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Last Name

Daniel Clark Files, M.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine - Pulmonary
Address
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    Other Positions
    TitleAssociate Professor
    InstitutionWake Forest School of Medicine
    DepartmentInternal Medicine-Gerontology and Geriatric Medicine


    Collapse Research 
    Collapse research activities and funding
    F32AR057637     (FILES, DANIEL CLARK)Sep 16, 2009 - Sep 15, 2011
    NIH/NIAMS
    Acute Lung Injury Induces Skeletal Muscle Atrophy
    Role: Principal Investigator

    U01HL123027     (MILLER, CHADWICK DAVID)Jun 17, 2014 - Apr 30, 2021
    NIH/NHLBI
    Wake Forest Clinical Center for the NHLBI PETAL Network
    Role: Co-Principal Investigator

    K08GM123322     (FILES, DANIEL CLARK)Jun 10, 2018 - May 31, 2023
    NIH/NIGMS
    Accelerating Muscle Recovery in Critical Illness
    Role: Principal Investigator

    R01HL143452     (SURATT, BENJAMIN T)Sep 15, 2018 - Jun 30, 2022
    NIH/NHLBI
    Effects of Exercise on Inflammation-Induced Lung and Muscle Injury in Critical Illness (NEXIS-FLAME)
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Parry SM, Denehy L, Granger CL, McGinley JL, Files DC, Berry MJ, Dhar S, Bakhru RN, Larkin JST, Puthucheary ZA, Clark RA, Morris PE. The fear and risk of community falls in patients following an intensive care admission: An exploratory cohort study. Aust Crit Care. 2019 Sep 05. PMID: 31495638.
      View in: PubMed
    2. Heyland DK, Day A, Clarke GJ, Hough CT, Files DC, Mourtzakis M, Deutz N, Needham DM, Stapleton R. Nutrition and Exercise in Critical Illness Trial (NEXIS Trial): a protocol of a multicentred, randomised controlled trial of combined cycle ergometry and amino acid supplementation commenced early during critical illness. BMJ Open. 2019 Jul 31; 9(7):e027893. PMID: 31371287.
      View in: PubMed
    3. Opina MTD, Nicklas BJ, Lovato JF, Files DC, Kritchevsky SB, Moore WC. Association of Symptoms of Obstructive Lung Disease and All-Cause Mortality in Older Adult Smokers. J Am Geriatr Soc. 2019 Jun 27. PMID: 31250432.
      View in: PubMed
    4. Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome. N Engl J Med. 2019 05 23; 380(21):1997-2008. PMID: 31112383.
      View in: PubMed
    5. Berry MJ, Files DC, Campos CL, Bakhru RN, Skaggs BM, Morris PE. Echogenicity Is Related to Skeletal Muscle Strength in Patients With Acute Respiratory Failure. J Cardiopulm Rehabil Prev. 2019 May; 39(3):E17-E20. PMID: 31022008.
      View in: PubMed
    6. Gandotra S, Lovato J, Case D, Bakhru RN, Gibbs K, Berry M, Files DC, Morris PE. Physical Function Trajectories in Survivors of Acute Respiratory Failure. Ann Am Thorac Soc. 2019 Apr; 16(4):471-477. PMID: 30571923.
      View in: PubMed
    7. Lanspa MJ, Gong MN, Schoenfeld DA, Lee KT, Grissom CK, Hou PC, Serpa-Neto A, Brown SM, Iwashyna TJ, Yealy DM, Hough CL, Brower RG, Calfee CS, Hyzy RC, Matthay MA, Miller RR, Steingrub JS, Thompson BT, Miller CD, Clemmer TP, Hendey GW, Huang DT, Mathews KS, Qadir N, Tidswell M. Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure. Ann Am Thorac Soc. 2019 03; 16(3):356-362. PMID: 30407869.
      View in: PubMed
    8. Berry MJ, Love NJ, Files DC, Bakhru RN, Morris PE. The relationship between self-report and performance-based measures of physical function following an ICU stay. J Crit Care. 2019 Jun; 51:19-23. PMID: 30690430.
