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Charles E. McCall MD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentInternal Medicine, Molecular Medicine
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    Other Positions
    InstitutionWake Forest School of Medicine
    DepartmentClinical and Translational Science Institute

    TitleAssociate Dean
    InstitutionWake Forest School of Medicine
    DepartmentClinical and Translational Science Institute

    TitleDirector
    InstitutionWake Forest School of Medicine
    DepartmentClinical and Translational Science Institute

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentMicrobiology and Immunology


    Collapse Research 
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    R01AI009169     (MCCALL, CHARLES EMORY)Apr 1, 1974 - Mar 31, 2004
    NIH
    FUNCTIONAL AND METABOLIC PROPERTIES OF TOXIC NEUTROPHILS
    Role: Principal Investigator
    R21AI009169     (MCCALL, CHARLES EMORY)Apr 1, 1974 - Mar 31, 2007
    NIH
    Function and Metabolic Properties of Toxic Neutrophils
    Role: Principal Investigator
    R01HL029293     (MCCALL, CHARLES E)Sep 1, 1982 - Aug 31, 1997
    NIH
    PATHOGENIC MECHANISMS PRODUCING LUNG INJURY
    Role: Principal Investigator
    K30HL004164     (MCCALL, CHARLES EMORY)Jun 1, 1999 - May 31, 2006
    NIH
    EDUCATION IN PATIENT ORIENTED RESEARCH
    Role: Principal Investigator
    R01AI065791     (MCCALL, CHARLES EMORY)Jul 1, 2005 - Jan 3, 2017
    NIH
    NF-kB and Chromatin Changes in Human Sepsis
    Role: Principal Investigator
    R56AI065791     (MCCALL, CHARLES EMORY)Feb 1, 2006 - Dec 31, 2018
    NIH
    Metabolic and Immune Properties of Sepsis
    Role: Principal Investigator
    P20RR023570     (MCCALL, CHARLES EMORY)Sep 22, 2006 - Sep 21, 2007
    NIH
    Planning Grant for Institutional Clinical and Translational Science Award
    Role: Principal Investigator
    R56AI079144     (MCCALL, CHARLES EMORY)Jun 5, 2009 - Nov 30, 2009
    NIH
    Epigenetics of Severe Systemic Inflammation
    Role: Principal Investigator
    R01AI079144     (MCCALL, CHARLES EMORY)Dec 1, 2009 - Nov 30, 2015
    NIH
    Epigenetics of Severe Systemic Inflammation
    Role: Principal Investigator
    R01GM102497     (MCCALL, CHARLES EMORY)Aug 5, 2014 - Apr 30, 2019
    NIH
    Mitochondrial Biogenesis is Regulated by RelB During Inflammation
    Role: Principal Investigator
    R35GM126922     (MCCALL, CHARLES EMORY)May 1, 2018 - Apr 30, 2023
    NIH
    Redox control over metabolism and mitochondrial bioenergetics directs the course of acute inflammation and sepsis.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Snider JM, You JK, Wang X, Snider AJ, Hallmark B, Seeds MC, Sergeant S, Johnstone L, Wang Q, Sprissler R, Zhang HH, Luberto C, Kew RR, Hannun YA, McCall CE, Yao G, Del Poeta M, Chilton FH. Group IIA Secreted Phospholipase A 2 Plays a Central Role in the Pathobiology of COVID-19. medRxiv. 2021 Feb 23. PMID: 33655264.
      Citations:    
    2. Mainali R, Zabalawi M, Long D, Buechler N, Quillen E, Key CC, Zhu X, Parks JS, Furdui C, Stacpoole PW, Martinez J, McCall CE, Quinn MA. Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction. Elife. 2021 Feb 22; 10. PMID: 33616039.
