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Last Name

Ramon Casanova, Ph.D.

TitleAssociate Professor
InstitutionWake Forest School of Medicine
DepartmentBiostatistical Sciences Faculty
Address
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    Collapse Research 
    Collapse research activities and funding
    NIRP-12-259281     (Casanova Ramon)Feb 1, 2013 - Aug 30, 2015
    Alzheimer's Association
    Novel biomarkers for early detection of Alzheimer's Disease
    Role: Principal Investigator

    R21AG051113     (CASANOVA, RAMON)Sep 1, 2015 - Apr 30, 2017
    NIH/NIA
    Regional Neurotoxicity & Early Biomarkers of Air Pollution Effects on Brain Aging
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Gaussoin SA, Espeland MA, Beavers DP, Casanova R, Garcia KR, Snively BM, Shumaker SA, Wallace RB, Rapp SR. Dementia outcomes after addition of proxy-based assessments for deceased or proxy-dependent participants. Int J Geriatr Psychiatry. 2019 Apr 29. PMID: 31034676.
      View in: PubMed
    2. Kuchibhatla M, Hunter JC, Plassman BL, Lutz MW, Casanova R, Saldana S, Hayden KM. The association between neighborhood socioeconomic status, cardiovascular and cerebrovascular risk factors, and cognitive decline in the Health and Retirement Study (HRS). Aging Ment Health. 2019 Apr 25; 1-8. PMID: 31018653.
      View in: PubMed
    3. Petkus AJ, Resnick SM, Rapp SR, Espeland MA, Gatz M, Widaman KF, Wang X, Younan D, Casanova R, Chui H, Barnard RT, Gaussoin S, Goveas JS, Hayden KM, Henderson VW, Sachs BC, Saldana S, Shadyab AH, Shumaker SA, Chen JC. General and domain-specific cognitive reserve, mild cognitive impairment, and dementia risk in older women. Alzheimers Dement (N Y). 2019; 5:118-128. PMID: 31011622.
      View in: PubMed
    4. Driscoll I, Snively BM, Espeland MA, Shumaker SA, Rapp SR, Goveas JS, Casanova RL, Wactawski-Wende J, Manson JE, Rossom R, Brooks J, Hernandez DG, Singleton AB, Resnick SM. A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study. Int J Geriatr Psychiatry. 2019 May; 34(5):692-699. PMID: 30706571.
      View in: PubMed
    5. Lutz MW, Casanova R, Saldana S, Kuchibhatla M, Plassman BL, Hayden KM. Analysis of pleiotropic genetic effects on cognitive impairment, systemic inflammation, and plasma lipids in the Health and Retirement Study. Neurobiol Aging. 2019 Aug; 80:173-186. PMID: 31201950.
      View in: PubMed
    6. Kristen M. Beavers, Rebecca H. Neiberg, Karen C. Johnson, Ramon Casanova, Ann V. Schwartz, Carolyn J. Crandall, Cora E. Lewis, Xavier Pi-Sunyer, Stephen B. Kritchevsky. Impact of Body Weight Dynamics Following Intentional Weight Loss on Fracture Risk: Results from The Action for Health in Diabetes Study. Journal of Bone and Mineral Research. 2019.
    7. Michael W. Lutz, Ramon Casanova, Maragatha Kuchibhatla, Brenda L. Plassman, Santiago Saldana, Kathleen M. Hayden. Analysis of pleiotropic genetic effects on cognitive impairment, systemic inflammation and plasma lipids in the Health and Retirement Study. Neurobiology of Aging. 2019.
    8. Beavers KM, Neiberg RH, Johnson KC, Davis CH, Casanova R, Schwartz AV, Crandall CJ, Lewis CE, Pi-Sunyer X, Kritchevsky SB. Impact of Body Weight Dynamics Following Intentional Weight Loss on Fracture Risk: Results from The Action for Health in Diabetes Study. JBMR Plus. 2019 May; 3(5):e10086. PMID: 31131339.
