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Chia-Chi C. Key PhD

TitleAssistant Professor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Pulmonary, Critical Care, Allergy and Immunologic Diseases
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    Other Positions
    TitleAssistant Professor
    InstitutionWake Forest School of Medicine
    DepartmentInternal Medicine, Molecular Medicine


    Collapse Research 
    Collapse research activities and funding
    K01DK117069     (KEY, CHIA-CHI CHUANG)Sep 1, 2018 - Aug 31, 2022
    NIH
    Role of Hepatic GDPD3 in Mechanisms of Lipid Metabolism
    Role: Principal Investigator
    R01DK120667     (SOLBERG WOODS, LEAH CATHERINE)Sep 20, 2019 - Jun 30, 2024
    NIH
    Systems genetics to identify neuronal genes for diet-induced obesity
    Role: Co-Investigator
    W81XWH-20-Primrp-EA     (CZECH, MICHAEL)Mar 1, 2021 - Feb 28, 2025
    The U.S. Department of Defense (DOD)
    Advancement of CRISPR-based adipose tissue therapies for Type 2 Diabetes to nonhuman primates
    Role: Co-Investigator
    Daryl and Marguerite Errett Discovery Award     (KEY, CHIA-CHI CHUANG)Sep 1, 2022 - Aug 31, 2023
    Errett Fisher Foundation
    Exploring a novel GRK5 specific inhibitor as a new treatment for obesity and its associated comorbidities
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mainali R, Buechler N, Otero C, Edwards L, Key CC, Furdui C, Quinn MA. Itaconate stabilizes CPT1a to enhance lipid utilization during inflammation. Elife. 2024 Feb 02; 12. PMID: 38305778.
      Citations:    
    2. Seramur ME, Sink S, Cox AO, Furdui CM, Key CC. ABHD4 regulates adipocyte differentiation in vitro but does not affect adipose tissue lipid metabolism in mice. J Lipid Res. 2023 Aug; 64(8):100405. PMID: 37352974.
      Citations:    
    3. Mishra S, Kumar A, Kim S, Su Y, Singh S, Sharma M, Almousa S, Rather HA, Jain H, Lee J, Furdui CM, Ahmad S, Ferrario CM, Punzi HA, Chuang CC, Wabitsch M, Kritchevsky SB, Register TC, Deep G. A Liquid Biopsy-Based Approach to Isolate and Characterize Adipose Tissue-Derived Extracellular Vesicles from Blood. ACS Nano. 2023 Jun 13; 17(11):10252-10268. PMID: 37224410.
      Citations:    
    4. Ji Z, Moore J, Devarie-Baez NO, Lewis J, Wu H, Shukla K, Lopez EIS, Vitvitsky V, Key CC, Porosnicu M, Kemp ML, Banerjee R, Parks JS, Tsang AW, Zhou X, Furdui CM. Redox integration of signaling and metabolism in a head and neck cancer model of radiation resistance using COSMRO. Front Oncol. 2022; 12:946320. PMID: 36686772.
      Citations:    
    5. Le TH, Crouse WL, Keele GR, Holl K, Seshie O, Tschannen M, Craddock A, Das SK, Szalanczy AM, McDonald B, Grzybowski M, Klotz J, Sharma NK, Geurts AM, Chuang Key CC, Hawkins G, Valdar W, Mott R, Solberg Woods LC. Genetic Mapping of Multiple Metabolic Traits Identifies Novel Genes for Adiposity, Lipids and Insulin Secretory Capacity in Outbred Rats. Diabetes. 2022 Oct 11. PMID: 36219827.
      Citations:    
    6. Szalanczy AM, Goff E, Seshie O, Deal A, Grzybowski M, Klotz J, Chuang Key CC, Geurts AM, Solberg Woods LC. Keratinocyte-associated protein 3 plays a role in body weight and adiposity with differential effects in males and females. Front Genet. 2022; 13:942574. PMID: 36212147.