      Citations:    
    3. Bah I, Kumbhare A, Nguyen L, McCall CE, El Gazzar M. Corrigendum to "IL-10 induces an immune repressor pathway in sepsis by promoting S100A9 nuclear localization and MDSC development" [Cell Immunol. 332 (2018) 32-38]. Cell Immunol. 2020 Nov; 357:104218. PMID: 32977158.
      Citations:    
    4. Alkhateeb T, Bah I, Kumbhare A, Youssef D, Yao ZQ, McCall CE, Gazzar ME. Long Non-Coding RNA Hotairm1 Promotes S100A9 Support of MDSC Expansion during Sepsis. J Clin Cell Immunol. 2020; 11(6). PMID: 33335790.
      Citations:    
    5. Alkhateeb T, Kumbhare A, Bah I, Youssef D, Yao ZQ, McCall CE, Gazzar ME. Corrigendum to "S100A9 maintains myeloid-derived suppressor cells in chronic sepsis by inducing miR-21 and miR-181b" [Mol. Immunol. 112 (August) (2019) 72-81]. Mol Immunol. 2020 Nov; 127:78. PMID: 32932049.
      Citations:    
    6. Bah I, Alkhateeb T, Kumbhare A, Youssef D, Yao ZQ, Hawkin GA, McCall CE, Gazzar ME. Corrigendum to: "HuR promotes miRNA-mediated upregulation of NFI-A protein expression in MDSCs during murine sepsis" (Mol Immunol., 2019, July, 123, 97-105). Mol Immunol. 2020 Nov; 127:56. PMID: 32927164.
      Citations:    
    7. Smith LM, Yoza BK, Hoth JJ, McCall CE, Vachharajani V. SIRT1 Mediates Septic Cardiomyopathy in a Murine Model of Polymicrobial Sepsis. Shock. 2020 07; 54(1):96-101. PMID: 31393272.
      Citations:    
    8. Bah I, Alkhateeb T, Kumbhare A, Youssef D, Yao ZQ, Hawkin GA, McCall CE, El Gazzar M. HuR promotes miRNA-mediated upregulation of NFI-A protein expression in MDSCs during murine sepsis. Mol Immunol. 2020 07; 123:97-105. PMID: 32474254.
      Citations:    
    9. Wang Z, Zhao Q, Nie Y, Yu Y, Misra BB, Zabalawi M, Chou JW, Key CC, Molina AJ, Quinn MA, Fessler MB, Parks JS, McCall CE, Zhu X. Solute Carrier Family 37 Member 2 (SLC37A2) Negatively Regulates Murine Macrophage Inflammation by Controlling Glycolysis. iScience. 2020 May 22; 23(5):101125. PMID: 32428862.
      Citations:    
    10. Vachharajani V, McCall CE. Sirtuins: potential therapeutic targets for regulating acute inflammatory response? Expert Opin Ther Targets. 2020 05; 24(5):489-497. PMID: 32174215.
      Citations:    
    11. Li L, McCall C, Hu X. Editorial: Innate Immunity Programming and Memory in Resolving and Non-Resolving Inflammation. Front Immunol. 2020; 11:177. PMID: 32117304.
      Citations:    
    12. Zhu X, Long D, Zabalawi M, Ingram B, Yoza BK, Stacpoole PW, McCall CE. Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes. J Leukoc Biol. 2020 03; 107(3):467-484. PMID: 31894617.
      Citations:    
    13. Zhang J, Tao J, Ling Y, Li F, Zhu X, Xu L, Wang M, Zhang S, McCall CE, Liu TF. Switch of NAD Salvage to de novo Biosynthesis Sustains SIRT1-RelB-Dependent Inflammatory Tolerance. Front Immunol. 2019; 10:2358. PMID: 31681271.
      Citations:    
    14. Alkhateeb T, Kumbhare A, Bah I, Youssef D, Yao ZQ, McCall CE, El Gazzar M. S100A9 maintains myeloid-derived suppressor cells in chronic sepsis by inducing miR-21 and miR-181b. Mol Immunol. 2019 08; 112:72-81. PMID: 31078118.
