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Peripheral nerve injury alters the alpha2 adrenoceptor subtype activated by clonidine for analgesia.
Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury.
Perineural clonidine reduces p38 mitogen-activated protein kinase activation in sensory neurons.
Gabapentin activates spinal noradrenergic activity in rats and humans and reduces hypersensitivity after surgery.
Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain.
Spinal noradrenaline transporter inhibition by reboxetine and Xen2174 reduces tactile hypersensitivity after surgery in rats.
Perineural clonidine reduces mechanical hypersensitivity and cytokine production in established nerve injury.
Adrenergic alpha Antagonists