An X-linked recessive disorder characterized by the accumulation of saturated very long chain fatty acids in the LYSOSOMES of ADRENAL CORTEX and the white matter of CENTRAL NERVOUS SYSTEM. This disease occurs almost exclusively in the males. Clinical features include the childhood onset of ATAXIA; NEUROBEHAVIORAL MANIFESTATIONS; HYPERPIGMENTATION; ADRENAL INSUFFICIENCY; SEIZURES; MUSCLE SPASTICITY; and DEMENTIA. The slowly progressive adult form is called adrenomyeloneuropathy. The defective gene ABCD1 is located at Xq28, and encodes the adrenoleukodystrophy protein (ATP-BINDING CASSETTE TRANSPORTERS).

Descriptor ID	D000326
MeSH Number(s)	C10.228.140.163.100.362.250 C10.228.140.163.100.680.100 C10.228.140.695.625.250 C10.228.518.625.250 C10.314.400.250 C10.597.606.643.455.124 C16.320.322.500.124 C16.320.400.525.124 C16.320.565.189.362.250 C16.320.565.189.680.100 C16.320.565.663.112 C18.452.132.100.362.250 C18.452.132.100.680.100 C18.452.648.189.362.250 C18.452.648.189.680.100 C18.452.648.663.112 C19.053.500.270
Concept/Terms	Adrenoleukodystrophy Adrenoleukodystrophy Adrenoleukodystrophies Schilder-Addison Complex Schilder Addison Complex X-Linked Adrenoleukodystrophy Adrenoleukodystrophies, X-Linked Adrenoleukodystrophy, X-Linked X Linked Adrenoleukodystrophy X-Linked Adrenoleukodystrophies ALD (Adrenoleukodystrophy) ALDs (Adrenoleukodystrophy) Adrenomyeloneuropathy Adrenomyeloneuropathy Adrenomyeloneuropathies

Below are MeSH descriptors whose meaning is more general than "Adrenoleukodystrophy".

Below are MeSH descriptors whose meaning is related to "Adrenoleukodystrophy".

Below are MeSH descriptors whose meaning is more specific than "Adrenoleukodystrophy".