| Item Type | Name |
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Academic Article
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c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for mitoxantrone- and anisomycin-induced apoptosis in HL-60 cells.
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Academic Article
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Influence of the a-ring on the proton affinity and anticancer properties of the prodigiosins.
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Academic Article
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Thermally inert metal ammines as light-inducible DNA-targeted agents. Synthesis, photochemistry, and photobiology of a prototypical rhodium(III)-intercalator conjugate.
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Academic Article
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Synthesis and cytotoxic activity of two novel 1-dodecylthio-2-decyloxypropyl-3-phosphatidic acid conjugates with gemcitabine and cytosine arabinoside.
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Academic Article
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Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects.
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Academic Article
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A novel phospholipid gemcitabine conjugate is able to bypass three drug-resistance mechanisms.
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Academic Article
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Synthesis, biological activity, and DNA-damage profile of platinum-threading intercalator conjugates designed to target adenine.
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Academic Article
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Cyclooxygenase inhibition and hyperthermia for the potentiation of the cytotoxic response in ovarian cancer cells.
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Academic Article
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Photoinduced cytotoxicity and thioadduct formation by a prodigiosin analogue.
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Academic Article
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A non-cross-linking platinum-acridine agent with potent activity in non-small-cell lung cancer.
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Academic Article
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Using a build-and-click approach for producing structural and functional diversity in DNA-targeted hybrid anticancer agents.
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Academic Article
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Using fluorescent post-labeling to probe the subcellular localization of DNA-targeted platinum anticancer agents.
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Academic Article
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Effect of the diamine nonleaving group in platinum-acridinylthiourea conjugates on DNA damage and cytotoxicity.
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Academic Article
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Tuning the DNA conformational perturbations induced by cytotoxic platinum-acridine bisintercalators: effect of metal cis/trans isomerism and DNA threading groups.
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Academic Article
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Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum-acridines.
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Academic Article
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Synthesis and biological evaluation of platinum-acridine hybrid agents modified with bipyridine non-leaving groups.
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Academic Article
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Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against Mycobacterium tuberculosis.
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Academic Article
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Analysis of the DNA damage produced by a platinum-acridine antitumor agent and its effects in NCI-H460 lung cancer cells.
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Academic Article
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Synthesis, aqueous reactivity, and biological evaluation of carboxylic acid ester-functionalized platinum-acridine hybrid anticancer agents.
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Academic Article
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Design of a platinum-acridine-endoxifen conjugate targeted at hormone-dependent breast cancer.
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Concept
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
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Concept
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Vero Cells
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Concept
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Carcinoma, Non-Small-Cell Lung
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Concept
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Cell Cycle
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Concept
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HL-60 Cells
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Concept
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Tumor Cells, Cultured
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Concept
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Cell-Free System
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Concept
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Molecular Structure
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Concept
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Genes, ras
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Concept
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Genes, Neoplasm
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Concept
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Genes, p53
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Concept
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Cell Proliferation
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Concept
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Cell Division
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Concept
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Cell Survival
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Concept
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Carcinoma, Squamous Cell
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Concept
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Cell Line
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Concept
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Oligonucleotide Array Sequence Analysis
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Concept
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Myeloid Cells
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Concept
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Base Sequence
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Concept
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Cell Line, Tumor
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Concept
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Molecular Sequence Data
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Academic Article
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Investigating the cellular fate of a DNA-targeted platinum-based anticancer agent by orthogonal double-click chemistry.
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Academic Article
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Redesigning the DNA-targeted chromophore in platinum-acridine anticancer agents: a structure-activity relationship study.
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Academic Article
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Design of enzymatically cleavable prodrugs of a potent platinum-containing anticancer agent.
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Academic Article
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Synthesis, reactivity, and biological activity of gold(I) complexes modified with thiourea-functionalized tyrosine kinase inhibitors.
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Academic Article
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Inhibition of DNA Synthesis by a Platinum-Acridine Hybrid Agent Leads to Potent Cell Kill in Non-Small Cell Lung Cancer.
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Grant
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DEOXYCYTIDINE ANALOG EFFECTS ON PHOSPHOLIPID METABOLISM
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Academic Article
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The novel phospholipid mimetic KPC34 is highly active against preclinical models of Philadelphia chromosome positive acute lymphoblastic leukemia.
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Academic Article
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Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq.
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