      View in: PubMed
    9. Rodrigues ACZ, Messi ML, Wang ZM, Abba MC, Pereyra A, Birbrair A, Zhang T, O'Meara M, Kwan P, Lopez EIS, Willis MS, Mintz A, Files DC, Furdui C, Oppenheim RW, Delbono O. The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability. Acta Physiol (Oxf). 2019 Mar; 225(3):e13195. PMID: 30269419.
      View in: PubMed
    10. Palakshappa JA, Reilly JP, Schweickert WD, Anderson BJ, Khoury V, Shashaty MG, Fitzgerald D, Forker C, Butler K, Ittner CA, Feng R, Files DC, Bonk MP, Christie JD, Meyer NJ. Quantitative peripheral muscle ultrasound in sepsis: Muscle area superior to thickness. J Crit Care. 2018 10; 47:324-330. PMID: 30224027.
      View in: PubMed
    11. Rice TW, Files DC, Morris PE, Bernard AC, Ziegler TR, Drover JW, Kress JP, Ham KR, Grathwohl DJ, Huhmann MB, Gautier JBO. Dietary Management of Blood Glucose in Medical Critically Ill Overweight and Obese Patients: An Open-Label Randomized Trial. JPEN J Parenter Enteral Nutr. 2019 May; 43(4):471-480. PMID: 30260488.
      View in: PubMed
    12. Files DC, Neiberg R, Rushing J, Morris PE, Young MP, Ayonayon H, Harris T, Newman A, Rubin S, Shiroma E, Houston D, Miller ME, Kritchevsky SB. Influence of Prehospital Function and Strength on Outcomes of Critically Ill Older Adults. J Am Geriatr Soc. 2018 03; 66(3):525-531. PMID: 29322491.
      View in: PubMed
    13. Limaye AP, Stapleton RD, Peng L, Gunn SR, Kimball LE, Hyzy R, Exline MC, Files DC, Morris PE, Frankel SK, Mikkelsen ME, Hite D, Enfield KB, Steingrub J, O'Brien J, Parsons PE, Cuschieri J, Wunderink RG, Hotchkin DL, Chen YQ, Rubenfeld GD, Boeckh M. Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness: A Randomized Clinical Trial. JAMA. 2017 08 22; 318(8):731-740. PMID: 28829877.
      View in: PubMed
    14. Brown SM, Duggal A, Hou PC, Tidswell M, Khan A, Exline M, Park PK, Schoenfeld DA, Liu M, Grissom CK, Moss M, Rice TW, Hough CL, Rivers E, Thompson BT, Brower RG. Nonlinear Imputation of PaO2/FIO2 From SpO2/FIO2 Among Mechanically Ventilated Patients in the ICU: A Prospective, Observational Study. Crit Care Med. 2017 Aug; 45(8):1317-1324. PMID: 28538439.
      View in: PubMed
    15. Pereyra AS, Wang ZM, Messi ML, Zhang T, Wu H, Register TC, Forbes E, Devarie-Baez NO, Files DC, Abba MC, Furdui C, Delbono O. BDA-410 Treatment Reduces Body Weight and Fat Content by Enhancing Lipolysis in Sedentary Senescent Mice. J Gerontol A Biol Sci Med Sci. 2017 Aug 01; 72(8):1045-1053. PMID: 27789616.
      View in: PubMed
    16. Xu Z, Feng X, Dong J, Wang ZM, Lee J, Furdui C, Files DC, Beavers KM, Kritchevsky S, Milligan C, Jin JP, Delbono O, Zhang T. Cardiac troponin T and fast skeletal muscle denervation in ageing. J Cachexia Sarcopenia Muscle. 2017 Oct; 8(5):808-823. PMID: 28419739.
      View in: PubMed
    17. LoVerde D, Files DC, Krishnaswamy G. Angioedema. Crit Care Med. 2017 Apr; 45(4):725-735. PMID: 28291095.
      View in: PubMed
    18. Hartman L, Barnes E, Bachmann L, Schafer K, Lovato J, Files DC. Opiate Injection-associated Infective Endocarditis in the Southeastern United States. Am J Med Sci. 2016 Dec; 352(6):603-608. PMID: 27916215.
