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Yusuke Shiozawa MD, PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentCancer Biology
Address
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    Collapse Research 
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    U54CA163124     (TAICHMAN, RUSSELL S)Sep 16, 2011 - Jul 31, 2017
    NIH
    Mechanisms of Prostate Cancer Dormancy in the Bone Marrow Niche
    Role: Co-Principal Investigator

    R44CA203184     (CHEN, MENGQIAN)Sep 23, 2015 - May 31, 2022
    NIH
    CDK8/19 inhibitors for therapy of advanced prostate cancer
    Role: Co-Principal Investigator

    R01CA238888     (SHIOZAWA, YUSUKE)Mar 5, 2020 - Feb 28, 2025
    NIH
    The contributions of sensory nerves to bone metastasis and associated bone pain
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Park SH, Eber MR, Taichman RS, Shiozawa Y. Determining Competitive Potential of Bone Metastatic Cancer Cells in the Murine Hematopoietic Stem Cell Niche. Methods Mol Biol. 2019; 2002:141-150. PMID: 30099699.
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    2. Park SH, Eber MR, Shiozawa Y. Models of Prostate Cancer Bone Metastasis. Methods Mol Biol. 2019; 1914:295-308. PMID: 30729472.
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    3. Widner DB, Park SH, Eber MR, Shiozawa Y. Interactions Between Disseminated Tumor Cells and Bone Marrow Stromal Cells Regulate Tumor Dormancy. Curr Osteoporos Rep. 2018 10; 16(5):596-602. PMID: 30128835.
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    4. Park SH, Eber MR, Widner DB, Shiozawa Y. Role of the Bone Microenvironment in the Development of Painful Complications of Skeletal Metastases. Cancers (Basel). 2018 May 10; 10(5). PMID: 29747461.
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    5. Park SH, Eber MR, Tsuzuki S, Booker ME, Sunil AG, Widner DB, Parker RA, Peters CM, Shiozawa Y. Adeno-associated virus serotype rh10 is a useful gene transfer vector for sensory nerves that innervate bone in immunodeficient mice. Sci Rep. 2017 12 12; 7(1):17428. PMID: 29233995.
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    6. Park SH, Keller ET, Shiozawa Y. Bone Marrow Microenvironment as a Regulator and Therapeutic Target for Prostate Cancer Bone Metastasis. Calcif Tissue Int. 2018 02; 102(2):152-162. PMID: 29094177.
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    7. Kast RE, Skuli N, Cos S, Karpel-Massler G, Shiozawa Y, Goshen R, Halatsch ME. The ABC7 regimen: a new approach to metastatic breast cancer using seven common drugs to inhibit epithelial-to-mesenchymal transition and augment capecitabine efficacy. Breast Cancer (Dove Med Press). 2017; 9:495-514. PMID: 28744157.
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    8. Shiozawa Y, Berry JE, Eber MR, Jung Y, Yumoto K, Cackowski FC, Yoon HJ, Parsana P, Mehra R, Wang J, McGee S, Lee E, Nagrath S, Pienta KJ, Taichman RS. Correction: The marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer. Oncotarget. 2017 06 06; 8(23):38075. PMID: 28598824.
      Citations:    
    9. Cackowski FC, Eber MR, Rhee J, Decker AM, Yumoto K, Berry JE, Lee E, Shiozawa Y, Jung Y, Aguirre-Ghiso JA, Taichman RS. Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy. J Cell Biochem. 2017 04; 118(4):891-902. PMID: 27753136.
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    10. Tsuzuki S, Park SH, Eber MR, Peters CM, Shiozawa Y. Skeletal complications in cancer patients with bone metastases. Int J Urol. 2016 10; 23(10):825-832. PMID: 27488133.
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    11. Sharma S, Xing F, Liu Y, Wu K, Said N, Pochampally R, Shiozawa Y, Lin HK, Balaji KC, Watabe K. Secreted Protein Acidic and Rich in Cysteine (SPARC) Mediates Metastatic Dormancy of Prostate Cancer in Bone. J Biol Chem. 2016 09 09; 291(37):19351-63. PMID: 27422817.
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    12. Shiozawa Y, Berry JE, Eber MR, Jung Y, Yumoto K, Cackowski FC, Yoon HJ, Parsana P, Mehra R, Wang J, McGee S, Lee E, Nagrath S, Pienta KJ, Taichman RS. The marrow niche controls the cancer stem cell phenotype of disseminated prostate cancer. Oncotarget. 2016 Jul 05; 7(27):41217-41232. PMID: 27172799.
