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Daniel C. Files MD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentPediatrics, Endocrinology
Address
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    Other Positions
    TitleCo-Director
    InstitutionWake Forest School of Medicine
    DepartmentCritical Illness Injury and Recovery Research Center (CIIRRC)

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentInternal Medicine, Gerontology & Geriatric Medicine

    TitleSection Head
    InstitutionWake Forest School of Medicine
    DepartmentInternal Medicine, Pulmonary, Critical Care, Allergy and Immunologic Diseases


    Collapse Research 
    Collapse research activities and funding
    F32AR057637     (FILES, DANIEL CLARK)Sep 16, 2009 - Sep 15, 2011
    NIH
    Acute Lung Injury Induces Skeletal Muscle Atrophy
    Role: Principal Investigator
    U01HL123027     (MILLER, CHADWICK DAVID)Jun 17, 2014 - Apr 30, 2021
    NIH
    Wake Forest Clinical Center for the NHLBI PETAL Network
    Role: Co-Principal Investigator
    K08GM123322     (FILES, DANIEL CLARK)Jun 10, 2018 - May 31, 2023
    NIH
    Accelerating Muscle Recovery in Critical Illness
    Role: Principal Investigator
    R01HL143452     (STAPLETON, RENEE D)Sep 9, 2018 - Jun 30, 2022
    NIH
    Effects of Exercise on Inflammation-Induced Lung and Muscle Injury in Critical Illness (NEXIS-FLAME)
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Files DC, Esserman L, Liu KD, Calfee CS. Informed consent process in the ISPY COVID trial is ethically acceptable. Eur J Intern Med. 2022 Sep 30. PMID: 36184277.
      Citations:    
    2. Kwon JH, Tenforde MW, Gaglani M, Talbot HK, Ginde AA, McNeal T, Ghamande S, Douin DJ, Casey JD, Mohr NM, Zepeski A, Shapiro NI, Gibbs KW, Files DC, Hager DN, Shehu A, Prekker ME, Caspers SD, Exline MC, Botros M, Gong MN, Li A, Mohamed A, Johnson NJ, Srinivasan V, Steingrub JS, Peltan ID, Brown SM, Martin ET, Khan A, Hough CL, Busse LW, Duggal A, Wilson JG, Perez C, Chang SY, Mallow C, Rovinski R, Babcock HM, Lauring AS, Felley L, Halasa N, Chappell JD, Grijalva CG, Rice TW, Womack KN, Lindsell CJ, Hart KW, Baughman A, Olson SM, Schrag S, Kobayashi M, Verani JR, Patel MM, Self WH. mRNA Vaccine Effectiveness Against Coronavirus Disease 2019 Hospitalization Among Solid Organ Transplant Recipients. J Infect Dis. 2022 Sep 13; 226(5):797-807. PMID: 35385875.
      Citations:    
    3. The Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19. Ann Intern Med. 2022 Oct; 175(10):1401-1410. PMID: 36037469.
      Citations:    
    4. Mylonakis E, Lutaakome J, Jain MK, Rogers AJ, Moltó J, Benet S, Mourad A, Files DC, Mugerwa H, Kityo C, Kiweewa F, Nalubega MG, Kitonsa J, Nabenkema E, Murray DD, Braun D, Kamel D, Higgs ES, Hatlen TJ, Kan VL, Sanchez A, Tierney J, Denner E, Wentworth D, Babiker AG, Davey VJ, Gelijns AC, Matthews GV, Thompson BT, Lane HC, Neaton JD, Lundgren JD. Lessons from an international trial evaluating vaccination strategies for recovered inpatients with COVID-19 (VATICO). Med (N Y). 2022 Aug 12; 3(8):531-537. PMID: 35963234.
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    5. Krall JTW, Gibbs KW, Belfield L, Liu C, Purcell L, Bivona JJ, Poynter ME, Stapleton RD, Toth MJ, Files DC. Skeletal muscle macrophage ablation in mice. J Immunol Methods. 2022 Oct; 509:113329. PMID: 35933049.
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    6. Palakshappa JA, Russell GB, Gibbs KW, Kloefkorn C, Hayden D, Moss M, Hough CL, Files DC. Association of early sedation level with patient outcomes in moderate-to-severe acute respiratory distress syndrome: Propensity-score matched analysis. J Crit Care. 2022 Jul 26; 71:154118. PMID: 35905586.
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    7. Files DC, Tacke F, O'Sullivan A, Dorr P, Ferguson WG, Powderly WG. Rationale of using the dual chemokine receptor CCR2/CCR5 inhibitor cenicriviroc for the treatment of COVID-19. PLoS Pathog. 2022 Jun; 18(6):e1010547. PMID: 35749425.
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    8. Bivona Iii JJ, Mank MM, Stapleton RD, Files DC, Toth MJ, Poynter ME. Skeletal Muscle Myofibers Directly Contribute to LPS-Induced Systemic Inflammatory Tone. Front Pharmacol. 2022; 13:917917. PMID: 35814217.
