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Ramon Casanova PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentPHS-Biostatistics and Data Science (Public Health Sciences)
Address
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    Collapse Research 
    Collapse research activities and funding
    NIRP-12-259281     (Casanova Ramon)Feb 1, 2013 - Aug 30, 2015
    Alzheimer's Association
    Novel biomarkers for early detection of Alzheimer's Disease
    Role: Principal Investigator
    R01AG042525     (MANINI, TODD)Jul 15, 2013 - Mar 31, 2019
    NIH
    Metabolic Costs of Daily Activities in Older Adults
    Role: Site Principal Investigator
         (Ramon Casanova)Sep 1, 2014 - Aug 31, 2015
    NIA
    Machine Learning Analyses of Longitudinal Plasma Metabolomics Data
    Role: Principal Investigator
    R21AG051113     (CASANOVA, RAMON)Sep 1, 2015 - Apr 30, 2018
    NIH
    Regional Neurotoxicity & Early Biomarkers of Air Pollution Effects on Brain Aging
    Role: Principal Investigator
    75N95 022P00019     (Ramon Casanova)Nov 15, 2021 - Oct 15, 2022
    NIA
    Investigating the Biology of Cognitive Resilience in WHIMS APOE e4 Escapees.
    Role: Site Principal Investigator
         (Casanova Ramon)Jul 1, 2022 - Jun 30, 2025
    The Duke Endowment Foundation
    Developing Biomarkers for Early Detection of Alzheimer's Disease Using Machine Learning and Artificial Intelligence
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Morandini F, Lu JY, Rechsteiner C, Shadyab AH, Casanova R, Snively BM, Seluanov A, Gorbunova V. Transposable element 5mC methylation state of blood cells predicts age and disease. Nat Aging. 2024 Nov 27. PMID: 39604704.
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    2. Walker KA, An Y, Moghekar A, Moaddel R, Duggan MR, Peng Z, Tian Q, Pilling LC, Drouin SM, Espeland MA, Rapp SR, Hayden KM, Shadyab AH, Casanova R, Thambisetty M, Rapp PR, Kapogiannis D, Ferrucci L, Resnick SM. Proteomic analysis of APOEe4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience. Mol Neurodegener. 2024 Oct 31; 19(1):81. PMID: 39482741.
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    3. Shen Y, Domingo-Relloso A, Kupsco A, Kioumourtzoglou MA, Tellez-Plaza M, Umans JG, Fretts AM, Zhang Y, Schnatz PF, Casanova R, Martin LW, Horvath S, Manson JE, Cole SA, Wu H, Whitsel EA, Baccarelli AA, Navas-Acien A, Gao F. AESurv: autoencoder survival analysis for accurate early prediction of coronary heart disease. Brief Bioinform. 2024 Sep 23; 25(6). PMID: 39323093.
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    4. Hrytsenko Y, Shea B, Elgart M, Kurniansyah N, Lyons G, Morrison AC, Carson AP, Haring B, Mitchell BD, Psaty BM, Jaeger BC, Gu CC, Kooperberg C, Levy D, Lloyd-Jones D, Choi E, Brody JA, Smith JA, Rotter JI, Moll M, Fornage M, Simon N, Castaldi P, Casanova R, Chung RH, Kaplan R, Loos RJF, Kardia SLR, Rich SS, Redline S, Kelly T, O'Connor T, Zhao W, Kim W, Guo X, Ida Chen YD. Machine learning models for predicting blood pressure phenotypes by combining multiple polygenic risk scores. Sci Rep. 2024 May 30; 14(1):12436. PMID: 38816422.
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    5. Beydoun MA, Beydoun HA, Ashe J, Georgescu MF, Horvath S, Lu A, Zannas AS, Shadyab AH, Jung SY, Wassertheil-Smoller S, Casanova R, Zonderman AB, Brunner RL. Relationships of depression and antidepressant use with epigenetic age acceleration and all-cause mortality among postmenopausal women. Aging (Albany NY). 2024 May 27; 16(10):8446-8471. PMID: 38809417.
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    6. Ostovaneh MR, Hughes TM, Wu CO, McClelland RL, Casanova R, Bluemke DA, Tracy RP, Shea S, Heckbert SR, Lima JAC, Ambale-Venkatesh B. Deep phenotyping of dementia in a multi-ethnic cardiovascular cohort: The Multi-Ethnic Study of Atherosclerosis (MESA). PLoS One. 2024; 19(4):e0298952. PMID: 38635767.
