An autosomal dominant familial disorder which presents in infancy or childhood and is characterized by episodes of weakness associated with hyperkalemia. During attacks, muscles of the lower extremities are initially affected, followed by the lower trunk and arms. Episodes last from 15-60 minutes and typically occur after a period of rest following exercise. A defect in skeletal muscle sodium channels has been identified as the cause of this condition. Normokalemic periodic paralysis is a closely related disorder marked by a lack of alterations in potassium levels during attacks of weakness. (Adams et al., Principles of Neurology, 6th ed, p1481)

Descriptor ID	D020513
MeSH Number(s)	C05.651.701.600 C10.668.491.650.600 C16.320.565.618.711.600 C18.452.648.618.711.600
Concept/Terms	Paralysis, Hyperkalemic Periodic Paralysis, Hyperkalemic Periodic Hyperkalemic Periodic Paralyses Paralyses, Hyperkalemic Periodic Periodic Paralyses, Hyperkalemic Periodic Paralysis, Hyperkalemic Adynamia Episodica Hereditaria with or without Myotonia Familial Hyperkalemic Periodic Paralysis Gamstorp Disease Disease, Gamstorp Gamstorp Episodic Adynamy Adynamy, Gamstorp Episodic Episodic Adynamy, Gamstorp Hyperkalemic Periodic Paralysis, Familial Myotonic Periodic Paralysis Myotonic Periodic Paralyses Paralyses, Myotonic Periodic Paralysis, Myotonic Periodic Periodic Paralyses, Myotonic Periodic Paralysis, Myotonic Paralysis, Periodic, Hyperkalemic, Familial Primary Hyperkalemic Periodic Paralysis Sodium Channel Muscle Disease Adynamia Episodica Hereditaria Hyperkalemic Periodic Paralysis Hyperkaliemic Periodic Paralysis Type 2 Hyperkaliemic Periodic Paralysis Type 2

Below are MeSH descriptors whose meaning is more general than "Paralysis, Hyperkalemic Periodic".

Below are MeSH descriptors whose meaning is related to "Paralysis, Hyperkalemic Periodic".

Below are MeSH descriptors whose meaning is more specific than "Paralysis, Hyperkalemic Periodic".