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    9. Files DC, Matthay MA, Calfee CS, Aggarwal NR, Asare AL, Beitler JR, Berger PA, Burnham EL, Cimino G, Coleman MH, Crippa A, Discacciati A, Gandotra S, Gibbs KW, Henderson PT, Ittner CAG, Jauregui A, Khan KT, Koff JL, Lang J, LaRose M, Levitt J, Lu R, McKeehan JD, Meyer NJ, Russell DW, Thomas KW, Eklund M, Esserman LJ, Liu KD. I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations. BMJ Open. 2022 Jun 06; 12(6):e060664. PMID: 35667714.
      Citations:    
    10. Gibbs KW, Forbes JL, O'Connell NS, Martin RS, Bakhru RN, Palakshappa JA, Files DC. Excess Tidal Volume Ventilation in Critically Ill Adults Receiving Adaptive Pressure Control: A Cohort Study. Ann Am Thorac Soc. 2022 May 27. PMID: 35622413.
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    11. Moskowitz A, Shotwell MS, Gibbs KW, Harkins M, Rosenberg Y, Troendle J, Merck LH, Files DC, de Wit M, Hudock K, Thompson BT, Gong MN, Ginde AA, Douin DJ, Brown SM, Rubin E, Joly MM, Wang L, Lindsell CJ, Bernard GR, Semler MW, Collins SP, Self WH. Oxygen-Free Days as an Outcome Measure in Clinical Trials of Therapies for COVID-19 and Other Causes of New-Onset Hypoxemia. Chest. 2022 Oct; 162(4):804-814. PMID: 35504307.
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    12. Ward MJ, Douin DJ, Gong W, Ginde AA, Hough CL, Exline MC, Tenforde MW, Stubblefield WB, Steingrub JS, Prekker ME, Khan A, Files DC, Gibbs KW, Rice TW, Casey JD, Henning DJ, Wilson JG, Brown SM, Patel MM, Self WH, Lindsell CJ. Modeling clinical trajectory status of critically ill COVID-19 patients over time: A method for analyzing discrete longitudinal and ordinal outcomes. J Clin Transl Sci. 2022; 6(1):e61. PMID: 35720967.
      Citations:    
    13. Han JH, Womack KN, Tenforde MW, Files DC, Gibbs KW, Shapiro NI, Prekker ME, Erickson HL, Steingrub JS, Qadir N, Khan A, Hough CL, Johnson NJ, Ely EW, Rice TW, Casey JD, Lindsell CJ, Gong MN, Srinivasan V, Lewis NM, Patel MM, Self WH. Associations between persistent symptoms after mild COVID-19 and long-term health status, quality of life, and psychological distress. Influenza Other Respir Viruses. 2022 Jul; 16(4):680-689. PMID: 35347854.
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    14. Lauring AS, Tenforde MW, Chappell JD, Gaglani M, Ginde AA, McNeal T, Ghamande S, Douin DJ, Talbot HK, Casey JD, Mohr NM, Zepeski A, Shapiro NI, Gibbs KW, Files DC, Hager DN, Shehu A, Prekker ME, Erickson HL, Exline MC, Gong MN, Mohamed A, Johnson NJ, Srinivasan V, Steingrub JS, Peltan ID, Brown SM, Martin ET, Monto AS, Khan A, Hough CL, Busse LW, Ten Lohuis CC, Duggal A, Wilson JG, Gordon AJ, Qadir N, Chang SY, Mallow C, Rivas C, Babcock HM, Kwon JH, Halasa N, Grijalva CG, Rice TW, Stubblefield WB, Baughman A, Womack KN, Rhoads JP, Lindsell CJ, Hart KW, Zhu Y, Adams K, Schrag SJ, Olson SM, Kobayashi M, Verani JR, Patel MM, Self WH. Clinical severity of, and effectiveness of mRNA vaccines against, covid-19 from omicron, delta, and alpha SARS-CoV-2 variants in the United States: prospective observational study. BMJ. 2022 Mar 09; 376:e069761. PMID: 35264324.
      Citations:    
    15. Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial. Ann Intern Med. 2022 Feb; 175(2):234-243. PMID: 34928698.
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    16. Tenforde MW, Self WH, Adams K, Gaglani M, Ginde AA, McNeal T, Ghamande S, Douin DJ, Talbot HK, Casey JD, Mohr NM, Zepeski A, Shapiro NI, Gibbs KW, Files DC, Hager DN, Shehu A, Prekker ME, Erickson HL, Exline MC, Gong MN, Mohamed A, Henning DJ, Steingrub JS, Peltan ID, Brown SM, Martin ET, Monto AS, Khan A, Hough CL, Busse LW, Ten Lohuis CC, Duggal A, Wilson JG, Gordon AJ, Qadir N, Chang SY, Mallow C, Rivas C, Babcock HM, Kwon JH, Halasa N, Chappell JD, Lauring AS, Grijalva CG, Rice TW, Jones ID, Stubblefield WB, Baughman A, Womack KN, Rhoads JP, Lindsell CJ, Hart KW, Zhu Y, Olson SM, Kobayashi M, Verani JR, Patel MM. Association Between mRNA Vaccination and COVID-19 Hospitalization and Disease Severity. JAMA. 2021 11 23; 326(20):2043-2054. PMID: 34734975.
