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Gregory L. Kucera PhD

TitleProfessor
InstitutionWake Forest School of Medicine
DepartmentOrthopedic Surgery
Address
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    Other Positions
    TitleAssociate Director
    InstitutionWake Forest School of Medicine
    DepartmentComprehensive Cancer Center (CCC)

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentBiochemistry

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentCancer Biology

    TitleProfessor
    InstitutionWake Forest School of Medicine
    DepartmentTranslational Neuroscience


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    R29CA058944     (KUCERA, GREGORY L)Feb 15, 1994 - Jan 31, 2000
    NIH
    DEOXYCYTIDINE ANALOG EFFECTS ON PHOSPHOLIPID METABOLISM
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cai Z, Li CF, Han F, Liu C, Zhang A, Hsu CC, Peng D, Zhang X, Jin G, Rezaeian AH, Wang G, Zhang W, Pan BS, Wang CY, Wang YH, Wu SY, Yang SC, Hsu FC, D'Agostino RB, Furdui CM, Kucera GL, Parks JS, Chilton FH, Huang CY, Tsai FJ, Pasche B, Watabe K, Lin HK. Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis. Mol Cell. 2020 10 15; 80(2):263-278.e7. PMID: 33022274.
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    2. Alexander PM, Kucera GL, Pladna KM, Pardee TS. The Novel Phospholipid Mimetic KPC34 Is Highly Active Against Acute Myeloid Leukemia with Activated Protein Kinase C. Transl Oncol. 2020 Jul; 13(7):100780. PMID: 32428837.
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    3. Sexton T, Kucera GL, Levine EA, Watabe K, O'Neill SS. Optimization of Tissue Microarrays from Banked Human Formalin-Fixed Paraffin Embedded Tissues in the Cancer Research Setting. Biopreserv Biobank. 2019 Oct; 17(5):452-457. PMID: 31194582.
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    4. Song Q, Hawkins GA, Wudel L, Chou PC, Forbes E, Pullikuth AK, Liu L, Jin G, Craddock L, Topaloglu U, Kucera G, O'Neill S, Levine EA, Sun P, Watabe K, Lu Y, Alexander-Miller MA, Pasche B, Miller LD, Zhang W. Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq. Cancer Med. 2019 06; 8(6):3072-3085. PMID: 31033233.
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    5. Mazzocchi A, Devarasetty M, Herberg S, Petty WJ, Marini F, Miller L, Kucera G, Dukes DK, Ruiz J, Skardal A, Soker S. Pleural Effusion Aspirate for use in 3D Lung Cancer Modeling and Chemotherapy Screening. ACS Biomater Sci Eng. 2019 Apr 08; 5(4):1937-1943. PMID: 31723594.
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    6. Alexander PM, Caudell DL, Kucera GL, Pladna KM, Pardee TS. The novel phospholipid mimetic KPC34 is highly active against preclinical models of Philadelphia chromosome positive acute lymphoblastic leukemia. PLoS One. 2017; 12(6):e0179798. PMID: 28644853.
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    7. Alexander P, Kucera G, Pardee TS. Improving nucleoside analogs via lipid conjugation: Is fatter any better? Crit Rev Oncol Hematol. 2016 Apr; 100:46-56. PMID: 26829896.
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    8. Yang M, Pickard AJ, Qiao X, Gueble MJ, Day CS, Kucera GL, Bierbach U. Synthesis, reactivity, and biological activity of gold(I) complexes modified with thiourea-functionalized tyrosine kinase inhibitors. Inorg Chem. 2015 Apr 06; 54(7):3316-24. PMID: 25793564.
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    9. Pickard AJ, Liu F, Bartenstein TF, Haines LG, Levine KE, Kucera GL, Bierbach U. Redesigning the DNA-targeted chromophore in platinum-acridine anticancer agents: a structure-activity relationship study. Chemistry. 2014 Dec 01; 20(49):16174-87. PMID: 25302716.
