No-Observed-Adverse-Effect Level
"No-Observed-Adverse-Effect Level" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The highest dosage administered that does not produce toxic effects. The NOAEL will depend on how closely dosages are spaced (lowest-observed-adverse-effect level and no-observed-effect level) and the number of animals examined. The ultimate objective is usually to determine not the "safe" dosage in laboratory animals but the "safe" dosage for humans. Therefore, the extrapolation most often required of toxicologists is from high-dosage studies in laboratory animals to low doses in humans. (Casarett and Doull's Toxicology: The Basic Science of Poisons, 4th ed)
| Descriptor ID |
D019055
|
| MeSH Number(s) |
E05.940.600 G07.690.620
|
| Concept/Terms |
No-Observed-Adverse-Effect Level- No-Observed-Adverse-Effect Level
- Level, No-Observed-Adverse-Effect
- Levels, No-Observed-Adverse-Effect
- No Observed Adverse Effect Level
- No-Observed-Adverse-Effect Levels
- NOAEL
No-Observed-Effect Level- No-Observed-Effect Level
- Level, No-Observed-Effect
- Levels, No-Observed-Effect
- No Observed Effect Level
- No-Observed-Effect Levels
- NOEL
|
Below are MeSH descriptors whose meaning is more general than "No-Observed-Adverse-Effect Level".
Below are MeSH descriptors whose meaning is more specific than "No-Observed-Adverse-Effect Level".
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