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Kiran Kumar Solingapuram Sai PhD

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentDiagnostic Radiology
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    1R01AG065839-01     (SOLINGAPURAM SAI, KIRAN)
    NATIONAL INSTITUTE ON AGING
    EVALUATING MICROTUBULE BINDING AS A POTENTIAL IMAGING BIOMARKER FOR ALZHEIMER'S DISEASE

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lockhart SN, Schaich CL, Craft S, Sachs BC, Rapp SR, Jung Y, Whitlow CT, Solingapuram Sai KK, Cleveland M, Williams BJ, Burke GL, Bertoni A, Hayden KM, Hughes TM. Associations among vascular risk factors, neuroimaging biomarkers, and cognition: Preliminary analyses from the Multi-Ethnic Study of Atherosclerosis (MESA). Alzheimers Dement. 2021 Sep 05. PMID: 34482601.
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    2. Chen DL, Agapov E, Wu K, Engle JT, Solingapuram Sai KK, Arentson E, Spayd KJ, Moreland KT, Toth K, Byers DE, Pierce RA, Atkinson JJ, Laforest R, Gelman AE, Holtzman MJ. Selective Imaging of Lung Macrophages Using [11C]PBR28-Based Positron Emission Tomography. Mol Imaging Biol. 2021 Jun 16. PMID: 34137002.
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    3. Damuka N, Orr M, Czoty PW, Weiner JL, Martin TJ, Nader MA, Bansode AH, Liyana Pathirannahel BS, Mintz A, Macauley SL, Craft S, Solingapuram Sai KK. Effect of ethanol and cocaine on [11C]MPC-6827 uptake in SH-SY5Y cells. Mol Biol Rep. 2021 Apr; 48(4):3871-3876. PMID: 33880672.
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    4. Petropoulou PI, Mosialou I, Shikhel S, Hao L, Panitsas K, Bisikirska B, Luo N, Bahna F, Kim J, Carberry P, Zanderigo F, Simpson N, Bakalian M, Kassir S, Shapiro L, Underwood MD, May CM, Soligapuram Sai KK, Jorgensen MJ, Confavreux CB, Shapses S, Laferrère B, Mintz A, Mann JJ, Rubin M, Kousteni S. Lipocalin-2 is an anorexigenic signal in primates. Elife. 2020 11 24; 9. PMID: 33231171.
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    5. Hsiaoju Lee, Naresh Damuka, John A Katzenellenbogen, Bhuddhika Liyana Pathirannahel, Jinbin Xu, Robert H Mach, Kiran Kumar Solingapuram Sai* . Initial Biological Evaluations of [18F]KS-7-51 to Image PPAR-? in Tumor Mice Model. Journal of Radiology & Radiation therapy. 2020; 1(7):1086. View Publication.
    6. Kiran Kumar Solingapuram Sai,*Jaya Prabhakaran,Naresh Damuka, Suzanne Craft, Shamyaa A. Rajagopal, Akiva Mintz, John Mann, and Dileep Kumar. Synthesis and Initial In Vivo Evaluations of [11C]WX-132-18B, a Microtubule PET Imaging Agent. Chemistry Select. 2020; 5:9623-9625. View Publication.
    7. Naresh Damuka, Paul W. Czoty, Ashley T. Davis, Michael A. Nader, Susan H. Nader, Suzanne Craft, Shannon L. Macauley, Lindsey K. Galbo, Phillip M. Epperly, Christopher T. Whitlow, April T. Davenport, Thomas J. Martin, James B. Daunais, Akiva Mintz and Kiran Kumar Solingapuram Sai*. PET Imaging of [11C]MPC-6827, a Microtubule-Based Radiotracer in Non-Human Primate Brains . Molecules . 2020; 2289(25):1-7. View Publication.
    8. J S Dileep Kumar, Jaya Prabhakaran, Naresh Damuka, Justin Wayne Hines, Skylar Norman, Meghana Dodda, J John Mann, Akiva Mintz, Kiran Kumar Solingapuram Sai* . In vivo comparison of N- 11 CH 3 vs O- 11 CH 3 radiolabeled microtubule targeted PET ligands. Bioorg Med Chem Lett. 2020; 2(30):126785. View Publication.