      View in: PubMed
    19. Files DC, Ilaiwy A, Parry TL, Gibbs KW, Liu C, Bain JR, Delbono O, Muehlbauer MJ, Willis MS. Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism. Metabolomics. 2016 Aug; 12(8). PMID: 28217037.
      View in: PubMed
    20. Morris PE, Berry MJ, Files DC, Thompson JC, Hauser J, Flores L, Dhar S, Chmelo E, Lovato J, Case LD, Bakhru RN, Sarwal A, Parry SM, Campbell P, Mote A, Winkelman C, Hite RD, Nicklas B, Chatterjee A, Young MP. Standardized Rehabilitation and Hospital Length of Stay Among Patients With Acute Respiratory Failure: A Randomized Clinical Trial. JAMA. 2016 Jun 28; 315(24):2694-702. PMID: 27367766.
      View in: PubMed
    21. D'Alessio FR, Craig JM, Singer BD, Files DC, Mock JR, Garibaldi BT, Fallica J, Tripathi A, Mandke P, Gans JH, Limjunyawong N, Sidhaye VK, Heller NM, Mitzner W, King LS, Aggarwal NR. Enhanced resolution of experimental ARDS through IL-4-mediated lung macrophage reprogramming. Am J Physiol Lung Cell Mol Physiol. 2016 04 15; 310(8):L733-46. PMID: 26895644.
      View in: PubMed
    22. Zhang T, Pereyra AS, Wang ZM, Birbrair A, Reisz JA, Files DC, Purcell L, Feng X, Messi ML, Feng H, Chalovich J, Jin JP, Furdui C, Delbono O. Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice. Aging Cell. 2016 06; 15(3):488-98. PMID: 26892246.
      View in: PubMed
    23. Miller JJ, Morris P, Files DC, Gower E, Young M. Decision conflict and regret among surrogate decision makers in the medical intensive care unit. J Crit Care. 2016 Apr; 32:79-84. PMID: 26810482.
      View in: PubMed
    24. Choi SJ, Files DC, Zhang T, Wang ZM, Messi ML, Gregory H, Stone J, Lyles MF, Dhar S, Marsh AP, Nicklas BJ, Delbono O. Intramyocellular Lipid and Impaired Myofiber Contraction in Normal Weight and Obese Older Adults. J Gerontol A Biol Sci Med Sci. 2016 Apr; 71(4):557-64. PMID: 26405061.
      View in: PubMed
    25. Files DC, Sanchez MA, Morris PE. A conceptual framework: the early and late phases of skeletal muscle dysfunction in the acute respiratory distress syndrome. Crit Care. 2015 Jul 02; 19:266. PMID: 26134116.
      View in: PubMed
    26. Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Sci Transl Med. 2015 Mar 11; 7(278):278ra32. PMID: 25761888.
      View in: PubMed
    27. Birbrair A, Zhang T, Files DC, Mannava S, Smith T, Wang ZM, Messi ML, Mintz A, Delbono O. Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner. Stem Cell Res Ther. 2014 Nov 06; 5(6):122. PMID: 25376879.
      View in: PubMed
    28. Silverstein MG, Ordanes D, Wylie AT, Files DC, Milligan C, Presley TD, Kavanagh K. Inducing Muscle Heat Shock Protein 70 Improves Insulin Sensitivity and Muscular Performance in Aged Mice. J Gerontol A Biol Sci Med Sci. 2015 Jul; 70(7):800-8. PMID: 25123646.
      View in: PubMed
    29. Mock JR, Garibaldi BT, Aggarwal NR, Jenkins J, Limjunyawong N, Singer BD, Chau E, Rabold R, Files DC, Sidhaye V, Mitzner W, Wagner EM, King LS, D'Alessio FR. Foxp3+ regulatory T cells promote lung epithelial proliferation. Mucosal Immunol. 2014 Nov; 7(6):1440-51. PMID: 24850425.