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    13. Dai J, Hensel J, Wang N, Kruithof-de Julio M, Shiozawa Y. Mouse models for studying prostate cancer bone metastasis. Bonekey Rep. 2016; 5:777. PMID: 26916039.
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    14. Shiozawa Y, Eber MR, Berry JE, Taichman RS. Bone marrow as a metastatic niche for disseminated tumor cells from solid tumors. Bonekey Rep. 2015; 4:689. PMID: 26029360.
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    15. Shiozawa Y, Taichman RS. Bone: Elucidating which cell erythropoietin targets in bone. Nat Rev Endocrinol. 2015 May; 11(5):263-4. PMID: 25752274.
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    16. Seib FP, Berry JE, Shiozawa Y, Taichman RS, Kaplan DL. Tissue engineering a surrogate niche for metastatic cancer cells. Biomaterials. 2015 May; 51:313-319. PMID: 25771021.
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    17. Jung Y, Wang J, Lee E, McGee S, Berry JE, Yumoto K, Dai J, Keller ET, Shiozawa Y, Taichman RS. Annexin 2-CXCL12 interactions regulate metastatic cell targeting and growth in the bone marrow. Mol Cancer Res. 2015 Jan; 13(1):197-207. PMID: 25139998.
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    18. Shiozawa Y, Taichman RS. HSCs and niche relations marked by CD166. Blood. 2014 Jul 24; 124(4):471-2. PMID: 25061166.
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    19. Yumoto K, Eber MR, Berry JE, Taichman RS, Shiozawa Y. Molecular pathways: niches in metastatic dormancy. Clin Cancer Res. 2014 Jul 01; 20(13):3384-9. PMID: 24756372.
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    20. Yumoto K, Berry JE, Taichman RS, Shiozawa Y. A novel method for monitoring tumor proliferation in vivo using fluorescent dye DiD. Cytometry A. 2014 Jun; 85(6):548-55. PMID: 24700602.
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    21. Havens AM, Sun H, Shiozawa Y, Jung Y, Wang J, Mishra A, Jiang Y, O'Neill DW, Krebsbach PH, Rodgerson DO, Taichman RS. Human and murine very small embryonic-like cells represent multipotent tissue progenitors, in vitro and in vivo. Stem Cells Dev. 2014 Apr 01; 23(7):689-701. PMID: 24372153.
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    22. Shiozawa Y, Takita J, Kato M, Sotomatsu M, Koh K, Ida K, Hayashi Y. Prognostic significance of leukopenia in childhood acute lymphoblastic leukemia. Oncol Lett. 2014 Apr; 7(4):1169-1174. PMID: 24944687.
      Citations:    
    23. Shiozawa Y, McGee S, Pienta MJ, McGregor N, Jung Y, Yumoto K, Wang J, Berry JE, Pienta KJ, Taichman RS. Erythropoietin supports the survival of prostate cancer, but not growth and bone metastasis. J Cell Biochem. 2013 Nov; 114(11):2471-8. PMID: 23696192.
      Citations:    
    24. Kim JK, Jung Y, Wang J, Joseph J, Mishra A, Hill EE, Krebsbach PH, Pienta KJ, Shiozawa Y, Taichman RS. TBK1 regulates prostate cancer dormancy through mTOR inhibition. Neoplasia. 2013 Sep; 15(9):1064-74. PMID: 24027431.
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    25. Shiozawa Y, Inuzuka R, Harita Y, Kagawa J. Age-related differences in the course of the acute phase symptoms of Kawasaki disease. Pediatr Infect Dis J. 2013 Sep; 32(9):e365-9. PMID: 23584583.
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    26. Taichman RS, Patel LR, Bedenis R, Wang J, Weidner S, Schumann T, Yumoto K, Berry JE, Shiozawa Y, Pienta KJ. GAS6 receptor status is associated with dormancy and bone metastatic tumor formation. PLoS One. 2013; 8(4):e61873. PMID: 23637920.
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    27. Shiozawa Y, Nie B, Pienta KJ, Morgan TM, Taichman RS. Cancer stem cells and their role in metastasis. Pharmacol Ther. 2013 May; 138(2):285-93. PMID: 23384596.