      View in: PubMed
    9. Casanova R, Barnard RT, Gaussoin SA, Saldana S, Hayden KM, Manson JE, Wallace RB, Rapp SR, Resnick SM, Espeland MA, Chen JC. Using high-dimensional machine learning methods to estimate an anatomical risk factor for Alzheimer's disease across imaging databases. Neuroimage. 2018 12; 183:401-411. PMID: 30130645.
      View in: PubMed
    10. Espeland MA, Chen JC, Weitlauf J, Hayden KM, Rapp SR, Resnick SM, Garcia L, Cannell B, Baker LD, Sachs BC, Tindle HA, Wallace R, Casanova R. Trajectories of Relative Performance with 2 Measures of Global Cognitive Function. J Am Geriatr Soc. 2018 Aug; 66(8):1575-1580. PMID: 29972592.
      View in: PubMed
    11. Casanova R, Saldana S, Lutz MW, Plassman BL, Kuchibhatla M, Hayden KM. Investigating predictors of cognitive decline using machine learning. J Gerontol B Psychol Sci Soc Sci. 2018 Apr 27. PMID: 29718387.
      View in: PubMed
    12. Hunter JC, Handing EP, Casanova R, Kuchibhatla M, Lutz MW, Saldana S, Plassman BL, Hayden KM. Neighborhoods, sleep quality, and cognitive decline: Does where you live and how well you sleep matter? Alzheimers Dement. 2018 04; 14(4):454-461. PMID: 29396109.
      View in: PubMed
    13. Varma VR, Oommen AM, Varma S, Casanova R, An Y, Andrews RM, O'Brien R, Pletnikova O, Troncoso JC, Toledo J, Baillie R, Arnold M, Kastenmueller G, Nho K, Doraiswamy PM, Saykin AJ, Kaddurah-Daouk R, Legido-Quigley C, Thambisetty M. Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study. PLoS Med. 2018 01; 15(1):e1002482. PMID: 29370177.
      View in: PubMed
    14. Gross AL, Payne BR, Casanova R, Davoudzadeh P, Dzierzewski JM, Farias S, Giovannetti T, Ip EH, Marsiske M, Rebok GW, Schaie KW, Thomas K, Willis S, Jones RN. The ACTIVE conceptual framework as a structural equation model. Exp Aging Res. 2018 Jan-Feb; 44(1):1-17. PMID: 29303475.
      View in: PubMed
    15. Espeland MA, Luchsinger JA, Neiberg RH, Carmichael O, Laurienti PJ, Pi-Sunyer X, Wing RR, Cook D, Horton E, Casanova R, Erickson K, Nick Bryan R. Long Term Effect of Intensive Lifestyle Intervention on Cerebral Blood Flow. J Am Geriatr Soc. 2018 01; 66(1):120-126. PMID: 29082505.
      View in: PubMed
    16. An Y, Varma VR, Varma S, Casanova R, Dammer E, Pletnikova O, Chia CW, Egan JM, Ferrucci L, Troncoso J, Levey AI, Lah J, Seyfried NT, Legido-Quigley C, O'Brien R, Thambisetty M. Evidence for brain glucose dysregulation in Alzheimer's disease. Alzheimers Dement. 2018 03; 14(3):318-329. PMID: 29055815.
      View in: PubMed
    17. Joseph JJ, Echouffo-Tcheugui JB, Kalyani RR, Yeh HC, Bertoni AG, Effoe VS, Casanova R, Sims M, Wu WC, Wand GS, Correa A, Golden SH. Aldosterone, Renin, Cardiovascular Events, and All-Cause Mortality Among African Americans: The Jackson Heart Study. JACC Heart Fail. 2017 09; 5(9):642-651. PMID: 28822744.
      View in: PubMed
    18. Hayden KM, Beavers DP, Steck SE, Hebert JR, Tabung FK, Shivappa N, Casanova R, Manson JE, Padula CB, Salmoirago-Blotcher E, Snetselaar LG, Zaslavsky O, Rapp SR. The association between an inflammatory diet and global cognitive function and incident dementia in older women: The Women's Health Initiative Memory Study. Alzheimers Dement. 2017 Nov; 13(11):1187-1196. PMID: 28531379.
