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Last Name

Emmanuel C. Opara, Ph.D.

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentWF Institute for Regen Medicine
Address
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    Other Positions
    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentRadiologic Sciences-Medical Engineering


    Collapse Research 
    Collapse research activities and funding
    R01DK080897     (OPARA, EMMANUEL C.)Sep 5, 2009 - Aug 31, 2012
    NIH/NIDDK
    Bioengineering A Bioartificial Pancreas
    Role: Principal Investigator

    R21AG061588     (GROBAN, LEANNE)Jan 15, 2019 - Nov 30, 2020
    NIH/NIA
    Effects of cell-based hormone therapy on LV diastolic dysfunction and hypertrophy progression after mid-life estrogen loss
    Role: Co-Principal Investigator

    R25DK121572     (OPARA, EMMANUEL C.)May 15, 2019 - May 14, 2020
    NIH/NIDDK
    Tissue Engineering and Regenerative Medicine Undergraduate Research Addressing Challenges In Diabetes, Kidney, Urologic and Hematologic Diseases
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sittadjody S, Enck KM, Wells A, Yoo JJ, Atala A, Saul JM, Opara EC. Encapsulation of Mesenchymal Stem Cells in 3D Ovarian Cell Constructs Promotes Stable and Long-Term Hormone Secretion with Improved Physiological Outcomes in a Syngeneic Rat Model. Ann Biomed Eng. 2019 Jul 31. PMID: 31367915.
      View in: PubMed
    2. Thompson EM, Sollinger JL, Opara EC, Adin CA. Selective Osmotic Shock for Islet Isolation in the Cadaveric Canine Pancreas. Cell Transplant. 2018 03; 27(3):542-550. PMID: 29869518.
      View in: PubMed
    3. Sittadjody S, Saul JM, McQuilling JP, Joo S, Register TC, Yoo JJ, Atala A, Opara EC. In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure. Nat Commun. 2017 12 05; 8(1):1858. PMID: 29208899.
      View in: PubMed
    4. McQuilling JP, Sittadjody S, Pendergraft S, Farney AC, Opara EC. Applications of particulate oxygen-generating substances (POGS) in the bioartificial pancreas. Biomater Sci. 2017 Nov 21; 5(12):2437-2447. PMID: 29051963.
      View in: PubMed
    5. Yan H, Zhong L, Jiang Y, Yang J, Deng J, Wei S, Opara E, Atala A, Mao X, Damaser MS, Zhang Y. Controlled release of insulin-like growth factor 1 enhances urethral sphincter function and histological structure in the treatment of female stress urinary incontinence in a rat model. BJU Int. 2018 02; 121(2):301-312. PMID: 28805303.
      View in: PubMed
    6. Balaji S, Zhou Y, Opara EC, Soker S. Combinations of Activin A or Nicotinamide with the Pancreatic Transcription Factor PDX1 Support Differentiation of Human Amnion Epithelial Cells Toward a Pancreatic Lineage. Cell Reprogram. 2017 08; 19(4):255-262. PMID: 28632450.
      View in: PubMed
    7. Opara EC. Applications of Cell Microencapsulation. Methods Mol Biol. 2017; 1479:23-39. PMID: 27738924.
      View in: PubMed
    8. Sharma V, Hunckler M, Ramasubramanian MK, Opara EC, Katuri KC. Microfluidic Approach to Cell Microencapsulation. Methods Mol Biol. 2017; 1479:71-76. PMID: 27738927.
      View in: PubMed
    9. Kendall WF, Opara EC. Polymeric Materials for Perm-Selective Coating of Alginate Microbeads. Methods Mol Biol. 2017; 1479:95-109. PMID: 27738929.
      View in: PubMed
    10. Darabbie MD, Opara EC. Determination of the Mechanical Strength of Microcapsules. Methods Mol Biol. 2017; 1479:111-118. PMID: 27738930.
      View in: PubMed
    11. McQuilling JP, Opara EC. Methods for Incorporating Oxygen-Generating Biomaterials into Cell Culture and Microcapsule Systems. Methods Mol Biol. 2017; 1479:135-141. PMID: 27738932.
      View in: PubMed
    12. McQuilling JP, Sittadjody S, Pareta R, Pendergraft S, Clark CJ, Farney AC, Opara EC. Retrieval of Microencapsulated Islet Grafts for Post-transplant Evaluation. Methods Mol Biol. 2017; 1479:157-171. PMID: 27738934.
      View in: PubMed
    13. Kendall WF, Opara EC. A Method of Porcine Pancreatic Islet Isolation for Microencapsulation. Methods Mol Biol. 2017; 1479:175-189. PMID: 27738935.