      Citations:    
    15. Vachharajani V, McCall CE. Epigenetic and metabolic programming of innate immunity in sepsis. Innate Immun. 2019 07; 25(5):267-279. PMID: 30997862.
      Citations:    
    16. Wang X, Buechler NL, Long DL, Furdui CM, Yoza BK, McCall CE, Vachharajani V. Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis. Inflammation. 2019 Feb; 42(1):156-169. PMID: 30203196.
      Citations:    
    17. Zhu X, Meyers A, Long D, Ingram B, Liu T, Yoza BK, Vachharajani V, McCall CE. Frontline Science: Monocytes sequentially rewire metabolism and bioenergetics during an acute inflammatory response. J Leukoc Biol. 2019 02; 105(2):215-228. PMID: 30633362.
      Citations:    
    18. Wang X, Buechler NL, Woodruff AG, Long DL, Zabalawi M, Yoza BK, McCall CE, Vachharajani V. Sirtuins and Immuno-Metabolism of Sepsis. Int J Mol Sci. 2018 Sep 13; 19(9). PMID: 30216989.
      Citations:    
    19. McCall CE, Zabalawi M, Liu T, Martin A, Long DL, Buechler NL, Arts RJW, Netea M, Yoza BK, Stacpoole PW, Vachharajani V. Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival. JCI Insight. 2018 08 09; 3(15). PMID: 30089711.
      Citations:    
    20. Hoth JJ, Smith LM, Furdui CM, Wells JD, Yoza BK, McCall CE. Antioxidant treatment after injury suppresses second hit immune priming. J Trauma Acute Care Surg. 2018 08; 85(2):367-374. PMID: 30080782.
      Citations:    
    21. Bah I, Kumbhare A, Nguyen L, McCall CE, El Gazzar M. IL-10 induces an immune repressor pathway in sepsis by promoting S100A9 nuclear localization and MDSC development. Cell Immunol. 2018 10; 332:32-38. PMID: 30025864.
      Citations:    
    22. Martin AN, Alexander-Miller M, Yoza BK, Vachharajani V, McCall CE. Sirtuin1 Targeting Reverses Innate and Adaptive Immune Tolerance in Septic Mice. J Immunol Res. 2018; 2018:2402593. PMID: 30069485.
      Citations:    
    23. Tao J, Zhang J, Ling Y, McCall CE, Liu TF. Mitochondrial Sirtuin 4 Resolves Immune Tolerance in Monocytes by Rebalancing Glycolysis and Glucose Oxidation Homeostasis. Front Immunol. 2018; 9:419. PMID: 29593712.
      Citations:    
    24. McPeak MB, Youssef D, Williams DA, Pritchett C, Yao ZQ, McCall CE, El Gazzar M. Correction for McPeak et al., "Myeloid Cell-Specific Knockout of NFI-A Improves Sepsis Survival". Infect Immun. 2018 03; 86(3). PMID: 29463685.
      Citations:    
    25. Dai J, Kumbhare A, Williams DA, Youssef D, Yao ZQ, McCall CE, El Gazzar M. Nfia deletion in myeloid cells blocks expansion of myeloid-derived suppressor cells during sepsis. Innate Immun. 2018 01; 24(1):54-65. PMID: 29172874.
      Citations:    
    26. Dai J, Kumbhare A, Youssef D, McCall CE, El Gazzar M. Intracellular S100A9 Promotes Myeloid-Derived Suppressor Cells during Late Sepsis. Front Immunol. 2017; 8:1565. PMID: 29204146.
      Citations:    
    27. Dai J, Kumbhare A, Youssef D, Yao ZQ, McCall CE, El Gazzar M. Expression of C/EBPß in myeloid progenitors during sepsis promotes immunosuppression. Mol Immunol. 2017 11; 91:165-172. PMID: 28934717.