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    7. Petkus AJ, Wang X, Younan D, Salminen LE, Resnick SM, Rapp SR, Espeland MA, Gatz M, Widaman KF, Casanova R, Chui H, Barnard RT, Gaussoin SA, Goveas JS, Hayden KM, Henderson VW, Sachs BC, Saldana S, Shadyab AH, Shumaker SA, Chen JC. 20-year depressive symptoms, dementia, and structural neuropathology in older women. Alzheimers Dement. 2024 Apr 09. PMID: 38591250.
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    8. Dunk MM, Rapp SR, Hayden KM, Espeland MA, Casanova R, Manson JE, Shadyab AH, Wild R, Driscoll I. Plasma oxysterols are associated with serum lipids and dementia risk in older women. Alzheimers Dement. 2024 Apr 04. PMID: 38574442.
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    9. Hughes TM, Tanley J, Chen H, Schaich CL, Yeboah J, Espeland MA, Lima JAC, Ambale-Venkatesh B, Michos ED, Ding J, Hayden K, Casanova R, Craft S, Rapp SR, Luchsinger JA, Fitzpatrick AL, Heckbert SR, Post WS, Burke GL. Subclinical vascular composites predict clinical cardiovascular disease, stroke, and dementia: The Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis. 2024 Mar 15; 392:117521. PMID: 38552474.
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    10. Casanova R, Walker KA, Justice JN, Anderson A, Duggan MR, Cordon J, Barnard RT, Lu L, Hsu FC, Sedaghat S, Prizment A, Kritchevsky SB, Wagenknecht LE, Hughes TM. Associations of plasma proteomics and age-related outcomes with brain age in a diverse cohort. Geroscience. 2024 Mar 04. PMID: 38438772.
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    11. Power MC, Bennett EE, Lynch KM, Stewart JD, Xu X, Park ES, Smith RL, Vizuete W, Margolis HG, Casanova R, Wallace R, Sheppard L, Ying Q, Serre ML, Szpiro AA, Chen JC, Liao D, Wellenius GA, van Donkelaar A, Yanosky JD, Whitsel E. Comparison of PM2.5 Air Pollution Exposures and Health Effects Associations Using 11 Different Modeling Approaches in the Women's Health Initiative Memory Study (WHIMS). Environ Health Perspect. 2024 Jan; 132(1):17003. PMID: 38226465.
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    12. Titcomb TJ, Richey P, Casanova R, Phillips LS, Liu S, Karanth SD, Saquib N, Nuño T, Manson JE, Shadyab AH, Liu L, Wahls TL, Snetselaar LG, Wallace RB, Bao W. Association of type 2 diabetes mellitus with dementia-related and non-dementia-related mortality among postmenopausal women: A secondary competing risks analysis of the women's health initiative. Alzheimers Dement. 2023 Aug 10. PMID: 37563765.
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    13. Dunk MM, Li J, Liu S, Casanova R, Chen JC, Espeland MA, Hayden KM, Manson JE, Rapp SR, Shadyab AH, Snetselaar LG, Van Horn L, Wild R, Driscoll I. Associations of dietary cholesterol and fat, blood lipids, and risk for dementia in older women vary by APOE genotype. Alzheimers Dement. 2023 Jul 12. PMID: 37438877.
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    14. Casanova R, Anderson AM, Barnard RT, Justice JN, Kucharska-Newton A, Windham BG, Palta P, Gottesman RF, Mosley TH, Hughes TM, Wagenknecht LE, Kritchevsky SB. Is an MRI-derived anatomical measure of dementia risk also a measure of brain aging? Geroscience. 2022 Sep 02. PMID: 36050589.
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    15. Posis AIB, Bellettiere J, Salem RM, LaMonte MJ, Manson JE, Casanova R, LaCroix AZ, Shadyab AH. Associations of Accelerometer-Measured Physical Activity and Sedentary Time With All-Cause Mortality by Genetic Predisposition for Longevity. J Aging Phys Act. 2022 Aug 24; 1-11. PMID: 36002033.
