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Emmanuel C. Opara PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentWake Forest Institute for Regenerative Medicine
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentBiomedical Engineering


    Collapse Research 
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    R01DK080897     (OPARA, EMMANUEL C.)Sep 5, 2009 - Aug 31, 2012
    NIH
    Bioengineering A Bioartificial Pancreas
    Role: Principal Investigator
    R21AG061588     (GROBAN, LEANNE)Jan 15, 2019 - Nov 30, 2021
    NIH
    Effects of cell-based hormone therapy on LV diastolic dysfunction and hypertrophy progression after mid-life estrogen loss
    Role: Co-Principal Investigator
    R25DK121572     (OPARA, EMMANUEL C.)May 15, 2019 - May 14, 2021
    NIH
    Tissue Engineering and Regenerative Medicine Undergraduate Research Addressing Challenges In Diabetes, Kidney, Urologic and Hematologic Diseases
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Marulanda K, Brokaw D, Gambarian M, Pareta R, McQuilling JP, Opara EC, McLean SE. Controlled Delivery of Slit3 Proteins from Alginate Microbeads Inhibits In Vitro Angiogenesis. J Surg Res. 2021 Mar 29; 264:90-98. PMID: 33794389.
      Citations:    
    2. Enck K, Tamburrini R, Deborah C, Gazia C, Jost A, Khalil F, Alwan A, Orlando G, Opara EC. Effect of alginate matrix engineered to mimic the pancreatic microenvironment on encapsulated islet function. Biotechnol Bioeng. 2021 Mar; 118(3):1177-1185. PMID: 33270214.
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    3. Asthana A, Tamburrini R, Chaimov D, Gazia C, Walker SJ, Van Dyke M, Tomei A, Lablanche S, Robertson J, Opara EC, Soker S, Orlando G. Comprehensive characterization of the human pancreatic proteome for bioengineering applications. Biomaterials. 2021 03; 270:120613. PMID: 33561625.
      Citations:    
    4. Tamburrini R, Chaimov D, Asthana A, Gazia C, Enck K, Muir SM, Aziz JM, Lablanche S, Tubbs E, Tomei AA, Van Dyke M, Soker S, Opara EC, Orlando G. Detergent-Free Decellularization of the Human Pancreas for Soluble Extracellular Matrix (ECM) Production. J Vis Exp. 2020 09 04; (163). PMID: 32955501.
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    5. Opara EC. Bioengineering and Enabling Technologies: ABME Special Issue Editorial. Ann Biomed Eng. 2020 May; 48(5):1445-1450. PMID: 32232693.
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    6. Enck K, Rajan SP, Aleman J, Castagno S, Long E, Khalil F, Hall AR, Opara EC. Design of an Adhesive Film-Based Microfluidic Device for Alginate Hydrogel-Based Cell Encapsulation. Ann Biomed Eng. 2020 Mar; 48(3):1103-1111. PMID: 31933001.
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    7. Enck K, Banks S, Yadav H, Welker ME, Opara EC. Development of a Novel Oral Delivery Vehicle for Probiotics. Curr Pharm Des. 2020; 26(26):3134-3140. PMID: 32039674.
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    8. Banks SR, Enck K, Wright M, Opara EC, Welker ME. Chemical Modification of Alginate for Controlled Oral Drug Delivery. J Agric Food Chem. 2019 Sep 18; 67(37):10481-10488. PMID: 31433940.
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    9. Sittadjody S, Enck KM, Wells A, Yoo JJ, Atala A, Saul JM, Opara EC. Encapsulation of Mesenchymal Stem Cells in 3D Ovarian Cell Constructs Promotes Stable and Long-Term Hormone Secretion with Improved Physiological Outcomes in a Syngeneic Rat Model. Ann Biomed Eng. 2020 Mar; 48(3):1058-1070. PMID: 31367915.
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    10. Thompson EM, Sollinger JL, Opara EC, Adin CA. Selective Osmotic Shock for Islet Isolation in the Cadaveric Canine Pancreas. Cell Transplant. 2018 03; 27(3):542-550. PMID: 29869518.