      Citations:    
    28. Long D, Wu H, Tsang AW, Poole LB, Yoza BK, Wang X, Vachharajani V, Furdui CM, McCall CE. The Oxidative State of Cysteine Thiol 144 Regulates the SIRT6 Glucose Homeostat. Sci Rep. 2017 09 08; 7(1):11005. PMID: 28887543.
      Citations:    
    29. Liu Y, Reynolds LM, Ding J, Hou L, Lohman K, Young T, Cui W, Huang Z, Grenier C, Wan M, Stunnenberg HG, Siscovick D, Hou L, Psaty BM, Rich SS, Rotter JI, Kaufman JD, Burke GL, Murphy S, Jacobs DR, Post W, Hoeschele I, Bell DA, Herrington D, Parks JS, Tracy RP, McCall CE, Stein JH. Blood monocyte transcriptome and epigenome analyses reveal loci associated with human atherosclerosis. Nat Commun. 2017 08 30; 8(1):393. PMID: 28855511.
      Citations:    
    30. Taylor J, Reynolds L, Hou L, Lohman K, Cui W, Kritchevsky S, McCall C, Liu Y. Transcriptomic profiles of aging in naïve and memory CD4+ cells from mice. Immun Ageing. 2017; 14:15. PMID: 28642803.
      Citations:    
    31. McPeak MB, Youssef D, Williams DA, Pritchett CL, Yao ZQ, McCall CE, El Gazzar M. Frontline Science: Myeloid cell-specific deletion of Cebpb decreases sepsis-induced immunosuppression in mice. J Leukoc Biol. 2017 08; 102(2):191-200. PMID: 28476751.
      Citations:    
    32. Buechler N, Wang X, Yoza BK, McCall CE, Vachharajani V. Sirtuin 2 Regulates Microvascular Inflammation during Sepsis. J Immunol Res. 2017; 2017:2648946. PMID: 28503576.
      Citations:    
    33. McPeak MB, Youssef D, Williams DA, Pritchett C, Yao ZQ, McCall CE, El Gazzar M. Myeloid Cell-Specific Knockout of NFI-A Improves Sepsis Survival. Infect Immun. 2017 04; 85(4). PMID: 28167668.
      Citations:    
    34. Chi GC, Liu Y, MacDonald JW, Barr RG, Donohue KM, Hensley MD, Hou L, McCall CE, Reynolds LM, Siscovick DS, Kaufman JD. Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA). Environ Health. 2016 12 01; 15(1):119. PMID: 27903268.
      Citations:    
    35. Wang X, Buechler NL, Yoza BK, McCall CE, Vachharajani V. Adiponectin treatment attenuates inflammatory response during early sepsis in obese mice. J Inflamm Res. 2016; 9:167-174. PMID: 27785087.
      Citations:    
    36. Wang X, Buechler NL, Martin A, Wells J, Yoza B, McCall CE, Vachharajani V. Correction: Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice. PLoS One. 2016; 11(9):e0162560. PMID: 27583522.
      Citations:    
    37. Wang X, Buechler NL, Martin A, Wells J, Yoza B, McCall CE, Vachharajani V. Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice. PLoS One. 2016; 11(8):e0160431. PMID: 27500833.
      Citations:    
    38. McClure C, McPeak MB, Youssef D, Yao ZQ, McCall CE, El Gazzar M. Stat3 and C/EBPß synergize to induce miR-21 and miR-181b expression during sepsis. Immunol Cell Biol. 2017 01; 95(1):42-55. PMID: 27430527.
      Citations:    
    39. Millet P, Vachharajani V, McPhail L, Yoza B, McCall CE. GAPDH Binding to TNF-a mRNA Contributes to Posttranscriptional Repression in Monocytes: A Novel Mechanism of Communication between Inflammation and Metabolism. J Immunol. 2016 Mar 15; 196(6):2541-51. PMID: 26843329.
      Citations:    
    40. Vachharajani VT, Liu T, Wang X, Hoth JJ, Yoza BK, McCall CE. Sirtuins Link Inflammation and Metabolism. J Immunol Res. 2016; 2016:8167273. PMID: 26904696.