    9. J. S. DILEEP KUMAR, JAYA PRABHAKARAN, NARESH DAMUKA JUSTIN W. HINES, STEVEN J. KRIDEL, J. JOHN MANN, AKIVA MINTZ, KIRAN KUMAR SOLINGAPURAM SAI*. EVALUATION OF [11C]MPC-6827 AS A MICROTUBULE TARGETING PET RADIOTRACER IN CANCER CELL LINES. International Journal of Pharmacy and Pharmaceutical Sciences. 2020; 12(1):43-47. View Publication.
    10. Dileep Kumar JS, Prabhakaran J, Damuka N, Hines JW, Norman S, Dodda M, John Mann J, Mintz A, Sai KKS. In vivo comparison of N-11CH3 vs O-11CH3 radiolabeled microtubule targeted PET ligands. Bioorg Med Chem Lett. 2020 01 15; 30(2):126785. PMID: 31753695.
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    11. Solingapuram Sai KK, Zuo Y, Rose JE, Garg PK, Garg S, Nazih R, Mintz A, Mukhin AG. Rapid Brain Nicotine Uptake from Electronic Cigarettes. J Nucl Med. 2020 06; 61(6):928-930. PMID: 31676729.
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    12. Solingapuram Sai JKK, Hurley RA, Dodda M, Taber KH. Positron Emission Tomography: Updates on Imaging of Addiction. J Neuropsychiatry Clin Neurosci. 2019 Fall; 31(4):A6-288. PMID: 31613195.
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    13. Neth BJ, Mintz A, Whitlow C, Jung Y, Solingapuram Sai K, Register TC, Kellar D, Lockhart SN, Hoscheidt S, Maldjian J, Heslegrave AJ, Blennow K, Cunnane SC, Castellano CA, Zetterberg H, Craft S. Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer's disease: a pilot study. Neurobiol Aging. 2020 02; 86:54-63. PMID: 31757576.
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    14. Bashetti N, Shanmukha Kumar JV, Seelam NV, Prasanna B, Mintz A, Damuka N, Devanathan S, Solingapuram Sai KK. One-pot synthesis of novel tert-butyl-4-substituted phenyl-1H-1,2,3-triazolo piperazine/piperidine carboxylates, potential GPR119 agonists. Bioorg Med Chem Lett. 2019 12 01; 29(23):126707. PMID: 31630858.
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    15. Claus C, Ferrara C, Xu W, Sam J, Lang S, Uhlenbrock F, Albrecht R, Herter S, Schlenker R, Hüsser T, Diggelmann S, Challier J, Mössner E, Hosse RJ, Hofer T, Brünker P, Joseph C, Benz J, Ringler P, Stahlberg H, Lauer M, Perro M, Chen S, Küttel C, Bhavani Mohan PL, Nicolini V, Birk MC, Ongaro A, Prince C, Gianotti R, Dugan G, Whitlow CT, Solingapuram Sai KK, Caudell DL, Burgos-Rodriguez AG, Cline JM, Hettich M, Ceppi M, Giusti AM, Crameri F, Driessen W, Morcos PN, Freimoser-Grundschober A, Levitsky V, Amann M, Grau-Richards S, von Hirschheydt T, Tournaviti S, Mølhøj M, Fauti T, Heinzelmann-Schwarz V, Teichgräber V, Colombetti S, Bacac M, Zippelius A, Klein C, Umaña P. Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy. Sci Transl Med. 2019 06 12; 11(496). PMID: 31189721.
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    16. Solingapuram Sai KK, Bashetti N, Chen X, Norman S, Hines JW, Meka O, Kumar JVS, Devanathan S, Deep G, Furdui CM, Mintz A. Initial biological evaluations of 18F-KS1, a novel ascorbate derivative to image oxidative stress in cancer. EJNMMI Res. 2019 May 17; 9(1):43. PMID: 31101996.
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    17. Prabhakaran J, Sai KKS, Sattiraju A, Mintz A, Mann JJ, Kumar JSD. Radiosynthesis and evaluation of [11C]CMP, a high affinity GSK3 ligand. Bioorg Med Chem Lett. 2019 03 15; 29(6):778-781. PMID: 30709652.
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    18. Pandya DN, Bhatt NB, Almaguel F, Rideout-Danner S, Gage HD, Solingapuram Sai KK, Wadas TJ. 89Zr-Chloride Can Be Used for Immuno-PET Radiochemistry Without Loss of Antigen Reactivity In Vivo. J Nucl Med. 2019 05; 60(5):696-701. PMID: 30442753.