      Citations:    
    17. Self WH, Tenforde MW, Rhoads JP, Gaglani M, Ginde AA, Douin DJ, Olson SM, Talbot HK, Casey JD, Mohr NM, Zepeski A, McNeal T, Ghamande S, Gibbs KW, Files DC, Hager DN, Shehu A, Prekker ME, Erickson HL, Gong MN, Mohamed A, Henning DJ, Steingrub JS, Peltan ID, Brown SM, Martin ET, Monto AS, Khan A, Hough CL, Busse LW, Ten Lohuis CC, Duggal A, Wilson JG, Gordon AJ, Qadir N, Chang SY, Mallow C, Rivas C, Babcock HM, Kwon JH, Exline MC, Halasa N, Chappell JD, Lauring AS, Grijalva CG, Rice TW, Jones ID, Stubblefield WB, Baughman A, Womack KN, Lindsell CJ, Hart KW, Zhu Y, Mills L, Lester SN, Stumpf MM, Naioti EA, Kobayashi M, Verani JR, Thornburg NJ, Patel MM. Comparative Effectiveness of Moderna, Pfizer-BioNTech, and Janssen (Johnson & Johnson) Vaccines in Preventing COVID-19 Hospitalizations Among Adults Without Immunocompromising Conditions - United States, March-August 2021. MMWR Morb Mortal Wkly Rep. 2021 Sep 24; 70(38):1337-1343. PMID: 34555004.
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    18. Collins SP, Chappell MC, Files DC. The Renin-Angiotensin-Aldosterone System in COVID-related and non-COVID-related ARDS: Not So Different After All? Am J Respir Crit Care Med. 2021 Sep 02. PMID: 34473935.
      Citations:    
    19. Gandotra S, Files DC, Shields KL, Berry M, Bakhru RN. Activity Levels in Survivors of the Intensive Care Unit. Phys Ther. 2021 Sep 01; 101(9). PMID: 34097055.
      Citations:    
    20. Lytle KL, Collins SP, Feldstein LR, Baughman AH, Brown SM, Casey JD, Erickson HL, Exline MC, Files DC, Gibbs KW, Ginde AA, Gong MN, Grijalva CG, Khan A, Lindsell CJ, Peltan ID, Prekker ME, Rice TW, Shapiro NI, Steingrub JS, Stubblefield WB, Tenforde MW, Womack KN, Patel MM, Self WH. Influenza vaccine acceptance and hesitancy among adults hospitalized with severe acute respiratory illnesses, United States 2019-2020. Vaccine. 2021 Aug 31; 39(37):5271-5276. PMID: 34376307.
      Citations:    
    21. Tenforde MW, Patel MM, Ginde AA, Douin DJ, Talbot HK, Casey JD, Mohr NM, Zepeski A, Gaglani M, McNeal T, Ghamande S, Shapiro NI, Gibbs KW, Files DC, Hager DN, Shehu A, Prekker ME, Erickson HL, Exline MC, Gong MN, Mohamed A, Henning DJ, Peltan ID, Brown SM, Martin ET, Monto AS, Khan A, Hough CT, Busse L, Ten Lohuis CC, Duggal A, Wilson JG, Gordon AJ, Qadir N, Chang SY, Mallow C, Gershengorn HB, Babcock HM, Kwon JH, Halasa N, Chappell JD, Lauring AS, Grijalva CG, Rice TW, Jones ID, Stubblefield WB, Baughman A, Womack KN, Lindsell CJ, Hart KW, Zhu Y, Olson SM, Stephenson M, Schrag SJ, Kobayashi M, Verani JR, Self WH. Effectiveness of SARS-CoV-2 mRNA Vaccines for Preventing Covid-19 Hospitalizations in the United States. Clin Infect Dis. 2021 Aug 06. PMID: 34358310.
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    22. Palakshappa JA, Krall JTW, Belfield LT, Files DC. Long-Term Outcomes in Acute Respiratory Distress Syndrome: Epidemiology, Mechanisms, and Patient Evaluation. Crit Care Clin. 2021 Oct; 37(4):895-911. PMID: 34548140.