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    16. Mahapatra G, Gao Z, Bateman JR, Lockhart SN, Bergstrom J, DeWitt AR, Piloso JE, Kramer PA, Gonzalez-Armenta JL, Amick KA, Casanova R, Craft S, Molina AJA. Blood-based bioenergetic profiling reveals differences in mitochondrial function associated with cognitive performance and Alzheimer's disease. Alzheimers Dement. 2022 Jul 23. PMID: 35870133.
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    17. Sachs BC, Gaussoin SA, Brenes GA, Casanova R, Chlebowski RT, Chen JC, Luo J, Rapp SR, Shadyab AH, Shumaker S, Wactawski-Wende J, Wells GL, Hayden KM. The relationship between optimism, MCI, and dementia among postmenopausal women. Aging Ment Health. 2022 Jun 11; 1-9. PMID: 35694859.
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    18. Bai C, Wanigatunga AA, Saldana S, Casanova R, Manini TM, Mardini MT. Are Machine Learning Models on Wrist Accelerometry Robust against Differences in Physical Performance among Older Adults? Sensors (Basel). 2022 Apr 15; 22(8). PMID: 35459045.
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    19. Casanova R, Lyday RG, Bahrami M, Burdette JH, Simpson SL, Laurienti PJ. Embedding Functional Brain Networks in Low Dimensional Spaces Using Manifold Learning Techniques. Front Neuroinform. 2021; 15:740143. PMID: 35002665.
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    20. Lenoir KM, Wagenknecht LE, Divers J, Casanova R, Dabelea D, Saydah S, Pihoker C, Liese AD, Standiford D, Hamman R, Wells BJ. Determining diagnosis date of diabetes using structured electronic health record (EHR) data: the SEARCH for diabetes in youth study. BMC Med Res Methodol. 2021 Oct 10; 21(1):210. PMID: 34629073.
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    21. Casanova R, Gaussoin SA, Wallace R, Baker L, Chen JC, Manson JE, Henderson VW, Sachs BC, Justice J, Whitsel EA, Hayden KM, Rapp SR. Investigating Predictors of Preserved Cognitive Function in Older Women Using Machine Learning: Women's Health Initiative Memory Study. J Alzheimers Dis. 2021 Oct 07. PMID: 34633318.
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    22. Shutta KH, Balasubramanian R, Huang T, Jha SC, Zeleznik OA, Kroenke CH, Tinker LF, Smoller JW, Casanova R, Tworoger SS, Manson JE, Clish CB, Rexrode KM, Hankinson SE, Kubzansky LD. Plasma metabolomic profiles associated with chronic distress in women. Psychoneuroendocrinology. 2021 Sep 20; 133:105420. PMID: 34597898.
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    23. Tison GH, Avram R, Nah G, Klein L, Howard BV, Allison MA, Casanova R, Blair RH, Breathett K, Foraker RE, Olgin JE, Parikh NI. Predicting incident heart failure in women with machine learning: The Women's Health Initiative Cohort. Can J Cardiol. 2021 Aug 13. PMID: 34400272.
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    24. Casanova R, Hsu FC, Barnard RT, Anderson AM, Talluri R, Whitlow CT, Hughes TM, Griswold M, Hayden KM, Gottesman RF, Wagenknecht LE. Comparing data-driven and hypothesis-driven MRI-based predictors of cognitive impairment in individuals from the Atherosclerosis Risk in Communities (ARIC) study. Alzheimers Dement. 2021 Jul 26. PMID: 34310039.
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    25. Mardini MT, Bai C, Wanigatunga AA, Saldana S, Casanova R, Manini TM. Age Differences in Estimating Physical Activity by Wrist Accelerometry Using Machine Learning. Sensors (Basel). 2021 May 12; 21(10). PMID: 34065906.
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    26. Fairley RR, Ahmed S, Schauer SG, Wampler DA, Tanaka K, Everitt B, Sparkman MK, Casanova R, Sifuentes J, Winckler CJ. A Pilot Study to Assess Urban, Fire-Based Paramedic Accuracy in Identification of Anatomical Landmarks Necessary for Cricothyrotomy and Needle Chest Decompression Using Live Patient Models. Prehosp Disaster Med. 2021 Apr 07; 1-4. PMID: 33823946.