      View in: PubMed
    14. Enck K, McQuilling JP, Orlando G, Tamburrini R, Sivanandane S, Opara EC. Selective Osmotic Shock (SOS)-Based Islet Isolation for Microencapsulation. Methods Mol Biol. 2017; 1479:191-198. PMID: 27738936.
      View in: PubMed
    15. Sittadjody S, Saul JM, Opara EC. Compartmentalization of Two Cell Types in Multilayered Alginate Microcapsules. Methods Mol Biol. 2017; 1479:225-235. PMID: 27738940.
      View in: PubMed
    16. Niu G, McQuilling JP, Zhou Y, Opara EC, Orlando G, Soker S. In Vitro Proliferation of Porcine Pancreatic Islet Cells for ß-Cell Therapy Applications. J Diabetes Res. 2016; 2016:5807876. PMID: 28050568.
      View in: PubMed
    17. Appel AA, Ibarra V, Somo SI, Larson JC, Garson AB, Guan H, McQuilling JP, Zhong Z, Anastasio MA, Opara EC, Brey EM. Imaging of Hydrogel Microsphere Structure and Foreign Body Response Based on Endogenous X-Ray Phase Contrast. Tissue Eng Part C Methods. 2016 11; 22(11):1038-1048. PMID: 27796159.
      View in: PubMed
    18. Yang Y, Opara EC, Liu Y, Atala A, Zhao W. Microencapsulation of porcine thyroid cell organoids within a polymer microcapsule construct. Exp Biol Med (Maywood). 2017 02; 242(3):286-296. PMID: 27708182.
      View in: PubMed
    19. Peloso A, Urbani L, Cravedi P, Katari R, Maghsoudlou P, Fallas ME, Sordi V, Citro A, Purroy C, Niu G, McQuilling JP, Sittadjody S, Farney AC, Iskandar SS, Zambon JP, Rogers J, Stratta RJ, Opara EC, Piemonti L, Furdui CM, Soker S, De Coppi P, Orlando G. The Human Pancreas as a Source of Protolerogenic Extracellular Matrix Scaffold for a New-generation Bioartificial Endocrine Pancreas. Ann Surg. 2016 07; 264(1):169-79. PMID: 26649588.
      View in: PubMed
    20. Ibarra V, Appel AA, Anastasio MA, Opara EC, Brey EM. This paper is a winner in the Undergraduate category for the SFB awards: Evaluation of the tissue response to alginate encapsulated islets in an omentum pouch model. J Biomed Mater Res A. 2016 07; 104(7):1581-90. PMID: 27144389.
      View in: PubMed
    21. Balaji S, Zhou Y, Ganguly A, Opara EC, Soker S. The combined effect of PDX1, epidermal growth factor and poly-L-ornithine on human amnion epithelial cells' differentiation. BMC Dev Biol. 2016 Apr 12; 16:8. PMID: 27068127.
      View in: PubMed
    22. Farney AC, Sutherland DE, Opara EC. Evolution of Islet Transplantation for the Last 30 Years. Pancreas. 2016 Jan; 45(1):8-20. PMID: 26658037.
      View in: PubMed
    23. Pareta R, McQuilling JP, Sittadjody S, Jenkins R, Bowden S, Orlando G, Farney AC, Brey EM, Opara EC. Long-term function of islets encapsulated in a redesigned alginate microcapsule construct in omentum pouches of immune-competent diabetic rats. Pancreas. 2014 May; 43(4):605-13. PMID: 24681880.
      View in: PubMed
    24. Yalcinkaya TM, Sittadjody S, Opara EC. Scientific principles of regenerative medicine and their application in the female reproductive system. Maturitas. 2014 Jan; 77(1):12-9. PMID: 24210634.
      View in: PubMed
    25. Fang X, Sittadjody S, Gyabaah K, Opara EC, Balaji KC. Novel 3D co-culture model for epithelial-stromal cells interaction in prostate cancer. PLoS One. 2013; 8(9):e75187. PMID: 24073251.
      View in: PubMed
    26. Khanna O, Huang JJ, Moya ML, Wu CW, Cheng MH, Opara EC, Brey EM. FGF-1 delivery from multilayer alginate microbeads stimulates a rapid and persistent increase in vascular density. Microvasc Res. 2013 Nov; 90:23-9. PMID: 23978335.
      View in: PubMed
    27. Campeau L, Soler R, Sittadjody S, Pareta R, Nomiya M, Zarifpour M, Opara EC, Yoo JJ, Andersson KE. Effects of allogeneic bone marrow derived mesenchymal stromal cell therapy on voiding function in a rat model of Parkinson disease. J Urol. 2014 Mar; 191(3):850-9. PMID: 23973520.
      View in: PubMed
    28. Pareta RA, Farney AC, Opara EC. Design of a bioartificial pancreas. Pathobiology. 2013; 80(4):194-202. PMID: 23652283.