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    23. Grijalva CG, Feldstein LR, Talbot HK, Aboodi M, Baughman AH, Brown SM, Casey JD, Erickson HL, Exline MC, Files DC, Gibbs KW, Ginde AA, Gong MN, Halasa N, Khan A, Lindsell CJ, Nwosu SK, Peltan ID, Prekker ME, Rice TW, Shapiro NI, Steingrub J, Stubblefield WB, Tenforde MW, Patel M, Self WH. Influenza Vaccine Effectiveness for Prevention of Severe Influenza-Associated Illness among Adults in the United States, 2019-2020: A test-negative study. Clin Infect Dis. 2021 May 20. PMID: 34014274.
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    24. Files DC, Gibbs KW, Schaich CL, Collins SP, Gwathmey TM, Casey JD, Self WH, Chappell MC. A Pilot Study to Assess the Circulating Renin-Angiotensin-System in COVID-19 Acute Respiratory Failure. Am J Physiol Lung Cell Mol Physiol. 2021 05 19. PMID: 34009036.
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    25. Langley RJ, Migaud ME, Flores L, Thompson JW, Kean EA, Mostellar MM, Mowry M, Luckett P, Purcell LD, Lovato J, Gandotra S, Benton R, Files DC, Harrod KS, Gillespie MN, Morris PE. A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure. Sci Rep. 2021 May 18; 11(1):10515. PMID: 34006901.
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    26. Widner DB, Liu C, Zhao Q, Sharp S, Eber MR, Park SH, Files DC, Shiozawa Y. Activated mast cells in skeletal muscle can be a potential mediator for cancer-associated cachexia. J Cachexia Sarcopenia Muscle. 2021 May 18. PMID: 34008339.
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    27. Sami S, Tenforde MW, Talbot HK, Lindsell CJ, Steingrub JS, Shapiro NI, Ginde AA, Douin DJ, Prekker ME, Erickson HL, Brown SM, Peltan ID, Gong MN, Khan A, Exline MC, Files DC, Gibbs KW, Rice TW, Casey JD, Grijalva CG, Stubblefield WB, Womack KN, Hager DN, Qadir N, Chang SY, Henning DJ, Wilson JG, Self WH, Patel MM. Adults Hospitalized with COVID-19 -United States, March-June and October-December 2020: Implications for the Potential Effects of COVID-19 Tier-1 Vaccination on Future Hospitalizations and Outcomes. Clin Infect Dis. 2021 May 12. PMID: 33977301.
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    28. Gibbs KW, Chuang Key CC, Belfield L, Krall J, Purcell L, Liu C, Files DC. Aging Influences the Metabolic and Inflammatory Phenotype in an Experimental Mouse Model of Acute Lung Injury. J Gerontol A Biol Sci Med Sci. 2021 Apr 30; 76(5):770-777. PMID: 32997738.
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    29. Bivona JJ, Crymble HM, Guigni BA, Stapleton RD, Files DC, Toth MJ, Poynter ME, Suratt BT. Macrophages augment the skeletal muscle proinflammatory response through TNFa following LPS-induced acute lung injury. FASEB J. 2021 04; 35(4):e21462. PMID: 33724561.
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    30. Palakshappa JA, Callahan KE, Pajewski NM, Files DC, Willard JJ, Williamson JD. Detection of Cognitive Impairment Following Critical Illness with the Medicare Annual Wellness Visit: A Cohort Study. Ann Am Thorac Soc. 2021 Mar 18. PMID: 33735597.
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    31. Douin DJ, Ward MJ, Lindsell CJ, Howell MP, Hough CL, Exline MC, Gong MN, Aboodi MS, Tenforde MW, Feldstein LR, Stubblefield WB, Steingrub JS, Prekker ME, Brown SM, Peltan ID, Khan A, Files DC, Gibbs KW, Rice TW, Casey JD, Hager DN, Qadir N, Henning DJ, Wilson JG, Patel MM, Self WH, Ginde AA. ICU Bed Utilization During the Coronavirus Disease 2019 Pandemic in a Multistate Analysis-March to June 2020. Crit Care Explor. 2021 Mar; 3(3):e0361. PMID: 33786437.
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    32. A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19. N Engl J Med. 2021 03 11; 384(10):905-914. PMID: 33356051.
      Citations:    
    33. Self WH, Tenforde MW, Stubblefield WB, Feldstein LR, Steingrub JS, Shapiro NI, Ginde AA, Prekker ME, Brown SM, Peltan ID, Gong MN, Aboodi MS, Khan A, Exline MC, Files DC, Gibbs KW, Lindsell CJ, Rice TW, Jones ID, Halasa N, Talbot HK, Grijalva CG, Casey JD, Hager DN, Qadir N, Henning DJ, Coughlin MM, Schiffer J, Semenova V, Li H, Thornburg NJ, Patel MM. Decline in SARS-CoV-2 Antibodies After Mild Infection Among Frontline Health Care Personnel in a Multistate Hospital Network - 12 States, April-August 2020. MMWR Morb Mortal Wkly Rep. 2020 Nov 27; 69(47):1762-1766. PMID: 33237893.