      Citations:    
    41. McClure C, Ali E, Youssef D, Yao ZQ, McCall CE, El Gazzar M. NFI-A disrupts myeloid cell differentiation and maturation in septic mice. J Leukoc Biol. 2016 Jan; 99(1):201-11. PMID: 26259914.
      Citations:    
    42. Ding J, Reynolds LM, Zeller T, Müller C, Lohman K, Nicklas BJ, Kritchevsky SB, Huang Z, de la Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR, Post W, Tracy RP, Wild PS, Blankenberg S, Hoeschele I, Herrington D, McCall CE, Liu Y. Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease. Diabetes. 2015 Oct; 64(10):3464-74. PMID: 26153245.
      Citations:    
    43. McClure C, Brudecki L, Yao ZQ, McCall CE, El Gazzar M. Processing Body Formation Limits Proinflammatory Cytokine Synthesis in Endotoxin-Tolerant Monocytes and Murine Septic Macrophages. J Innate Immun. 2015; 7(6):572-83. PMID: 25998849.
      Citations:    
    44. Wang X, Buechler NL, Yoza BK, McCall CE, Vachharajani VT. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring). 2015 Jun; 23(6):1209-17. PMID: 25959124.
      Citations:    
    45. Smith LM, Wells JD, Vachharajani VT, Yoza BK, McCall CE, Hoth JJ. SIRT1 mediates a primed response to immune challenge after traumatic lung injury. J Trauma Acute Care Surg. 2015 May; 78(5):1034-8. PMID: 25909427.
      Citations:    
    46. Reynolds LM, Ding J, Taylor JR, Lohman K, Soranzo N, de la Fuente A, Liu TF, Johnson C, Barr RG, Register TC, Donohue KM, Talor MV, Cihakova D, Gu C, Divers J, Siscovick D, Burke G, Post W, Shea S, Jacobs DR, Hoeschele I, McCall CE, Kritchevsky SB, Herrington D, Tracy RP, Liu Y. Transcriptomic profiles of aging in purified human immune cells. BMC Genomics. 2015 Apr 22; 16:333. PMID: 25898983.
      Citations:    
    47. Reynolds LM, Taylor JR, Ding J, Lohman K, Johnson C, Siscovick D, Burke G, Post W, Shea S, Jacobs DR, Stunnenberg H, Kritchevsky SB, Hoeschele I, McCall CE, Herrington D, Tracy RP, Liu Y. Age-related variations in the methylome associated with gene expression in human monocytes and T cells. Nat Commun. 2014 Nov 18; 5:5366. PMID: 25404168.
      Citations:    
    48. Liu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CE. Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis. J Biol Chem. 2015 Jan 02; 290(1):396-408. PMID: 25404738.
      Citations:    
    49. Vachharajani V, Liu T, McCall CE. Epigenetic coordination of acute systemic inflammation: potential therapeutic targets. Expert Rev Clin Immunol. 2014 Sep; 10(9):1141-50. PMID: 25088223.
      Citations:    
    50. Vachharajani VT, Liu T, Brown CM, Wang X, Buechler NL, Wells JD, Yoza BK, McCall CE. SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome. J Leukoc Biol. 2014 Nov; 96(5):785-96. PMID: 25001863.
      Citations:    
    51. McClure C, Brudecki L, Ferguson DA, Yao ZQ, Moorman JP, McCall CE, El Gazzar M. MicroRNA 21 (miR-21) and miR-181b couple with NFI-A to generate myeloid-derived suppressor cells and promote immunosuppression in late sepsis. Infect Immun. 2014 Sep; 82(9):3816-25. PMID: 24980967.
      Citations:    
    52. Hoth JJ, Wells JD, Jones SE, Yoza BK, McCall CE. Complement mediates a primed inflammatory response after traumatic lung injury. J Trauma Acute Care Surg. 2014 Mar; 76(3):601-8; discussion 608-9. PMID: 24553525.