      View in: PubMed
    29. Mirmalek-Sani SH, Orlando G, McQuilling JP, Pareta R, Mack DL, Salvatori M, Farney AC, Stratta RJ, Atala A, Opara EC, Soker S. Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering. Biomaterials. 2013 Jul; 34(22):5488-95. PMID: 23583038.
      View in: PubMed
    30. Gandhi JK, Opara EC, Brey EM. Alginate-based strategies for therapeutic vascularization. Ther Deliv. 2013 Mar; 4(3):327-41. PMID: 23442080.
      View in: PubMed
    31. Opara EC, McQuilling JP, Farney AC. Microencapsulation of pancreatic islets for use in a bioartificial pancreas. Methods Mol Biol. 2013; 1001:261-6. PMID: 23494435.
      View in: PubMed
    32. Sittadjody S, Saul JM, Joo S, Yoo JJ, Atala A, Opara EC. Engineered multilayer ovarian tissue that secretes sex steroids and peptide hormones in response to gonadotropins. Biomaterials. 2013 Mar; 34(10):2412-20. PMID: 23274068.
      View in: PubMed
    33. Liu G, Pareta RA, Wu R, Shi Y, Zhou X, Liu H, Deng C, Sun X, Atala A, Opara EC, Zhang Y. Skeletal myogenic differentiation of urine-derived stem cells and angiogenesis using microbeads loaded with growth factors. Biomaterials. 2013 Jan; 34(4):1311-26. PMID: 23137393.
      View in: PubMed
    34. Pareta R, Sanders B, Babbar P, Soker T, Booth C, McQuilling J, Sivanandane S, Stratta RJ, Orlando G, Opara EC. Immunoisolation: where regenerative medicine meets solid organ transplantation. Expert Rev Clin Immunol. 2012 Sep; 8(7):685-92. PMID: 23078065.
      View in: PubMed
    35. Khanna O, Larson JC, Moya ML, Opara EC, Brey EM. Generation of alginate microspheres for biomedical applications. J Vis Exp. 2012 Aug 12; (66). PMID: 22907205.
      View in: PubMed
    36. Tendulkar S, Mirmalek-Sani SH, Childers C, Saul J, Opara EC, Ramasubramanian MK. A three-dimensional microfluidic approach to scaling up microencapsulation of cells. Biomed Microdevices. 2012 Jun; 14(3):461-9. PMID: 22245953.
      View in: PubMed
    37. Orlando G, Wood KJ, De Coppi P, Baptista PM, Binder KW, Bitar KN, Breuer C, Burnett L, Christ G, Farney A, Figliuzzi M, Holmes JH, Koch K, Macchiarini P, Mirmalek Sani SH, Opara E, Remuzzi A, Rogers J, Saul JM, Seliktar D, Shapira-Schweitzer K, Smith T, Solomon D, Van Dyke M, Yoo JJ, Zhang Y, Atala A, Stratta RJ, Soker S. Regenerative medicine as applied to general surgery. Ann Surg. 2012 May; 255(5):867-80. PMID: 22330032.
      View in: PubMed
    38. Moya ML, Morley M, Khanna O, Opara EC, Brey EM. Stability of alginate microbead properties in vitro. J Mater Sci Mater Med. 2012 Apr; 23(4):903-12. PMID: 22350778.
      View in: PubMed
    39. Orlando G, Baptista P, Birchall M, De Coppi P, Farney A, Guimaraes-Souza NK, Opara E, Rogers J, Seliktar D, Shapira-Schweitzer K, Stratta RJ, Atala A, Wood KJ, Soker S. Regenerative medicine as applied to solid organ transplantation: current status and future challenges. Transpl Int. 2011 Mar; 24(3):223-32. PMID: 21062367.
      View in: PubMed
    40. Khanna O, Moya ML, Greisler HP, Opara EC, Brey EM. Multilayered microcapsules for the sustained-release of angiogenic proteins from encapsulated cells. Am J Surg. 2010 Nov; 200(5):655-8. PMID: 21056148.
      View in: PubMed
    41. Khanna O, Moya ML, Opara EC, Brey EM. Synthesis of multilayered alginate microcapsules for the sustained release of fibroblast growth factor-1. J Biomed Mater Res A. 2010 Nov; 95(2):632-40. PMID: 20725969.
      View in: PubMed
    42. Opara EC, Mirmalek-Sani SH, Khanna O, Moya ML, Brey EM. Design of a bioartificial pancreas(+). J Investig Med. 2010 Oct; 58(7):831-7. PMID: 20683347.