      Citations:    
    34. Fisher KA, Olson SM, Tenforde MW, Feldstein LR, Lindsell CJ, Shapiro NI, Files DC, Gibbs KW, Erickson HL, Prekker ME, Steingrub JS, Exline MC, Henning DJ, Wilson JG, Brown SM, Peltan ID, Rice TW, Hager DN, Ginde AA, Talbot HK, Casey JD, Grijalva CG, Flannery B, Patel MM, Self WH. Telework Before Illness Onset Among Symptomatic Adults Aged =18 Years With and Without COVID-19 in 11 Outpatient Health Care Facilities - United States, July 2020. MMWR Morb Mortal Wkly Rep. 2020 Nov 06; 69(44):1648-1653. PMID: 33151918.
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    35. Dosso B, Waits CMK, Simms KN, Sergeant S, Files DC, Howard TD, Langefeld CD, Chilton FH, Rahbar E. Impact of rs174537 on Critically Ill Patients with Acute Lung Injury: A Secondary Analysis of the OMEGA Randomized Clinical Trial. Curr Dev Nutr. 2020 Oct; 4(10):nzaa147. PMID: 33024925.
      Citations:    
    36. Fisher KA, Tenforde MW, Feldstein LR, Lindsell CJ, Shapiro NI, Files DC, Gibbs KW, Erickson HL, Prekker ME, Steingrub JS, Exline MC, Henning DJ, Wilson JG, Brown SM, Peltan ID, Rice TW, Hager DN, Ginde AA, Talbot HK, Casey JD, Grijalva CG, Flannery B, Patel MM, Self WH. Community and Close Contact Exposures Associated with COVID-19 Among Symptomatic Adults =18 Years in 11 Outpatient Health Care Facilities - United States, July 2020. MMWR Morb Mortal Wkly Rep. 2020 Sep 11; 69(36):1258-1264. PMID: 32915165.
      Citations:    
    37. Self WH, Tenforde MW, Stubblefield WB, Feldstein LR, Steingrub JS, Shapiro NI, Ginde AA, Prekker ME, Brown SM, Peltan ID, Gong MN, Aboodi MS, Khan A, Exline MC, Files DC, Gibbs KW, Lindsell CJ, Rice TW, Jones ID, Halasa N, Talbot HK, Grijalva CG, Casey JD, Hager DN, Qadir N, Henning DJ, Coughlin MM, Schiffer J, Semenova V, Li H, Thornburg NJ, Patel MM. Seroprevalence of SARS-CoV-2 Among Frontline Health Care Personnel in a Multistate Hospital Network - 13 Academic Medical Centers, April-June 2020. MMWR Morb Mortal Wkly Rep. 2020 Sep 04; 69(35):1221-1226. PMID: 32881855.
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    38. Files DC, Liu KD, Matthay M. Need for Additional Trials of Vitamin C for Sepsis. JAMA. 2020 08 11; 324(6):607-608. PMID: 32780134.
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    39. Tenforde MW, Billig Rose E, Lindsell CJ, Shapiro NI, Files DC, Gibbs KW, Prekker ME, Steingrub JS, Smithline HA, Gong MN, Aboodi MS, Exline MC, Henning DJ, Wilson JG, Khan A, Qadir N, Stubblefield WB, Patel MM, Self WH, Feldstein LR. Characteristics of Adult Outpatients and Inpatients with COVID-19 - 11 Academic Medical Centers, United States, March-May 2020. MMWR Morb Mortal Wkly Rep. 2020 Jul 03; 69(26):841-846. PMID: 32614810.
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    40. Jones JRA, Berney S, Berry MJ, Files DC, Griffith DM, McDonald LA, Morris PE, Moss M, Nordon-Craft A, Walsh T, Gordon I, Karahalios A, Puthucheary Z, Denehy L. Response to physical rehabilitation and recovery trajectories following critical illness: individual participant data meta-analysis protocol. BMJ Open. 2020 05 04; 10(5):e035613. PMID: 32371516.
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    41. Files DC, Hume PS, Krall J, Montemayor K, Schmidt EP, King LS. Grant Writing for Clinicians in Training: An Important Career Development Exercise. Chest. 2020 04; 157(4):932-935. PMID: 31730834.
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    42. Files DC, Heinrich T, Shields KL, Love NJ, Brailer C, Bakhru RN, Purcell L, Flores L, Gibbs K, Miller GD, Morris PE, Berry MJ. A randomized pilot study of nitrate supplementation with beetroot juice in acute respiratory failure. Nitric Oxide. 2020 01 01; 94:63-68. PMID: 31669503.
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    43. Parry S, Denehy L, Granger C, McGinley J, Files DC, Berry M, Dhar S, Bakhru R, Larkin J, Puthucheary Z, Clark R, Morris P. The fear and risk of community falls in patients following an intensive care admission: An exploratory cohort study. Aust Crit Care. 2020 03; 33(2):144-150. PMID: 31495638.