      Citations:    
    53. Millet P, McCall C, Yoza B. RelB: an outlier in leukocyte biology. J Leukoc Biol. 2013 Nov; 94(5):941-51. PMID: 23922380.
      Citations:    
    54. Brudecki L, Ferguson DA, McCall CE, El Gazzar M. MicroRNA-146a and RBM4 form a negative feed-forward loop that disrupts cytokine mRNA translation following TLR4 responses in human THP-1 monocytes. Immunol Cell Biol. 2013 Sep; 91(8):532-40. PMID: 23897118.
      Citations:    
    55. Liu Y, Ding J, Reynolds LM, Lohman K, Register TC, De La Fuente A, Howard TD, Hawkins GA, Cui W, Morris J, Smith SG, Barr RG, Kaufman JD, Burke GL, Post W, Shea S, McCall CE, Siscovick D, Jacobs DR, Tracy RP, Herrington DM, Hoeschele I. Methylomics of gene expression in human monocytes. Hum Mol Genet. 2013 Dec 15; 22(24):5065-74. PMID: 23900078.
      Citations:    
    56. Brudecki L, Ferguson DA, McCall CE, El Gazzar M. Mitogen-activated protein kinase phosphatase 1 disrupts proinflammatory protein synthesis in endotoxin-adapted monocytes. Clin Vaccine Immunol. 2013 Sep; 20(9):1396-404. PMID: 23825193.
      Citations:    
    57. Liu TF, McCall CE. Deacetylation by SIRT1 Reprograms Inflammation and Cancer. Genes Cancer. 2013 Mar; 4(3-4):135-47. PMID: 24020005.
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    58. Brudecki L, Ferguson DA, McCall CE, El Gazzar M. Adoptive transfer of CD34(+) cells during murine sepsis rebalances macrophage lipopolysaccharide responses. Immunol Cell Biol. 2012 Nov; 90(10):925-34. PMID: 22732898.
      Citations:    
    59. Liu TF, Vachharajani VT, Yoza BK, McCall CE. NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response. J Biol Chem. 2012 Jul 27; 287(31):25758-69. PMID: 22700961.
      Citations:    
    60. Liu TF, Brown CM, El Gazzar M, McPhail L, Millet P, Rao A, Vachharajani VT, Yoza BK, McCall CE. Fueling the flame: bioenergy couples metabolism and inflammation. J Leukoc Biol. 2012 Sep; 92(3):499-507. PMID: 22571857.
      Citations:    
    61. Hoth JJ, Wells JD, Yoza BK, McCall CE. Innate immune response to pulmonary contusion: identification of cell type-specific inflammatory responses. Shock. 2012 Apr; 37(4):385-91. PMID: 22293596.
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    62. Brudecki L, Ferguson DA, McCall CE, El Gazzar M. Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response. Infect Immun. 2012 Jun; 80(6):2026-34. PMID: 22451518.
      Citations:    
    63. Kavanagh K, Wylie AT, Chavanne TJ, Jorgensen MJ, Voruganti VS, Comuzzie AG, Kaplan JR, McCall CE, Kritchevsky SB. Aging does not reduce heat shock protein 70 in the absence of chronic insulin resistance. J Gerontol A Biol Sci Med Sci. 2012 Oct; 67(10):1014-21. PMID: 22403054.
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    64. Brudecki L, Ferguson DA, Yin D, Lesage GD, McCall CE, El Gazzar M. Hematopoietic stem-progenitor cells restore immunoreactivity and improve survival in late sepsis. Infect Immun. 2012 Feb; 80(2):602-11. PMID: 22144495.
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    65. Vachharajani V, Cunningham C, Yoza B, Carson J, Vachharajani TJ, McCall C. Adiponectin-deficiency exaggerates sepsis-induced microvascular dysfunction in the mouse brain. Obesity (Silver Spring). 2012 Mar; 20(3):498-504. PMID: 21996662.