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    28. Jung Y, Kim JK, Shiozawa Y, Wang J, Mishra A, Joseph J, Berry JE, McGee S, Lee E, Sun H, Wang J, Jin T, Zhang H, Dai J, Krebsbach PH, Keller ET, Pienta KJ, Taichman RS. Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis. Nat Commun. 2013; 4:1795. PMID: 23653207.
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    29. Shiozawa Y, Taichman RS, Keller ET. Detection and isolation of human disseminated tumor cells in the murine bone marrow stem cell niche. Methods Mol Biol. 2013; 1035:207-15. PMID: 23959994.
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    30. Havens AM, Shiozawa Y, Jung Y, Sun H, Wang J, McGee S, Mishra A, Taichman LS, Danciu T, Jiang Y, Yavanian G, Leary E, Krebsbach PH, Rodgerson D, Taichman RS. Human very small embryonic-like cells generate skeletal structures, in vivo. Stem Cells Dev. 2013 Feb 15; 22(4):622-30. PMID: 23020187.
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    31. Sun H, Jung Y, Shiozawa Y, Taichman RS, Krebsbach PH. Erythropoietin modulates the structure of bone morphogenetic protein 2-engineered cranial bone. Tissue Eng Part A. 2012 Oct; 18(19-20):2095-105. PMID: 22703029.
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    32. Shiozawa Y, Taichman RS. Getting blood from bone: an emerging understanding of the role that osteoblasts play in regulating hematopoietic stem cells within their niche. Exp Hematol. 2012 Sep; 40(9):685-94. PMID: 22640993.
      Citations:    
    33. Jung Y, Shiozawa Y, Wang J, McGregor N, Dai J, Park SI, Berry JE, Havens AM, Joseph J, Kim JK, Patel L, Carmeliet P, Daignault S, Keller ET, McCauley LK, Pienta KJ, Taichman RS. Prevalence of prostate cancer metastases after intravenous inoculation provides clues into the molecular basis of dormancy in the bone marrow microenvironment. Neoplasia. 2012 May; 14(5):429-39. PMID: 22745589.
      Citations:    
    34. Mishra A, Wang J, Shiozawa Y, McGee S, Kim J, Jung Y, Joseph J, Berry JE, Havens A, Pienta KJ, Taichman RS. Hypoxia stabilizes GAS6/Axl signaling in metastatic prostate cancer. Mol Cancer Res. 2012 Jun; 10(6):703-12. PMID: 22516347.
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    35. Shiozawa Y, Taichman RS. Cancer Stem Cells and the Bone Marrow Microenvironment. Bonekey Rep. 2012 Mar 01; 2012(1). PMID: 23745167.
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    36. Pedersen EA, Shiozawa Y, Pienta KJ, Taichman RS. The prostate cancer bone marrow niche: more than just 'fertile soil'. Asian J Androl. 2012 May; 14(3):423-7. PMID: 22367179.
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    37. Joseph J, Shiozawa Y, Jung Y, Kim JK, Pedersen E, Mishra A, Zalucha JL, Wang J, Keller ET, Pienta KJ, Taichman RS. Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype. Mol Cancer Res. 2012 Mar; 10(3):282-92. PMID: 22241219.
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    38. D'Souza S, Kurihara N, Shiozawa Y, Joseph J, Taichman R, Galson DL, Roodman GD. Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment. Blood. 2012 Feb 23; 119(8):1888-96. PMID: 22223826.
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    39. Kim J, Jung Y, Sun H, Joseph J, Mishra A, Shiozawa Y, Wang J, Krebsbach PH, Taichman RS. Erythropoietin mediated bone formation is regulated by mTOR signaling. J Cell Biochem. 2012 Jan; 113(1):220-8. PMID: 21898543.
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    40. Pedersen EA, Shiozawa Y, Mishra A, Taichman RS. Structure and function of the solid tumor niche. Front Biosci (Schol Ed). 2012 Jan 01; 4:1-15. PMID: 22202039.
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    41. Yu C, Shiozawa Y, Taichman RS, McCauley LK, Pienta K, Keller E. Prostate cancer and parasitism of the bone hematopoietic stem cell niche. Crit Rev Eukaryot Gene Expr. 2012; 22(2):131-48. PMID: 22856431.
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    42. Patel LR, Camacho DF, Shiozawa Y, Pienta KJ, Taichman RS. Mechanisms of cancer cell metastasis to the bone: a multistep process. Future Oncol. 2011 Nov; 7(11):1285-97. PMID: 22044203.