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    11. Sittadjody S, Saul JM, McQuilling JP, Joo S, Register TC, Yoo JJ, Atala A, Opara EC. In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure. Nat Commun. 2017 12 05; 8(1):1858. PMID: 29208899.
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    12. McQuilling JP, Sittadjody S, Pendergraft S, Farney AC, Opara EC. Applications of particulate oxygen-generating substances (POGS) in the bioartificial pancreas. Biomater Sci. 2017 Nov 21; 5(12):2437-2447. PMID: 29051963.
      Citations:    
    13. Yan H, Zhong L, Jiang Y, Yang J, Deng J, Wei S, Opara E, Atala A, Mao X, Damaser MS, Zhang Y. Controlled release of insulin-like growth factor 1 enhances urethral sphincter function and histological structure in the treatment of female stress urinary incontinence in a rat model. BJU Int. 2018 02; 121(2):301-312. PMID: 28805303.
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    14. Balaji S, Zhou Y, Opara EC, Soker S. Combinations of Activin A or Nicotinamide with the Pancreatic Transcription Factor PDX1 Support Differentiation of Human Amnion Epithelial Cells Toward a Pancreatic Lineage. Cell Reprogram. 2017 08; 19(4):255-262. PMID: 28632450.
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    15. Opara EC. Applications of Cell Microencapsulation. Methods Mol Biol. 2017; 1479:23-39. PMID: 27738924.
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    16. Sharma V, Hunckler M, Ramasubramanian MK, Opara EC, Katuri KC. Microfluidic Approach to Cell Microencapsulation. Methods Mol Biol. 2017; 1479:71-76. PMID: 27738927.
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    17. Kendall WF, Opara EC. Polymeric Materials for Perm-Selective Coating of Alginate Microbeads. Methods Mol Biol. 2017; 1479:95-109. PMID: 27738929.
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    18. Darabbie MD, Opara EC. Determination of the Mechanical Strength of Microcapsules. Methods Mol Biol. 2017; 1479:111-118. PMID: 27738930.
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    19. McQuilling JP, Opara EC. Methods for Incorporating Oxygen-Generating Biomaterials into Cell Culture and Microcapsule Systems. Methods Mol Biol. 2017; 1479:135-141. PMID: 27738932.
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    20. McQuilling JP, Sittadjody S, Pareta R, Pendergraft S, Clark CJ, Farney AC, Opara EC. Retrieval of Microencapsulated Islet Grafts for Post-transplant Evaluation. Methods Mol Biol. 2017; 1479:157-171. PMID: 27738934.
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    21. Kendall WF, Opara EC. A Method of Porcine Pancreatic Islet Isolation for Microencapsulation. Methods Mol Biol. 2017; 1479:175-189. PMID: 27738935.
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    22. Enck K, McQuilling JP, Orlando G, Tamburrini R, Sivanandane S, Opara EC. Selective Osmotic Shock (SOS)-Based Islet Isolation for Microencapsulation. Methods Mol Biol. 2017; 1479:191-198. PMID: 27738936.
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    23. Sittadjody S, Saul JM, Opara EC. Compartmentalization of Two Cell Types in Multilayered Alginate Microcapsules. Methods Mol Biol. 2017; 1479:225-235. PMID: 27738940.
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    24. Niu G, McQuilling JP, Zhou Y, Opara EC, Orlando G, Soker S. In Vitro Proliferation of Porcine Pancreatic Islet Cells for ß-Cell Therapy Applications. J Diabetes Res. 2016; 2016:5807876. PMID: 28050568.
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    25. Appel AA, Ibarra V, Somo SI, Larson JC, Garson AB, Guan H, McQuilling JP, Zhong Z, Anastasio MA, Opara EC, Brey EM. Imaging of Hydrogel Microsphere Structure and Foreign Body Response Based on Endogenous X-Ray Phase Contrast. Tissue Eng Part C Methods. 2016 11; 22(11):1038-1048. PMID: 27796159.