      Citations:    
    66. El Gazzar M, McCall CE. MicroRNAs regulatory networks in myeloid lineage development and differentiation: regulators of the regulators. Immunol Cell Biol. 2012 Jul; 90(6):587-93. PMID: 21912420.
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    67. Hoth JJ, Wells JD, Hiltbold EM, McCall CE, Yoza BK. Mechanism of neutrophil recruitment to the lung after pulmonary contusion. Shock. 2011 Jun; 35(6):604-9. PMID: 21330942.
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    68. McCall CE, El Gazzar M, Liu T, Vachharajani V, Yoza B. Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. J Leukoc Biol. 2011 Sep; 90(3):439-46. PMID: 21610199.
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    69. El Gazzar M, Church A, Liu T, McCall CE. MicroRNA-146a regulates both transcription silencing and translation disruption of TNF-a during TLR4-induced gene reprogramming. J Leukoc Biol. 2011 Sep; 90(3):509-19. PMID: 21562054.
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    70. Yoza BK, McCall CE. Facultative heterochromatin formation at the IL-1 beta promoter in LPS tolerance and sepsis. Cytokine. 2011 Feb; 53(2):145-52. PMID: 21078560.
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    71. Liu TF, Yoza BK, El Gazzar M, Vachharajani VT, McCall CE. NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. J Biol Chem. 2011 Mar 18; 286(11):9856-64. PMID: 21245135.
      Citations:    
    72. Vachharajani V, Wang SW, Mishra N, El Gazzar M, Yoza B, McCall C. Curcumin modulates leukocyte and platelet adhesion in murine sepsis. Microcirculation. 2010 Aug; 17(6):407-16. PMID: 20690979.
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    73. El Gazzar M, McCall CE. MicroRNAs distinguish translational from transcriptional silencing during endotoxin tolerance. J Biol Chem. 2010 Jul 02; 285(27):20940-51. PMID: 20435889.
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    74. McCall CE, Yoza B, Liu T, El Gazzar M. Gene-specific epigenetic regulation in serious infections with systemic inflammation. J Innate Immun. 2010; 2(5):395-405. PMID: 20733328.
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    75. El Gazzar M, Liu T, Yoza BK, McCall CE. Dynamic and selective nucleosome repositioning during endotoxin tolerance. J Biol Chem. 2010 Jan 08; 285(2):1259-71. PMID: 19901031.
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    76. Chen X, El Gazzar M, Yoza BK, McCall CE. The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance. J Biol Chem. 2009 Oct 09; 284(41):27857-27865. PMID: 19690169.
      Citations:    
    77. Hoth JJ, Martin RS, Yoza BK, Wells JD, Meredith JW, McCall CE. Pulmonary contusion primes systemic innate immunity responses. J Trauma. 2009 Jul; 67(1):14-21; discussion 21-2. PMID: 19590302.
      Citations:    
    78. Hoth JJ, Wells JD, Brownlee NA, Hiltbold EM, Meredith JW, McCall CE, Yoza BK. Toll-like receptor 4-dependent responses to lung injury in a murine model of pulmonary contusion. Shock. 2009 Apr; 31(4):376-81. PMID: 18665044.
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    79. El Gazzar M, Yoza BK, Chen X, Garcia BA, Young NL, McCall CE. Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Mol Cell Biol. 2009 Apr; 29(7):1959-71. PMID: 19158276.
      Citations:    
    80. Chen X, Yoza BK, El Gazzar M, Hu JY, Cousart SL, McCall CE. RelB sustains IkappaBalpha expression during endotoxin tolerance. Clin Vaccine Immunol. 2009 Jan; 16(1):104-10. PMID: 19020113.
      Citations:    
    81. El Gazzar M, Yoza BK, Chen X, Hu J, Hawkins GA, McCall CE. G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance. J Biol Chem. 2008 Nov 21; 283(47):32198-208. PMID: 18809684.