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    19. Solingapuram Sai KK, Prabhakaran J, Ramanathan G, Rideout S, Whitlow C, Mintz A, Mann JJ, Kumar JSD. Radiosynthesis and Evaluation of [11C]HD-800, a High Affinity Brain Penetrant PET Tracer for Imaging Microtubules. ACS Med Chem Lett. 2018 May 10; 9(5):452-456. PMID: 29795758.
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    20. Prudner BC, Sun F, Kremer JC, Xu J, Huang C, Sai KKS, Morgan Z, Leeds H, McConathy J, Van Tine BA. Amino Acid Uptake Measured by [18F]AFETP Increases in Response to Arginine Starvation in ASS1-Deficient Sarcomas. Theranostics. 2018; 8(8):2107-2116. PMID: 29721066.
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    21. Kumar JSD, Solingapuram Sai KK, Prabhakaran J, Oufkir HR, Ramanathan G, Whitlow CT, Dileep H, Mintz A, Mann JJ. Radiosynthesis and in Vivo Evaluation of [11C]MPC-6827, the First Brain Penetrant Microtubule PET Ligand. J Med Chem. 2018 03 08; 61(5):2118-2123. PMID: 29457976.
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    22. John WS, Martin TJ, Solingapuram Sai KK, Nader SH, Gage HD, Mintz A, Nader MA. Chronic ?9-THC in Rhesus Monkeys: Effects on Cognitive Performance and Dopamine D2/D3 Receptor Availability. J Pharmacol Exp Ther. 2018 02; 364(2):300-310. PMID: 29203575.
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    23. Solingapuram Sai KK, Donald Gage H, Almaguel F, Neth B, Hughes TM, Tremblay S, Castellano CA, Cunnane SC, Jorgensen MJ, Craft S, Mintz A. Automated synthesis of 1-[11C]acetoacetate on a TRASIS AIO module. Appl Radiat Isot. 2017 Nov; 129:57-61. PMID: 28806598.
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    24. Sattiraju A, Solingapuram Sai KK, Xuan A, Pandya DN, Almaguel FG, Wadas TJ, Herpai DM, Debinski W, Mintz A. IL13RA2 targeted alpha particle therapy against glioblastomas. Oncotarget. 2017 Jun 27; 8(26):42997-43007. PMID: 28562337.
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    25. Sattiraju A, Xiong X, Pandya DN, Wadas TJ, Xuan A, Sun Y, Jung Y, Sai KKS, Dorsey JF, Li KC, Mintz A. Alpha Particle Enhanced Blood Brain/Tumor Barrier Permeabilization in Glioblastomas Using Integrin Alpha-v Beta-3-Targeted Liposomes. . 2017 10; 16(10):2191-2200. PMID: 28619756.
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    26. Prabhakaran J, Zanderigo F, Sai KKS, Rubin-Falcone H, Jorgensen MJ, Kaplan JR, Mintz A, Mann JJ, Kumar JSD. Radiosynthesis and in Vivo Evaluation of [11C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain. ACS Chem Neurosci. 2017 08 16; 8(8):1697-1703. PMID: 28485573.
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    27. Sai KKS, Zachar Z, Bingham PM, Mintz A. Metabolic PET Imaging in Oncology. AJR Am J Roentgenol. 2017 Aug; 209(2):270-276. PMID: 28463521.
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    28. Solingapuram Sai KK, Prabhakaran J, Sattiraju A, Mann JJ, Mintz A, Kumar JSD. Radiosynthesis and evaluation of IGF1R PET ligand [11C]GSK1838705A. Bioorg Med Chem Lett. 2017 07 01; 27(13):2895-2897. PMID: 28479199.
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    29. Sai KKS, Sattiraju A, Almaguel FG, Xuan A, Rideout S, Krishnaswamy RS, Zhang J, Herpai DM, Debinski W, Mintz A. Peptide-based PET imaging of the tumor restricted IL13RA2 biomarker. Oncotarget. 2017 Aug 01; 8(31):50997-51007. PMID: 28881623.
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    30. Solingapuram Sai KK, Das BC, Sattiraju A, Almaguel FG, Craft S, Mintz A. Radiolabeling and initial biological evaluation of [18F]KBM-1 for imaging RAR-a receptors in neuroblastoma. Bioorg Med Chem Lett. 2017 03 15; 27(6):1425-1427. PMID: 28216044.