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    26. Yang Y, Opara EC, Liu Y, Atala A, Zhao W. Microencapsulation of porcine thyroid cell organoids within a polymer microcapsule construct. Exp Biol Med (Maywood). 2017 02; 242(3):286-296. PMID: 27708182.
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    27. Peloso A, Urbani L, Cravedi P, Katari R, Maghsoudlou P, Fallas ME, Sordi V, Citro A, Purroy C, Niu G, McQuilling JP, Sittadjody S, Farney AC, Iskandar SS, Zambon JP, Rogers J, Stratta RJ, Opara EC, Piemonti L, Furdui CM, Soker S, De Coppi P, Orlando G. The Human Pancreas as a Source of Protolerogenic Extracellular Matrix Scaffold for a New-generation Bioartificial Endocrine Pancreas. Ann Surg. 2016 07; 264(1):169-79. PMID: 26649588.
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    28. Ibarra V, Appel AA, Anastasio MA, Opara EC, Brey EM. This paper is a winner in the Undergraduate category for the SFB awards: Evaluation of the tissue response to alginate encapsulated islets in an omentum pouch model. J Biomed Mater Res A. 2016 07; 104(7):1581-90. PMID: 27144389.
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    29. Balaji S, Zhou Y, Ganguly A, Opara EC, Soker S. The combined effect of PDX1, epidermal growth factor and poly-L-ornithine on human amnion epithelial cells' differentiation. BMC Dev Biol. 2016 Apr 12; 16:8. PMID: 27068127.
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    30. Sunwook K, Nussbaum MA, Quandt SA, Laurienti PJ, Arcury TA. Effects of Lifetime Occupational Pesticide Exposure on Postural Control Among Farmworkers and Non-Farmworkers. J Occup Environ Med. 2016 Feb; 58(2):133-9. PMID: 23442080.
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    31. Farney AC, Sutherland DE, Opara EC. Evolution of Islet Transplantation for the Last 30 Years. Pancreas. 2016 Jan; 45(1):8-20. PMID: 26658037.
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    32. Pareta R, McQuilling JP, Sittadjody S, Jenkins R, Bowden S, Orlando G, Farney AC, Brey EM, Opara EC. Long-term function of islets encapsulated in a redesigned alginate microcapsule construct in omentum pouches of immune-competent diabetic rats. Pancreas. 2014 May; 43(4):605-13. PMID: 24681880.
      Citations:    
    33. Yalcinkaya TM, Sittadjody S, Opara EC. Scientific principles of regenerative medicine and their application in the female reproductive system. Maturitas. 2014 Jan; 77(1):12-9. PMID: 24210634.
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    34. Fang X, Sittadjody S, Gyabaah K, Opara EC, Balaji KC. Novel 3D co-culture model for epithelial-stromal cells interaction in prostate cancer. PLoS One. 2013; 8(9):e75187. PMID: 24073251.
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    35. Khanna O, Huang JJ, Moya ML, Wu CW, Cheng MH, Opara EC, Brey EM. FGF-1 delivery from multilayer alginate microbeads stimulates a rapid and persistent increase in vascular density. Microvasc Res. 2013 Nov; 90:23-9. PMID: 23978335.
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    36. Campeau L, Soler R, Sittadjody S, Pareta R, Nomiya M, Zarifpour M, Opara EC, Yoo JJ, Andersson KE. Effects of allogeneic bone marrow derived mesenchymal stromal cell therapy on voiding function in a rat model of Parkinson disease. J Urol. 2014 Mar; 191(3):850-9. PMID: 23973520.
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    37. Pareta RA, Farney AC, Opara EC. Design of a bioartificial pancreas. Pathobiology. 2013; 80(4):194-202. PMID: 23652283.
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    38. Mirmalek-Sani SH, Orlando G, McQuilling JP, Pareta R, Mack DL, Salvatori M, Farney AC, Stratta RJ, Atala A, Opara EC, Soker S. Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering. Biomaterials. 2013 Jul; 34(22):5488-95. PMID: 23583038.
      Citations:    
    39. Opara EC, McQuilling JP, Farney AC. Microencapsulation of pancreatic islets for use in a bioartificial pancreas. Methods Mol Biol. 2013; 1001:261-6. PMID: 23494435.