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    82. Loza MJ, McCall CE, Li L, Isaacs WB, Xu J, Chang BL. Assembly of inflammation-related genes for pathway-focused genetic analysis. PLoS One. 2007 Oct 17; 2(10):e1035. PMID: 17940599.
      Citations:    
    83. Hoth JJ, Hudson WP, Brownlee NA, Yoza BK, Hiltbold EM, Meredith JW, McCall CE. Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion. Shock. 2007 Oct; 28(4):447-52. PMID: 17558351.
      Citations:    
    84. El Gazzar M, Yoza BK, Hu JY, Cousart SL, McCall CE. Epigenetic silencing of tumor necrosis factor alpha during endotoxin tolerance. J Biol Chem. 2007 Sep 14; 282(37):26857-26864. PMID: 17646159.
      Citations:    
    85. El Mezayen R, El Gazzar M, Seeds MC, McCall CE, Dreskin SC, Nicolls MR. Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. Immunol Lett. 2007 Jul 31; 111(1):36-44. PMID: 17568691.
      Citations:    
    86. McCall CE, Yoza BK. Gene silencing in severe systemic inflammation. Am J Respir Crit Care Med. 2007 Apr 15; 175(8):763-7. PMID: 17255558.
      Citations:    
    87. Yoza BK, Hu JY, Cousart SL, Forrest LM, McCall CE. Induction of RelB participates in endotoxin tolerance. J Immunol. 2006 Sep 15; 177(6):4080-5. PMID: 16951372.
      Citations:    
    88. Hoth JJ, Stitzel JD, Gayzik FS, Brownlee NA, Miller PR, Yoza BK, McCall CE, Meredith JW, Payne RM. The pathogenesis of pulmonary contusion: an open chest model in the rat. J Trauma. 2006 Jul; 61(1):32-44; discussion 44-5. PMID: 16832247.
      Citations:    
    89. Romero-Sandoval EA, McCall C, Eisenach JC. Alpha2-adrenoceptor stimulation transforms immune responses in neuritis and blocks neuritis-induced pain. J Neurosci. 2005 Sep 28; 25(39):8988-94. PMID: 16192389.
      Citations:    
    90. Chan C, Li L, McCall CE, Yoza BK. Endotoxin tolerance disrupts chromatin remodeling and NF-kappaB transactivation at the IL-1beta promoter. J Immunol. 2005 Jul 01; 175(1):461-8. PMID: 15972680.
      Citations:    
    91. Bensen JT, Langefeld CD, Li L, McCall CE, Cousart SL, Dryman BN, Freedman BI, Bowden DW. Association of an IL-1A 3'UTR polymorphism with end-stage renal disease and IL-1 alpha expression. Kidney Int. 2003 Apr; 63(4):1211-9. PMID: 12631337.
      Citations:    
    92. Li L, Jacinto R, Yoza B, McCall CE. Distinct post-receptor alterations generate gene- and signal-selective adaptation and cross-adaptation of TLR4 and TLR2 in human leukocytes. J Endotoxin Res. 2003; 9(1):39-44. PMID: 12691617.
      Citations:    
    93. Jacinto R, Hartung T, McCall C, Li L. Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: distinct alterations in IL-1 receptor-associated kinase. J Immunol. 2002 Jun 15; 168(12):6136-41. PMID: 12055225.
      Citations:    
    94. Hu J, Jacinto R, McCall C, Li L. Regulation of IL-1 receptor-associated kinases by lipopolysaccharide. J Immunol. 2002 Apr 15; 168(8):3910-4. PMID: 11937546.
      Citations:    
    95. Yoza BK, Hu JY, McCall CE. Inhibition of histone deacetylation enhances endotoxin-stimulated transcription but does not reverse endotoxin tolerance. J Endotoxin Res. 2002; 8(2):109-14. PMID: 12028750.
      Citations:    
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