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    27. Mardini MT, Nerella S, Wanigatunga AA, Saldana S, Casanova R, Manini TM. Deep CHORES: Estimating Hallmark Measures of Physical Activity Using Deep Learning. AMIA Annu Symp Proc. 2020; 2020:803-812. PMID: 33936455.
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    28. Younan D, Wang X, Casanova R, Barnard R, Gaussoin SA, Saldana S, Petkus AJ, Beavers DP, Resnick SM, Manson JE, Serre ML, Vizuete W, Henderson VW, Sachs BC, Salinas JA, Gatz M, Espeland MA, Chui HC, Shumaker SA, Rapp SR, Chen JC. PM2.5 associated with gray matter atrophy reflecting increased Alzheimers risk in older women. Neurology. 2020 11 18. PMID: 33208540.
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    29. Huckfeldt PJ, Frenier C, Pajewski NM, Espeland M, Peters A, Casanova R, Pi-Sunyer X, Cheskin L, Goldman DP. Associations of Intensive Lifestyle Intervention in Type 2 Diabetes With Health Care Use, Spending, and Disability: An Ancillary Study of the Look AHEAD Study. JAMA Netw Open. 2020 11 02; 3(11):e2025488. PMID: 33231638.
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    30. Wells BJ, Lenoir KM, Wagenknecht LE, Mayer-Davis EJ, Lawrence JM, Dabelea D, Pihoker C, Saydah S, Casanova R, Turley C, Liese AD, Standiford D, Kahn MG, Hamman R, Divers J. Detection of Diabetes Status and Type in Youth Using Electronic Health Records: The SEARCH for Diabetes in Youth Study. Diabetes Care. 2020 10; 43(10):2418-2425. PMID: 32737140.
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    31. Casanova R, Saldana S, Lutz MW, Plassman BL, Kuchibhatla M, Hayden KM. Investigating Predictors of Cognitive Decline Using Machine Learning. J Gerontol B Psychol Sci Soc Sci. 2020 03 09; 75(4):733-742. PMID: 29718387.
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    32. Younan D, Petkus AJ, Widaman KF, Wang X, Casanova R, Espeland MA, Gatz M, Henderson VW, Manson JE, Rapp SR, Sachs BC, Serre ML, Gaussoin SA, Barnard R, Saldana S, Vizuete W, Beavers DP, Salinas JA, Chui HC, Resnick SM, Shumaker SA, Chen JC. Particulate matter and episodic memory decline mediated by early neuroanatomic biomarkers of Alzheimer's disease. Brain. 2020 01 01; 143(1):289-302. PMID: 31746986.
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    33. Bahrami M, Lyday RG, Casanova R, Burdette JH, Simpson SL, Laurienti PJ. Using Low-Dimensional Manifolds to Map Relationships Between Dynamic Brain Networks. Front Hum Neurosci. 2019; 13:430. PMID: 31920590.
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    34. Bancks MP, Casanova R, Gregg EW, Bertoni AG. Epidemiology of diabetes phenotypes and prevalent cardiovascular risk factors and diabetes complications in the National Health and Nutrition Examination Survey 2003-2014. Diabetes Res Clin Pract. 2019 Dec; 158:107915. PMID: 31704094.
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    35. Gaussoin SA, Espeland MA, Beavers DP, Casanova R, Garcia KR, Snively BM, Shumaker SA, Wallace RB, Rapp SR. Dementia outcomes after addition of proxy-based assessments for deceased or proxy-dependent participants. Int J Geriatr Psychiatry. 2019 10; 34(10):1403-1411. PMID: 31034676.
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    36. Kuchibhatla M, Hunter JC, Plassman BL, Lutz MW, Casanova R, Saldana S, Hayden KM. The association between neighborhood socioeconomic status, cardiovascular and cerebrovascular risk factors, and cognitive decline in the Health and Retirement Study (HRS). Aging Ment Health. 2020 09; 24(9):1479-1486. PMID: 31018653.
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    37. Petkus AJ, Resnick SM, Rapp SR, Espeland MA, Gatz M, Widaman KF, Wang X, Younan D, Casanova R, Chui H, Barnard RT, Gaussoin S, Goveas JS, Hayden KM, Henderson VW, Sachs BC, Saldana S, Shadyab AH, Shumaker SA, Chen JC. General and domain-specific cognitive reserve, mild cognitive impairment, and dementia risk in older women. Alzheimers Dement (N Y). 2019; 5:118-128. PMID: 31011622.
