| Item Type | Name |
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Academic Article
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Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells.
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Academic Article
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Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts.
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Academic Article
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Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I.
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Academic Article
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Novel chemical strategies for thymidylate synthase inhibition.
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Academic Article
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Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
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Academic Article
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Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons.
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Academic Article
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Effects of site-specific substitution of 5-fluorouridine on the stabilities of duplex DNA and RNA.
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Academic Article
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NMR spectroscopy as a tool to investigate the structural basis of anticancer drugs.
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Academic Article
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Shape-selective recognition of a model Okazaki fragment by geometrically-constrained bis-distamycins.
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Academic Article
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Implications of SH3 domain structure and dynamics for protein regulation and drug design.
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Academic Article
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Energetic and conformational contributions to the stability of Okazaki fragments.
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Academic Article
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A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
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Academic Article
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Cytotoxicity and in-vivo tolerance of FdUMP[10]: a novel pro-drug of the TS inhibitory nucleotide FdUMP.
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Academic Article
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Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU.
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Academic Article
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Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation.
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Concept
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Doxorubicin
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Concept
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Thymidylate Synthase
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Concept
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Nanotubes, Carbon
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Concept
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Zidovudine
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Concept
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BRCA1 Protein
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Concept
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Membrane Glycoproteins
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Concept
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DNA, Viral
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Concept
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DNA, Bacterial
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Concept
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Drug Screening Assays, Antitumor
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Concept
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Reactive Oxygen Species
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Concept
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Membrane Transport Proteins
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Concept
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Ribonuclease H
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Concept
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Caspases
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Concept
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Zinc
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Concept
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Ethidium
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Concept
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Liposomes
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Concept
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Camptothecin
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Concept
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Antigens, Surface
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Concept
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Magnesium
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Concept
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Recombinant Fusion Proteins
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Concept
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DNA, Neoplasm
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Concept
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Phosphoric Diester Hydrolases
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Concept
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nef Gene Products, Human Immunodeficiency Virus
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Concept
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Autoantigens
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Concept
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Oligonucleotides, Antisense
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Concept
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Glutamates
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Concept
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Binding Sites
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Concept
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Alkaloids
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Concept
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Potassium
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Concept
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Protein Kinase Inhibitors
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Concept
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Mitochondrial Proteins
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Concept
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Stearic Acids
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Concept
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Carrier Proteins
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Concept
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Ligands
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Concept
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Strontium
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Concept
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Proto-Oncogene Proteins c-bcl-2
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Concept
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Zalcitabine
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Concept
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DNA
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Concept
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Drug Delivery Systems
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Concept
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Anticarcinogenic Agents
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Concept
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Peptide Fragments
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Concept
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DNA, Mitochondrial
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Concept
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Topotecan
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Concept
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Antineoplastic Agents
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Concept
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Antiviral Agents
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Concept
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Calcium
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Concept
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Pyrazines
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Concept
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Recombinant Proteins
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Concept
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Water
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Concept
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Guanine
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Concept
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Photosensitizing Agents
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Concept
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Thrombin
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Concept
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Thiophenes
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Concept
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Pyrimidines
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Concept
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Endoribonucleases
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Concept
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Antineoplastic Agents, Phytogenic
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Concept
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Amides
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Concept
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Dose-Response Relationship, Drug
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Concept
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Fluorouracil
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Concept
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Intercalating Agents
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Concept
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Ribonucleoprotein, U2 Small Nuclear
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Concept
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Ribonucleoprotein, U4-U6 Small Nuclear
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Concept
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snRNP Core Proteins
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Concept
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Rad51 Recombinase
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Concept
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Aspartic Acid
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Concept
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Anti-HIV Agents
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Concept
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Floxuridine
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Concept
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Complement System Proteins
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Concept
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Lysine
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Concept
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Prodrugs
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Concept
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Ribonucleoproteins, Small Nuclear
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Concept
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Oligonucleotides
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Concept
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Protons
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Concept
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Proteins
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Concept
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Coordination Complexes
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Concept
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Chorionic Gonadotropin
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Concept
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Drug Synergism
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Concept
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Proto-Oncogene Proteins c-hck
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Concept
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Fluorine Compounds
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Concept
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RNA, Messenger
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Concept
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Protein-Tyrosine Kinases
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Concept
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Piperazines
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Concept
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Membrane Proteins
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Concept