      Citations:    
    7. Kirk LM, Waits CMK, Bashore AC, Dosso B, Meyers AK, Renaldo AC, DePalma TJ, Simms KN, Hauser N, Chuang Key CC, McCall CE, Parks JS, Sergeant S, Langefeld CD, Skardal A, Rahbar E. Exploiting three-dimensional human hepatic constructs to investigate the impact of rs174537 on fatty acid metabolism. PLoS One. 2022; 17(1):e0262173. PMID: 35051193.
      Citations:    
    8. Szalanczy AM, Key CC, Solberg Woods LC. Genetic variation in satiety signaling and hypothalamic inflammation: merging fields for the study of obesity. J Nutr Biochem. 2021 Dec 20; 101:108928. PMID: 34936921.
      Citations:    
    9. Gibbs KW, Chuang Key CC, Belfield L, Krall J, Purcell L, Liu C, Files DC. Aging Influences the Metabolic and Inflammatory Phenotype in an Experimental Mouse Model of Acute Lung Injury. J Gerontol A Biol Sci Med Sci. 2021 Apr 30; 76(5):770-777. PMID: 32997738.
      Citations:    
    10. Mainali R, Zabalawi M, Long D, Buechler N, Quillen E, Key CC, Zhu X, Parks JS, Furdui C, Stacpoole PW, Martinez J, McCall CE, Quinn MA. Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction. Elife. 2021 Feb 22; 10. PMID: 33616039.
      Citations:    
    11. Ruggiero AD, Key CC, Kavanagh K. Adipose Tissue Macrophage Polarization in Healthy and Unhealthy Obesity. Front Nutr. 2021; 8:625331. PMID: 33681276.
      Citations:    
    12. Key CC, Bishop AC, Wang X, Zhao Q, Chen GY, Quinn MA, Zhu X, Zhang Q, Parks JS. Human GDPD3 overexpression promotes liver steatosis by increasing lysophosphatidic acid production and fatty acid uptake. J Lipid Res. 2020 07; 61(7):1075-1086. PMID: 32430316.
      Citations:    
    13. Wang Z, Zhao Q, Nie Y, Yu Y, Misra BB, Zabalawi M, Chou JW, Key CC, Molina AJ, Quinn MA, Fessler MB, Parks JS, McCall CE, Zhu X. Solute Carrier Family 37 Member 2 (SLC37A2) Negatively Regulates Murine Macrophage Inflammation by Controlling Glycolysis. iScience. 2020 May 22; 23(5):101125. PMID: 32428862.
      Citations:    
    14. Bashore AC, Liu M, Key CC, Boudyguina E, Wang X, Carroll CM, Sawyer JK, Mullick AE, Lee RG, Macauley SL, Parks JS. Targeted Deletion of Hepatocyte Abca1 Increases Plasma HDL (High-Density Lipoprotein) Reverse Cholesterol Transport via the LDL (Low-Density Lipoprotein) Receptor. Arterioscler Thromb Vasc Biol. 2019 09; 39(9):1747-1761. PMID: 31167565.
      Citations:    
    15. Sharma NK, Chuang Key CC, Civelek M, Wabitsch M, Comeau ME, Langefeld CD, Parks JS, Das SK. Genetic Regulation of Enoyl-CoA Hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans. Diabetes. 2019 07; 68(7):1508-1522. PMID: 31010960.
      Citations:    
    16. Liu M, Chuang Key CC, Weckerle A, Boudyguina E, Sawyer JK, Gebre AK, Spoo W, Makwana O, Parks JS. Feeding of tobacco blend or nicotine induced weight loss associated with decreased adipocyte size and increased physical activity in male mice. Food Chem Toxicol. 2018 Mar; 113:287-295. PMID: 29421645.
      Citations:    
    17. Cuffe H, Liu M, Key CC, Boudyguina E, Sawyer JK, Weckerle A, Bashore A, Fried SK, Chung S, Parks JS. Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity. Arterioscler Thromb Vasc Biol. 2018 04; 38(4):733-743. PMID: 29348118.
      Citations:    
    18. Shen L, Yang Y, Ou T, Key CC, Tong SH, Sequeira RC, Nelson JM, Nie Y, Wang Z, Boudyguina E, Shewale SV, Zhu X. Dietary PUFAs attenuate NLRP3 inflammasome activation via enhancing macrophage autophagy. J Lipid Res. 2017 09; 58(9):1808-1821. PMID: 28729463.