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    38. Driscoll I, Snively BM, Espeland MA, Shumaker SA, Rapp SR, Goveas JS, Casanova RL, Wactawski-Wende J, Manson JE, Rossom R, Brooks J, Hernandez DG, Singleton AB, Resnick SM. A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study. Int J Geriatr Psychiatry. 2019 05; 34(5):692-699. PMID: 30706571.
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    39. Lutz MW, Casanova R, Saldana S, Kuchibhatla M, Plassman BL, Hayden KM. Analysis of pleiotropic genetic effects on cognitive impairment, systemic inflammation, and plasma lipids in the Health and Retirement Study. Neurobiol Aging. 2019 08; 80:173-186. PMID: 31201950.
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    40. Kristen M. Beavers, Rebecca H. Neiberg, Karen C. Johnson, Ramon Casanova, Ann V. Schwartz, Carolyn J. Crandall, Cora E. Lewis, Xavier Pi-Sunyer, Stephen B. Kritchevsky. Impact of Body Weight Dynamics Following Intentional Weight Loss on Fracture Risk: Results from The Action for Health in Diabetes Study. Journal of Bone and Mineral Research. 2019.
    41. Beavers KM, Neiberg RH, Johnson KC, Davis CH, Casanova R, Schwartz AV, Crandall CJ, Lewis CE, Pi-Sunyer X, Kritchevsky SB. Impact of Body Weight Dynamics Following Intentional Weight Loss on Fracture Risk: Results from The Action for Health in Diabetes Study. JBMR Plus. 2019 May; 3(5):e10086. PMID: 31131339.
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    42. Casanova R, Barnard RT, Gaussoin SA, Saldana S, Hayden KM, Manson JE, Wallace RB, Rapp SR, Resnick SM, Espeland MA, Chen JC. Using high-dimensional machine learning methods to estimate an anatomical risk factor for Alzheimer's disease across imaging databases. Neuroimage. 2018 12; 183:401-411. PMID: 30130645.
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    43. Espeland MA, Chen JC, Weitlauf J, Hayden KM, Rapp SR, Resnick SM, Garcia L, Cannell B, Baker LD, Sachs BC, Tindle HA, Wallace R, Casanova R. Trajectories of Relative Performance with 2 Measures of Global Cognitive Function. J Am Geriatr Soc. 2018 08; 66(8):1575-1580. PMID: 29972592.
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    44. Hunter JC, Handing EP, Casanova R, Kuchibhatla M, Lutz MW, Saldana S, Plassman BL, Hayden KM. Neighborhoods, sleep quality, and cognitive decline: Does where you live and how well you sleep matter? Alzheimers Dement. 2018 04; 14(4):454-461. PMID: 29396109.
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    45. Varma VR, Oommen AM, Varma S, Casanova R, An Y, Andrews RM, O'Brien R, Pletnikova O, Troncoso JC, Toledo J, Baillie R, Arnold M, Kastenmueller G, Nho K, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Legido-Quigley C, Thambisetty M. Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study. PLoS Med. 2018 01; 15(1):e1002482. PMID: 29370177.
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    46. Gross AL, Payne BR, Casanova R, Davoudzadeh P, Dzierzewski JM, Farias S, Giovannetti T, Ip EH, Marsiske M, Rebok GW, Schaie KW, Thomas K, Willis S, Jones RN. The ACTIVE conceptual framework as a structural equation model. Exp Aging Res. 2018 Jan-Feb; 44(1):1-17. PMID: 29303475.
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    47. Espeland MA, Luchsinger JA, Neiberg RH, Carmichael O, Laurienti PJ, Pi-Sunyer X, Wing RR, Cook D, Horton E, Casanova R, Erickson K, Nick Bryan R. Long Term Effect of Intensive Lifestyle Intervention on Cerebral Blood Flow. J Am Geriatr Soc. 2018 01; 66(1):120-126. PMID: 29082505.
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    48. An Y, Varma VR, Varma S, Casanova R, Dammer E, Pletnikova O, Chia CW, Egan JM, Ferrucci L, Troncoso J, Levey AI, Lah J, Seyfried NT, Legido-Quigley C, O'Brien R, Thambisetty M. Evidence for brain glucose dysregulation in Alzheimer's disease. Alzheimers Dement. 2018 03; 14(3):318-329. PMID: 29055815.
