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Iris J. Edwards

TitleAssociate Professor Emeritus of Pathology, Winston-Salem
InstitutionWake Forest School of Medicine
DepartmentPathology, Winston-Salem
Address
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    Collapse Research 
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    R03AG014190     (EDWARDS, IRIS J)Sep 30, 1997 - Aug 31, 1999
    NIH/NIA
    AGING, ARTERIAL PROTEOGLYCANS AND CALORIC RESTRICTION
    Role: Principal Investigator
    R01CA115958     (EDWARDS, IRIS J)Sep 23, 2005 - Jun 30, 2011
    NIH/NCI
    Regulation of syndecan 1 in by n-3 PUFA
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. O'Flaherty JT, Wooten RE, Samuel MP, Thomas MJ, Levine EA, Case LD, Akman SA, Edwards IJ. Fatty acid metabolites in rapidly proliferating breast cancer. PLoS One. 2013; 8(5):e63076. PMID: 23658799.
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    2. Gu Z, Wu J, Wang S, Suburu J, Chen H, Thomas MJ, Shi L, Edwards IJ, Berquin IM, Chen YQ. Polyunsaturated fatty acids affect the localization and signaling of PIP3/AKT in prostate cancer cells. Carcinogenesis. 2013 Sep; 34(9):1968-75. PMID: 23633519.
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    3. Hu Y, Sun H, O'Flaherty JT, Edwards IJ. 15-Lipoxygenase-1-mediated metabolism of docosahexaenoic acid is required for syndecan-1 signaling and apoptosis in prostate cancer cells. Carcinogenesis. 2013 Jan; 34(1):176-82. PMID: 23066085.
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    4. O'Flaherty JT, Hu Y, Wooten RE, Horita DA, Samuel MP, Thomas MJ, Sun H, Edwards IJ. 15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival. PLoS One. 2012; 7(9):e45480. PMID: 23029040.
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    5. Edwards IJ. Proteoglycans in prostate cancer. Nat Rev Urol. 2012 Feb 21; 9(4):196-206. PMID: 22349653.
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    6. Wang S, Wu J, Suburu J, Gu Z, Cai J, Axanova LS, Cramer SD, Thomas MJ, Perry DL, Edwards IJ, Mucci LA, Sinnott JA, Loda MF, Sui G, Berquin IM, Chen YQ. Effect of dietary polyunsaturated fatty acids on castration-resistant Pten-null prostate cancer. Carcinogenesis. 2012 Feb; 33(2):404-12. PMID: 22159221.
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    7. Berquin IM, Edwards IJ, Kridel SJ, Chen YQ. Polyunsaturated fatty acid metabolism in prostate cancer. Cancer Metastasis Rev. 2011 Dec; 30(3-4):295-309. PMID: 22015690.
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    8. Sun H, Hu Y, Gu Z, Owens RT, Chen YQ, Edwards IJ. Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway. Carcinogenesis. 2011 Oct; 32(10):1518-24. PMID: 21771724.
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    9. Sun H, Hu Y, Gu Z, Wilson MD, Chen YQ, Rudel LL, Willingham MC, Edwards IJ. Endogenous synthesis of n-3 polyunsaturated fatty acids in Fat-1 mice is associated with increased mammary gland and liver syndecan-1. PLoS One. 2011; 6(5):e20502. PMID: 21655218.
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    10. Hu Y, Sun H, Owens RT, Gu Z, Wu J, Chen YQ, O'Flaherty JT, Edwards IJ. Syndecan-1-dependent suppression of PDK1/Akt/bad signaling by docosahexaenoic acid induces apoptosis in prostate cancer. Neoplasia. 2010 Oct; 12(10):826-36. PMID: 20927321.
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    11. Hu Y, Sun H, Owens RT, Wu J, Chen YQ, Berquin IM, Perry D, O'Flaherty JT, Edwards IJ. Decorin suppresses prostate tumor growth through inhibition of epidermal growth factor and androgen receptor pathways. Neoplasia. 2009 Oct; 11(10):1042-53. PMID: 19794963.
