168-175. PMID: 33296255.
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    9. Palakshappa JA, Bakhru RN. Bedside Ultrasonography Can and Should Be Used in the Intensive Care Unit to Evaluate Muscle Atrophy. Ann Am Thorac Soc. 2019 09; 16(9):1107-1111. PMID: 30978111.
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    10. Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ. Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis. Intensive Care Med. 2018 Nov; 44(11):1849-1858. PMID: 30343317.
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    11. Palakshappa JA, Reilly JP, Schweickert WD, Anderson BJ, Khoury V, Shashaty MG, Fitzgerald D, Forker C, Butler K, Ittner CA, Feng R, Files DC, Bonk MP, Christie JD, Meyer NJ. Quantitative peripheral muscle ultrasound in sepsis: Muscle area superior to thickness. J Crit Care. 2018 10; 47:324-330. PMID: 30224027.
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    12. McDonald MD, Sandsmark DK, Palakshappa JA, Mikkelsen ME, Anderson BJ, Gutsche JT. Long-Term Outcomes After Extracorporeal Life Support for Acute Respiratory Failure. J Cardiothorac Vasc Anesth. 2019 Jan; 33(1):72-79. PMID: 30049521.
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    13. Meyer NJ, Reilly JP, Anderson BJ, Palakshappa JA, Jones TK, Dunn TG, Shashaty MGS, Feng R, Christie JD, Opal SM. Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration. Crit Care Med. 2018 01; 46(1):21-28. PMID: 28991823.
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    14. Palakshappa JA, Christie JD. Survivorship Research: Studying the Past to Define the Future. Crit Care Med. 2016 07; 44(7):1422-3. PMID: 27309158.
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    15. Anderson BJ, Reilly JP, Shashaty MGS, Palakshappa JA, Wysoczanski A, Dunn TG, Kazi A, Tommasini A, Mikkelsen ME, Schweickert WD, Kolson DL, Christie JD, Meyer NJ. Admission plasma levels of the neuronal injury marker neuron-specific enolase are associated with mortality and delirium in sepsis. J Crit Care. 2016 12; 36:18-23. PMID: 27546742.
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    16. Palakshappa JA, Anderson BJ, Reilly JP, Shashaty MG, Ueno R, Wu Q, Ittner CA, Tommasini A, Dunn TG, Charles D, Kazi A, Christie JD, Meyer NJ. Low Plasma Levels of Adiponectin Do Not Explain Acute Respiratory Distress Syndrome Risk: a Prospective Cohort Study of Patients with Severe Sepsis. Crit Care. 2016 Mar 16; 20:71. PMID: 26984771.
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    17. Palakshappa JA, Mikkelsen ME. Implementation of Evidence-Based Critical Care Practices: A Sound Strategy, but Not for the Faint of Heart. Crit Care Med. 2016 Mar; 44(3):629-30. PMID: 26901545.
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    18. Palakshappa JA, Meyer NJ. Which patients with ARDS benefit from lung biopsy? Chest. 2015 Oct; 148(4):1073-1082. PMID: 25950989.
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    19. Palakshappa JA, Christie JD. Prehospital aspirin use and acute respiratory distress syndrome--a case for aspirin in the drinking water? Crit Care Med. 2015 Apr; 43(4):916-7. PMID: 25768357.
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    20. Al Zamel G, Micheletti RG, Nasta SD, Palakshappa J, Stoopler ET. The importance of multidisciplinary healthcare for paraneoplastic pemphigus. Spec Care Dentist. 2015 May-Jun; 35(3):143-7. PMID: 25257550.
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