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    49. Joseph JJ, Echouffo-Tcheugui JB, Kalyani RR, Yeh HC, Bertoni AG, Effoe VS, Casanova R, Sims M, Wu WC, Wand GS, Correa A, Golden SH. Aldosterone, Renin, Cardiovascular Events, and All-Cause Mortality Among African Americans: The Jackson Heart Study. JACC Heart Fail. 2017 09; 5(9):642-651. PMID: 28822744.
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    50. Hayden KM, Beavers DP, Steck SE, Hebert JR, Tabung FK, Shivappa N, Casanova R, Manson JE, Padula CB, Salmoirago-Blotcher E, Snetselaar LG, Zaslavsky O, Rapp SR. The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women's Health Initiative Memory Study. Alzheimers Dement. 2017 Nov; 13(11):1187-1196. PMID: 28531379.
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    51. Toledo JB, Arnold M, Kastenmüller G, Chang R, Baillie RA, Han X, Thambisetty M, Tenenbaum JD, Suhre K, Thompson JW, John-Williams LS, MahmoudianDehkordi S, Rotroff DM, Jack JR, Motsinger-Reif A, Risacher SL, Blach C, Lucas JE, Massaro T, Louie G, Zhu H, Dallmann G, Klavins K, Koal T, Kim S, Nho K, Shen L, Casanova R, Varma S, Legido-Quigley C, Moseley MA, Zhu K, Henrion MYR, van der Lee SJ, Harms AC, Demirkan A, Hankemeier T, van Duijn CM, Trojanowski JQ, Shaw LM, Saykin AJ, Weiner MW, Doraiswamy PM, Kaddurah-Daouk R. Metabolic network failures in Alzheimer's disease: A biochemical road map. Alzheimers Dement. 2017 Sep; 13(9):965-984. PMID: 28341160.
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    52. Corbett DB, Wanigatunga AA, Valiani V, Handberg EM, Buford TW, Brumback B, Casanova R, Janelle CM, Manini TM. Metabolic costs of daily activity in older adults (Chores XL) study: design and methods. Contemp Clin Trials Commun. 2017 Jun; 6:1-8. PMID: 28649668.
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    53. Effoe VS, Wagenknecht LE, Echouffo Tcheugui JB, Chen H, Joseph JJ, Kalyani RR, Bell RA, Wu WH, Casanova R, Bertoni AG. Sex Differences in the Association Between Insulin Resistance and Incident Coronary Heart Disease and Stroke Among Blacks Without Diabetes Mellitus: The Jackson Heart Study. J Am Heart Assoc. 2017 02 02; 6(2). PMID: 28154164.
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    54. Thambisetty M, Casanova R, Varma S, Legido Quigley C. Peril beyond the winner's curse: A small sample size is the bane of biomarker discovery. Alzheimers Dement. 2017 05; 13(5):606-607. PMID: 28119051.
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    55. Varma VR, Varma S, An Y, Hohman TJ, Seddighi S, Casanova R, Beri A, Dammer EB, Seyfried NT, Pletnikova O, Moghekar A, Wilson MR, Lah JJ, O'Brien RJ, Levey AI, Troncoso JC, Albert MS, Thambisetty M. Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. Mol Psychiatry. 2017 01; 22(1):13-23. PMID: 27872486.
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    56. Casanova R, Wang X, Reyes J, Akita Y, Serre ML, Vizuete W, Chui HC, Driscoll I, Resnick SM, Espeland MA, Chen JC. A Voxel-Based Morphometry Study Reveals Local Brain Structural Alterations Associated with Ambient Fine Particles in Older Women. Front Hum Neurosci. 2016; 10:495. PMID: 27790103.
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    57. Casanova R, Saldana S, Simpson SL, Lacy ME, Subauste AR, Blackshear C, Wagenknecht L, Bertoni AG. Prediction of Incident Diabetes in the Jackson Heart Study Using High-Dimensional Machine Learning. PLoS One. 2016; 11(10):e0163942. PMID: 27727289.
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    58. Casanova R, Hayasaka S, Saldana S, Bryan NR, Demos KE, Desiderio L, Erickson KI, Espeland MA, Nasrallah IM, Wadden T, Laurienti PJ. Relative differences in resting-state brain connectivity associated with long term intensive lifestyle intervention. Psychoneuroendocrinology. 2016 12; 74:231-239. PMID: 27685338.