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    12. Berquin IM, Edwards IJ, Chen YQ. Multi-targeted therapy of cancer by omega-3 fatty acids. Cancer Lett. 2008 Oct 08; 269(2):363-77. PMID: 18479809.
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    13. Edwards IJ, Sun H, Hu Y, Berquin IM, O'Flaherty JT, Cline JM, Rudel LL, Chen YQ. In vivo and in vitro regulation of syndecan 1 in prostate cells by n-3 polyunsaturated fatty acids. J Biol Chem. 2008 Jun 27; 283(26):18441-9. PMID: 18450755.
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    14. Sun H, Berquin IM, Owens RT, O'Flaherty JT, Edwards IJ. Peroxisome proliferator-activated receptor gamma-mediated up-regulation of syndecan-1 by n-3 fatty acids promotes apoptosis of human breast cancer cells. Cancer Res. 2008 Apr 15; 68(8):2912-9. PMID: 18413760.
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    15. Edwards IJ, O'Flaherty JT. Omega-3 Fatty Acids and PPARgamma in Cancer. PPAR Res. 2008; 2008:358052. PMID: 18769551.
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    16. Chen YQ, Edwards IJ, Kridel SJ, Thornburg T, Berquin IM. Dietary fat-gene interactions in cancer. Cancer Metastasis Rev. 2007 Dec; 26(3-4):535-51. PMID: 17849170.
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    17. Berquin IM, Min Y, Wu R, Wu J, Perry D, Cline JM, Thomas MJ, Thornburg T, Kulik G, Smith A, Edwards IJ, D'Agostino R, Zhang H, Wu H, Kang JX, Chen YQ. Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids. J Clin Invest. 2007 Jul; 117(7):1866-75. PMID: 17607361.
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    18. Chen YQ, Berquin IM, Daniel LW, Edwards IJ, O'Flaherty JT, Thomas MJ, Tooze JA, Wykle B. Omega-3 fatty acids and cancer risk. JAMA. 2006 Jul 19; 296(3):282; author reply 282. PMID: 16849660.
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    19. Sun H, Berquin IM, Edwards IJ. Omega-3 polyunsaturated fatty acids regulate syndecan-1 expression in human breast cancer cells. Cancer Res. 2005 May 15; 65(10):4442-7. PMID: 15899837.
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    20. Edwards IJ, Berquin IM, Sun H, O'flaherty JT, Daniel LW, Thomas MJ, Rudel LL, Wykle RL, Chen YQ. Differential effects of delivery of omega-3 fatty acids to human cancer cells by low-density lipoproteins versus albumin. Clin Cancer Res. 2004 Dec 15; 10(24):8275-83. PMID: 15623603.
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    21. Edwards IJ, Wagner JD, Vogl-Willis CA, Litwak KN, Cefalu WT. Arterial heparan sulfate is negatively associated with hyperglycemia and atherosclerosis in diabetic monkeys. Cardiovasc Diabetol. 2004 Apr 29; 3:6. PMID: 15117408.
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    22. Vogl-Willis CA, Edwards IJ. High-glucose-induced structural changes in the heparan sulfate proteoglycan, perlecan, of cultured human aortic endothelial cells. Biochim Biophys Acta. 2004 Apr 07; 1672(1):36-45. PMID: 15056491.
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    23. Vogl-Willis CA, Edwards IJ. High glucose-induced alterations in subendothelial matrix perlecan leads to increased monocyte binding. Arterioscler Thromb Vasc Biol. 2004 May; 24(5):858-63. PMID: 15031130.
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    24. Edwards IJ, Terry JG, Bell-Farrow AD, Cefalu WT. Improved glucose control decreases the interaction of plasma low-density lipoproteins with arterial proteoglycans. Metabolism. 2002 Oct; 51(10):1223-9. PMID: 12370838.
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