      Citations:    
    19. Key CC, Liu M, Kurtz CL, Chung S, Boudyguina E, Dinh TA, Bashore A, Phelan PE, Freedman BI, Osborne TF, Zhu X, Ma L, Sethupathy P, Biddinger SB, Parks JS. Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis. Cell Rep. 2017 06 06; 19(10):2116-2129. PMID: 28591582.
      Citations:    
    20. Collins B, Hoffman J, Martinez K, Grace M, Lila MA, Cockrell C, Nadimpalli A, Chang E, Chuang CC, Zhong W, Mackert J, Shen W, Cooney P, Hopkins R, McIntosh M. A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice. J Nutr Biochem. 2016 05; 31:150-65. PMID: 27133434.
      Citations:    
    21. Baldwin J, Collins B, Wolf PG, Martinez K, Shen W, Chuang CC, Zhong W, Cooney P, Cockrell C, Chang E, Gaskins HR, McIntosh MK. Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice. J Nutr Biochem. 2016 Jan; 27:123-35. PMID: 26423887.
      Citations:    
    22. Ding J, Reynolds LM, Zeller T, Müller C, Lohman K, Nicklas BJ, Kritchevsky SB, Huang Z, de la Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR, Post W, Tracy RP, Wild PS, Blankenberg S, Hoeschele I, Herrington D, McCall CE, Liu Y. Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease. Diabetes. 2015 Oct; 64(10):3464-74. PMID: 26153245.
      Citations:    
    23. Shen W, Baldwin J, Collins B, Hixson L, Lee KT, Herberg T, Starnes J, Cooney P, Chuang CC, Hopkins R, Reid T, Gupta S, McIntosh M. Low level of trans-10, cis-12 conjugated linoleic acid decreases adiposity and increases browning independent of inflammatory signaling in overweight Sv129 mice. J Nutr Biochem. 2015 Jun; 26(6):616-25. PMID: 25801353.
      Citations:    
    24. Liu M, Allegood J, Zhu X, Seo J, Gebre AK, Boudyguina E, Cheng D, Chuang CC, Shelness GS, Spiegel S, Parks JS. Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles. J Biol Chem. 2015 Mar 20; 290(12):7861-70. PMID: 25627684.
      Citations:    
    25. Huang Y, DiDonato JA, Levison BS, Schmitt D, Li L, Wu Y, Buffa J, Kim T, Gerstenecker GS, Gu X, Kadiyala CS, Wang Z, Culley MK, Hazen JE, Didonato AJ, Fu X, Berisha SZ, Peng D, Nguyen TT, Liang S, Chuang CC, Cho L, Plow EF, Fox PL, Gogonea V, Tang WH, Parks JS, Fisher EA, Smith JD, Hazen SL. An abundant dysfunctional apolipoprotein A1 in human atheroma. Nat Med. 2014 Feb; 20(2):193-203. PMID: 24464187.
      Citations:    
    26. Zhu X, Chung S, Bi X, Chuang CC, Brown AL, Liu M, Seo J, Cuffe H, Gebre AK, Boudyguina E, Parks JS. Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse models. J Lipid Res. 2013 Oct; 54(10):2708-17. PMID: 23894207.
      Citations:    
    27. Shen W, Martinez K, Chuang CC, McIntosh M. The phospholipase C inhibitor U73122 attenuates trans-10, cis-12 conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes. J Nutr. 2013 May; 143(5):584-90. PMID: 23468551.
      Citations:    
    28. Shen W, Chuang CC, Martinez K, Reid T, Brown JM, Xi L, Hixson L, Hopkins R, Starnes J, McIntosh M. Conjugated linoleic acid reduces adiposity and increases markers of browning and inflammation in white adipose tissue of mice. J Lipid Res. 2013 Apr; 54(4):909-22. PMID: 23401602.