      View in: PubMed
    19. Toledo JB, Arnold M, Kastenmüller G, Chang R, Baillie RA, Han X, Thambisetty M, Tenenbaum JD, Suhre K, Thompson JW, John-Williams LS, MahmoudianDehkordi S, Rotroff DM, Jack JR, Motsinger-Reif A, Risacher SL, Blach C, Lucas JE, Massaro T, Louie G, Zhu H, Dallmann G, Klavins K, Koal T, Kim S, Nho K, Shen L, Casanova R, Varma S, Legido-Quigley C, Moseley MA, Zhu K, Henrion MYR, van der Lee SJ, Harms AC, Demirkan A, Hankemeier T, van Duijn CM, Trojanowski JQ, Shaw LM, Saykin AJ, Weiner MW, Doraiswamy PM, Kaddurah-Daouk R. Metabolic network failures in Alzheimer's disease: A biochemical road map. Alzheimers Dement. 2017 Sep; 13(9):965-984. PMID: 28341160.
      View in: PubMed
    20. Corbett DB, Wanigatunga AA, Valiani V, Handberg EM, Buford TW, Brumback B, Casanova R, Janelle CM, Manini TM. Metabolic costs of daily activity in older adults (Chores XL) study: design and methods. Contemp Clin Trials Commun. 2017 Jun; 6:1-8. PMID: 28649668.
      View in: PubMed
    21. Effoe VS, Wagenknecht LE, Echouffo Tcheugui JB, Chen H, Joseph JJ, Kalyani RR, Bell RA, Wu WH, Casanova R, Bertoni AG. Sex Differences in the Association Between Insulin Resistance and Incident Coronary Heart Disease and Stroke Among Blacks Without Diabetes Mellitus: The Jackson Heart Study. J Am Heart Assoc. 2017 02 02; 6(2). PMID: 28154164.
      View in: PubMed
    22. Thambisetty M, Casanova R, Varma S, Legido Quigley C. Peril beyond the winner's curse: A small sample size is the bane of biomarker discovery. Alzheimers Dement. 2017 05; 13(5):606-607. PMID: 28119051.
      View in: PubMed
    23. Varma VR, Varma S, An Y, Hohman TJ, Seddighi S, Casanova R, Beri A, Dammer EB, Seyfried NT, Pletnikova O, Moghekar A, Wilson MR, Lah JJ, O'Brien RJ, Levey AI, Troncoso JC, Albert MS, Thambisetty M. Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. Mol Psychiatry. 2017 01; 22(1):13-23. PMID: 27872486.
      View in: PubMed
    24. Casanova R, Wang X, Reyes J, Akita Y, Serre ML, Vizuete W, Chui HC, Driscoll I, Resnick SM, Espeland MA, Chen JC. A Voxel-Based Morphometry Study Reveals Local Brain Structural Alterations Associated with Ambient Fine Particles in Older Women. Front Hum Neurosci. 2016; 10:495. PMID: 27790103.
      View in: PubMed
    25. Casanova R, Saldana S, Simpson SL, Lacy ME, Subauste AR, Blackshear C, Wagenknecht L, Bertoni AG. Prediction of Incident Diabetes in the Jackson Heart Study Using High-Dimensional Machine Learning. PLoS One. 2016; 11(10):e0163942. PMID: 27727289.
      View in: PubMed
    26. Casanova R, Hayasaka S, Saldana S, Bryan NR, Demos KE, Desiderio L, Erickson KI, Espeland MA, Nasrallah IM, Wadden T, Laurienti PJ. Relative differences in resting-state brain connectivity associated with long term intensive lifestyle intervention. Psychoneuroendocrinology. 2016 12; 74:231-239. PMID: 27685338.
      View in: PubMed
    27. Zhang T, Casanova R, Resnick SM, Manson JE, Baker LD, Padual CB, Kuller LH, Bryan RN, Espeland MA, Davatzikos C. Effects of Hormone Therapy on Brain Volumes Changes of Postmenopausal Women Revealed by Optimally-Discriminative Voxel-Based Morphometry. PLoS One. 2016; 11(3):e0150834. PMID: 26974440.