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    44. Bakhru RN, Davidson JF, Bookstaver RE, Kenes MT, Peters SP, Welborn KG, Creech OR, Morris PE, Files DC. Implementation of an ICU Recovery Clinic at a Tertiary Care Academic Center. Crit Care Explor. 2019 Aug; 1(8):e0034. PMID: 32166275.
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    45. Heyland DK, Day A, Clarke GJ, Hough CT, Files DC, Mourtzakis M, Deutz N, Needham DM, Stapleton R. Nutrition and Exercise in Critical Illness Trial (NEXIS Trial): a protocol of a multicentred, randomised controlled trial of combined cycle ergometry and amino acid supplementation commenced early during critical illness. BMJ Open. 2019 07 31; 9(7):e027893. PMID: 31371287.
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    46. Opina MTD, Nicklas BJ, Lovato JF, Files DC, Kritchevsky SB, Moore WC. Association of Symptoms of Obstructive Lung Disease and All-Cause Mortality in Older Adult Smokers. J Am Geriatr Soc. 2019 10; 67(10):2116-2122. PMID: 31250432.
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    47. Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Khan A, Liu KD, Talmor D, Thompson BT, Ulysse CA, Yealy DM, Angus DC. Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome. N Engl J Med. 2019 05 23; 380(21):1997-2008. PMID: 31112383.
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    48. Berry MJ, Files DC, Campos CL, Bakhru RN, Skaggs BM, Morris PE. Echogenicity Is Related to Skeletal Muscle Strength in Patients With Acute Respiratory Failure. J Cardiopulm Rehabil Prev. 2019 05; 39(3):E17-E20. PMID: 31022008.
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    49. Gandotra S, Lovato J, Case D, Bakhru RN, Gibbs K, Berry M, Files DC, Morris PE. Physical Function Trajectories in Survivors of Acute Respiratory Failure. Ann Am Thorac Soc. 2019 04; 16(4):471-477. PMID: 30571923.
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    50. Lanspa MJ, Gong MN, Schoenfeld DA, Lee KT, Grissom CK, Hou PC, Serpa-Neto A, Brown SM, Iwashyna TJ, Yealy DM, Hough CL, Brower RG, Calfee CS, Hyzy RC, Matthay MA, Miller RR, Steingrub JS, Thompson BT, Miller CD, Clemmer TP, Hendey GW, Huang DT, Mathews KS, Qadir N, Tidswell M. Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure. Ann Am Thorac Soc. 2019 03; 16(3):356-362. PMID: 30407869.
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    51. Berry MJ, Love NJ, Files DC, Bakhru RN, Morris PE. The relationship between self-report and performance-based measures of physical function following an ICU stay. J Crit Care. 2019 06; 51:19-23. PMID: 30690430.
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    52. Rodrigues ACZ, Messi ML, Wang ZM, Abba MC, Pereyra A, Birbrair A, Zhang T, O'Meara M, Kwan P, Lopez EIS, Willis MS, Mintz A, Files DC, Furdui C, Oppenheim RW, Delbono O. The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability. Acta Physiol (Oxf). 2019 03; 225(3):e13195. PMID: 30269419.
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    53. Palakshappa JA, Reilly JP, Schweickert WD, Anderson BJ, Khoury V, Shashaty MG, Fitzgerald D, Forker C, Butler K, Ittner CA, Feng R, Files DC, Bonk MP, Christie JD, Meyer NJ. Quantitative peripheral muscle ultrasound in sepsis: Muscle area superior to thickness. J Crit Care. 2018 10; 47:324-330. PMID: 30224027.
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    54. Rice TW, Files DC, Morris PE, Bernard AC, Ziegler TR, Drover JW, Kress JP, Ham KR, Grathwohl DJ, Huhmann MB, Gautier JBO. Dietary Management of Blood Glucose in Medical Critically Ill Overweight and Obese Patients: An Open-Label Randomized Trial. JPEN J Parenter Enteral Nutr. 2019 05; 43(4):471-480. PMID: 30260488.
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    55. Files DC, Neiberg R, Rushing J, Morris PE, Young MP, Ayonayon H, Harris T, Newman A, Rubin S, Shiroma E, Houston D, Miller ME, Kritchevsky SB. Influence of Prehospital Function and Strength on Outcomes of Critically Ill Older Adults. J Am Geriatr Soc. 2018 03; 66(3):525-531. PMID: 29322491.
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    56. Limaye AP, Stapleton RD, Peng L, Gunn SR, Kimball LE, Hyzy R, Exline MC, Files DC, Morris PE, Frankel SK, Mikkelsen ME, Hite D, Enfield KB, Steingrub J, O'Brien J, Parsons PE, Cuschieri J, Wunderink RG, Hotchkin DL, Chen YQ, Rubenfeld GD, Boeckh M. Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness: A Randomized Clinical Trial. JAMA. 2017 08 22; 318(8):731-740. PMID: 28829877.