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    40. Sittadjody S, Saul JM, Joo S, Yoo JJ, Atala A, Opara EC. Engineered multilayer ovarian tissue that secretes sex steroids and peptide hormones in response to gonadotropins. Biomaterials. 2013 Mar; 34(10):2412-20. PMID: 23274068.
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    41. Liu G, Pareta RA, Wu R, Shi Y, Zhou X, Liu H, Deng C, Sun X, Atala A, Opara EC, Zhang Y. Skeletal myogenic differentiation of urine-derived stem cells and angiogenesis using microbeads loaded with growth factors. Biomaterials. 2013 Jan; 34(4):1311-26. PMID: 23137393.
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    42. Pareta R, Sanders B, Babbar P, Soker T, Booth C, McQuilling J, Sivanandane S, Stratta RJ, Orlando G, Opara EC. Immunoisolation: where regenerative medicine meets solid organ transplantation. Expert Rev Clin Immunol. 2012 Sep; 8(7):685-92. PMID: 23078065.
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    43. Khanna O, Larson JC, Moya ML, Opara EC, Brey EM. Generation of alginate microspheres for biomedical applications. J Vis Exp. 2012 Aug 12; (66). PMID: 22907205.
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    44. Tendulkar S, Mirmalek-Sani SH, Childers C, Saul J, Opara EC, Ramasubramanian MK. A three-dimensional microfluidic approach to scaling up microencapsulation of cells. Biomed Microdevices. 2012 Jun; 14(3):461-9. PMID: 22245953.
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    45. Orlando G, Wood KJ, De Coppi P, Baptista PM, Binder KW, Bitar KN, Breuer C, Burnett L, Christ G, Farney A, Figliuzzi M, Holmes JH, Koch K, Macchiarini P, Mirmalek Sani SH, Opara E, Remuzzi A, Rogers J, Saul JM, Seliktar D, Shapira-Schweitzer K, Smith T, Solomon D, Van Dyke M, Yoo JJ, Zhang Y, Atala A, Stratta RJ, Soker S. Regenerative medicine as applied to general surgery. Ann Surg. 2012 May; 255(5):867-80. PMID: 22330032.
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    46. Moya ML, Morley M, Khanna O, Opara EC, Brey EM. Stability of alginate microbead properties in vitro. J Mater Sci Mater Med. 2012 Apr; 23(4):903-12. PMID: 22350778.
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    47. Orlando G, Baptista P, Birchall M, De Coppi P, Farney A, Guimaraes-Souza NK, Opara E, Rogers J, Seliktar D, Shapira-Schweitzer K, Stratta RJ, Atala A, Wood KJ, Soker S. Regenerative medicine as applied to solid organ transplantation: current status and future challenges. Transpl Int. 2011 Mar; 24(3):223-32. PMID: 21062367.
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    48. Khanna O, Moya ML, Greisler HP, Opara EC, Brey EM. Multilayered microcapsules for the sustained-release of angiogenic proteins from encapsulated cells. Am J Surg. 2010 Nov; 200(5):655-8. PMID: 21056148.
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    49. Khanna O, Moya ML, Opara EC, Brey EM. Synthesis of multilayered alginate microcapsules for the sustained release of fibroblast growth factor-1. J Biomed Mater Res A. 2010 Nov; 95(2):632-40. PMID: 20725969.
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    50. Opara EC, Mirmalek-Sani SH, Khanna O, Moya ML, Brey EM. Design of a bioartificial pancreas(+). J Investig Med. 2010 Oct; 58(7):831-7. PMID: 20683347.
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    51. Moya ML, Cheng MH, Huang JJ, Francis-Sedlak ME, Kao SW, Opara EC, Brey EM. The effect of FGF-1 loaded alginate microbeads on neovascularization and adipogenesis in a vascular pedicle model of adipose tissue engineering. Biomaterials. 2010 Apr; 31(10):2816-26. PMID: 20080298.