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    59. Zhang T, Casanova R, Resnick SM, Manson JE, Baker LD, Padual CB, Kuller LH, Bryan RN, Espeland MA, Davatzikos C. Effects of Hormone Therapy on Brain Volumes Changes of Postmenopausal Women Revealed by Optimally-Discriminative Voxel-Based Morphometry. PLoS One. 2016; 11(3):e0150834. PMID: 26974440.
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    60. Driscoll I, Gaussoin SA, Wassertheil-Smoller S, Limacher M, Casanova R, Yaffe K, Resnick SM, Espeland MA. Obesity and Structural Brain Integrity in Older Women: The Women's Health Initiative Magnetic Resonance Imaging Study. J Gerontol A Biol Sci Med Sci. 2016 09; 71(9):1216-1222. PMID: 26961581.
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    61. Joseph JJ, Echouffo-Tcheugui JB, Kalyani RR, Yeh HC, Bertoni AG, Effoe VS, Casanova R, Sims M, Correa A, Wu WC, Wand GS, Golden SH. Aldosterone, Renin, and Diabetes Mellitus in African Americans: The Jackson Heart Study. J Clin Endocrinol Metab. 2016 04; 101(4):1770-8. PMID: 26908112.
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    62. Casanova R, Varma S, Simpson B, Kim M, An Y, Saldana S, Riveros C, Moscato P, Griswold M, Sonntag D, Wahrheit J, Klavins K, Jonsson PV, Eiriksdottir G, Aspelund T, Launer LJ, Gudnason V, Legido Quigley C, Thambisetty M. Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals. Alzheimers Dement. 2016 07; 12(7):815-22. PMID: 26806385.
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    63. Zhang G, Smith BP, Plate JF, Casanova R, Hsu FC, Li J, Xia L, Li KC, Poehling GG, Zhou X. A systematic approach to predicting the risk of unicompartmental knee arthroplasty revision. Osteoarthritis Cartilage. 2016 06; 24(6):991-9. PMID: 26774734.
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    64. Chen JC, Wang X, Wellenius GA, Serre ML, Driscoll I, Casanova R, McArdle JJ, Manson JE, Chui HC, Espeland MA. Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study. Ann Neurol. 2015 Sep; 78(3):466-76. PMID: 26075655.
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    65. Espeland MA, Brinton RD, Manson JE, Yaffe K, Hugenschmidt C, Vaughan L, Craft S, Edwards BJ, Casanova R, Masaki K, Resnick SM. Postmenopausal hormone therapy, type 2 diabetes mellitus, and brain volumes. Neurology. 2015 Sep 29; 85(13):1131-8. PMID: 26163429.
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    66. Casanova R, Saldana S, Chew EY, Danis RP, Greven CM, Ambrosius WT. Application of random forests methods to diabetic retinopathy classification analyses. PLoS One. 2014; 9(6):e98587. PMID: 24940623.
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    67. Casanova R, Hsu FC, Sink KM, Rapp SR, Williamson JD, Resnick SM, Espeland MA. Alzheimer's disease risk assessment using large-scale machine learning methods. PLoS One. 2013; 8(11):e77949. PMID: 24250789.
      Citations:    
    68. Casanova R, Hsu FC, Espeland MA. Classification of structural MRI images in Alzheimer's disease from the perspective of ill-posed problems. PLoS One. 2012; 7(10):e44877. PMID: 23071501.
      Citations:    
    69. Espeland MA, Bryan RN, Goveas JS, Robinson JG, Siddiqui MS, Liu S, Hogan PE, Casanova R, Coker LH, Yaffe K, Masaki K, Rossom R, Resnick SM. Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the Women's Health Initiative Magnetic Resonance Imaging studies. Diabetes Care. 2013 Jan; 36(1):90-7. PMID: 22933440.
      Citations:    
    70. Haan M, Espeland MA, Klein BE, Casanova R, Gaussoin SA, Jackson RD, Millen AE, Resnick SM, Rossouw JE, Shumaker SA, Wallace R, Yaffe K. Cognitive function and retinal and ischemic brain changes: the Women's Health Initiative. Neurology. 2012 Mar 27; 78(13):942-9. PMID: 22422889.