      View in: PubMed
    43. Moya ML, Cheng MH, Huang JJ, Francis-Sedlak ME, Kao SW, Opara EC, Brey EM. The effect of FGF-1 loaded alginate microbeads on neovascularization and adipogenesis in a vascular pedicle model of adipose tissue engineering. Biomaterials. 2010 Apr; 31(10):2816-26. PMID: 20080298.
      View in: PubMed
    44. Moya ML, Garfinkel MR, Liu X, Lucas S, Opara EC, Greisler HP, Brey EM. Fibroblast growth factor-1 (FGF-1) loaded microbeads enhance local capillary neovascularization. J Surg Res. 2010 May 15; 160(2):208-12. PMID: 19959194.
      View in: PubMed
    45. Moya ML, Lucas S, Francis-Sedlak M, Liu X, Garfinkel MR, Huang JJ, Cheng MH, Opara EC, Brey EM. Sustained delivery of FGF-1 increases vascular density in comparison to bolus administration. Microvasc Res. 2009 Sep; 78(2):142-7. PMID: 19555698.
      View in: PubMed
    46. Darrabie MD, Kendall WF, Opara EC. Effect of alginate composition and gelling cation on microbead swelling. J Microencapsul. 2006 Sep; 23(6):613-21. PMID: 17118877.
      View in: PubMed
    47. Opara EC. Oxidative stress. Dis Mon. 2006 May; 52(5):183-98. PMID: 16828360.
      View in: PubMed
    48. Opara EC, Rockway SW. Antioxidants and micronutrients. Dis Mon. 2006 Apr; 52(4):151-63. PMID: 16828355.
      View in: PubMed
    49. Darrabie MD, Kendall WF, Opara EC. Effect of alginate composition and gelling cation on micro-bead swelling. J Microencapsul. 2006 Feb; 23(1):29-37. PMID: 16830975.
      View in: PubMed
    50. Darrabie MD, Kendall WF, Opara EC. Characteristics of Poly-L-Ornithine-coated alginate microcapsules. Biomaterials. 2005 Dec; 26(34):6846-52. PMID: 15955558.
      View in: PubMed
    51. Kizilel S, Garfinkel M, Opara E. The bioartificial pancreas: progress and challenges. Diabetes Technol Ther. 2005 Dec; 7(6):968-85. PMID: 16386103.
      View in: PubMed
    52. Koch TR, Petro A, Darrabie M, Opara EC. Effects of esomeprazole magnesium on nonsteroidal anti-inflammatory drug gastropathy. Dig Dis Sci. 2005 Jan; 50(1):86-93. PMID: 15712643.
      View in: PubMed
    53. Gawrieh S, Opara EC, Koch TR. Oxidative stress in nonalcoholic fatty liver disease: pathogenesis and antioxidant therapies. J Investig Med. 2004 Dec; 52(8):506-14. PMID: 15682682.
      View in: PubMed
    54. Koch TR, Petro A, Darrabie M, Opara EC. Effect of the H, K-ATPase inhibitor, esomeprazole magnesium, on gut total antioxidant capacity in mice. J Nutr Biochem. 2004 Sep; 15(9):522-6. PMID: 15350983.
      View in: PubMed
    55. Opara EC. Role of oxidative stress in the etiology of type 2 diabetes and the effect of antioxidant supplementation on glycemic control. J Investig Med. 2004 Jan; 52(1):19-23. PMID: 14989366.
      View in: PubMed
    56. El-Shewy HM, Kendall WF, Darrabie M, Collins BH, Opara EC. Polyvinyl pyrrolidone: a novel cryoprotectant in islet cell cryopreservation. Cell Transplant. 2004; 13(3):237-43. PMID: 15191161.
      View in: PubMed
    57. Koch TR, Telford GL, Walgenbach-Telford S, Kendall WF, Opara EC. Total antioxidant capacity following extrinsic denervation and small intestinal transplantation in the rat. Neurosci Lett. 2003 May 15; 342(1-2):135-7. PMID: 12727336.
      View in: PubMed
    58. Koch TR, Yuan LX, Petro A, Opara EC. Effects of omeprazole and ascorbate on gastric emptying and antioxidant levels in a mouse model of glutathione depletion. Dig Dis Sci. 2002 Nov; 47(11):2486-92. PMID: 12452384.
      View in: PubMed
    59. Opara EC, Kendall WF. Immunoisolation techniques for islet cell transplantation. Expert Opin Biol Ther. 2002 Jun; 2(5):503-11. PMID: 12079486.
      View in: PubMed
    60. Freemark M, Avril I, Fleenor D, Driscoll P, Petro A, Opara E, Kendall W, Oden J, Bridges S, Binart N, Breant B, Kelly PA. Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance. Endocrinology. 2002 Apr; 143(4):1378-85. PMID: 11897695.
      View in: PubMed
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