      Citations:    
    57. Pereyra AS, Wang ZM, Messi ML, Zhang T, Wu H, Register TC, Forbes E, Devarie-Baez NO, Files DC, Abba MC, Furdui C, Delbono O. BDA-410 Treatment Reduces Body Weight and Fat Content by Enhancing Lipolysis in Sedentary Senescent Mice. J Gerontol A Biol Sci Med Sci. 2017 Aug 01; 72(8):1045-1053. PMID: 27789616.
      Citations:    
    58. Brown SM, Duggal A, Hou PC, Tidswell M, Khan A, Exline M, Park PK, Schoenfeld DA, Liu M, Grissom CK, Moss M, Rice TW, Hough CL, Rivers E, Thompson BT, Brower RG. Nonlinear Imputation of PaO2/FIO2 From SpO2/FIO2 Among Mechanically Ventilated Patients in the ICU: A Prospective, Observational Study. Crit Care Med. 2017 Aug; 45(8):1317-1324. PMID: 28538439.
      Citations:    
    59. Xu Z, Feng X, Dong J, Wang ZM, Lee J, Furdui C, Files DC, Beavers KM, Kritchevsky S, Milligan C, Jin JP, Delbono O, Zhang T. Cardiac troponin T and fast skeletal muscle denervation in ageing. J Cachexia Sarcopenia Muscle. 2017 Oct; 8(5):808-823. PMID: 28419739.
      Citations:    
    60. LoVerde D, Files DC, Krishnaswamy G. Angioedema. Crit Care Med. 2017 Apr; 45(4):725-735. PMID: 28291095.
      Citations:    
    61. Hartman L, Barnes E, Bachmann L, Schafer K, Lovato J, Files DC. Opiate Injection-associated Infective Endocarditis in the Southeastern United States. Am J Med Sci. 2016 Dec; 352(6):603-608. PMID: 27916215.
      Citations:    
    62. Files DC, Ilaiwy A, Parry TL, Gibbs KW, Liu C, Bain JR, Delbono O, Muehlbauer MJ, Willis MS. Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism. Metabolomics. 2016 Aug; 12(8). PMID: 28217037.
      Citations:    
    63. Morris PE, Berry MJ, Files DC, Thompson JC, Hauser J, Flores L, Dhar S, Chmelo E, Lovato J, Case LD, Bakhru RN, Sarwal A, Parry SM, Campbell P, Mote A, Winkelman C, Hite RD, Nicklas B, Chatterjee A, Young MP. Standardized Rehabilitation and Hospital Length of Stay Among Patients With Acute Respiratory Failure: A Randomized Clinical Trial. JAMA. 2016 Jun 28; 315(24):2694-702. PMID: 27367766.
      Citations:    
    64. D'Alessio FR, Craig JM, Singer BD, Files DC, Mock JR, Garibaldi BT, Fallica J, Tripathi A, Mandke P, Gans JH, Limjunyawong N, Sidhaye VK, Heller NM, Mitzner W, King LS, Aggarwal NR. Enhanced resolution of experimental ARDS through IL-4-mediated lung macrophage reprogramming. . 2016 04 15; 310(8):L733-46. PMID: 26895644.
      Citations:    
    65. Zhang T, Pereyra AS, Wang ZM, Birbrair A, Reisz JA, Files DC, Purcell L, Feng X, Messi ML, Feng H, Chalovich J, Jin JP, Furdui C, Delbono O. Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice. Aging Cell. 2016 06; 15(3):488-98. PMID: 26892246.
      Citations:    
    66. Miller JJ, Morris P, Files DC, Gower E, Young M. Decision conflict and regret among surrogate decision makers in the medical intensive care unit. J Crit Care. 2016 Apr; 32:79-84. PMID: 26810482.
      Citations:    
    67. Choi SJ, Files DC, Zhang T, Wang ZM, Messi ML, Gregory H, Stone J, Lyles MF, Dhar S, Marsh AP, Nicklas BJ, Delbono O. Intramyocellular Lipid and Impaired Myofiber Contraction in Normal Weight and Obese Older Adults. J Gerontol A Biol Sci Med Sci. 2016 Apr; 71(4):557-64. PMID: 26405061.
      Citations:    
    68. Files DC, Sanchez MA, Morris PE. A conceptual framework: the early and late phases of skeletal muscle dysfunction in the acute respiratory distress syndrome. Crit Care. 2015 Jul 02; 19:266. PMID: 26134116.
      Citations:    
    69. Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Sci Transl Med. 2015 Mar 11; 7(278):278ra32. PMID: 25761888.
      Citations:    
    70. Birbrair A, Zhang T, Files DC, Mannava S, Smith T, Wang ZM, Messi ML, Mintz A, Delbono O. Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner. Stem Cell Res Ther. 2014 Nov 06; 5(6):122. PMID: 25376879.
