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Rebecca M. Sappington PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentBiochemistry
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentOphthalmology, Head & Neck Surgery


    Collapse Research 
    Collapse research activities and funding
    R01EY020496     (SAPPINGTON, REBECCA M)Apr 1, 2010 - Aug 31, 2021
    NIH
    Interleukin-6 and Retinal Ganglion Cell Degeneration in Glaucoma
    Role: Principal Investigator
    R21EY026176     (XU, YAQIONG)Dec 1, 2015 - Nov 30, 2018
    NIH
    Graphene Optoelectronic Probes for Mapping Electrical Activities in Retina
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fischer RA, Risner ML, Roux AL, Wareham LK, Sappington RM. Impairment of Membrane Repolarization Accompanies Axon Transport Deficits in Glaucoma. Front Neurosci. 2019; 13:1139. PMID: 31736686.
      Citations:    
    2. Fischer RA, Roux AL, Wareham LK, Sappington RM. Pressure-dependent modulation of inward-rectifying K+ channels: implications for cation homeostasis and K+ dynamics in glaucoma. . 2019 08 01; 317(2):C375-C389. PMID: 31166711.
      Citations:    
    3. Backstrom JR, Sheng J, Fischer RA, Sappington RM, Rex TS. Phenotypes of primary retinal macroglia: Implications for purification and culture conditions. Exp Eye Res. 2019 05; 182:85-92. PMID: 30902621.
      Citations:    
    4. Fitzgerald ML, Tsai S, Bellan LM, Sappington R, Xu Y, Li D. The relationship between the Young's modulus and dry etching rate of polydimethylsiloxane (PDMS). Biomed Microdevices. 2019 03 02; 21(1):26. PMID: 30826983.
      Citations:    
    5. Duncan DS, Weiner RL, Weitlauf C, Risner ML, Roux AL, Sanford ER, Formichella CR, Sappington RM. Ccl5 Mediates Proper Wiring of Feedforward and Lateral Inhibition Pathways in the Inner Retina. Front Neurosci. 2018; 12:702. PMID: 30369865.
      Citations:    
    6. Wareham LK, Dordea AC, Schleifer G, Yao V, Batten A, Fei F, Mertz J, Gregory-Ksander M, Pasquale LR, Buys ES, Sappington RM. Increased bioavailability of cyclic guanylate monophosphate prevents retinal ganglion cell degeneration. Neurobiol Dis. 2019 01; 121:65-75. PMID: 30213732.
      Citations:    
    7. Fischer RA, Zhang Y, Risner ML, Li D, Xu Y, Sappington RM. Impact of Graphene on the Efficacy of Neuron Culture Substrates. Adv Healthc Mater. 2018 07; 7(14):e1701290. PMID: 29943431.
      Citations:    
    8. Wareham LK, Buys ES, Sappington RM. The nitric oxide-guanylate cyclase pathway and glaucoma. Nitric Oxide. 2018 07 01; 77:75-87. PMID: 29723581.
      Citations:    
    9. Calkins DJ, Lambert WS, Formichella CR, McLaughlin WM, Sappington RM. The Microbead Occlusion Model of Ocular Hypertension in Mice. Methods Mol Biol. 2018; 1695:23-39. PMID: 29190015.
      Citations:    
    10. Echevarria FD, Formichella CR, Sappington RM. Interleukin-6 Deficiency Attenuates Retinal Ganglion Cell Axonopathy and Glaucoma-Related Vision Loss. Front Neurosci. 2017; 11:318. PMID: 28620279.
      Citations:    
    11. Duncan DS, McLaughlin WM, Vasilakes N, Echevarria FD, Formichella CR, Sappington RM. Constitutive and Stress-induced Expression of CCL5 Machinery in Rodent Retina. J Clin Cell Immunol. 2017 Jun; 8(3). PMID: 28936366.
      Citations:    
    12. Lambert WS, Carlson BJ, Formichella CR, Sappington RM, Ahlem C, Calkins DJ. Oral Delivery of a Synthetic Sterol Reduces Axonopathy and Inflammation in a Rodent Model of Glaucoma. Front Neurosci. 2017; 11:45. PMID: 28223915.
      Citations:    
    13. Zhang Y, Dodson KH, Fischer R, Wang R, Li D, Sappington RM, Xu YQ. Probing electrical signals in the retina via graphene-integrated microfluidic platforms. Nanoscale. 2016 Dec 07; 8(45):19043-19049. PMID: 27812594.
      Citations:    
    14. Echevarria FD, Rickman AE, Sappington RM. Interleukin-6: A Constitutive Modulator of Glycoprotein 130, Neuroinflammatory and Cell Survival Signaling in Retina. J Clin Cell Immunol. 2016 Aug; 7(4). PMID: 27747134.
      Citations:    
    15. Dodson KH, Echevarria FD, Li D, Sappington RM, Edd JF. Retina-on-a-chip: a microfluidic platform for point access signaling studies. Biomed Microdevices. 2015 Dec; 17(6):114. PMID: 26559199.