      View in: PubMed
    28. Driscoll I, Gaussoin SA, Wassertheil-Smoller S, Limacher M, Casanova R, Yaffe K, Resnick SM, Espeland MA. Obesity and Structural Brain Integrity in Older Women: The Women's Health Initiative Magnetic Resonance Imaging Study. J Gerontol A Biol Sci Med Sci. 2016 Mar 09. PMID: 26961581.
      View in: PubMed
    29. Joseph JJ, Echouffo-Tcheugui JB, Kalyani RR, Yeh HC, Bertoni AG, Effoe VS, Casanova R, Sims M, Correa A, Wu WC, Wand GS, Golden SH. Aldosterone, Renin, and Diabetes Mellitus in African Americans: The Jackson Heart Study. J Clin Endocrinol Metab. 2016 04; 101(4):1770-8. PMID: 26908112.
      View in: PubMed
    30. Casanova R, Varma S, Simpson B, Kim M, An Y, Saldana S, Riveros C, Moscato P, Griswold M, Sonntag D, Wahrheit J, Klavins K, Jonsson PV, Eiriksdottir G, Aspelund T, Launer LJ, Gudnason V, Legido Quigley C, Thambisetty M. Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals. Alzheimers Dement. 2016 07; 12(7):815-22. PMID: 26806385.
      View in: PubMed
    31. Zhang G, Smith BP, Plate JF, Casanova R, Hsu FC, Li J, Xia L, Li KC, Poehling GG, Zhou X. A systematic approach to predicting the risk of unicompartmental knee arthroplasty revision. Osteoarthritis Cartilage. 2016 06; 24(6):991-9. PMID: 26774734.
      View in: PubMed
    32. Chen JC, Wang X, Wellenius GA, Serre ML, Driscoll I, Casanova R, McArdle JJ, Manson JE, Chui HC, Espeland MA. Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study. Ann Neurol. 2015 Sep; 78(3):466-76. PMID: 26075655.
      View in: PubMed
    33. Espeland MA, Brinton RD, Manson JE, Yaffe K, Hugenschmidt C, Vaughan L, Craft S, Edwards BJ, Casanova R, Masaki K, Resnick SM. Postmenopausal hormone therapy, type 2 diabetes mellitus, and brain volumes. Neurology. 2015 Sep 29; 85(13):1131-8. PMID: 26163429.
      View in: PubMed
    34. Casanova R, Saldana S, Chew EY, Danis RP, Greven CM, Ambrosius WT. Application of random forests methods to diabetic retinopathy classification analyses. PLoS One. 2014; 9(6):e98587. PMID: 24940623.
      View in: PubMed
    35. Casanova R, Hsu FC, Sink KM, Rapp SR, Williamson JD, Resnick SM, Espeland MA. Alzheimer's disease risk assessment using large-scale machine learning methods. PLoS One. 2013; 8(11):e77949. PMID: 24250789.
      View in: PubMed
    36. Casanova R, Hsu FC, Espeland MA. Classification of structural MRI images in Alzheimer's disease from the perspective of ill-posed problems. PLoS One. 2012; 7(10):e44877. PMID: 23071501.
      View in: PubMed
    37. Espeland MA, Bryan RN, Goveas JS, Robinson JG, Siddiqui MS, Liu S, Hogan PE, Casanova R, Coker LH, Yaffe K, Masaki K, Rossom R, Resnick SM. Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the Women's Health Initiative Magnetic Resonance Imaging studies. Diabetes Care. 2013 Jan; 36(1):90-7. PMID: 22933440.
      View in: PubMed
    38. Haan M, Espeland MA, Klein BE, Casanova R, Gaussoin SA, Jackson RD, Millen AE, Resnick SM, Rossouw JE, Shumaker SA, Wallace R, Yaffe K. Cognitive function and retinal and ischemic brain changes: the Women's Health Initiative. Neurology. 2012 Mar 27; 78(13):942-9. PMID: 22422889.
      View in: PubMed
    39. Casanova R, Whitlow CT, Wagner B, Espeland MA, Maldjian JA. Combining graph and machine learning methods to analyze differences in functional connectivity across sex. Open Neuroimag J. 2012; 6:1-9. PMID: 22312418.