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    43. Mishra A, Shiozawa Y, Pienta KJ, Taichman RS. Homing of cancer cells to the bone. Cancer Microenviron. 2011 Dec; 4(3):221-35. PMID: 21826451.
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    44. Shiozawa Y, Pienta KJ, Taichman RS. Hematopoietic stem cell niche is a potential therapeutic target for bone metastatic tumors. Clin Cancer Res. 2011 Sep 01; 17(17):5553-8. PMID: 21676926.
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    45. Shiozawa Y, Pedersen EA, Havens AM, Jung Y, Mishra A, Joseph J, Kim JK, Patel LR, Ying C, Ziegler AM, Pienta MJ, Song J, Wang J, Loberg RD, Krebsbach PH, Pienta KJ, Taichman RS. Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. J Clin Invest. 2011 Apr; 121(4):1298-312. PMID: 21436587.
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    46. Jung Y, Shiozawa Y, Wang J, Patel LR, Havens AM, Song J, Krebsbach PH, Roodman GD, Taichman RS. Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche. Exp Hematol. 2011 Feb; 39(2):151-166.e1. PMID: 21108988.
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    47. Taichman RS, Wang Z, Shiozawa Y, Jung Y, Song J, Balduino A, Wang J, Patel LR, Havens AM, Kucia M, Ratajczak MZ, Krebsbach PH. Prospective identification and skeletal localization of cells capable of multilineage differentiation in vivo. Stem Cells Dev. 2010 Oct; 19(10):1557-70. PMID: 20446812.
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    48. Shiozawa Y, Jung Y, Ziegler AM, Pedersen EA, Wang J, Wang Z, Song J, Wang J, Lee CH, Sud S, Pienta KJ, Krebsbach PH, Taichman RS. Erythropoietin couples hematopoiesis with bone formation. PLoS One. 2010 May 27; 5(5):e10853. PMID: 20523730.
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    49. Shiozawa Y, Taichman RS. Dysfunctional niches as a root of hematopoietic malignancy. Cell Stem Cell. 2010 May 07; 6(5):399-400. PMID: 20452309.
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    50. Shiozawa Y, Pedersen EA, Patel LR, Ziegler AM, Havens AM, Jung Y, Wang J, Zalucha S, Loberg RD, Pienta KJ, Taichman RS. GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche. Neoplasia. 2010 Feb; 12(2):116-27. PMID: 20126470.
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    51. Shiozawa Y, Pedersen EA, Taichman RS. GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche. Exp Hematol. 2010 Feb; 38(2):132-40. PMID: 19922767.
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    52. Jung Y, Shiozawa Y, Wang J, Wang J, Wang Z, Pedersen EA, Lee CH, Hall CL, Hogg PJ, Krebsbach PH, Keller ET, Taichman RS. Expression of PGK1 by prostate cancer cells induces bone formation. Mol Cancer Res. 2009 Oct; 7(10):1595-604. PMID: 19825988.
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    53. Shiozawa Y, Takenouchi H, Taguchi T, Saito M, Katagiri YU, Okita H, Shimizu T, Yamashiro Y, Fujimoto J, Kiyokawa N. Human osteoblasts support hematopoietic cell development in vitro. Acta Haematol. 2008; 120(3):134-45. PMID: 19039204.
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    54. Shiozawa Y, Havens AM, Jung Y, Ziegler AM, Pedersen EA, Wang J, Wang J, Lu G, Roodman GD, Loberg RD, Pienta KJ, Taichman RS. Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer. J Cell Biochem. 2008 Oct 01; 105(2):370-80. PMID: 18636554.
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    55. Sun YX, Pedersen EA, Shiozawa Y, Havens AM, Jung Y, Wang J, Pienta KJ, Taichman RS. CD26/dipeptidyl peptidase IV regulates prostate cancer metastasis by degrading SDF-1/CXCL12. Clin Exp Metastasis. 2008; 25(7):765-76. PMID: 18563594.
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    56. Shiozawa Y, Sakaguchi S, Sakakibara O, Yagishita K, Saito M, Yamashiro Y. Urolithiasis in an acute lymphoblastic leukemia child during induction chemotherapy. Pediatr Hematol Oncol. 2008 Jun; 25(4):359-63. PMID: 18484482.