      Citations:    
    71. Casanova R, Whitlow CT, Wagner B, Espeland MA, Maldjian JA. Combining graph and machine learning methods to analyze differences in functional connectivity across sex. Open Neuroimag J. 2012; 6:1-9. PMID: 22312418.
      Citations:    
    72. Casanova R, Whitlow CT, Wagner B, Williamson J, Shumaker SA, Maldjian JA, Espeland MA. High dimensional classification of structural MRI Alzheimer's disease data based on large scale regularization. Front Neuroinform. 2011; 5:22. PMID: 22016732.
      Citations:    
    73. Whitlow CT, Casanova R, Maldjian JA. Effect of resting-state functional MR imaging duration on stability of graph theory metrics of brain network connectivity. Radiology. 2011 May; 259(2):516-24. PMID: 21406628.
      Citations:    
    74. Casanova R, Espeland MA, Goveas JS, Davatzikos C, Gaussoin SA, Maldjian JA, Brunner RL, Kuller LH, Johnson KC, Mysiw WJ, Wagner B, Resnick SM. Application of machine learning methods to describe the effects of conjugated equine estrogens therapy on region-specific brain volumes. Magn Reson Imaging. 2011 May; 29(4):546-53. PMID: 21292420.
      Citations:    
    75. Casanova R, Maldjian JA, Espeland MA. Evaluating the Impact of Different Factors on Voxel-Based Classification Methods of ADNI Structural MRI Brain Images. International Journal of Biomedical Data Mining. 2011; 1:1-11. View Publication.
    76. Casanova R, Yang L, Hairston WD, Laurienti PJ, Maldjian JA. Evaluating the impact of spatio-temporal smoothness constraints on the BOLD hemodynamic response function estimation: an analysis based on Tikhonov regularization. Physiol Meas. 2009 May; 30(5):N37-51. PMID: 19417238.
      Citations:    
    77. Peiffer AM, Hugenschmidt CE, Maldjian JA, Casanova R, Srikanth R, Hayasaka S, Burdette JH, Kraft RA, Laurienti PJ. Aging and the interaction of sensory cortical function and structure. Hum Brain Mapp. 2009 Jan; 30(1):228-40. PMID: 18072271.
      Citations:    
    78. Casanova R, Ryali S, Serences J, Yang L, Kraft R, Laurienti PJ, Maldjian JA. The impact of temporal regularization on estimates of the BOLD hemodynamic response function: a comparative analysis. Neuroimage. 2008 May 01; 40(4):1606-18. PMID: 18329292.
      Citations:    
    79. Hairston WD, Hodges DA, Casanova R, Hayasaka S, Kraft R, Maldjian JA, Burdette JH. Closing the mind's eye: deactivation of visual cortex related to auditory task difficulty. Neuroreport. 2008 Jan 22; 19(2):151-4. PMID: 18185099.
      Citations:    
    80. Hugenschmidt CE, Peiffer AM, Kraft RA, Casanova R, Deibler AR, Burdette JH, Maldjian JA, Laurienti PJ. Relating imaging indices of white matter integrity and volume in healthy older adults. Cereb Cortex. 2008 Feb; 18(2):433-42. PMID: 17575289.
      Citations:    
    81. Casanova R, Srikanth R, Baer A, Laurienti PJ, Burdette JH, Hayasaka S, Flowers L, Wood F, Maldjian JA. Biological parametric mapping: A statistical toolbox for multimodality brain image analysis. Neuroimage. 2007 Jan 01; 34(1):137-43. PMID: 17070709.
      Citations:    
    82. Srikanth R, Casanova R, Laurienti PJ, Peiffer AM, Maldjian JA. Estimation of false discovery rates for wavelet-denoised statistical parametric maps. Neuroimage. 2006 Oct 15; 33(1):72-84. PMID: 16919480.
      Citations:    
    83. Casanova R, Silva A, Borges AR. MIT image reconstruction based on edge-preserving regularization. Physiol Meas. 2004 Feb; 25(1):195-207. PMID: 15005316.
      Citations:    
    84. Casanova R, Silva A, Borges AR. . A quantitative algorithm for parameter estimation in magnetic induction tomography. Measurement Science and Technology. 2004; 15. View Publication.
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