      View in: PubMed
    40. Casanova R, Whitlow CT, Wagner B, Williamson J, Shumaker SA, Maldjian JA, Espeland MA. High dimensional classification of structural MRI Alzheimer's disease data based on large scale regularization. Front Neuroinform. 2011; 5:22. PMID: 22016732.
      View in: PubMed
    41. Whitlow CT, Casanova R, Maldjian JA. Effect of resting-state functional MR imaging duration on stability of graph theory metrics of brain network connectivity. Radiology. 2011 May; 259(2):516-24. PMID: 21406628.
      View in: PubMed
    42. Casanova R, Espeland MA, Goveas JS, Davatzikos C, Gaussoin SA, Maldjian JA, Brunner RL, Kuller LH, Johnson KC, Mysiw WJ, Wagner B, Resnick SM. Application of machine learning methods to describe the effects of conjugated equine estrogens therapy on region-specific brain volumes. Magn Reson Imaging. 2011 May; 29(4):546-53. PMID: 21292420.
      View in: PubMed
    43. Casanova R, Maldjian JA, Espeland MA. Evaluating the Impact of Different Factors on Voxel-Based Classification Methods of ADNI Structural MRI Brain Images. International Journal of Biomedical Data Mining. 2011; 1:1-11.
    44. Casanova R, Yang L, Hairston WD, Laurienti PJ, Maldjian JA. Evaluating the impact of spatio-temporal smoothness constraints on the BOLD hemodynamic response function estimation: an analysis based on Tikhonov regularization. Physiol Meas. 2009 May; 30(5):N37-51. PMID: 19417238.
      View in: PubMed
    45. Peiffer AM, Hugenschmidt CE, Maldjian JA, Casanova R, Srikanth R, Hayasaka S, Burdette JH, Kraft RA, Laurienti PJ. Aging and the interaction of sensory cortical function and structure. Hum Brain Mapp. 2009 Jan; 30(1):228-40. PMID: 18072271.
      View in: PubMed
    46. Casanova R, Ryali S, Serences J, Yang L, Kraft R, Laurienti PJ, Maldjian JA. The impact of temporal regularization on estimates of the BOLD hemodynamic response function: a comparative analysis. Neuroimage. 2008 May 01; 40(4):1606-18. PMID: 18329292.
      View in: PubMed
    47. Hairston WD, Hodges DA, Casanova R, Hayasaka S, Kraft R, Maldjian JA, Burdette JH. Closing the mind's eye: deactivation of visual cortex related to auditory task difficulty. Neuroreport. 2008 Jan 22; 19(2):151-4. PMID: 18185099.
      View in: PubMed
    48. Hugenschmidt CE, Peiffer AM, Kraft RA, Casanova R, Deibler AR, Burdette JH, Maldjian JA, Laurienti PJ. Relating imaging indices of white matter integrity and volume in healthy older adults. Cereb Cortex. 2008 Feb; 18(2):433-42. PMID: 17575289.
      View in: PubMed
    49. Casanova R, Srikanth R, Baer A, Laurienti PJ, Burdette JH, Hayasaka S, Flowers L, Wood F, Maldjian JA. Biological parametric mapping: A statistical toolbox for multimodality brain image analysis. Neuroimage. 2007 Jan 01; 34(1):137-43. PMID: 17070709.
      View in: PubMed
    50. Srikanth R, Casanova R, Laurienti PJ, Peiffer AM, Maldjian JA. Estimation of false discovery rates for wavelet-denoised statistical parametric maps. Neuroimage. 2006 Oct 15; 33(1):72-84. PMID: 16919480.
      View in: PubMed
    51. Casanova R, Silva A, Borges AR. MIT image reconstruction based on edge-preserving regularization. Physiol Meas. 2004 Feb; 25(1):195-207. PMID: 15005316.
      View in: PubMed
    52. Casanova R, Silva A, Borges AR. . A quantitative algorithm for parameter estimation in magnetic induction tomography. Measurement Science and Technology. 2004; 15.
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