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Drug Stability
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Concept
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RNA
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Concept
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Apoptosis
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Concept
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I-kappa B Kinase
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Concept
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Folic Acid
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Concept
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RNA, Small Nuclear
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Concept
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RNA, Small Interfering
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Concept
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Nucleic Acid Heteroduplexes
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Concept
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ras GTPase-Activating Proteins
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Concept
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Hydrogels
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Concept
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Phosphorus Radioisotopes
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Concept
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Netropsin
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Concept
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Deuterium
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Concept
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G-Quadruplexes
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Concept
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Aptamers, Nucleotide
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Concept
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Uracil
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Concept
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Cytosine
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Concept
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Quinazolines
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Concept
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Drug Design
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Concept
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Polymers
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Concept
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Cytotoxins
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Concept
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Uridine
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Concept
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DNA Topoisomerases, Type I
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Concept
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Pyrazoles
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Concept
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Gene Products, nef
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Concept
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Creatine
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Concept
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Radiopharmaceuticals
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Concept
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Receptors, Cell Surface
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Concept
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Cytarabine
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Concept
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Glutamate Carboxypeptidase II
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Concept
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Peptides
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Concept
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Porphyrins
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Concept
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Orotate Phosphoribosyltransferase
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Concept
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Neoplasm Proteins
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Concept
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Acyclovir
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Concept
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Folic Acid Antagonists
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Concept
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Imines
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Concept
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Distamycins
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Concept
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Cations, Divalent
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Concept
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Carbon Isotopes
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Concept
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Oxygen Isotopes
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Concept
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Fas Ligand Protein
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Concept
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Glycine
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Concept
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Nucleosides
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Concept
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Macromolecular Substances
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Concept
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Hydrogen
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Concept
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Ribonucleoprotein, U1 Small Nuclear
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Concept
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Antimetabolites, Antineoplastic
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Concept
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Wnt Proteins
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Concept
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Thymine
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Concept
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Chelating Agents
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Concept
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Solutions
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Concept
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Drug Resistance, Neoplasm
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Concept
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Oligodeoxyribonucleotides
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Concept
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Proline
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Concept
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Thymidine Kinase
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Concept
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Ions
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Concept
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Thymidine
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Concept
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Enzyme Inhibitors
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Concept
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Serine Endopeptidases
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Concept
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Phosphopeptides
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Concept
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Curcumin
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Concept
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Oligoribonucleotides
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Concept
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Organometallic Compounds
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|
Concept
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Fluorodeoxyuridylate
|
|
Concept
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Ethylenediamines
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Concept
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Deoxyribonucleosides
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Concept
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MicroRNAs
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Concept
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Deoxycytidine
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Concept
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Proto-Oncogene Proteins
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Concept
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Phthalazines
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Concept
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Pepsin A
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|
Concept
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Base Sequence
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Concept
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Choline
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Concept
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Drug Combinations
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Concept
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DNA, Single-Stranded
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Concept
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Antibiotics, Antineoplastic
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Concept
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Deoxyuridine
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Concept
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RNA-Binding Proteins
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Concept
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RNA, Double-Stranded
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Academic Article
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Development of modified siRNA molecules incorporating 5-fluoro-2'-deoxyuridine residues to enhance cytotoxicity.
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Academic Article
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Dimeric DNA Aptamer Complexes for High-capacity-targeted Drug Delivery Using pH-sensitive Covalent Linkages.
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Academic Article
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Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors.
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Academic Article
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Prostate-specific membrane antigen-targeted liposomes specifically deliver the Zn(2+) chelator TPEN inducing oxidative stress in prostate cancer cells.
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Grant
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IMPACT OF 5-FU ON THE STRUCTURE OF THE U4-U6 COMPLEX
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|
Grant
|
IMPACT OF 5FU ON THE STRUCTURE OF THE U4/U6 COMPLEX
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Grant
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DNA-DIRECTED EFFECTS OF FdUMP(N)
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Academic Article
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Curcumin stably interacts with DNA hairpin through minor groove binding and demonstrates enhanced cytotoxicity in combination with FdU nucleotides.
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Grant
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Development of a CF10 Predictive Gene Signature in CRC Organoids.
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Grant
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Aptamer-Based Radiopharmaceuticals for the Targeted Alpha Particle Therapy of Prostate Cancer
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Academic Article
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Thymineless Death by the Fluoropyrimidine Polymer F10 Involves Replication Fork Collapse and Is Enhanced by Chk1 Inhibition.
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Academic Article
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Development of a Colorectal Cancer 3D Micro-tumor Construct Platform From Cell Lines and Patient Tumor Biospecimens for Standard-of-Care and Experimental Drug Screening.
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Academic Article
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Improved potency of F10 relative to 5-fluorouracil in colorectal cancer cells with p53 mutations.
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Academic Article
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Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells.
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Academic Article
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Chemistry of Fluorinated Pyrimidines in the Era of Personalized Medicine.
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Academic Article
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Entrapment of DNA topoisomerase-DNA complexes by nucleotide/nucleoside analogs.
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Academic Article
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Recent Advances in Our Knowledge of mCRC Tumor Biology and Genetics: A Focus on Targeted Therapy Development.
|