      Citations:    
    29. Martinez K, Shyamasundar S, Kennedy A, Chuang CC, Marsh A, Kincaid J, Reid T, McIntosh M. Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes. J Lipid Res. 2013 Mar; 54(3):662-70. PMID: 23264678.
      Citations:    
    30. Chuang CC, Shen W, Chen H, Xie G, Jia W, Chung S, McIntosh MK. Differential effects of grape powder and its extract on glucose tolerance and chronic inflammation in high-fat-fed obese mice. J Agric Food Chem. 2012 Dec 26; 60(51):12458-68. PMID: 23210691.
      Citations:    
    31. Chuang CC, McIntosh MK. Potential mechanisms by which polyphenol-rich grapes prevent obesity-mediated inflammation and metabolic diseases. Annu Rev Nutr. 2011 Aug 21; 31:155-76. PMID: 21548775.
      Citations:    
    32. Overman A, Chuang CC, McIntosh M. Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media. Int J Obes (Lond). 2011 Sep; 35(9):1165-72. PMID: 21224828.
      Citations:    
    33. Chuang CC, Martinez K, Xie G, Kennedy A, Bumrungpert A, Overman A, Jia W, McIntosh MK. Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-{alpha}-mediated inflammation and insulin resistance in primary human adipocytes. Am J Clin Nutr. 2010 Dec; 92(6):1511-21. PMID: 20943792.
      Citations:    
    34. Chuang CC, Bumrungpert A, Kennedy A, Overman A, West T, Dawson B, McIntosh MK. Grape powder extract attenuates tumor necrosis factor a-mediated inflammation and insulin resistance in primary cultures of human adipocytes. J Nutr Biochem. 2011 Jan; 22(1):89-94. PMID: 20382011.
      Citations:    
    35. Bumrungpert A, Kalpravidh RW, Chuang CC, Overman A, Martinez K, Kennedy A, McIntosh M. Xanthones from mangosteen inhibit inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. J Nutr. 2010 Apr; 140(4):842-7. PMID: 20181789.
      Citations:    
    36. Overman A, Bumrungpert A, Kennedy A, Martinez K, Chuang CC, West T, Dawson B, Jia W, McIntosh M. Polyphenol-rich grape powder extract (GPE) attenuates inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. Int J Obes (Lond). 2010 May; 34(5):800-8. PMID: 20101247.
      Citations:    
    37. Yang RS, Tzeng HP, Ho FM, Chuang CC, Chen BL, Huang CF, Chen YW, Chen RM, Liu SH. Titanium implants alter endothelial function and vasoconstriction via a protein kinase C-regulated pathway. Acta Biomater. 2009 Oct; 5(8):3258-64. PMID: 19446049.
      Citations:    
    38. Bumrungpert A, Kalpravidh RW, Chitchumroonchokchai C, Chuang CC, West T, Kennedy A, McIntosh M. Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes. J Nutr. 2009 Jun; 139(6):1185-91. PMID: 19403722.
      Citations:    
    39. Kennedy A, Martinez K, Chuang CC, LaPoint K, McIntosh M. Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: mechanisms of action and implications. J Nutr. 2009 Jan; 139(1):1-4. PMID: 19056664.
      Citations:    
    40. Kennedy A, Overman A, Lapoint K, Hopkins R, West T, Chuang CC, Martinez K, Bell D, McIntosh M. Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol. J Lipid Res. 2009 Feb; 50(2):225-32. PMID: 18776171.
      Citations:    
    41. Chuang CC, Yang RS, Tsai KS, Ho FM, Liu SH. Hyperglycemia enhances adipogenic induction of lipid accumulation: involvement of extracellular signal-regulated protein kinase 1/2, phosphoinositide 3-kinase/Akt, and peroxisome proliferator-activated receptor gamma signaling. Endocrinology. 2007 Sep; 148(9):4267-75. PMID: 17540722.
      Citations:    
    42. Chao KC, Chao KF, Chuang CC, Liu SH. Blockade of interleukin 6 accelerates acinar cell apoptosis and attenuates experimental acute pancreatitis in vivo. Br J Surg. 2006 Mar; 93(3):332-8. PMID: 16392107.
      Citations:    
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