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    10. Ding S, Pickard AJ, Kucera GL, Bierbach U. Design of enzymatically cleavable prodrugs of a potent platinum-containing anticancer agent. Chemistry. 2014 Dec 01; 20(49):16164-73. PMID: 25303639.
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    11. Qiao X, Ding S, Liu F, Kucera GL, Bierbach U. Investigating the cellular fate of a DNA-targeted platinum-based anticancer agent by orthogonal double-click chemistry. J Biol Inorg Chem. 2014 Mar; 19(3):415-26. PMID: 24407462.
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    12. Ding S, Qiao X, Kucera GL, Bierbach U. Design of a platinum-acridine-endoxifen conjugate targeted at hormone-dependent breast cancer. Chem Commun (Camb). 2013 Mar 25; 49(24):2415-7. PMID: 23416453.
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    13. Ding S, Qiao X, Suryadi J, Marrs GS, Kucera GL, Bierbach U. Using fluorescent post-labeling to probe the subcellular localization of DNA-targeted platinum anticancer agents. Angew Chem Int Ed Engl. 2013 Mar 18; 52(12):3350-4. PMID: 23427109.
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    14. Ding S, Qiao X, Kucera GL, Bierbach U. Using a build-and-click approach for producing structural and functional diversity in DNA-targeted hybrid anticancer agents. J Med Chem. 2012 Nov 26; 55(22):10198-203. PMID: 23074987.
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    15. Graham LA, Suryadi J, West TK, Kucera GL, Bierbach U. Synthesis, aqueous reactivity, and biological evaluation of carboxylic acid ester-functionalized platinum-acridine hybrid anticancer agents. J Med Chem. 2012 Sep 13; 55(17):7817-27. PMID: 22871158.
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    16. Qiao X, Zeitany AE, Wright MW, Essader AS, Levine KE, Kucera GL, Bierbach U. Analysis of the DNA damage produced by a platinum-acridine antitumor agent and its effects in NCI-H460 lung cancer cells. Metallomics. 2012 Jul; 4(7):645-52. PMID: 22456976.
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    17. Graham LA, Wilson GM, West TK, Day CS, Kucera GL, Bierbach U. Unusual Reactivity of a Potent Platinum-Acridine Hybrid Antitumor Agent. ACS Med Chem Lett. 2011 Sep 08; 2(9):687-691. PMID: 21927647.
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    18. Smyre CL, Saluta G, Kute TE, Kucera GL, Bierbach U. Inhibition of DNA Synthesis by a Platinum-Acridine Hybrid Agent Leads to Potent Cell Kill in Non-Small Cell Lung Cancer. ACS Med Chem Lett. 2011 Aug 31; 2(11):870-874. PMID: 22328962.
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    19. Rao L, West TK, Saluta G, Kucera GL, Bierbach U. Probing platinum-adenine-n3 adduct formation with DNA minor-groove binding agents. Chem Res Toxicol. 2010 Jul 19; 23(7):1148-50. PMID: 20578739.
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    20. Eiter LC, Hall NW, Day CS, Saluta G, Kucera GL, Bierbach U. Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against Mycobacterium tuberculosis. J Med Chem. 2009 Nov 12; 52(21):6519-22. PMID: 19803526.
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    21. Kheradi AR, Saluta G, Kucera GL, Day CS, Bierbach U. Synthesis and biological evaluation of platinum-acridine hybrid agents modified with bipyridine non-leaving groups. Bioorg Med Chem Lett. 2009 Jul 01; 19(13):3423-5. PMID: 19477643.
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    22. Ma Z, Choudhury JR, Wright MW, Day CS, Saluta G, Kucera GL, Bierbach U. A non-cross-linking platinum-acridine agent with potent activity in non-small-cell lung cancer. J Med Chem. 2008 Dec 11; 51(23):7574-80. PMID: 19012390.
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    23. Ma Z, Saluta G, Kucera GL, Bierbach U. Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum-acridines. Bioorg Med Chem Lett. 2008 Jul 01; 18(13):3799-801. PMID: 18515101.