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    57. Jung Y, Song J, Shiozawa Y, Wang J, Wang Z, Williams B, Havens A, Schneider A, Ge C, Franceschi RT, McCauley LK, Krebsbach PH, Taichman RS. Hematopoietic stem cells regulate mesenchymal stromal cell induction into osteoblasts thereby participating in the formation of the stem cell niche. Stem Cells. 2008 Aug; 26(8):2042-51. PMID: 18499897.
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    58. Havens AM, Chiu E, Taba M, Wang J, Shiozawa Y, Jung Y, Taichman LS, D'Silva NJ, Gopalakrishnan R, Wang C, Giannobile WV, Taichman RS. Stromal-derived factor-1alpha (CXCL12) levels increase in periodontal disease. J Periodontol. 2008 May; 79(5):845-53. PMID: 18454663.
      Citations:    
    59. Havens AM, Pedersen EA, Shiozawa Y, Ying C, Jung Y, Sun Y, Neeley C, Wang J, Mehra R, Keller ET, McCauley LK, Loberg RD, Pienta KJ, Taichman RS. An in vivo mouse model for human prostate cancer metastasis. Neoplasia. 2008 Apr; 10(4):371-80. PMID: 18392141.
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    60. Wang J, Shiozawa Y, Wang J, Wang Y, Jung Y, Pienta KJ, Mehra R, Loberg R, Taichman RS. The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. J Biol Chem. 2008 Feb 15; 283(7):4283-94. PMID: 18057003.
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    61. Taguchi T, Takenouchi H, Shiozawa Y, Matsui J, Kitamura N, Miyagawa Y, Katagiri YU, Takahashi T, Okita H, Fujimoto J, Kiyokawa N. Interleukin-7 contributes to human pro-B-cell development in a mouse stromal cell-dependent culture system. Exp Hematol. 2007 Sep; 35(9):1398-407. PMID: 17656007.
      Citations:    
    62. Jung Y, Wang J, Song J, Shiozawa Y, Wang J, Havens A, Wang Z, Sun YX, Emerson SG, Krebsbach PH, Taichman RS. Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation. Blood. 2007 Jul 01; 110(1):82-90. PMID: 17360942.
      Citations:    
    63. Taguchi T, Takenouchi H, Matsui J, Tang WR, Itagaki M, Shiozawa Y, Suzuki K, Sakaguchi S, Ktagiri YU, Takahashi T, Okita H, Fujimoto J, Kiyokawa N. Involvement of insulin-like growth factor-I and insulin-like growth factor binding proteins in pro-B-cell development. Exp Hematol. 2006 Apr; 34(4):508-18. PMID: 16569597.
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    64. Shiozawa Y, Kiyokawa N, Fujimura J, Suzuki K, Yarita Y, Fujimoto J, Saito M, Yamashiro Y. Primary malignant lymphoma of the central nervous system in an immunocompetent child: a case report. J Pediatr Hematol Oncol. 2005 Oct; 27(10):561-4. PMID: 16217262.
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    65. Shiozawa Y, Kiyokawa N, Saito M, Fujimoto J, Hata J, Yamashiro Y. Granulocytic sarcoma of the spine in a child without bone marrow involvement: a case report and literature review. Eur J Pediatr. 2005 Oct; 164(10):616-20. PMID: 16012854.
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    66. Matsui J, Kiyokawa N, Takenouchi H, Taguchi T, Suzuki K, Shiozawa Y, Saito M, Tang WR, Katagiri YU, Okita H, Fujimoto J. Dietary bioflavonoids induce apoptosis in human leukemia cells. Leuk Res. 2005 May; 29(5):573-81. PMID: 15755510.
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    67. Taguchi T, Kiyokawa N, Takenouch H, Matsui J, Tang WR, Nakajima H, Suzuki K, Shiozawa Y, Saito M, Katagiri YU, Takahashi T, Karasuyama H, Matsuo Y, Okita H, Fujimoto J. Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells. Immunology. 2004 Aug; 112(4):575-82. PMID: 15270728.
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    68. Shiozawa Y, Fujita H, Fujimura J, Suzuki K, Sato H, Saito M, Shimizu T, Yamashiro Y. A fetal case of transient abnormal myelopoiesis with severe liver failure in Down syndrome: prognostic value of serum markers. Pediatr Hematol Oncol. 2004 Apr-May; 21(3):273-8. PMID: 15202167.
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