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    31. Sattiraju A, Sai KKS, Mintz A. Glioblastoma Stem Cells and Their Microenvironment. Adv Exp Med Biol. 2017; 1041:119-140. PMID: 29204831.
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    32. Prabhakaran J, Solingapuram Sai KK, Zanderigo F, Rubin-Falcone H, Jorgensen MJ, Kaplan JR, Tooke KI, Mintz A, Mann JJ, Kumar JSD. In vivo evaluation of [18F]FECIMBI-36, an agonist 5-HT2A/2C receptor PET radioligand in nonhuman primate. Bioorg Med Chem Lett. 2017 01 01; 27(1):21-23. PMID: 27889455.
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    33. Birbrair A, Sattiraju A, Zhu D, Zulato G, Batista I, Nguyen VT, Messi ML, Solingapuram Sai KK, Marini FC, Delbono O, Mintz A. Novel Peripherally Derived Neural-Like Stem Cells as Therapeutic Carriers for Treating Glioblastomas. Stem Cells Transl Med. 2017 02; 6(2):471-481. PMID: 28191774.
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    34. Kiran Kumar Solingapuram Sai *, Don Gage , Mike Nader, Robert H. Mach , Akiva Mintz . Improved Automated Radiosynthesis of [11C]PBR28. Sci. Pharm. 2015; (83):413-427.
    35. Solingapuram Sai KK, Gage D, Nader M, Mach RH, Mintz A. Improved Automated Radiosynthesis of [(11)C]PBR28. Sci Pharm. 2015 Jul-Sep; 83(3):413-27. PMID: 26839827.
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    36. Wadas TJ, Pandya DN, Solingapuram Sai KK, Mintz A. Molecular targeted a-particle therapy for oncologic applications. AJR Am J Roentgenol. 2014 Aug; 203(2):253-60. PMID: 25055256.
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    37. Sai KK, Fan J, Tu Z, Zerkel P, Mach RH, Kharasch ED. Automated radiochemical synthesis and biodistribution of [¹¹C]l-a-acetylmethadol ([¹¹C]LAAM). Appl Radiat Isot. 2014 Sep; 91:135-40. PMID: 24935116.
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    38. Sai KK, Huang C, Yuan L, Zhou D, Piwnica-Worms D, Garbow JR, Engelbach JA, Mach RH, Rich KM, McConathy J. 18F-AFETP, 18F-FET, and 18F-FDG imaging of mouse DBT gliomas. J Nucl Med. 2013 Jul; 54(7):1120-6. PMID: 23650628.
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    39. Sai KK, Jones LA, Mach RH. Development of (18)F-labeled PET probes for imaging cell proliferation. Curr Top Med Chem. 2013; 13(8):892-908. PMID: 23590172.
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    40. Solingapuram Sai KK, Kil KE, Tu Z, Chu W, Finck BN, Rothfuss JM, Shoghi KI, Welch MJ, Gropler RJ, Mach RH. Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-a receptors. Bioorg Med Chem Lett. 2012 Oct 01; 22(19):6233-6. PMID: 22939697.
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    41. Sai KK, O'Connor MJ, Klumpp DA. Aza-Nazarov cyclization cascades. Tetrahedron Lett. 2011 Apr 27; 52(17):2195-2198. PMID: 21660198.
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    42. Sai KK, Tokarz MJ, Malunchuk AP, Zheng C, Gilbert TM, Klumpp DA. N-heterocyclic superelectrophiles and evidence for single electron transfer chemistry. J Am Chem Soc. 2008 Nov 05; 130(44):14388-9. PMID: 18841889.
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    43. Sai KK, Esteves PM, da Penha ET, Klumpp DA. Superacid-promoted reactions of alpha-ketoamides and related systems. J Org Chem. 2008 Sep 05; 73(17):6506-12. PMID: 18665649.
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    44. Sai KK, Gilbert TM, Klumpp DA. Knorr cyclizations and distonic superelectrophiles. J Org Chem. 2007 Dec 07; 72(25):9761-4. PMID: 17999519.
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    45. Zhang Y, DeSchepper DJ, Gilbert TM, Sai KK, Klumpp DA. Superacid promoted reactions of N-acyliminium salts and evidence for the involvement of superelectrophiles. Chem Commun (Camb). 2007 Oct 21; (39):4032-4. PMID: 17912406.
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