      View in: PubMed
    30. Files DC, Xiao K, Zhang T, Liu C, Qian J, Zhao W, Morris PE, Delbono O, Feng X. The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury. PLoS One. 2014; 9(1):e87587. PMID: 24498144.
      View in: PubMed
    31. Aggarwal NR, D'Alessio FR, Eto Y, Chau E, Avalos C, Waickman AT, Garibaldi BT, Mock JR, Files DC, Sidhaye V, Polotsky VY, Powell J, Horton M, King LS. Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury. Am J Respir Cell Mol Biol. 2013 May; 48(5):635-46. PMID: 23349051.
      View in: PubMed
    32. Files DC, Hite RD. Predicting acute lung injury resolution: a role for chest CT? Crit Care Med. 2013 Feb; 41(2):668. PMID: 23353949.
      View in: PubMed
    33. Andres-Mateos E, Brinkmeier H, Burks TN, Mejias R, Files DC, Steinberger M, Soleimani A, Marx R, Simmers JL, Lin B, Finanger Hedderick E, Marr TG, Lin BM, Hourdé C, Leinwand LA, Kuhl D, Föller M, Vogelsang S, Hernandez-Diaz I, Vaughan DK, Alvarez de la Rosa D, Lang F, Cohn RD. Activation of serum/glucocorticoid-induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy. EMBO Mol Med. 2013 01; 5(1):80-91. PMID: 23161797.
      View in: PubMed
    34. Garibaldi BT, D'Alessio FR, Mock JR, Files DC, Chau E, Eto Y, Drummond MB, Aggarwal NR, Sidhaye V, King LS. Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment. Am J Respir Cell Mol Biol. 2013 Jan; 48(1):35-43. PMID: 23002097.
      View in: PubMed
    35. D'Alessio FR, Tsushima K, Aggarwal NR, Mock JR, Eto Y, Garibaldi BT, Files DC, Avalos CR, Rodriguez JV, Waickman AT, Reddy SP, Pearse DB, Sidhaye VK, Hassoun PM, Crow MT, King LS. Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase. J Immunol. 2012 Sep 01; 189(5):2234-45. PMID: 22844117.
      View in: PubMed
    36. Files DC, D'Alessio FR, Johnston LF, Kesari P, Aggarwal NR, Garibaldi BT, Mock JR, Simmers JL, DeGorordo A, Murdoch J, Willis MS, Patterson C, Tankersley CG, Messi ML, Liu C, Delbono O, Furlow JD, Bodine SC, Cohn RD, King LS, Crow MT. A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting. Am J Respir Crit Care Med. 2012 Apr 15; 185(8):825-34. PMID: 22312013.
      View in: PubMed
    37. Zaiman AL, Damico R, Thoms-Chesley A, Files DC, Kesari P, Johnston L, Swaim M, Mozammel S, Myers AC, Halushka M, El-Haddad H, Shimoda LA, Peng CF, Hassoun PM, Champion HC, Kitsis RN, Crow MT. A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension. Circulation. 2011 Dec 06; 124(23):2533-42. PMID: 22082675.
      View in: PubMed
    38. Finanger Hedderick EL, Simmers JL, Soleimani A, Andres-Mateos E, Marx R, Files DC, King L, Crawford TO, Corse AM, Cohn RD. Loss of sarcolemmal nNOS is common in acquired and inherited neuromuscular disorders. Neurology. 2011 Mar 15; 76(11):960-7. PMID: 21403107.
      View in: PubMed
    39. Aggarwal NR, D'Alessio FR, Tsushima K, Files DC, Damarla M, Sidhaye VK, Fraig MM, Polotsky VY, King LS. Moderate oxygen augments lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2010 Mar; 298(3):L371-81. PMID: 20034961.
      View in: PubMed
    40. Files DC, Patel N, Gebretsadik T, Moore PE, Sheller J. A retrospective characterization of African- and European American asthmatic children in a pediatric critical care unit. J Natl Med Assoc. 2009 Nov; 101(11):1119-24. PMID: 19998640.
      View in: PubMed
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