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    24. Choudhury JR, Guddneppanavar R, Saluta G, Kucera GL, Bierbach U. Tuning the DNA conformational perturbations induced by cytotoxic platinum-acridine bisintercalators: effect of metal cis/trans isomerism and DNA threading groups. J Med Chem. 2008 Jun 12; 51(11):3069-72. PMID: 18457380.
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    25. Lentz SS, Miller BE, Kucera GL, Levine EA. Intraperitoneal hyperthermic chemotherapy using carboplatin: a phase I analysis in ovarian carcinoma. Gynecol Oncol. 2007 Jul; 106(1):207-10. PMID: 17498782.
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    26. Guddneppanavar R, Choudhury JR, Kheradi AR, Steen BD, Saluta G, Kucera GL, Day CS, Bierbach U. Effect of the diamine nonleaving group in platinum-acridinylthiourea conjugates on DNA damage and cytotoxicity. J Med Chem. 2007 May 03; 50(9):2259-63. PMID: 17408248.
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    27. Tomlinson JT, Park G, Misenheimer JA, Kucera GL, Hesp K, Manderville RA. Photoinduced cytotoxicity and thioadduct formation by a prodigiosin analogue. Org Lett. 2006 Oct 12; 8(21):4951-4. PMID: 17020344.
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    28. Barnes AP, Miller BE, Kucera GL. Cyclooxygenase inhibition and hyperthermia for the potentiation of the cytotoxic response in ovarian cancer cells. Gynecol Oncol. 2007 Feb; 104(2):443-50. PMID: 16996114.
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    29. Guddneppanavar R, Saluta G, Kucera GL, Bierbach U. Synthesis, biological activity, and DNA-damage profile of platinum-threading intercalator conjugates designed to target adenine. J Med Chem. 2006 Jun 01; 49(11):3204-14. PMID: 16722638.
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    30. Alexander RL, Greene BT, Torti SV, Kucera GL. A novel phospholipid gemcitabine conjugate is able to bypass three drug-resistance mechanisms. Cancer Chemother Pharmacol. 2005 Jul; 56(1):15-21. PMID: 15789226.
      Citations:    
    31. Alexander RL, Kucera GL. Lipid nucleoside conjugates for the treatment of cancer. Curr Pharm Des. 2005; 11(9):1079-89. PMID: 15853657.
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    32. Xu M, Floyd HS, Greth SM, Chang WC, Lohman K, Stoyanova R, Kucera GL, Kute TE, Willingham MC, Miller MS. Perillyl alcohol-mediated inhibition of lung cancer cell line proliferation: potential mechanisms for its chemotherapeutic effects. Toxicol Appl Pharmacol. 2004 Mar 01; 195(2):232-46. PMID: 14998688.
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    33. Alexander RL, Morris-Natschke SL, Ishaq KS, Fleming RA, Kucera GL. Synthesis and cytotoxic activity of two novel 1-dodecylthio-2-decyloxypropyl-3-phosphatidic acid conjugates with gemcitabine and cytosine arabinoside. J Med Chem. 2003 Sep 11; 46(19):4205-8. PMID: 12954073.
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    34. Barry CG, Turney EC, Day CS, Saluta G, Kucera GL, Bierbach U. Thermally inert metal ammines as light-inducible DNA-targeted agents. Synthesis, photochemistry, and photobiology of a prototypical rhodium(III)-intercalator conjugate. Inorg Chem. 2002 Dec 30; 41(26):7159-69. PMID: 12495358.
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    35. Melvin MS, Tomlinson JT, Park G, Day CS, Saluta GR, Kucera GL, Manderville RA. Influence of the a-ring on the proton affinity and anticancer properties of the prodigiosins. Chem Res Toxicol. 2002 May; 15(5):734-41. PMID: 12018996.
      Citations:    
    36. Stadheim TA, Kucera GL. c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for mitoxantrone- and anisomycin-induced apoptosis in HL-60 cells. Leuk Res. 2002 Jan; 26(1):55-65. PMID: 11734304.
      Citations:    
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