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One or more keywords matched the following properties of Olivier, Michael
keywords Next Generation Sequencing
overview My laboratory uses a wide range of genomics, proteomics, metabolomics and bioinformatics tools to study the molecular basis of common human diseases. We routinely use next generation sequencing, gene expression analysis, and mass spectrometry to profile cells and tissues from human patients and animal models to identify early molecular changes that happen in target tissues and organs during the initial development of diseases such as obesity, cardiovascular diseases, or dylipidemias and fatty liver disease. Our lab group has been developing novel methodologies to functionally study human genome variation, and to help understand how mutations and sequence variants that have been identified in large scale genetic studies (e.g. genome-wide association studies) actually affect the normal function of cells. Work in our lab ranges from basic molecular biology to tissue culture, high-end sequencing and mass spectrometry, and computational data analysis.
One or more keywords matched the following items that are connected to Olivier, Michael
Item TypeName
Concept Sequence Analysis, RNA
Concept Genome, Human
Concept Amino Acid Sequence
Concept Genetic Loci
Concept Consensus Sequence
Concept Gene Expression Profiling
Concept Sequence Analysis, DNA
Concept Multigene Family
Concept Sequence Tagged Sites
Concept Epistasis, Genetic
Concept Polymorphism, Single Nucleotide
Concept Genes, Dominant
Concept Quantitative Trait Loci
Concept Gene Components
Concept Oligonucleotide Array Sequence Analysis
Concept Base Sequence
Concept Alleles
Concept Molecular Sequence Data
Academic Article Proteomics in non-human primates: utilizing RNA-Seq data to improve protein identification by mass spectrometry in vervet monkeys.
Academic Article Discovery of Chromatin-Associated Proteins via Sequence-Specific Capture and Mass Spectrometric Protein Identification in Saccharomyces cerevisiae.
Grant Functional characterization of regulatory sequence variants in complex diseases
Grant Wisconsin Center of Excellence in Genomics Science
Grant Genomic dissection of a QTL affecting the lipid profile
Academic Article A haplotype map of the human genome.
Academic Article Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expression.
Academic Article Current analysis platforms and methods for detecting copy number variation.
Academic Article Localization and characterization of nucleotide sequences from the canine Y chromosome.
Academic Article Single nucleotide polymorphisms in protein tyrosine phosphatase 1beta (PTPN1) are associated with essential hypertension and obesity.
Academic Article Accounting for a quantitative trait locus for plasma triglyceride levels: utilization of variants in multiple genes.
Academic Article Integration of cytogenetic landmarks into the draft sequence of the human genome.
Academic Article Automated SNP genotype clustering algorithm to improve data completeness in high-throughput SNP genotyping datasets from custom arrays.
Academic Article Two DNA sequences specific for the canine Y chromosome.
Academic Article Radiation hybrid mapping with BAC ends.
Academic Article Parallel single nucleotide polymorphism genotyping by surface invasive cleavage with universal detection.
Academic Article From SNPs to function: the effect of sequence variation on gene expression. Focus on "a survey of genetic and epigenetic variation affecting human gene expression".
Academic Article A high-resolution radiation hybrid map of the human genome draft sequence.
Academic Article Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels.
Academic Article Sequential abundant ion fragmentation analysis (SAIFA): an alternative approach for phosphopeptide identification using an ion trap mass spectrometer.
Academic Article Relative quantification of peptide phosphorylation in a complex mixture using 18O labeling.
Academic Article Variant discovery in targeted resequencing using whole genome amplified DNA.
Academic Article Random amplified polymorphic DNA (RAPD) sequences as markers for canine genetic studies.
Academic Article Sequence-specific capture of protein-DNA complexes for mass spectrometric protein identification.
Academic Article Analysis of concordance of different haplotype block partitioning algorithms.
Academic Article High-throughput genotyping of single nucleotide polymorphisms using new biplex invader technology.
Academic Article A novel procedure for genotyping of single nucleotide polymorphisms in trisomy with genomic DNA and the invader assay.
Academic Article Simultaneous quantification and identification using 18O labeling with an ion trap mass spectrometer and the analysis software application "ZoomQuant".
Academic Article Gene expression reveals vulnerability to oxidative stress and interstitial fibrosis of renal outer medulla to nonhypertensive elevations of ANG II.
Grant HyCCAPP: A new method for the functional analysis of regulatory SNPs
Grant Integrated Omics Analysis of Pain: Omics Data Generation Center
Academic Article Efficiency of whole-exome sequencing in old world and new world primates using human capture reagents.
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