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    52. Moya ML, Garfinkel MR, Liu X, Lucas S, Opara EC, Greisler HP, Brey EM. Fibroblast growth factor-1 (FGF-1) loaded microbeads enhance local capillary neovascularization. J Surg Res. 2010 May 15; 160(2):208-12. PMID: 19959194.
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    53. Moya ML, Lucas S, Francis-Sedlak M, Liu X, Garfinkel MR, Huang JJ, Cheng MH, Opara EC, Brey EM. Sustained delivery of FGF-1 increases vascular density in comparison to bolus administration. Microvasc Res. 2009 Sep; 78(2):142-7. PMID: 19555698.
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    54. Darrabie MD, Kendall WF, Opara EC. Effect of alginate composition and gelling cation on microbead swelling. J Microencapsul. 2006 Sep; 23(6):613-21. PMID: 17118877.
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    55. Opara EC. Oxidative stress. Dis Mon. 2006 May; 52(5):183-98. PMID: 16828360.
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    56. Opara EC, Rockway SW. Antioxidants and micronutrients. Dis Mon. 2006 Apr; 52(4):151-63. PMID: 16828355.
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    57. Darrabie MD, Kendall WF, Opara EC. Effect of alginate composition and gelling cation on micro-bead swelling. J Microencapsul. 2006 Feb; 23(1):29-37. PMID: 16830975.
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    58. Darrabie MD, Kendall WF, Opara EC. Characteristics of Poly-L-Ornithine-coated alginate microcapsules. Biomaterials. 2005 Dec; 26(34):6846-52. PMID: 15955558.
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    59. Kizilel S, Garfinkel M, Opara E. The bioartificial pancreas: progress and challenges. Diabetes Technol Ther. 2005 Dec; 7(6):968-85. PMID: 16386103.
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    60. Koch TR, Petro A, Darrabie M, Opara EC. Effects of esomeprazole magnesium on nonsteroidal anti-inflammatory drug gastropathy. Dig Dis Sci. 2005 Jan; 50(1):86-93. PMID: 15712643.
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    61. Gawrieh S, Opara EC, Koch TR. Oxidative stress in nonalcoholic fatty liver disease: pathogenesis and antioxidant therapies. J Investig Med. 2004 Dec; 52(8):506-14. PMID: 15682682.
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    62. Koch TR, Petro A, Darrabie M, Opara EC. Effect of the H, K-ATPase inhibitor, esomeprazole magnesium, on gut total antioxidant capacity in mice. J Nutr Biochem. 2004 Sep; 15(9):522-6. PMID: 15350983.
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    63. Opara EC. Role of oxidative stress in the etiology of type 2 diabetes and the effect of antioxidant supplementation on glycemic control. J Investig Med. 2004 Jan; 52(1):19-23. PMID: 14989366.
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    64. El-Shewy HM, Kendall WF, Darrabie M, Collins BH, Opara EC. Polyvinyl pyrrolidone: a novel cryoprotectant in islet cell cryopreservation. Cell Transplant. 2004; 13(3):237-43. PMID: 15191161.
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    65. Koch TR, Telford GL, Walgenbach-Telford S, Kendall WF, Opara EC. Total antioxidant capacity following extrinsic denervation and small intestinal transplantation in the rat. Neurosci Lett. 2003 May 15; 342(1-2):135-7. PMID: 12727336.
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    66. Koch TR, Yuan LX, Petro A, Opara EC. Effects of omeprazole and ascorbate on gastric emptying and antioxidant levels in a mouse model of glutathione depletion. Dig Dis Sci. 2002 Nov; 47(11):2486-92. PMID: 12452384.
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    67. Opara EC, Kendall WF. Immunoisolation techniques for islet cell transplantation. Expert Opin Biol Ther. 2002 Jun; 2(5):503-11. PMID: 12079486.
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    68. Freemark M, Avril I, Fleenor D, Driscoll P, Petro A, Opara E, Kendall W, Oden J, Bridges S, Binart N, Breant B, Kelly PA. Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance. Endocrinology. 2002 Apr; 143(4):1378-85. PMID: 11897695.
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