A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)

Descriptor ID	D020386
MeSH Number(s)	C05.651.392 C10.668.402 C10.668.829.425
Concept/Terms	Isaacs Syndrome Isaacs Syndrome Gamstorp-Wohlfart Syndrome Gamstorp Wohlfart Syndrome Gamstorp-Wohlfart Syndromes Syndromes, Gamstorp-Wohlfart Isaacs' Syndrome Isaac Syndrome Isaacs-Mertens Syndrome Isaacs Mertens Syndrome Syndromes, Isaacs-Mertens Myokymia, Myotonia, Muscle Wasting, And Hyperhidrosis Neuromyotonia Pseudomyotonia Pseudomyotonia Syndrome of Isaacs Isaacs Pseudomyotonia Syndrome Quantal Squander Syndrome of Continuous Muscle Activity Continuous Muscle Activity Syndrome Myokymia, Continuous Continuous Myokymia Continuous Myokymias Myokymias, Continuous Acquired Neuromyotonia Acquired Neuromyotonia Neuromyotonia, Acquired

Below are MeSH descriptors whose meaning is more general than "Isaacs Syndrome".

Below are MeSH descriptors whose meaning is related to "Isaacs Syndrome".

Below are MeSH descriptors whose meaning is more specific than "Isaacs Syndrome".