      Citations:    
    16. Bond WS, Hines-Beard J, GoldenMerry YL, Davis M, Farooque A, Sappington RM, Calkins DJ, Rex TS. Virus-mediated EpoR76E Therapy Slows Optic Nerve Axonopathy in Experimental Glaucoma. Mol Ther. 2016 Feb; 24(2):230-239. PMID: 26502777.
      Citations:    
    17. Lee SJ, Duncan DS, Echevarria FD, McLaughlin WM, Hatcher JB, Sappington RM. Pressure-Induced Alterations in PEDF and PEDF-R Expression: Implications for Neuroprotective Signaling in Glaucoma. J Clin Exp Ophthalmol. 2015 Oct; 6(5). PMID: 26807306.
      Citations:    
    18. Sappington RM, Sidorova T, Ward NJ, Chakravarthy R, Ho KW, Calkins DJ. Activation of transient receptor potential vanilloid-1 (TRPV1) influences how retinal ganglion cell neurons respond to pressure-related stress. Channels (Austin). 2015; 9(2):102-13. PMID: 25713995.
      Citations:    
    19. Weitlauf C, Ward NJ, Lambert WS, Sidorova TN, Ho KW, Sappington RM, Calkins DJ. Short-term increases in transient receptor potential vanilloid-1 mediate stress-induced enhancement of neuronal excitation. J Neurosci. 2014 Nov 12; 34(46):15369-81. PMID: 25392504.
      Citations:    
    20. Formichella CR, Abella SK, Sims SM, Cathcart HM, Sappington RM. Astrocyte Reactivity: A Biomarker for Retinal Ganglion Cell Health in Retinal Neurodegeneration. J Clin Cell Immunol. 2014 Feb; 5(1). PMID: 25133067.
      Citations:    
    21. Sims SM, Holmgren L, Cathcart HM, Sappington RM. Spatial regulation of interleukin-6 signaling in response to neurodegenerative stressors in the retina. Am J Neurodegener Dis. 2012; 1(2):168-79. PMID: 23024928.
      Citations:    
    22. Chen H, Wei X, Cho KS, Chen G, Sappington R, Calkins DJ, Chen DF. Optic neuropathy due to microbead-induced elevated intraocular pressure in the mouse. Invest Ophthalmol Vis Sci. 2011 Jan 05; 52(1):36-44. PMID: 20702815.
      Citations:    
    23. Joos KM, Li C, Sappington RM. Morphometric changes in the rat optic nerve following short-term intermittent elevations in intraocular pressure. Invest Ophthalmol Vis Sci. 2010 Dec; 51(12):6431-40. PMID: 20688743.
      Citations:    
    24. Crish SD, Sappington RM, Inman DM, Horner PJ, Calkins DJ. Distal axonopathy with structural persistence in glaucomatous neurodegeneration. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5196-201. PMID: 20194762.
      Citations:    
    25. Sappington RM, Carlson BJ, Crish SD, Calkins DJ. The microbead occlusion model: a paradigm for induced ocular hypertension in rats and mice. Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):207-16. PMID: 19850836.
      Citations:    
    26. Wax MB, Tezel G, Yang J, Peng G, Patil RV, Agarwal N, Sappington RM, Calkins DJ. Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand. J Neurosci. 2008 Nov 12; 28(46):12085-96. PMID: 19005073.
      Citations:    
    27. Sappington RM, Sidorova T, Long DJ, Calkins DJ. TRPV1: contribution to retinal ganglion cell apoptosis and increased intracellular Ca2+ with exposure to hydrostatic pressure. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):717-28. PMID: 18952924.
      Citations:    
    28. Sappington RM, Calkins DJ. Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure. Invest Ophthalmol Vis Sci. 2008 Jul; 49(7):3004-17. PMID: 18362111.
      Citations:    
    29. Sappington RM, Calkins DJ. Pressure-induced regulation of IL-6 in retinal glial cells: involvement of the ubiquitin/proteasome pathway and NFkappaB. Invest Ophthalmol Vis Sci. 2006 Sep; 47(9):3860-9. PMID: 16936098.
      Citations:    
    30. Sappington RM, Chan M, Calkins DJ. Interleukin-6 protects retinal ganglion cells from pressure-induced death. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):2932-42. PMID: 16799036.
      Citations:    
    31. Inman DM, Sappington RM, Horner PJ, Calkins DJ. Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA/2 mouse model of glaucoma. Invest Ophthalmol Vis Sci. 2006 Mar; 47(3):986-96. PMID: 16505033.
      Citations:    
    32. Calkins DJ, Sappington RM, Hendry SH. Morphological identification of ganglion cells expressing the alpha subunit of type II calmodulin-dependent protein kinase in the macaque retina. J Comp Neurol. 2005 Jan 10; 481(2):194-209. PMID: 15562509.
      Citations:    
    33. Sappington RM, Pearce DA, Calkins DJ. Optic nerve degeneration in a murine model of juvenile ceroid lipofuscinosis. Invest Ophthalmol Vis Sci. 2003 Sep; 44(9):3725-31. PMID: 12939285.
      Citations:    
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