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One or more keywords matched the following properties of Olivier, Michael
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overview My laboratory uses a wide range of genomics, proteomics, metabolomics and bioinformatics tools to study the molecular basis of common human diseases. We routinely use next generation sequencing, gene expression analysis, and mass spectrometry to profile cells and tissues from human patients and animal models to identify early molecular changes that happen in target tissues and organs during the initial development of diseases such as obesity, cardiovascular diseases, or dylipidemias and fatty liver disease. Our lab group has been developing novel methodologies to functionally study human genome variation, and to help understand how mutations and sequence variants that have been identified in large scale genetic studies (e.g. genome-wide association studies) actually affect the normal function of cells. Work in our lab ranges from basic molecular biology to tissue culture, high-end sequencing and mass spectrometry, and computational data analysis.
One or more keywords matched the following items that are connected to Olivier, Michael
Item TypeName
Concept Gene Expression Regulation
Concept Gene Expression Profiling
Grant Functional characterization of regulatory sequence variants in complex diseases
Grant Wisconsin Center of Excellence in Genomics Science
Academic Article Insights into Dahl salt-sensitive hypertension revealed by temporal patterns of renal medullary gene expression.
Academic Article Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.
Academic Article Characterization of vascular endothelial growth factor receptors on the endothelial cell surface during hypoxia using whole cell binding arrays.
Academic Article From SNPs to function: the effect of sequence variation on gene expression. Focus on "a survey of genetic and epigenetic variation affecting human gene expression".
Academic Article Hepatic gene networks in morbidly obese patients with nonalcoholic fatty liver disease.
Academic Article A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic syndrome (MetS) genes with potential role in carcinogenesis and systemic inflammation.
Academic Article To understand the whole, you must know the parts: unraveling the roles of protein-DNA interactions in genome regulation.
Academic Article Gene expression reveals vulnerability to oxidative stress and interstitial fibrosis of renal outer medulla to nonhypertensive elevations of ANG II.
Grant HyCCAPP: A new method for the functional analysis of regulatory SNPs
Search Criteria
  • Gene Expression