Cholesterol Side-Chain Cleavage Enzyme

"Cholesterol Side-Chain Cleavage Enzyme" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.

Descriptor ID	D002786
MeSH Number(s)	D08.244.453.915.212 D08.811.600.200 D08.811.682.690.708.170.915.212 D08.811.682.690.708.783.212 D12.776.422.220.453.915.212
Concept/Terms	Cholesterol Side-Chain Cleavage Enzyme Cholesterol Side-Chain Cleavage Enzyme Cholesterol Side Chain Cleavage Enzyme 20,22-Desmolase 20,22 Desmolase Cholesterol Desmolase Cytochrome P450 11A1 CYP 11A1 CYP11A1 Cytochrome P-450 CYP11A1 Cytochrome P 450 CYP11A1 Cytochrome P-450(scc) Cytochrome P450scc Cholesterol Monooxygenase (Side-Chain-Cleaving)

Below are MeSH descriptors whose meaning is more general than "Cholesterol Side-Chain Cleavage Enzyme".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Cytochromes [D08.244]
Cytochrome P-450 Enzyme System [D08.244.453]
Steroid Hydroxylases [D08.244.453.915]
Cholesterol Side-Chain Cleavage Enzyme [D08.244.453.915.212]
Enzymes [D08.811]
Multienzyme Complexes [D08.811.600]
Cholesterol Side-Chain Cleavage Enzyme [D08.811.600.200]
Oxidoreductases [D08.811.682]
Oxygenases [D08.811.682.690]
Mixed Function Oxygenases [D08.811.682.690.708]
Cytochrome P-450 Enzyme System [D08.811.682.690.708.170]
Steroid Hydroxylases [D08.811.682.690.708.170.915]
Cholesterol Side-Chain Cleavage Enzyme [D08.811.682.690.708.170.915.212]
Steroid Hydroxylases [D08.811.682.690.708.783]
Cholesterol Side-Chain Cleavage Enzyme [D08.811.682.690.708.783.212]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Hemeproteins [D12.776.422]
Cytochromes [D12.776.422.220]
Cytochrome P-450 Enzyme System [D12.776.422.220.453]
Steroid Hydroxylases [D12.776.422.220.453.915]
Cholesterol Side-Chain Cleavage Enzyme [D12.776.422.220.453.915.212]

Below are MeSH descriptors whose meaning is related to "Cholesterol Side-Chain Cleavage Enzyme".

Below are MeSH descriptors whose meaning is more specific than "Cholesterol Side-Chain Cleavage Enzyme".

publications

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