      Citations:    
    71. Silverstein MG, Ordanes D, Wylie AT, Files DC, Milligan C, Presley TD, Kavanagh K. Inducing Muscle Heat Shock Protein 70 Improves Insulin Sensitivity and Muscular Performance in Aged Mice. J Gerontol A Biol Sci Med Sci. 2015 Jul; 70(7):800-8. PMID: 25123646.
      Citations:    
    72. Mock JR, Garibaldi BT, Aggarwal NR, Jenkins J, Limjunyawong N, Singer BD, Chau E, Rabold R, Files DC, Sidhaye V, Mitzner W, Wagner EM, King LS, D'Alessio FR. Foxp3+ regulatory T cells promote lung epithelial proliferation. Mucosal Immunol. 2014 Nov; 7(6):1440-51. PMID: 24850425.
      Citations:    
    73. Files DC, Xiao K, Zhang T, Liu C, Qian J, Zhao W, Morris PE, Delbono O, Feng X. The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury. PLoS One. 2014; 9(1):e87587. PMID: 24498144.
      Citations:    
    74. Aggarwal NR, D'Alessio FR, Eto Y, Chau E, Avalos C, Waickman AT, Garibaldi BT, Mock JR, Files DC, Sidhaye V, Polotsky VY, Powell J, Horton M, King LS. Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury. Am J Respir Cell Mol Biol. 2013 May; 48(5):635-46. PMID: 23349051.
      Citations:    
    75. Files DC, Hite RD. Predicting acute lung injury resolution: a role for chest CT? Crit Care Med. 2013 Feb; 41(2):668. PMID: 23353949.
      Citations:    
    76. Andres-Mateos E, Brinkmeier H, Burks TN, Mejias R, Files DC, Steinberger M, Soleimani A, Marx R, Simmers JL, Lin B, Finanger Hedderick E, Marr TG, Lin BM, Hourdé C, Leinwand LA, Kuhl D, Föller M, Vogelsang S, Hernandez-Diaz I, Vaughan DK, Alvarez de la Rosa D, Lang F, Cohn RD. Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy. EMBO Mol Med. 2013 01; 5(1):80-91. PMID: 23161797.
      Citations:    
    77. Garibaldi BT, D'Alessio FR, Mock JR, Files DC, Chau E, Eto Y, Drummond MB, Aggarwal NR, Sidhaye V, King LS. Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment. Am J Respir Cell Mol Biol. 2013 Jan; 48(1):35-43. PMID: 23002097.
      Citations:    
    78. D'Alessio FR, Tsushima K, Aggarwal NR, Mock JR, Eto Y, Garibaldi BT, Files DC, Avalos CR, Rodriguez JV, Waickman AT, Reddy SP, Pearse DB, Sidhaye VK, Hassoun PM, Crow MT, King LS. Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase. J Immunol. 2012 Sep 01; 189(5):2234-45. PMID: 22844117.
      Citations:    
    79. Files DC, D'Alessio FR, Johnston LF, Kesari P, Aggarwal NR, Garibaldi BT, Mock JR, Simmers JL, DeGorordo A, Murdoch J, Willis MS, Patterson C, Tankersley CG, Messi ML, Liu C, Delbono O, Furlow JD, Bodine SC, Cohn RD, King LS, Crow MT. A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting. Am J Respir Crit Care Med. 2012 Apr 15; 185(8):825-34. PMID: 22312013.
      Citations:    
    80. Zaiman AL, Damico R, Thoms-Chesley A, Files DC, Kesari P, Johnston L, Swaim M, Mozammel S, Myers AC, Halushka M, El-Haddad H, Shimoda LA, Peng CF, Hassoun PM, Champion HC, Kitsis RN, Crow MT. A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension. Circulation. 2011 Dec 06; 124(23):2533-42. PMID: 22082675.
      Citations:    
    81. Finanger Hedderick EL, Simmers JL, Soleimani A, Andres-Mateos E, Marx R, Files DC, King L, Crawford TO, Corse AM, Cohn RD. Loss of sarcolemmal nNOS is common in acquired and inherited neuromuscular disorders. Neurology. 2011 Mar 15; 76(11):960-7. PMID: 21403107.
      Citations:    
    82. Aggarwal NR, D'Alessio FR, Tsushima K, Files DC, Damarla M, Sidhaye VK, Fraig MM, Polotsky VY, King LS. Moderate oxygen augments lipopolysaccharide-induced lung injury in mice. . 2010 Mar; 298(3):L371-81. PMID: 20034961.
      Citations:    
    83. Files DC, Patel N, Gebretsadik T, Moore PE, Sheller J. A retrospective characterization of African- and European American asthmatic children in a pediatric critical care unit. J Natl Med Assoc. 2009 Nov; 101(11):1119-24. PMID: 19998640.
      Citations:    
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